Linda Hildegard Bergersen

Professor - Faculty of Dentistry
Image of Linda Hildegard Bergersen
Norwegian version of this page
Phone +47-22840288
Mobile phone +47-97032049
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Visiting address Geitmyrsveien 69 0455 OSLO
Postal address Postboks 1142 Blindern 0318 OSLO

Academic interests

My overarching interest is signaling and energy supply in excitable tissue, in normal and pathological conditions.

Main projects:

  • Molecular investigations of synaptic and glial function by light and electron microscopic immunocyto-chemistry and molecular cell biology approaches (J Neurosci 1997; Eur J Neurosci 2003; J Comp Neurol 2004; Neuroscience 2005; Nat Neurosci 2007; Nat Protoc 2008; J Appl Physiol 2009ab; Cereb Cortex 2009, 2011). Collaborators include Andrea Voterra, University of Lausanne. A main focus of interest is monocarboxylate transport (Neuroscience 1999; Exp Brain Res 2001; Cereb Cortex 2005; Neuroscience 2006; review Neuroscience 2007; J Neurosci 2011).
  • Combined patch-clamp electrophysiology, fluorescent pH imaging and electron microscopy to clarify the roles of lactate and neurotransmitter receptors in myelin: multidisciplinary collaboration with David Attwell, University College London (joint papers in Nature 2005 and J Neurosci 2011).
  • ADHD animal model studies. Collaborators include Terje Sagvolden (deceased 2011), and Øyvind Hvalby, Dep of Physiology, UiO, on neurotransmitter receptors (joint papers Neuropharmacology 2009; Neuroscience 2009; Neuroscience 2011).
  • Epilepsy in patients and rat models, changes in lactate transport. Collaboration with Tore Eid, Yale University Medical School (Neurobiol Dis 2011; Neurobiol Dis 2012).
  • DNA repair and dementia: collaboration with Magnar Bjørås, Rikshospitalet. Transgenic mice lacking different glycosylases show synaptic alterations in the hippocampal formation (IARU Congress 2010; Submitted 2012).
  • Transgenic mice models to explore mtDNA dependent mitochondrial dysfunction in dementia: collaboration with Arne Klungland, Rikshospitalet, and Lene Juel Rasmussen, Center of Healthy Aging, University of Copenhagen. Neuronal dysfunction caused by mitochondria-specific damage after inducible expression of a mutated mtDNA repair enzyme (Mol Cell Biol 2009; DNA Repair 2011).
  • Roles of MCTs in different tumor cells under hypoxic conditions. Collaboration with Erik O Pettersen, Department of Physics, UiO (Submitted 2011).
  • Mitochondria in myelin? Postdoc JE Rinholm (RCN fellowship 2012-14 as one of four awarded among 64 applicants) uses super-resolution imaging technique (structured illumination microscopy, SIM) to test the hypothesis that mitochondria are located in cytoplasmic loops in myelin. Collaboration with David A Clayton, Howard Hughes Medical Institute, Janelia Farm, Ashburn VA (Rinholm JE et al. In preparation).
  • Theoretical investigations into the roles of lactate in the brain. Collaboration with Albert Gjedde, University of Copenhagen (Submitted 2012).

Select key publications are indicated, see extensive list.

Courses taught

  • Medical curriculum, 4th Semester, Locomotion, Anatomy (in Norwegian only)
  • MBV4340 - Advanced neurobiology
  • MBV9340 - Advanced neurobiology

Background

Scientific employment and service, after the PhD:

  • 2011-: Associate Professor and Leader (from 2010) of the Synaptic Neurochemistry Laboratory (SN-Lab), Department of Anatomy, Institute of Basic Medical Sciences (IMB, http://www.med.uio.no/imb/english) and Centre for Molecular Biology and Neuroscience (CMBN, http://www.cmbn.no), University of Oslo (UiO).
  • 2011-: Professor Neurobiology of Aging (part-time post, initially sponsored by a Lundbeckfonden’s Visiting Porofessorship grant) at the Center for Healthy Aging (CEHA, Molecular Aging, http://healthyaging.ku.dk) and the Department of Neuroscience and Pharmacology (INF, http://inf.ku.dk), Panum Institute, Faculty of Health Sciences, University of Copenhagen (International Alliance of Research Universities, IARU).
  • 2004 -: Leader of the “Brain and Muscle Energy Group” in the field of mechanisms underlying synaptic transmission and energy metabolism in brain and skeletal muscle. Employed as Senior Researcher, IMB, UiO 2004 - 2010.
  • 2002-2004: Postdoc (grant from the Research Council of Norway, RCN) at the Synaptic Neurochemistry Laboratory (SN-Lab), Department of Anatomy, and CMBN, UiO, and including a one year study period in Lausanne, Switzerland, 2003.
  • 2001-2002: Postdoc at the the Neurotransporter Group, CMBN, UiO.

Scientific education:

  • 2003 abroad: Postdoc training one year in the laboratory of Professor Pierre Magistretti, Institute of Physiology, University of Lausanne, Switzerland.
  • 2002&2004: Postdoc in the lab of Professor Jon Storm-Mathisen, Department of Anatomy, UiO.
  • 2001-2002: Postdoctoral training in the lab of Professor Niels Christian Danbolt, Department of Anatomy, UiO.
  • 2001 PhD: PhD dissertation “Monocarboxylate transporters in excitable tissue” 9th of March 2001.
  • 1995-2000: PhD student at the Anatomical Institute, UiO under the supervision of Professor Ole Petter Ottersen from December 1995 to December 2000 (I had maternity leave for one year, 1996-1997, i.e. dissertation completed on scheduled time).
  • 1994 MSc: Master degree on the work “Quantitative determination of cell surface beta-adrenoceptors in different rat skeletal muscles” at the University of Sport and Physical Education, Oslo.

Other web pages

Awards

  • Lundbeckfonden’s Visiting Professorship, Univ Copenhagen, 2011.
  • CMBN Career Development Award 2009.
  • Professor Kristen Kjelsberg Osen Prize for Young Neuroscientists 2006.
  • The RCN funded my 2010 proposal to FRIBO as one of 23 selected among 247 applications for researcher grants. The evaluator panel stated: ‘..the panel unanimously decided second place for this excellent project due to its originality, novelty, excellent working plan and background of PI.’

Positions held

  • Leader of the Medical Faculty’s Equal Opportunities Commission 2010-2011, menber 2010-2014.
  • Evaluator Akademiska Kollegors Ansvar (AKKA): Genusintegrerat ledarskapsprogram, Lund University, monthly meetings 2011-2012.
  • Member of the Medical Faculty’s committee for grant and trust funds (2006-2009).

Collaboration

 

Tags: Brain and nervous system, Signal transmission in the nervous system, Brain metabolism, Physical activity and brain function

Publications

  • Saeed, Muhammad; Rafiq, Sikander; Bergersen, Linda Hildegard & Deng, Liyuan (2017). Tailoring of Water swollen PVA membrane for hosting carriers in CO2 facilitated transport membranes. Separation and Purification Technology.  ISSN 1383-5866.  179, s 550- 560 . doi: 10.1016/j.seppur.2017.02.022
  • Hamilton, Nicola; Clarke, Laura E.; Arancibia-Carcamo, IL; Kougioumtzidou, E; Matthey, Moritz; Karadottir, Ragnhildur; Whiteley, Louise; Bergersen, Linda Hildegard; Richardson, William D. & Attwell, David (2016). Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internodelength. Glia.  ISSN 0894-1491. . doi: 10.1002/glia.23093
  • Holm-Hansen, Signe; Low, J.K.; Zieba, J; Gjedde, A.; Bergersen, Linda Hildegard & Karl, Tim (2016). Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1. Genes, Brain and Behavior.  ISSN 1601-1848.  15(3), s 295- 304 . doi: 10.1111/gbb.12267
  • Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan, Mahdi; Diget, Elisabeth Holm; Vohra, Rupali; Gurubaran, Iswariya Raja Sridevi; Gjedde, Albert; Mariga, Shelton Tendai; Skytt, Dorte M.; Utheim, Tor Paaske; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). Lactate transport and receptor actions in retina: potential roles in retinal function and disease. Neurochemical Research.  ISSN 0364-3190.  41(6), s 1229- 1236 . doi: 10.1007/s11064-015-1792-x
  • Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging.  ISSN 0197-4580.  48, s 34- 47 . doi: 10.1016/j.neurobiolaging.2016.08.005
  • Rinholm, Johanne Egge; Vervaeke, Koen Gerard Alois; Tadross, Michael; Tkachuk, Ariana; Kopek, Benjamin; Brown, Timothy A; Bergersen, Linda Hildegard & Clayton, David A (2016). Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths . Glia.  ISSN 0894-1491.  64(5), s 810- 825 . doi: 10.1002/glia.22965
  • Skytt, D. M.; Toft-Kehler, A. K.; Brændstrup, C. T.; Cejvanovic, S.; Gurubaran, I. S.; Bergersen, Linda Hildegard & Kolko, M. (2016). Glia-neuron interactions in the retina can be studied in cocultures of Müller cells and retinal ganglion cells. BioMed Research International.  ISSN 2314-6133.  2016 . doi: 10.1155/2016/1087647
  • Bergersen, Linda Hildegard (2015). Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  35(2), s 176- 185 . doi: 10.1038/jcbfm.2014.206
  • Gundersen, Vidar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Neuroglial transmission. Physiological Reviews.  ISSN 0031-9333.  95(3), s 695- 726 . doi: 10.1152/physrev.00024.2014
  • Lauritzen, Fredrik; Eid, Tore & Bergersen, Linda Hildegard (2015). Monocarboxylate transporters in temporal lobe epilepsy: roles of lactate and ketogenic diet . Brain Structure and Function.  ISSN 1863-2653.  220(1), s 1- 12 . doi: 10.1007/s00429-013-0672-x
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Øyvind Pernell; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  309(3), s H434- H449 . doi: 10.1152/ajpheart.00253.2014
  • Morland, Cecilie; Lauritzen, Knut Husø; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Andersson, Krister; Gjedde, Albert; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of Neuroscience Research.  ISSN 0360-4012.  93(7), s 1045- 1055 . doi: 10.1002/jnr.23593
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology.  ISSN 0955-3002.  90(7), s 527- 537 . doi: 10.3109/09553002.2014.906767
  • Knudsen Scheibye, Morten; Mitchell, SJ; Fang, EF; Iyama, T; Ward, T.; Wang, J; Dunn, CA; Singh, N; Veith, S; Hasan-Olive, MM; Mangerich, A; Wilson, MA; Mattson, MP; Bergersen, Linda Hildegard; Cogger, VC; Warren, A; Le Couteur, DG; Moaddel, R; Wilson, DM; Croteau, DL; de Cabo, R & Bohr, VA (2014). A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. Cell Metabolism.  ISSN 1550-4131.  20(5), s 840- 855 . doi: 10.1016/j.cmet.2014.10.005
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn; Lauritzen, Fredrik; Attramadal, Håvard; Storm-Mathisen, Jon; Gjedde, Albert & Bergersen, Linda Hildegard (2014). Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex. Cerebral Cortex.  ISSN 1047-3211.  s 2784- 2795 . doi: 10.1093/cercor/bht136
  • Mariga, Shelton T.; Kolko, Miriam; Gjedde, Albert & Bergersen, Linda Hildegard (2014). Lactate transport and receptor actions in cerebral malaria. Frontiers in Neuroenergetics.  ISSN 1662-6427.  6(MAY) . doi: 10.3389/fnins.2014.00125
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2014). White matter lactate - Does it matter?. Neuroscience.  ISSN 0306-4522.  276, s 109- 116 . doi: 10.1016/j.neuroscience.2013.10.002
  • Bergersen, Linda Hildegard; Bramham, Clive R.; Hugdahl, Kenneth; Sander, Miriam & Storm-Mathisen, Jon (2013). The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. Neuroscience.  ISSN 0306-4522.  247, s 412- 422 . doi: 10.1016/j.neuroscience.2013.04.012
  • Eid, Tore; Lee, Tih-Shih W.; Wang, Yue; Perez, Edgar; Drummond, Jana; Lauritzen, Fredrik; Bergersen, Linda Hildegard; Meador-Woodruff, James H.; Spencer, Dennis D.; de Lanerolle, Nihal C. & McCullumsmith, Robert E. (2013). Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy. Epilepsia.  ISSN 0013-9580.  54(2), s 228- 238 . doi: 10.1111/epi.12008
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn; Lauritzen, Fredrik; Attramadal, Håvard; Storm-Mathisen, Jon; Gjedde, Albert & Bergersen, Linda Hildegard (2013). Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism. Cerebral Cortex.  ISSN 1047-3211. . doi: 10.1093/cercor/bht136
  • Medin, Tirill; Rinholm, Johanne Egge; Owe, Simen Gylterud; Sagvolden, Terje; Gjedde, A.; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2013). LOW DOPAMINE D5 RECEPTOR DENSITY IN HIPPOCAMPUS IN AN ANIMAL MODEL OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD). Neuroscience.  ISSN 0306-4522.  242, s 11- 20 . doi: 10.1016/j.neuroscience.2013.03.036
  • Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood; Bergersen, Linda Hildegard; Bjaalie, Jan G.; Eriksson, Jens; Gundersen, Vidar; Leergaard, Trygve Brauns; Morth, Jens Preben; Storm-Mathisen, Jon; Torp, Reidun; Walhovd, Kristine B & Tønjum, Tone (2013). The glia doctrine: Addressing the role of glial cells in healthy brain ageing. Mechanisms of Ageing and Development.  ISSN 0047-6374.  134(10), s 449- 459 . doi: 10.1016/j.mad.2013.10.001
  • Puchades, Maja Amedjkouh; Sogn, Carl Johan; Mæhlen, Jan; Bergersen, Linda Hildegard & Gundersen, Vidar (2013). Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease. Parkinson's Disease.  ISSN 2090-8083.  3(3), s 371- 385 . doi: 10.3233/JPD-130190
  • Rasmussen, Lene Juel; Shiloh, Y.; Bergersen, Linda Hildegard; Sander, Miriam; Bohr, Vilhelm A. & Tønjum, Tone (2013). DNA damage response, bioenergetics, and neurological disease: The challenge of maintaining brain health in an aging human population. Mechanisms of Ageing and Development.  ISSN 0047-6374.  134(10), s 427- 433 . doi: 10.1016/j.mad.2013.05.001
  • Rodell, Anders; Rasmussen, Lene Juel; Bergersen, Linda Hildegard; Singh, KK & Gjedde, Albert (2013). Natural selection of mitochondria during somatic lifetime promotes healthy aging . Frontiers in Neuroenergetics.  ISSN 1662-6427. . doi: 10.3389/fnene.2013.00007
  • Bergersen, Linda Hildegard & Gjedde, Albert (2012). Is lactate a volume transmitter of metabolic states of the brain?. Frontiers in Neuroenergetics.  ISSN 1662-6427.  5(4)
  • Bergersen, Linda Hildegard; Morland, Cecilie; Ormel, Lasse; Rinholm, Johanne Egge; Larsson, Max David; Wold, Johan Fredrik Hustad; Røe, Åsmund Treu; Stranna, Andrea; Santello, M; Bouvier, David; Ottersen, Ole Petter; Volterra, Andrea & Gundersen, Vidar (2012). Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes. Cerebral Cortex.  ISSN 1047-3211.  22(7), s 1690- 1697 . doi: 10.1093/cercor/bhr254
  • Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Gao, Xiaoqun & Bergersen, Linda Hildegard (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology.  ISSN 1570-5870.  35(3), s 217- 227 . doi: 10.1007/s13402-012-0081-9
  • Lauritzen, Fredrik; Heuser, Kjell; de Lanerolle, Nihal C.; Lee, Tih-Shih W.; Spencer, Dennis D.; Kim, Jung H.; Gjedde, Albert; Eid, Tore & Bergersen, Linda Hildegard (2012). Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. Glia.  ISSN 0894-1491.  60(7), s 1172- 1181 . doi: 10.1002/glia.22344
  • Lauritzen, Fredrik; Perez, Edgar L.; Melillo, Eric R.; Roh, Jung-Min; Zaveri, Hitten P.; Lee, Tih-Shih W.; Wang, Yue; Bergersen, Linda Hildegard & Eid, Tore (2012). Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. Neurobiology of Disease.  ISSN 0969-9961.  45(1), s 165- 176 . doi: 10.1016/j.nbd.2011.08.001
  • Ormel, Lasse; Stensrud, Mats Julius; Bergersen, Linda Hildegard & Gundersen, Vidar (2012). VGLUT1 is localized in astrocytic processes in several brain regions. Glia.  ISSN 0894-1491.  60(2), s 229- 238 . doi: 10.1002/glia.21258
  • Perez, Edgar L.; Lauritzen, Fredrik; Wang, Yue; Lee, Tih-Shih W.; Kang, Dewey; Zaveri, Hitten P.; Chaudhry, Farrukh Abbas; Ottersen, Ole Petter; Bergersen, Linda Hildegard & Eid, Tore (2012). Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy. Neurobiology of Disease.  ISSN 0969-9961.  47(3), s 331- 337 . doi: 10.1016/j.nbd.2012.05.010
  • Regnell, Christine E; Hildrestrand, Gunn Annette; Sejersted, Yngve; Medin, Tirill; Moldestad, Olve; Rolseth, Veslemøy; Krokeide, Silje Zandstra; Suganthan, Rajikala; Luna, Luisa; Bjørås, Magnar & Bergersen, Linda Hildegard (2012). Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells. Cell reports.  ISSN 2211-1247.  2(3), s 503- 510 . doi: 10.1016/j.celrep.2012.08.008
  • Vafaee, Manouchehr S; Vang, Kim; Bergersen, Linda Hildegard & Gjedde, Albert (2012). Oxygen consumption and blood flow coupling in human motor cortex during intense finger tapping:implication for a role of lactate. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  32(10), s 1859- 1868 . doi: 10.1038/jcbfm.2012.89
  • Lauritzen, Fredrik; de Lanerolle, Nihal; Lee, Tih-Shih W.; Spencer, Dennis D.; Kim, Jung H.; Bergersen, Linda Hildegard & Eid, Tore (2011). Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiology of Disease.  ISSN 0969-9961.  41(2), s 577- 584
  • Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair.  ISSN 1568-7864.  10(6), s 639- 653 . doi: 10.1016/j.dnarep.2011.04.011
  • Medin, Tirill; Owe, Simen Gylterud; Rinholm, Johanne Egge; Larsson, Max; Sagvolden, Terje; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2011). Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus. Neuroscience.  ISSN 0306-4522.  192, s 164- 171 . doi: 10.1016/j.neuroscience.2011.06.056
  • Rinholm, Johanne Egge; Hamilton, Nicola; Kessaris, Nicoletta; Richardson, William D.; Bergersen, Linda Hildegard & Attwell, David (2011). Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate. Journal of Neuroscience.  ISSN 0270-6474.  31(2), s 538- 548 . doi: 10.1523/JNEUROSCI.3516-10.2011
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute; Storm, Johan Frederik; Mansuy, Isabelle M.; Bergersen, Linda Hildegard & Klungland, Arne (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology.  ISSN 0270-7306.  30(6), s 1357- 1367 . doi: 10.1128/MCB.01149-09
  • Raastad, Truls; Owe, Simen Gylterud; Paulsen, Gøran; Enns, Deborah; Overgaard, Kristian; Crameri, R; Kiil, Steinar; Belcastro, Angelo; Bergersen, Linda Hildegard & Hallén, Jostein (2010). Changes in Calpain Activity, Muscle Structure, and Function after Eccentric Exercise . Medicine & Science in Sports & Exercise.  ISSN 0195-9131.  42(1), s 86- 95 . doi: 10.1249/MSS.0b013e3181ac7afa
  • Paulsen, G; Lauritzen, Fredrik; Bayer, ML; Kalhovde, JM; Ugelstad, I; Owe, Simen Gylterud; Hallén, Jostein; Bergersen, Linda Hildegard & Raastad, T (2009). Subcellular movement and expression of HSP27, alpha beta-crystallin, and HSP70 after two bouts of eccentric exercise in humans. Journal of applied physiology.  ISSN 8750-7587.  107(2), s 570- 582 . doi: 10.1152/japplphysiol.00209.2009
  • Bergersen, Linda Hildegard & Gundersen, Vidar (2009). MORPHOLOGICAL EVIDENCE FOR VESICULAR GLUTAMATE RELEASE FROM ASTROCYTES. Neuroscience.  ISSN 0306-4522.  158(1), s 260- 265 . doi: 10.1016/j.neuroscience.2008.03.074
  • Jensen, Vidar; Rinholm, Johanne Egge; Johansen, Tine Jeanette; Medin, Tirill; Storm-Mathisen, Jon; Sagvolden, Terje; Hvalby, Øyvind Christian & Bergersen, Linda Hildegard (2009). N-methyl-d-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder . Neuroscience.  ISSN 0306-4522.  158(1), s 353- 364 . doi: 10.1016/j.neuroscience.2008.05.016
  • Lauritzen, Fredrik; Paulsen, Gøran; Raastad, T.; Bergersen, Linda Hildegard & Owe, Simen Gylterud (2009). Gross ultrastructural changes and necrotic fiber segments in elbow flexor muscles after maximal voluntary eccentric action in humans. Journal of applied physiology.  ISSN 8750-7587.  107(6), s 1923- 1934 . doi: 10.1152/japplphysiol.00148.2009
  • Lauritzen, Fredrik; Paulsen, Gøran; Raastad, Truls; Bergersen, Linda Hildegard & Owe, Simen Gylterud (2009). Gross ultrastructural changes and necrotic fiber segments in elbow flexor muscles after maximal voluntary eccentric action in humans. Journal of applied physiology.  ISSN 8750-7587.  107(6), s 1923- 1934
  • Martinov, Vladimir Nikolkaev; Rizvi, Syed Mohammad H.; Sagave, Julia Fritzi; Bergersen, Linda Hildegard & Valen, Guro (2009). Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated perfused mouse hearts. Life Sciences.  ISSN 0024-3205.  85, s 379- 385
  • Owe, Simen Gylterud; Jensen, Vidar; Evergren, E; Ruiz, A; Shupliakov, O; Kullmann, DM; Storm-Mathisen, Jon; Walaas, S. Ivar; Hvalby, Øyvind Christian & Bergersen, Linda Hildegard (2009). Synapsin- and Actin-Dependent Frequency Enhancement in Mouse Hippocampal Mossy Fiber Synapses. Cerebral Cortex.  ISSN 1047-3211.  19(3), s 511- 523 . doi: 10.1093/cercor/bhn101
  • Paulsen, Gøran; Lauritzen, Fredrik; Bayer, Monica; Kalhovde, John Magne; Ugelstad, Ingrid; Owe, Simen Gylterud; Hallén, Jostein; Bergersen, Linda Hildegard & Raastad, Truls (2009). Subcellular movement and expression of HSP27, alpha beta-crystallin, and HSP70 after two bouts of eccentric exercise in humans. Journal of applied physiology.  ISSN 8750-7587.  107(2), s 570- 582
  • Sagvolden, Terje; Johansen, Espen Borgå; Wøien, Grete; Walaas, S Ivar; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Hvalby, Øivind; Jensen, Vidar; Aase, Heidi; Russell, Vivienne A; Killeen, Peter R; DasBanerjee, Tania; Middleton, Frank A. & Faraone, Stephen V (2009). The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain. Neuropharmacology.  ISSN 0028-3908.  57(7-8), s 619- 626 . doi: 10.1016/j.neuropharm.2009.08.004
  • Sander, M; Bergersen, Linda & Storm-Mathisen, Jon (2009). Molecular approaches to understanding neural network plasticity and memory: the Kavli Prize Inaugural Symposium on Neuroscience. Neuroscience.  ISSN 0306-4522.  163(4), s 965- 976 . doi: 10.1016/j.neuroscience.2009.07.046

View all works in Cristin

View all works in Cristin

  • Bergersen, Linda Hildegard (2016). Exercise induces brain VEGFA and angiogenesis through the lactate receptor.
  • Bergersen, Linda Hildegard (2016). Hvor ligger forskningsfronten innen demens nå? Hva vet vi og hva vet vi ikke?.
  • Bergersen, Linda Hildegard (2016). "Lactate transport and receptor action in the brain: rescue of cognitive decline”.
  • Bergersen, Linda Hildegard (2016). Novel mechanism for exercise‐induced angiogenesis in the brain.
  • Bergersen, Linda Hildegard (2016). The brain has a lactate receptor..
  • Bergersen, Linda Hildegard (2016). The lactate receptor is important for brain vascularization.
  • Hadzic, Alena; Andersson, Krister; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Stølen, Tomas; Wisløff, Ulrik; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Lactate receptor HCAR1 mediates synaptic plasticity.
  • Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan-Olive, Md Mahdi; Diget, Elisabeth Holm; Vohra, Rupali; Gurubaran, Iswariya Raja Sridevi; Gjedde, Albert; Mariga, Shelton Tendai; Skytt, Dorte M.; Utheim, Tor Paaske; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). Erratum to: Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease. Neurochemical Research.  ISSN 0364-3190.  41(6), s 1237- 1237 . doi: 10.1007/s11064-016-1916-y
  • Moretti, Laura; Stølen, Tomas; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Effects of intrinsic fitness level on mitochondria during exercise.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Elisabeth, Holm Diget; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Bergersen, Linda Hildegard (2015). Clinical use of lactate monitoring in malaria.
  • Bergersen, Linda Hildegard (2015). Exercise in healthy aging.
  • Bergersen, Linda Hildegard (2015). Gir melkesyre bedre hjernehelse?.
  • Bergersen, Linda Hildegard (2015). Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body-Brain Interaction.
  • Bergersen, Linda Hildegard (2015). Lactate transport and receptor actions in cerebral malaria.
  • Bergersen, Linda Hildegard (2015). Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction.
  • Bergersen, Linda Hildegard (2015). Monocarboxylate transporters and lactate receptor expression and function in the brain.
  • Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Eide, Lars; Tønseth, Kim Aleksander; Bergersen, Linda Hildegard; Dartt, Darlene A.; Griffith, May & Utheim, Tor Paaske (2015). Storage of cultured skin cell sheets for treatment of limbal stem cell deficiency.
  • Larsson, Max; Bergersen, Linda Hildegard & Gundersen, Vidar (2015). Immunogold electron microscopic quantification of small molecular compounds and proteins at synapses and other neural profiles, In Adalberto Merighi & Laura Lossi (ed.),  Immunocytochemistry and related techniques.  Springer.  ISBN 978-1-4939-2312-0.  protokoll, kapittel 15.  s 281 - 297
  • Bergersen, Linda Hildegard (2014). A ketogenic diet accelerates neurodegeneration in forebrain neurons during mitochondrial DNA toxicity.
  • Bergersen, Linda Hildegard (2014, 13. januar). I FORM ekspert med spesiale: Sunn aldring . [Internett].  iFORM.nu.
  • Bergersen, Linda Hildegard (2014). Lactate as messenger in the CNS.
  • Bergersen, Linda Hildegard (2014). Lactate receptor in the brain.
  • Bergersen, Linda Hildegard (2014). Mutasjon i transportørgen kan gi ketoacidose. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  134(23/24), s 2257- 2257 . doi: 10.4045/tidsskr.14.1326
  • Bergersen, Linda Hildegard (2014, 17. januar). Professor i fysiologi och expert på sunt åldrande . [Internett].  iform.se - expertpanelen.
  • Bergersen, Linda Hildegard (2014, 16. januar). Professor i fysiologi, ekspert i sund aldring . [Internett].  iform.dk - advisory-board.
  • Bergersen, Linda Hildegard (2014). The brain lactate receptor – does it matter in cognitive impairment.
  • Bergersen, Linda Hildegard (2014). Trening for et bedre og lengre liv - Hjerne og trening.
  • Bergersen, Linda Hildegard (2014). Trening for hjernehelse.
  • Bergersen, Linda Hildegard & Eid, Tore (2014). Monocarboxylate transport matters. New England Journal of Medicine.  ISSN 0028-4793.  371(20), s 1931- 1932 . doi: 10.1056/NEJMe1411903
  • Bergersen, Linda Hildegard (2013). How to implement brain research methods in exercise medicine? Lactate as a signal substance. How does physical exercise translate onto better brains?.
  • Bergersen, Linda Hildegard (2013). Lactate is a volume transmitter – 'New Deal' for understanding brain function and brain disease.
  • Bergersen, Linda Hildegard (2013). Lactate receptor in the Brain.
  • Bergersen, Linda Hildegard (2013, 01. oktober). Laktat har signalfunksjon i hjernen . [Fagblad].  Tidsskrift for Den norske legeforening.
  • Bergersen, Linda Hildegard (2013). Melkesyre har en egen reseptor i hjernen- viktig for den aldrende hjernen?.
  • Bergersen, Linda Hildegard (2013). Views from new research group Leader: how to succeed as leader and to build a new group?.
  • Bergersen, Linda Hildegard (2012). Lactate, a volume transmitter in the brain.
  • Bergersen, Linda Hildegard (2012). Mitochondrial DNA damage in hippocampus.
  • Bergersen, Linda Hildegard; Lauritzen, Knut Husø; Lauritzen, Fredrik; Puchades, Maja Amedjkouh & Gjedde, Albert (2012). Lactate receptor locations link neurotransmission, neurovascular coupling, and brain energy metabolism. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  32, s S183- S183
  • Bergersen, Linda Hildegard & Storm-Mathisen, Jon (2012). Kavliprisvinnerne i nevrovitenskap 2012 (Cover illustration / story). NSB-nytt.  36(4), s 6- 8
  • Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng; Vollan, Hilde Synnøve; Görlach, Agnes; Reger, Katharina & Ebbesen, Peter (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
  • Gjedde, Albert; Kumakura, Yoshitaka & Bergersen, Linda Hildegard (2012). Modulation of brain activity by DOPAergic volume transmission. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  32, s S93- S93
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2012). The wrap that feeds neurons. Nature.  ISSN 0028-0836.  487(7408), s 435- 436 . doi: 10.1038/487435a
  • Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2012). Unikard oppstart - hjertet og hjernen.
  • Bergersen, Linda Hildegard; Sander, M. & Storm-Mathisen, Jon (2011). What the nose knows, what the eyes see, how we feel, how we learn, how we understand motor acts, why “YY” is essential for ion transport, how epigenetics meet neurobiology in Rett syndrome: seven topics at the 2010 Kavli Prize Symposium on Neuroscience. Neuroscience.  ISSN 0306-4522.  190, s 1- 11 . doi: 10.1016/j.neuroscience.2011.05.036
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes; Bergersen, Linda Hildegard & Pettersen, Erik O (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Ormel, Lasse; Volterra, A; Bergersen, Linda Hildegard & Gundersen, Vidar (2009). VGLUT1 IS PRESENT IN CORTICAL, HIPPOCAMPAL AND STRIATAL ASTROCYTES. Glia.  ISSN 0894-1491.  57(13), s S42- S42
  • Rinholm, Johanne Egge; Hamilton, NB; Ianarelli, P; Kessaris, N; Richardson, WD; Bergersen, Linda Hildegard & Attwell, David (2009). LACTATE TRANSPORTERS IN DEVELOPING OLIGODENDROCYTES. Glia.  ISSN 0894-1491.  57(13), s S113- S113

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Published June 24, 2013 11:16 AM - Last modified May 11, 2017 12:10 PM