About the project
Periodontitis was responsible for a significant loss of € 158.64 billion in Europe in 2018. Due to the complexity of the grafting treatment techniques, the efficiency of these procedures is notably affected. A bioactive multiphasic membrane/scaffold with different layers has been advised for this. Until now, few commercial companies using synthetic polymers like polylactic acid (PLA), and woven fibers made up of polyglactin 910 copolymer together with collagen have developed this type of membrane/scaffold. However, different limitations of these materials make their application difficult. MultiphaseGTR focuses on the preparation of bioactive multiphase hydrogel-based biomembrane for periodontal regeneration.
Objectives
The fundamental objectives of the study are: I. Development and characterization of the two components of the biomembrane, i.e., non-mineralized hydrogel and mineralized hydrogel membranes (WP1); II. Preparation of a multiphase hydrogel membrane by combining the two components, i.e., non-mineralized and mineralized hydrogel membranes, and characterization of their physicomechanical properties (WP2); and III. Assessment of the bioactive properties of the multiphase biomembranes in relation to periodontal regeneration (WP3).
Finally, a suitable multiphase membrane will be recommended.
Figure 1. Outline of MultiphaseGTR
(Prepared in BioRender.com)
Outcomes
The outcome of this proposed work not only intends to fill the current gap for the requirement of a suitable cost-effective alternative to the current limited reported materials but also to elaborate the opportunity to increase the knowledge regarding the utilization of biomembrane in dental and maxillofacial tissue regeneration.
Cooperation
1. Dr. Manuel Gomez-Florit, Ph.D. Health Research Institute of the Balearic Islands (IdISBa), Balearic Islands, Spain.
2. Prof. Sandra Van Vlierberghe, Ph.D. Polymer Chemistry & Biomaterials Group, Centre of Macromolecular Chemistry, Ghent University, Belgium.
Duration
01.07.2023 to 30.06.2025
Financing
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101108847.
