Thomas Michel Kuntziger

Bilde av Thomas Michel Kuntziger
English version of this page
Telefon +47-22840383
Brukernavn
Besøksadresse Sognsvannsveien 10 Domus Odontologica 0372 OSLO
Postadresse Postboks 1052 Blindern 0316 OSLO

Education

1996-2001         Ph.D. in Cell and Molecular Biology

  • Dr Michel Bornens’ group, Institut Curie / CNRS, Paris, France.
  • Thesis: “On some aspects of microtubule dynamics and centrosome duplication in Xenopus oocytes” obtained summa cum laude (Très honorable avec félicitations).

1992-1996        École Normale Supérieure (ENS) de Cachan, Cachan, France.

1989-1992        Lycée Lakanal, Sceaux, France.

1989                 Baccalauréat, Lycée Henri IV, Paris, France.

 

Work experience

2015-present      Associate Professor (Førsteamanuensis)

  • Department of Oral Biology, University of Oslo, Norway.
  • Research area: epigenetic mechanisms in cancer progression.
  • 24 referenced publications (h index = 15, Google Scholar).

2001-2015          Postdoc and Senior Scientist

  • Professor P. Collas’ group, Institute of Basic Medical Sciences (IMB) and Norwegian Center for Stem Cell Research, University of Oslo, Norway.
  • Research area: nuclear anchoring proteins.
  • In charge of the microscopy resources (three live cell imaging stations).

 

Fellowships and awards

2016                      Faculty of Dentistry (UiO) research grant (Mitotic roles of AKAP95 in chromosomal instability): 11 k€.

2015                      Kreftforeningen Running Costs project (AKAP95 in chromosomal instability and cancer gene bookmarking; 6858142): 20 k€.

2014                      Coordinated and wrote “NuArch: Nuclear Architecture in the regulation of autophagy, DNA repair and gene expression » European Economic Association (EEA) grant project in the frame of the Czech-Norwegian Research Programme (3 years): 1000 k€

2002                      Marie Curie Individual Fellowship MCFI-2001-01266, European Commission, Brussels, Belgium.

2001                      Scientific funding for post-doctoral stay abroad, Fondation pour la Recherche Médicale, Paris, France.

1992                      Selective stipend from the French National Education Ministry to study at ENS de Cachan (4 years).

 

Teaching and supervision experience:

  • Supervisor of:
    • two Ph.D. students (two completed: M. Rogne, 2 first and 1 second authorships; G. Lopez-Soop: 1 first authorship);
    • one postdoc (H.B. Landsverk, 1 first and 1 second authorship);
    • two lab engineers/Master students (A. Rogala: 1 third authorship).
  • Co-supervisor of:
    • two Ph.D. student (two completed: H.B. Landsverk, 2 first and 1 second authorships);
    • one postdoc (E. Delbarre, 3 first and 1 second authorships).
  • General Metabolism lectures, Problem-based learning (PBL) and teacher-led small group courses (LSB) to first-year medical faculty students.
  • Courses in “Gene Regulation and Epigenetics” and “Genome Browsing” to first-year medical faculty students (2014-2015).
  • Representative member of the first-year medical faculty examination commission.
  • Courses in “Techniques in Microscopy” to Master in Biomedicine students at Oslo and Akershus University College of Applied Sciences, Oslo, Norway.
  • Theoretical and practical courses in Cell Biology to bachelor and master students at the Paris VI University, France (1996-2001).

 

Referee experience:

  • PhD evaluation committees: Catholic University of Leuven (Belgium) and University of Oslo.
  • Scientific expert for the Luxembourg National Research Fund (FNR), for the Wallonie National Scientific Research Fund (FNRS) and for the Research Foundation – Flanders (FWO); panel member for the FNR (2012-2015).
  • Referee for Biochemical Journal, Biochemical Society Transactions, Bioinformatics, Cell Biology and Toxicology, Experimental Cell Research, FEBS Journal, European Journal of Cell Biology, PLOS Genetics.

 

Outreach:

  • Life Science Lunch seminar organized by the Science Library and UiO:Life Science (16/11/2016)

 

Courses and training

2017                     Basic Pedagogical Requirements (Pedagogisk Basiskompetanse); Academic Development Unit (FUP), Oslo University, Norway.

2012                     Next-generation sequencing hands-on course; Microarray and Sequencing Core Facility, Oslo University Hospital, Norway.

 2005                     Digital Imaging in Biology, Université Paris VI, France.

2003                     EMBO Course: “Deciphering Chromosomes by Chromatin Immunoprecipitation, Institute of Genetics and Biophysics, Naples. Italy.

 1993                     Internship in the laboratory of Dr D. Louvard, Institut Pasteur, Paris, France.

 

Skills and competences

Mother tongue   French

Other languages Norwegian: Fluent

                              English: Fluent

                              German: Basic/Good

                              Luxembourgish: Basic/Good

Computer skills   Imaging software (Adobe Photoshop, Image J, Olympus microscopes software), proteomic (Scaffold) and genomic browsers (IGV, Galaxy, SignalMap).

 

Organisational / managerial skills

Member of IMB organizing committee for the celebration of UiO’s bicentennial (2011).

Member of IMB seminar arranging committee (2007-2015).

Member of the board for the Skovveien 6A co-ownership.

Publikasjoner

  • Delbarre, Erwan; Ivanauskiene, Kristina; Spirkoski, Jane; Shah, Akshay; Vekterud, Kristin; Moskaug, Jan Øivind; Bøe, Stig Ove; Wong, Lee H.; Küntziger, Thomas M. & Collas, Philippe (2017). PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Research.  ISSN 1088-9051.  27(6), s 913- 921 . doi: 10.1101/gr.215830.116
  • Lopez Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil; Thiede, Bernd; Collas, Philippe & Küntziger, Thomas M. (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle.  ISSN 1538-4101.  16(10), s 947- 956 . doi: 10.1080/15384101.2017.1310350
  • Legartová, Soña; Sehnalová, Petra; Malyšková, Barbora; Küntziger, Thomas M.; Collas, Philippe; Cmarko, Dušan; Raška, Ivan; Sorokin, Dmitry; Kozubek, Stanislav & Bártová, Eva (2016). Localized Movement and Levels of 53BP1 Protein Are Changed by g-irradiation in PML Deficient Cells. Journal of Cellular Biochemistry.  ISSN 0730-2312.  117(11), s 2583- 2596 . doi: 10.1002/jcb.25551
  • Suchánková, Jana; Kozubek, Stanislav; Legartová, Soña; Sehnalová, Petra; Küntziger, Thomas Michel & Bártová, Eva (2015). Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci. Biology of the Cell.  ISSN 0248-4900.  107(12), s 440- 454 . doi: 10.1111/boc.201500050
  • Ivanauskiene, Kristina; Delbarre, Erwan; McGhie, James; Küntziger, Thomas Michel; Wong, Lee-Jun C. & Collas, Philippe (2014). The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Research.  ISSN 1088-9051.  24(10), s 1584- 1594 . doi: 10.1101/gr.173831.114
  • Delbarre, Erwan; Ivanauskiene, Kristina; Küntziger, Thomas Michel & Collas, Philippe (2013). DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. Genome Research.  ISSN 1088-9051.  23(3), s 440- 451 . doi: 10.1101/gr.142703.112
  • Ørpetveit, Irene; Küntziger, Thomas Michel; Sindre, Hilde; Rimstad, Espen & Dannevig, Birgit Helene (2012). Infectious pancreatic necrosis virus (IPNV) from salmonid fish enters, but does not replicate in, mammalian cells. Virology Journal.  ISSN 1743-422X.  9, s 228 . doi: 10.1186/1743-422X-9-228
  • Kuntziger, Thomas Michel; Landsverk, Helga Bjarnason; Collas, Philippe & Syljuåsen, Randi (2011). Protein phosphatase 1 regulators in DNA damage signaling. Cell Cycle.  ISSN 1538-4101.  10(9), s 1356- 1362 . doi: 10.4161/cc.10.9.15442
  • Pidoux, Guillaume; Witczak, Oliwia; Jarnæss, Elisabeth; Myrvold, Linda; Urlaub, Henning; Stokka, Anne Jorunn; Küntziger, Thomas Michel & Tasken, Kjetil (2011). Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO Journal.  ISSN 0261-4189.  30(21), s 4371- 4386 . doi: 10.1038/emboj.2011.365 Fulltekst i vitenarkiv.
  • Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Reiner, Andrew Henry; Sørensen, Anita Løvstad; Kuntziger, Thomas Michel & Collas, Philippe (2010). Chromatin Environment of Histone Variant H3.3 Revealed by Quantitative Imaging and Genome-scale Chromatin and DNA Immunoprecipitation. Molecular Biology of the Cell.  ISSN 1059-1524.  21(11), s 1872- 1884 . doi: 10.1091/mbc.E09-09-0839
  • Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil; Bakke, Oddmund; Ellenberg, Jan; Collas, Philippe; Syljuåsen, Randi & Kuntziger, Thomas Michel (2010). The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Reports.  ISSN 1469-221X.  11(11), s 868- 875 . doi: 10.1038/embor.2010.134
  • Rogne, Marie; Stokka, Anne Jorunn; Tasken, Kjetil; Collas, Philippe & Kuntziger, Thomas Michel (2009). Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Human Molecular Genetics.  ISSN 0964-6906.  18(5), s 978- 987 . doi: 10.1093/hmg/ddn425
  • Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Gaustad, Kristine Gjul; Marstad, Anne & Collas, Philippe (2006). In vitro reprogramming of nuclei and cells. Methods in molecular biology.  ISSN 1064-3745.  (348), s 259- 268
  • Kuntziger, Thomas Michel; Rogne, Marie; Folstad, Rikke Lise & Collas, Philippe (2006). Association of PP1 with its regulatory subunit AKAP149 is regulated by serine phosphorylation flanking the RVXF motif of AKAP149. Biochemistry.  ISSN 1520-4995.  45(18), s 5868- 5877
  • Rogne, Marie; Landsverk, Bjarnason Helga; Eynde, A.V.; Beullens, Monique; Bollen, M.; Collas, Philippe & Kuntziger, Thomas Michel (2006). The KH-Tudor domain of A-Kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry.  ISSN 1520-4995.  45(50), s 14980- 14989
  • Håkelien, Anne-Mari; Gaustad, Kristine Gjul; Taranger, Christel Kjær; Skålhegg, Bjørn Steen; Kuntziger, Thomas Michel & Collas, Philippe (2005). Long-term in vitro, cell-type-specific genome-wide reprogramming of gene expression. Experimental Cell Research.  ISSN 0014-4827.  10, s 32- 47
  • Landsverk, Bjarnason Helga; Rogne, Marie; Bollen, M.; Kuntziger, Thomas Michel & Collas, Philippe (2005). PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochemical Journal.  ISSN 0264-6021.  15, s 709- 17
  • Collas, Philippe; Kuntziger, Thomas Michel & Landsverk, Helga Bjarnason (2004). Anchoring of protein kinase and phosphatase signaling units. Topics in Current Genetics.  ISSN 1610-2096.  5, s 145- 165
  • Kuntziger, Thomas Michel & Collas, Philippe (2004). Transdifferentiation, In Robert Lanza (ed.),  Adult and Fetal Stem Cells.  Academic Press.  ISBN 0124366414.  kapittel.  s 147 - 151
  • Landsverk, Helga B.; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Robl, J.M.; Skålhegg, Bjørn Steen & Collas, Philippe (2002). Reprogrammed gene expression in a somatic cell-free extract. EMBO Reports.  ISSN 1469-221X.  3(4), s 384- 389

Se alle arbeider i Cristin

  • Küntziger, Thomas M. (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint..
  • Küntziger, Thomas Michel (2016). A-Kinase Anchoring Protein AKAP95 interacts with Nuclear Pore Complex Protein Tpr and prevents chromosome lagging during cell division.
  • Lopez Soop, Graciela; Reiner, Andrew Henry; Thiede, Bernd; Collas, Philippe & Küntziger, Thomas Michel (2015). Regulation of Normal Mitotic Progression by A-kinase Anchoring Protein 95 (AKAP95).
  • Küntziger, Thomas Michel (2014). Respective roles of histone chaperone DEK and A-Kinase anchoring protein AKAP95 in chromatin deposition of histone H3.3 and in genome architecture..
  • Küntziger, Thomas Michel; Lund, Eivind Gard & Collas, Philippe (2013). Signal molecules anchoring at proliferation and differentiation genes by A-Kinase Anchoring Protein (AKAP) 95.
  • Collas, Philippe; Delbarre, Erwan; Küntziger, Thomas Michel; Lund, Eivind Gard; Ruppelt, Anja; Reiner, Andrew Henry & Sørensen, Anita Løvstad (2012). Epigenetic programming of stromal cell fate. International Journal of Molecular Medicine.  ISSN 1107-3756.  30, s S57- S57
  • Ivanauskiene, Kristina; Delbarre, Erwan; Küntziger, Thomas Michel & Collas, Philippe (2012). DAXX-dependent recruitment of histone variant H3.3 to PML bodies before deposition into chromatin. The FEBS Journal.  ISSN 1742-464X.  279, s 505- 505
  • Küntziger, Thomas Michel; Lund, Eivind Gard & Collas, Philippe (2012). Signal molecules anchoring at proliferation and differentiation genes by A-Kinase Anchoring Protein (AKAP) 95.
  • Küntziger, Thomas Michel (2011). Mikroskopiske teknikker.
  • Kuntziger, Thomas Michel (2010). Mikrotubuli og celledeling.
  • Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil; Bakke, Oddmund; Ellenberg, Jan; Collas, Philippe; Syljuåsen, Randi & Kuntziger, Thomas Michel (2010). The protein phosphatase 1 regulator PNUTS is a novel component of the DNA damage response.
  • Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Kuntziger, Thomas Michel & Collas, Philippe (2009). Epigenetic environment of the histone variant H3.3 revealed by integration of imaging and genome-scale ChIP information.
  • Kuntziger, Thomas Michel (2009). Mikrotubuli og celledeling.
  • Kuntziger, Thomas Michel (2009). Mutually exclusive binding of PP1 and RNA to A-kinase-anchoring protein AKAP149 affects the mitochondrial network.
  • Landsverk, Helga Bjarnason; Mora-Bermudez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil; Bakke, Oddmund; Syljuåsen, Randi; Ellenberg, Jan; Collas, Philippe & Kuntziger, Thomas Michel (2009). PP1 nuclear targeting subunit (PNUTS/p99/R111/CAT53) is an integral part of the G2 DNA damage checkpoint.
  • Kuntziger, Thomas Michel (2008). Mikrotubuli og celledeling.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Kuntziger, Thomas Michel (2007). Sur quelques aspects de l’organisation et de la dynamique de la chromatine dans le noyau des cellules animales.
  • Folstad, Rikke Lise Steen; Kuntziger, Thomas Michel; Beullens, Monique; Landsverk, Helga Bjarnason; Bollen, Mathieu & Collas, Philippe (2003). Nuclear envelope anchoring of PP1 by A-kinase anchoring protein AKAP149.
  • Kuntziger, Thomas Michel (2003). Study of chromatin-associated proteins anchoring signaling complexes.
  • Landsverk, Helga Bjarnason; Beullens, Monique; Kuntziger, Thomas Michel; Bollen, Mathieu & Collas, Philippe (2003). AKAP149 is a novel PP1 specifier required to maintain nuclear intergrity in G1 phase.
  • Kuntziger, Thomas Michel (2002). Chromatin remodeling in in vitro reprogrammed nuclei.

Se alle arbeider i Cristin

Publisert 1. okt. 2015 10:34 - Sist endret 15. mars 2018 10:35