Sigrid defended her PhD

Sigrid Haugen successfully defended her dissertation for the degree of Ph.D. (philosophiae doctor) : A study of adiponectin and adiponectin receptor agonist ADP355 on bone and orthodontic tooth movement.

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Sigrid Haugen

Sigrid Haugen's dissertation shows the effect of adiponectin and adiponectin's receptor agonist ADP355 on bone cells and bones, and that local injection of adiponectin can affect orthodontic tooth transfer and was successfully defended on September 11th. 

Adiponectin can modify bone growth by increasing the number of human osteoblasts and in addition increasing the expression of markers for early osteoblastogenesis. Adiponectin may also affect bone degradation as it increased the number of osteoclasts but did not affect the activity of the osteoclasts. Adiponectin was associated with a more flexible bone, which was supported by rat bone analyzes and by a 3-dimensional bone model of primary human osteoblasts and osteoclasts in vitro .

In a treatment strategy, a peptide would be advantageous to use over a large complex protein, and therefore the effect of ADP355 was analyzed. ADP355 has been shown to bind the same receptor as adiponectin, AdiopR1, but the effect of ADP355 and adiponectin was not similar in primary human osteoblasts. ADP355 produced less differentiation of the osteoblasts compared to adiponectin. Furthermore, our data showed that adiponectin decreased, while ADP355 increased the expression of AdipoR1 in primary human osteoblasts, which may explain why there was a different response to the cells. In addition, we observed donor variations in the levels of adiponectin receptors ( AdipoR1 and AdipoR2), and how these were affected by treatment with either peptide or protein. In a rat study, topical administration of adiponectin reduced experimental tooth displacement compared to control. 

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Sigrid trial lecture topic was "Clinical applications of the adipokine adiponectin in the craniofacial region" 

Published papers inculded in Sigrid's thesis

adiponectin reduces Bone stiffness: Verified in a Three-Dimensional artificial human Bone Model In Vitro

Adiponectin prevents orthodontic tooth movement in rats

The evaluation committee

1st opponent: Professor Martyn Cobourne,  Guy's and St Thomas' NHS Foundation Trust,  King's College London, UK

2nd opponent: Professor Therese Standal, Center of Molecular Inflammation Research, NTNU, Trondheim

3rd opponent: Professor Anne Merete Aass, Department of Clinical Dentistry, University of Oslo

Main supervisor

Professor Janne Reseland, Department of Clinical Dentistry, University of Oslo

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Sigrid after completed her PhD together with vice-dean of research and her supervisors


Tags: PhD defences, Life Science, Biomaterial and Tissue regeneration, Bone regeneration and remodelling, protein
Published Sep. 12, 2020 5:22 PM - Last modified Oct. 29, 2020 12:20 PM