Quartz crystal microbalance with dissipation
The Q-Sense E4 is based on the quartz crystal microbalance with dissipation technology, which takes advantage of the piezoelectric character of quartz in order to characterize the formation and structural properties of thin films in real time. This is done by simultaneously measuring the changes in the resonant frequency related to the mass/thickness of the film in contact with the surface and energy dissipation associated with the rheological properties of the adsorbed film, induced by adsorption/desorption processes or by structural changes produced within the thin film.
The 4-sensor chambers of the Q-Sense E4 enable the performance of four simultaneous measurements under controlled experimental conditions (temperature, flow rate…) increasing reproducibility and decreasing experiments duration. Also, different coatings (gold, silicon dioxide, titanium, hydroxyapatite…) can be used, broadening the application field of the technique.
QCM-D is a very useful method for studying the behavior of biomolecules, polymers and nanoparticles at the liquid-solid interface, which makes it a very powerful technique in research areas such as biomedicine (biomaterials, drug delivery and cellular and molecular biology) and environmental sciences (biosensing).