Tine Merete Søland

• Hanson, Ingunn; Juvkam, Inga; Zlygosteva, Olga; Søland, Tine Merete; Galtung, Hilde & Malinen, Eirik [Vis alle 7 forfattere av denne artikkelen] (2024). TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model. International Journal of Radiation Biology. ISSN 0955-3002. doi: 10.1080/09553002.2024.2324476.
• Juvkam, Inga Solgård; Zlygosteva, Olga; Sitarz, Mateusz; Thiede, Bernd; Sørensen, Brita Singers & Malinen, Eirik [Vis alle 9 forfattere av denne artikkelen] (2023). Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles. International Journal of Molecular Sciences. ISSN 1661-6596. 24(23), s. 1–17. doi: 10.3390/ijms242316983. Fulltekst i vitenarkiv
• Zlygosteva, Olga; Juvkam, Inga; Aass, Hans Christian; Galtung, Hilde; Søland, Tine Merete & Malinen, Eirik [Vis alle 7 forfattere av denne artikkelen] (2023). Cytokine Levels in Saliva Are Associated with Salivary Gland Fibrosis and Hyposalivation in Mice after Fractionated Radiotherapy of the Head and Neck. International Journal of Molecular Sciences. ISSN 1661-6596. 24(20). doi: 10.3390/ijms242015218. Fulltekst i vitenarkiv
• Haugsten, Helene Rygvold; Kristoffersen, Anne Karin; Haug, Trude Marie; Søland, Tine Merete; Øvstebø, Reidun & Aass, Hans Christian [Vis alle 8 forfattere av denne artikkelen] (2023). Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains. MicrobiologyOpen. ISSN 2045-8827. 12(5). doi: 10.1002/mbo3.1388. Fulltekst i vitenarkiv
• Zlygosteva, Olga; Juvkam, Inga; Arous, Delmon; Sitarz, Mateusz; Sørensen, Brita Singers & Ankjærgaard, Christina [Vis alle 11 forfattere av denne artikkelen] (2023). Acute normal tissue responses in a murine model following fractionated irradiation of the head and neck with protons or X-rays. Acta Oncologica. ISSN 0284-186X. doi: 10.1080/0284186X.2023.2254481. Fulltekst i vitenarkiv
• Toközlü, Burcu; Sapkota, Dipak; Vallenari, Evan Michael; Schreurs, Olaf Joseph Franciscus & Søland, Tine Merete (2023). Cortactin expression in a Norwegian cohort of human papilloma virus negative oral squamous cell carcinomas of the mobile tongue. European Journal of Oral Sciences. ISSN 0909-8836. doi: 10.1111/eos.12925.
• Solheim, Tore Torsteinson; Wilberg, Petter & Søland, Tine Merete (2022). Lokalisert juvenil spongiotisk gingival hyperplasi: En relativt ny sykdomsenhet. Norsk tannlegeforening Tidende. doi: 10.56373/2022-9-5.
• Juvkam, Inga; Zlygosteva, Olga; Arous, Delmon; Galtung, Hilde; Malinen, Eirik & Søland, Tine Merete [Vis alle 7 forfattere av denne artikkelen] (2022). A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck. Journal of radiation research. ISSN 0449-3060. s. 1–9. doi: 10.1093/jrr/rrac066. Fulltekst i vitenarkiv
• Sofizadeh , Narmin ; Bjerkehagen, Bodil; Solheim, Tore Torsteinson; Sapkota, Dipak & Søland, Tine Merete (2022). The spectrum and frequency of histopathological diagnosis of oral diseases in Oslo: Implications to oral pathology syllabus. European journal of dental education. ISSN 1396-5883. 00, s. 1–7. doi: 10.1111/eje.12808. Fulltekst i vitenarkiv
• Søland, Tine Merete; Solhaug, Maren Bråten; Bjerkli, Inger-Heidi; Schreurs, Olaf Joseph Franciscus & Sapkota, Dipak (2022). The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas. European Journal of Oral Sciences. ISSN 0909-8836. s. 1–11. doi: 10.1111/eos.12866. Fulltekst i vitenarkiv
• Golburean, Olga; Hagen, Maria Helene; Uncuta, Diana; Tighineanu, Marcela; Manrikyan, Gayane & Vardanian, Izabella [Vis alle 17 forfattere av denne artikkelen] (2021). Knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus and Armenia: a multi-country cross-sectional study. BMC Oral Health. ISSN 1472-6831. 21. doi: 10.1186/s12903-021-02011-2. Fulltekst i vitenarkiv
• Sapkota, Dipak; Sharma, Sunita; Søland, Tine Merete; Braz-Silva, Paulo & Teh, Muy-Teck (2021). Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma. Clinical and Experimental Dental Research. ISSN 2057-4347. s. 1–6. doi: 10.1002/cre2.510. Fulltekst i vitenarkiv
• Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi; Sand, Lars Peter; Petersen, Fernanda Cristina & Costea, Daniela Elena [Vis alle 8 forfattere av denne artikkelen] (2021). Combined loss of expression of involucrin and cytokeratin 13 is associated with poor prognosis in squamous cell carcinoma of mobile tongue. Head and Neck. ISSN 1043-3074. 43(11), s. 3374–3385. doi: 10.1002/hed.26826. Fulltekst i vitenarkiv
• Søland, Tine Merete; Bjerkli, Inger-Heidi; Georgsen, Jeanette B; Schreurs, Olaf Joseph Franciscus; Jebsen, Peter Wilhelm & Laurvik, Helene [Vis alle 7 forfattere av denne artikkelen] (2020). High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue. Clinical and Experimental Dental Research. ISSN 2057-4347. 7(1), s. 70–77. doi: 10.1002/cre2.342. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Objectives: The presence of and the causative role of high-risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high-risk HPV in a homogenous Norwegian cohort of primary and second primary OSCC of the mobile tongue (oral tongue squamous cell carcinoma—OTSCC). Methods: Tissue microarrays containing formalin-fixed and paraffin-embedded cores of 146 OTSCC from the anterior 2/3 of the tongue (n = 128 primary and n = 18 second primary) from a multicentric Norwegian cohort were examined for the presence of high-risk HPV by DNA- and RNA-in situ hybridization (ISH) assays and p16 immunohistochemistry. Results: Transcriptionally active HPV (E6/E7 mRNA) was not identified in any of the OTSCC specimens. In parallel, no tumors were positive for HPV by DNA ISH. Although, 61 (42%) OTSCC demonstrated p16 positivity with varying staining intensity and subcellular localization, only two cases demonstrated strong and uniform p16-staining (both cytoplasmic and nuclear) in >70% of cancer cells. The absence of transcriptionally active high-risk HPV in this cohort of OTSCC indicates that high-risk HPV is an unlikely causative factor in the present material.

• Sapkota, Dipak; Søland, Tine Merete; Galtung, Hilde; Sand, Lars Peter; Giannecchini, Simone & To, Kelvin KW [Vis alle 10 forfattere av denne artikkelen] (2020). COVID-19 salivary signature: diagnostic and research opportunities. Journal of Clinical Pathology. ISSN 0021-9746. 0, s. 1–6. doi: 10.1136/jclinpath-2020-206834.
• Bjerkli, Inger-Heidi; Laurvik, Helene; Nginamau, Elisabeth Sivy; Søland, Tine Merete; Costea, Daniela Elena & Hov, Håkon [Vis alle 9 forfattere av denne artikkelen] (2020). Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report. PLOS ONE. ISSN 1932-6203. 15:e0239783(9), s. 1–13. doi: 10.1371/journal.pone.0239783. Fulltekst i vitenarkiv
• Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Costea, Daniela Elena; Søland, Tine Merete & Galtung, Hilde (2020). Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics. PLOS ONE. ISSN 1932-6203. 15(9), s. 1–20. doi: 10.1371/journal.pone.0238591. Fulltekst i vitenarkiv
• Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete & Costea, Daniela Elena [Vis alle 8 forfattere av denne artikkelen] (2020). A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer. Virchows Archiv. ISSN 0945-6317. 477, s. 865–872. doi: 10.1007/s00428-020-02875-9. Fulltekst i vitenarkiv
• Skaare, Anne B; Szyszko, Ewa Alicja; Herlofson, Bente Brokstad & Søland, Tine Merete (2020). Orofacial granulomatosis: a questionnaire study among Norwegian dental clinicians. European Archives of Paediatric Dentistry. ISSN 1818-6300. 21(5), s. 557–564. doi: 10.1007/s40368-020-00511-3.
• Steigen, Sonja Eriksson; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela Elena & Johannessen, Anne Christine [Vis alle 10 forfattere av denne artikkelen] (2020). Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better? Journal of Oral Pathology & Medicine. ISSN 0904-2512. 49, s. 630–635. doi: 10.1111/jop.12990. Fulltekst i vitenarkiv
• Guerreiro, Eduarda; Vestad, Beate; Steffensen, Lilly Alice; Aass, Hans Christian Dalsbotten; Saeed, Muhammad & Øvstebø, Reidun [Vis alle 9 forfattere av denne artikkelen] (2018). Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography. PLOS ONE. ISSN 1932-6203. 13:e0204276(9), s. 1–17. doi: 10.1371/journal.pone.0204276. Fulltekst i vitenarkiv
• Søland, Tine Merete; Skarstein, Kathrine; Johannessen, Anne Christine & Solheim, Tore (2014). Biopsier i odontologisk praksis - håndtering og innsendelse. Den norske tannlegeforenings tidende. ISSN 0029-2303. 124(9), s. 734–738.
• Søland, Tine Merete & Brusevold, Ingvild Johnsen (2014). Prognostiske markører i kreftsvulster fra munnhulen – quo vadis? Den norske tannlegeforenings tidende. ISSN 0029-2303. s. 364–368. Vis sammendrag

  Plateepitelkarsinom i munnhulen er en alvorlig sykdom. Ca. 40 prosent av pasientene dør innen fem år etter at diagnosen er stilt, men på diagnosetidspunktet kan vi ikke forutsi hvilke. To prognosesystemer brukes i dag: TNM-systemet i klinikken og histologisk gradering (WHO). Verktøyene kan si noe om prognose for en gruppe pasienter, men er ikke gode nok til å forutsi prognosen for den enkelte pasient. Mange forskningsgrupper, inkludert vår egen, har prøvd å finne bedre prognostiske markører uten å lykkes. Problemet er ikke spesifikt for munnhulekreft, men gjelder de fleste krefttyper. Vi ønsker å plukke ut pasienter med en forventet dårlig prognose fordi de vil trenge en annen behandling og oppfølging enn pasienter med forventet god prognose. I denne artikkelen presenterer vi funn fra vår oversiktsartikkel i Histopathology (2013) (1). Vi har gått igjennom 172 artikler, publisert i perioden 2006–2012, som beskriver molekylære prognostiske studier basert på immunhistokjemi i orale plateepitelkarsinom. Konklusjonen er at det fortsatt ikke finnes noen optimale prognostiske molekylære markører for orale plateepitelkarsinomer. Dette skyldes at det generelt ikke finnes noen form for standardisering av hverken studiene eller metodene. Dermed er ikke studier og resultater reproduserbare. I tillegg er ofte pasientutvalget for lite til at man kan trekke generelle konklusjoner.

• Søland, Tine Merete & Brusevold, Ingvild Johnsen (2013). Prognostic molecular markers in cancer - quo vadis? Histopathology. ISSN 0309-0167. 63(3), s. 297–308. doi: 10.1111/his.12184. Vis sammendrag

  Despite the tremendous number of studies of prognostic molecular markers in cancer, only a few such markers have entered clinical practise. The lack of clinical prognostic markers clearly reflects limitations in or an inappropriate approach to prognostic studies. This situation should be of great concern for the research community, clinicians and patients. In the present review, we evaluate immunohistochemical prognostic marker studies in oral squamous cell carcinomas (OSCC) from 2006 to 2012. We comment upon general issues such as study design, assay methods and statistical methods, applicable to prognostic marker studies irrespective of cancer type. The three most frequently studied markers in OSCC are reviewed. Our analysis revealed that most new molecular markers are reported only once. To draw conclusions of clinical relevance based on the few markers that appeared in more than one study was problematic due to between-study heterogeneity. Currently, much valuable tissue material, time and money are wasted on irrelevant studies.

• Kragelund, Camilla; Reibel, Jesper; Jarkko, Hietanen; Hadler-Olsen, Elin Synnøve; Johannessen, Anne Chr. & Kenrad, Birgit [Vis alle 14 forfattere av denne artikkelen] (2012). Scandinavian Fellowship for Oral Pathology and Oral Medicine: guidelines for oral pathology and oral medicine in the dental curriculum. European journal of dental education. ISSN 1396-5883. 16(4), s. 246–253. doi: 10.1111/j.1600-0579.2012.00758.x.
• Kragelund, Charlotte; Reibel, Jesper; Hadler-Olsen, Elin Synnøve; Hietanen, Jarkko; Johannessen, Anne Chr. & Kenrad, Birgit [Vis alle 15 forfattere av denne artikkelen] (2010). Scandinavian Fellowship for Oral Pathology and Oral Medicine: statement on oral pathology and oral medicine in the European Dental Curriculum. Journal of Oral Pathology & Medicine. ISSN 0904-2512. 39(10), s. 800–e1. doi: 10.1111/j.1600-0714.2010.00939.x.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne (2010). Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model. European Journal of Oral Sciences. ISSN 0909-8836. 118(4), s. 342–349.
• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by CoCl2, a hypoxia mimetic. European Journal of Oral Sciences. ISSN 0909-8836. 118(2), s. 168–176.
• Kolltveit, Kristin Melkevik; Schreurs, Olav Joseph F; Østrem, Janet M; Søland, Tine Merete; Khuu, Cuong & Berge, Tone [Vis alle 11 forfattere av denne artikkelen] (2010). Expression of the T-cell-specific adapter protein in oral epithelium. European Journal of Oral Sciences. ISSN 0909-8836. 118(2), s. 159–167. Vis sammendrag

  The multifunctional T-cell-specific adapter protein (TSAd) was originally described in T cells but is also expressed in epithelial cells from the respiratory tract and in endothelium. In this study, we found expression of TSAd messenger RNA (mRNA) and protein in both human and murine oral mucosal epithelium as well as in human primary oral keratinocyte cell cultures. In TSAd(-/-) mice, the mucosa and skin appeared macroscopically normal, but severe disturbances were observed in the fine structures of the basal membrane and intercellular epithelial spaces upon analysis using transmission electron microscopy. Oral epithelial cells from TSAd(-/-) mice displayed decreased migration compared with cells from wild-type mice, whereas overexpression of TSAd in a human epithelial cell line resulted in impaired proliferation. This study is the first to show that TSAd is expressed in normal oral mucosa, that it is important for the normal ultrastructural morphology of the epithelium and the basal membrane, and that it is involved in the migration and proliferation of oral keratinocytes.

• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Koppang, Hanna Strømme; Schenck, Karl & Bryne, Magne (2008). Nerve growth factor receptor (p75NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma. Histopathology. ISSN 0309-0167. 53, s. 62–72. doi: 10.1111/j.1365-2559.2008.03063.x.
• Søland, Tine Merete; Husvik, Camilla; Koppang, Hanna Strømme; Boysen, Morten Ebbe; Sandvik, Leiv & Clausen, Ole Petter Fraas [Vis alle 8 forfattere av denne artikkelen] (2008). A study of phosphorylated ERK1/2 and COX-2 in early stage (T1–T2) oral squamous cell carcinomas. Journal of Oral Pathology & Medicine. ISSN 0904-2512. 37(9), s. 535–542. doi: 10.1111/j.1600-0714.2008.00656.x.
• Sudbø, Jon; Bryne, Magne; Mao, Li; Lotan, Reuben; Reith, Albrecht & Kildal, Wanja [Vis alle 9 forfattere av denne artikkelen] (2003). TRUKKET - Molecular based treatment of oral cancer. Oral Oncology. ISSN 1368-8375. 39(8), s. 749–758.

Se alle arbeider i Cristin

• Solheim, Tore & Søland, Tine Merete (2010). Oral patologi for tannpleiere. Universitetet i Oslo. ISBN 978-82-992482-9-7. 116 s.

Se alle arbeider i Cristin

• Rykkelid, Anne Marit; sinha, Priyanshu; Folefac, Charlemagne; Horsman, Michael; Sørensen, Brita Singers & Søland, Tine Merete [Vis alle 9 forfattere av denne artikkelen] (2023). Synergistic effects of combining proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers.
• Rykkelid, Anne Marit; sinha, Priyanshu; Folefac, Charlemagne; Horsman, Michael; Sørensen, Brita Singers & Søland, Tine Merete [Vis alle 9 forfattere av denne artikkelen] (2023). Synergistic effects of combining proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers.
• Søland, Tine Merete; Wilberg, Petter; Pham, Maria H & Solheim, Tore Torsteinson (2022). Lokalisert juvenil spongiotisk gingival hyperplasi: En relativt ny sykdomsenhet. NTFs Tidende. 131(9).
• Søland, Tine Merete; Andersen, Eivind; Tingberg, Marianne; Farran, Mirna; Haugstvedt, Åse & Solheim, Tore Torsteinson (2022). Oral syfilis er en sykdom som tannleger bør kjenne til. Den norske tannlegeforenings tidende. ISSN 0029-2303. 132(5). doi: 10.56373/2022-5-6.
• Skaare, Anne B; Herlofson, Bente Brokstad & Søland, Tine Merete (2020). Orofacial granulomatose og Crohns sykdom – et klinisk kasus og en litteraturgjennomgang. Den norske tannlegeforenings tidende. ISSN 0029-2303. 130(11), s. 914–920.
• Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi; Sand, Lars Peter; Costea, Daniela Elena & Senguven, Brucu [Vis alle 7 forfattere av denne artikkelen] (2020). Low involucrin expression correlates to poor prognosis in oral squamous cell carcinoma of mobile tongue .
• Søland, Tine Merete; Andersen, Eivind & Solheim, Tore (2019). Sår i munnhulen som ikke vil tilhele kan være traumatisk ulcerativt granulom med stromal eosinofili (TUGSE). Den norske tannlegeforenings tidende. ISSN 0029-2303. 129, s. 1008–1013.
• Søland, Tine Merete (2017). Oralpatologi for tannteknikere .
• Guerreiro, Eduarda; Vestad, Beate; Øvstebø, Reidun; Søland, Tine Merete & Galtung, Hilde (2016). Isolation of extracellular vesicles - towards understanding vesicles signaling pathway in oral squamous cell carcinoma cells.
• Guerreiro, Eduarda; Vestad, Beate; Øvstebø, Reidun; Galtung, Hilde & Søland, Tine Merete (2016). Extracellular vesicles from oral squamous cell carcinoma cells in culture: isolation and characterization.
• Frettem, Åshild Kvammen; Edin, Nina Frederike J; Galtung, Hilde & Søland, Tine Merete (2016). Tumour associated Aquaporin-3 and hypoxia in an oral squamous cell carcinoma cell line .
• Søland, Tine Merete; Frafjord, Roshi & Solheim, Tore (2016). Et tilfelle av sentralt ossifiserende fibrom. Den norske tannlegeforenings tidende. ISSN 0029-2303. 116(10), s. 780–782.
• Søland, Tine Merete; Kjølle, Gry Karina & Solheim, Tore (2016). Oral melanotisk flekk - en kasuistikk. Den norske tannlegeforenings tidende. ISSN 0029-2303. s. 294–296.
• Guerreiro, Eduarda; Vestad, Beate; Øvstebø, Reidun; Galtung, Hilde & Søland, Tine Merete (2016). Extracellular vesicles from oral squamous cell carcinoma cells in culture: isolation and characterization. Journal of Extracellular Vesicles. ISSN 2001-3078.
• Sletten, Elisabeth; Soleng, Kristina A; Søland, Tine Merete; Fløisand, Yngve & Herlofson, Bente Brokstad (2015). Kronisk oral transplantat-mot-vert sykdom, en utfordring også for tannhelsepersonell?
• Frettem, Åshild Kvammen; Ulekleiv, Camilla Husvik; Søland, Tine Merete & Galtung, Hilde (2014). The effect of hypoxia on aquaporin 3 expression and cell volume regulation in oral squamous cell carcinomas. Acta Physiologica. ISSN 1748-1708.
• Frettem, Åshild Kvammen; Ulekleiv, Camilla Husvik; Søland, Tine Merete & Galtung, Hilde (2014). The effect of hypoxia on aquaporin 3 expression and cell volume regulation in oral squamous cell carcinomas.
• Søland, Tine Merete; Ulekleiv, Camilla Husvik & Galtung, Hilde (2014). Hypoxia influences aquaporin 3 and migration in oral squamous cell carcinoma.
• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic.
• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic. European Journal of Cancer. ISSN 0959-8049. 8(5), s. 149–149.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne (2009). Nuclear Met and p-p38 in oral squamous cell carcinoma and organotypic oral cancer model.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne (2009). Nuclear c-Met and p-p38 in oral sqamous cell carcinoma and organotypic oral cancer model.
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Koppang, Hanna Strømme; Schenck, Karl & Bryne, Magne (2008). p75NTR and pattern of invasion predict poor prognosis in oral squamous cell carcinomas. European Journal of Cancer. ISSN 0959-8049. 6, s. 76–76.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong & Bryne, Magne (2008). Nuclear c-Met and p-p38 at the invasive front of oral squamous cell carcinomas. European Journal of Cancer. ISSN 0959-8049. 6, s. 76–76.
• Søland, Tine Merete (2008). Munnhulekreft: hvilke pasienter får tilbakefall av sykdommen?
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl & Bryne, Magne (2008). Manipulation of invasion in a 3D-co-culture organotypic oral cancer model.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne (2008). C-Met and p-p38 in oral cancer.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne (2008). Nuclear c-Met and p-p38 at the invasive front of oral squamous cell carcinoma (OSCC.
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Koppang, Hanna Strømme; Schenck, Karl & Bryne, Magne (2008). p75NTR and pattern of invasion predict poor prognosis in oral squamous cell carcinomas.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Husvik, Camilla; Khuu, Cuong & Bryne, Magne (2007). Nerve growth factor receptor (p75 NTR) in an organotypic oral cancer model.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete; Husvik, Camilla; Khuu, Cuong & Bryne, Magne (2007). Nerve growth factor receptor (p75 NTR) in an organotypic oral cancer model.
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Khuu, Cuong; Hayashi, Katsuhiko & Schenck, Karl [Vis alle 7 forfattere av denne artikkelen] (2007). Nerve growth factor receptor (p75NTR)is a marker of poor prognosis in T1-T2 oral squamous cell carcinomas.
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Khuu, Cuong; Hayashi, Katsuhiko & Schenck, Karl [Vis alle 7 forfattere av denne artikkelen] (2007). Nerve growth factor receptor (p75NTR) is a marker of poor prognosis in T1-T2 oral squamous cell carcinomas.
• Brusevold, Ingvild Johnsen; Søland, Tine Merete & Bryne, Magne (2006). Hepatocyte growth factor receptor in oral cancer.
• Søland, Tine Merete; Husvik, Camilla; Koppang, Hanna Strømme; Boysen, Morten Ebbe; Sandvik, Leiv & Clausen, Ole Petter Fraas [Vis alle 7 forfattere av denne artikkelen] (2006). Clinical importance of phosphorylated ERK1/2 MAPK and COX-2 at the invasive front of T1-T2 oral squamous cell carcinoma.
• Søland, Tine Merete; Husvik, Camilla; Kleinberg, Lilach; Koppang, Hanna Strømme; Boysen, Morten Ebbe & Davidson, Ben [Vis alle 9 forfattere av denne artikkelen] (2005). Prognostic markers in the invasive front of of OSCC.
• Søland, Tine Merete; Husvik, Camilla; Koppang, Hanna Strømme; Boysen, Morten Ebbe; Sandvik, Leiv & Clausen, Ole Petter Fraas [Vis alle 8 forfattere av denne artikkelen] (2005). Singel cell invasion in high risk patients.
• Søland, Tine Merete; Schreurs, Olav; Husvik, Camilla; Clausen, Ole Petter; Boysen, Morten & Sudbø, Jon [Vis alle 7 forfattere av denne artikkelen] (2004). Expression of COX-2, APC and β-catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
• Søland, Tine Merete; Schreurs, Olav; Husvik, Camilla; Clausen, Ole Petter; Boysen, Morten & Sudbø, Jon [Vis alle 7 forfattere av denne artikkelen] (2004). Expression of COX-2, APC and β -catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
• Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Clausen, Ole Petter Fraas; Boysen, Morten Ebbe & Sudbø, Jon [Vis alle 7 forfattere av denne artikkelen] (2004). COX-2, APC and beta-catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
• Bryne, Magne; Søland, Tine Merete; Husvik, Camilla & Sudbø, Jon (2004). Concomitance of COX-2 up-regulation and genomic instability in precancers: a rationale for targeted use of coxibs to prevent oral cancer.
• Søland, Tine Merete; Bryne, Magne; Lee, J.Jack; Lippman, Scott; Mao, Li & Kildal, Wanja [Vis alle 8 forfattere av denne artikkelen] (2004). Resection margins and cancer risk from DNA diploid oral leukoplakia.
• Søland, Tine Merete; Sudbø, Jon; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne (2003). Selective COX-2 up-regulation in DNA aneuploid oral precancers: an opportunity for targeted preventive treatment of oral cancers?
• Bryne, Magne; Husvik, Camilla; Søland, Tine Merete; Kolltveit, Kristin Melkevik & Sudbø, Jon (2003). The invasion of malignant oral keratinocytes is inhibited by a COX-2 inhibitor.
• Husvik, Camilla; Søland, Tine Merete; Kolltveit, Kristin Melkevik; Sudbø, Jon & Bryne, Magne (2003). Effect of COX-2 inhibitors on proliferation, invasion and migration of cell lines from oral squamous cell carcinoma.
• Aase, Steinar Torbjørn; Koppang, Hanna Strømme & Søland, Tine Merete (2003). Oral patologi ved norske sykehus.
• Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne (2003). Selective COX-2 up-regulation in DNA aneuploid oral precancers; an opportunity for targeted preventive treatment of oral cancer.
• Aase, Steinar Torbjørn; Koppang, Hanna Strømme & Søland, Tine Merete (2003). Oral Pathology in Norwegian Hospitals.
• Søland, Tine Merete; Chardin, Hélène; Lyberg, Torstein & Ahlfors, Eva Elisabeth (2002). Adoptive transfer as a method in oral mucosa contact sensitivity. Vis sammendrag

  Lichenoid reactions are chronic, superficial T-cell dominated inflammatory reactions found in the oral mucosa. Suggestive of contact sensitivity (CS), lichenoid reactions have been investigated in skin patch tests in order to find the causative agent. Different outcomes have emerged from these tests, not clearly stating the CS status of the lesions. However, also the gastrointestinal tract with its immune system is exposed to a vast number of transient antigens that may influence the reactions in the oral mucosa. We hypothesise that T-cell dominated reactions in the oral mucosa are the result of antigen exposures in the gastrointestinal tract as well as locally in the oral mucosa and on skin. To further elucidate cell phenotypes active in these reactions a mouse model for transferring immunologically active cells from fed and/or sensitised individuals to untreated animals, so called adoptive transfer (AT), is being developed. In initial experiments, cell donor mice received cyclophosphamide and were sensitised on two consecutive days with the hapten trinitrochlorobenzene (TNCB, 1%, w/v) in acetone/olive oil (1/10, v/v) on both ears. Submandibular and auricular lymph nodes (LN), axillary and inguinal LN and the spleen were removed four days after the last sensitisation. Single cell suspensions were prepared and 50x106 cells injected intravenously in normal, untreated, genetically identical recipient mice which were then elicited on both ears and in the oral mucosa with 0.5% TNCB. The mice were sacrificed after 24h. Specimens of ear skin and oral mucosa were frozen. Sections were stained routinely with haematoxylin /eosin or with immuno-histochemistry for CD4 and CD8. AT gave a more pronounced CS reaction in the oral mucosa of recipient mice compared to simultaneously elicited skin, as did cells from regional LN and spleen, compared to distant LN. Cells from local regional LN had inflammatory reactions containing more CD4+ T cells while spleen cells displayed more CD8+ T cells in the oral mucosa inflammatory CS reactions. Injection of serum from sensitised animals did not give local inflammatory reactions after hapten exposure. We conclude that the oral mucosa displays inflammation after AT of sensitised cells and elicitation. Preliminary results indicate that different cell populations dominate the cellular infiltrates in the oral mucosa depending on whether regional local LN or spleen is the origin of the transferred cells. This research was supported by the University of Oslo and the Faculty of Dentistry, University of Oslo.

• Søland, Tine Merete; Lyberg, Torstein; Dahl, J. & Ahlfors, Eva Elisabeth (2002). Regional lymph node weight, IFN-gamma and IL-2 content in contact sensitivity or irritant reactions in the murine oral mucosa and ear skin.
• Ahlfors, Eva Elisabeth; Dahl, Jon E.; Søland, Tine Merete & Lyberg, Torstein (2002). Regional lymph node weight and IL-2 content in contact sensitivity- or irritant reactions in murine oral mucosa and ear skin. Vis sammendrag

  Skin contact sensitivity (CS) reactions and skin reactions seen after exposure to an irritant substance (like sodium lauryl sulphate [SLS]) have similar or identical clinical picture, tissue morphology and phenotypic expression of inflammatory cells as well as cytokine expression. In order to differentiate the two types of reactions we investigated the weight of draining lymph nodes and the presence of interleukin (IL)-2 in the regional lymph nodes (LN) of both reaction types following either sensitisation/elicitation to a hapten (oxazolone) or one exposure to the irritant substance SLS. Mice were sensitised in the oral mucosa or on ear skin and one week later elicited in both tissues with the hapten. Control mice were exposed to the hapten once. Other animals were exposed once in the oral mucosa and ear skin to 2%, 4%, or 8% SLS solution. LN were collected at 4h, 6h, 8h, 12h, 24h, 48h, 72h and 168h after substance application, weighed and ELISA assays were performed to determine IL-2 in LN tissue extracts. LN draining elicited oral mucosa and ear skin doubled the weight, from normally 10mg to around 20mg at 8h. At 12h, CS and irritant reactions produced similar increase in LN weight. However, at 24h, 48h or 72h after substance application there were considerable weight increases in the challenged mice (up to 35mg) compared to SLS exposure, which at this phase demonstrated virtually no LN weight increase. One application of the hapten gave rise to similar LN weight values as challenged mice at 72h and thereafter. IL-2 in LN extracts demonstrated considerable peaks 4h after exposure of hapten. After that only minor variations were found in any of the groups. SLS caused a decrease of IL-2 content at 4h and then a slow increase. We conclude that the weight of regional LN increased more after oral mucosa and ear skin sensitisation/elicitation then after application of SLS. Furthermore, there was no direct relationship between IL-2 levels and weight increase of the regional LN.

• Søland, Tine Merete; Lyberg, Torstein & Ahlfors, Eva Elisabeth (2001). ELISA analyses of IFNy in developing oral mucosa contact sensitivity reactions.
• Søland, Tine Merete; Eide, Dag Marcus; Lyberg, Torstein & Ahlfors, Eva Elisabeth (2001). Oral mucosa and T cell immunity in antigen fed heterozygous, knock-out polyimmunoglobulin receptor deficient mice.
• Søland, Tine Merete; Lyberg, Torstein & Ahlfors, Eva Elisabeth (2001). T cell immunity of the oral mucosa; ELISA analyses of the cytokines IL-2 and IFN in developing contact sensitivity reactions.
• Søland, Tine Merete (2008). A study of possible prognostic markers in oral squamous cell carcinomas and their expression in an organotypic co-culture oral cancer model. Unipub forlag. ISSN 978-82-91757-45-2.

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