The effect of fluoride modified TiO2 scaffolds on bone cells and in vivo bone regeneration
About the project
In the present project titanium dioxide (TiO2) has been chosen as bone- graft substitute material. This material has proven to fulfil many of the demands for a bone- graft substitute material. TiO2 has shown to be biocompatible, enhance bone and vascular ingrowth and to have a certain degree of bacteriostatic effect. One of the major obstacles with a bone- graft substitute is its function as load bearing device, so also with TiO2 bone- graft substitutes.
However, initial testing in our laboratory with the so- called polymer sponge method has shown that it is possible to produce porous structures with this material, where porous bone- graft materials have had compressive strength above 2 MPa. We are interested in the effect of fluoride modified TiO2 scaffolds on bone cells and in vivo bone regeneration.