Catherine Joan Jackson

• Cross, Tanya; Øvstebø, Reidun; Brusletto, Berit; Siebke, Anne-Marie; Olstad, Ole Kristoffer & Aspelin, Trude [Show all 10 contributors for this article] (2023). RNA Profiles of Tear Fluid Extracellular Vesicles in Patients with Dry Eye-Related Symptoms. International Journal of Molecular Sciences. ISSN 1661-6596. 24(20). doi: 10.3390/ijms242015390. Show summary

  Currently, diagnosing and stratifying dry eye disease (DED) require multiple tests, motivating interest in a single definitive test. The purpose of this study was to investigate the potential for using tear fluid extracellular vesicle (EV)-RNA in DED diagnostics. With a role in intercellular communication, nanosized EVs facilitate the protected transport of diverse bioactive molecules in biofluids, including tears. Schirmer strips were used to collect tears from 10 patients presenting with dry eye-related symptoms at the Norwegian Dry Eye Clinic. The samples comprised two groups, five from patients with a tear film break-up time (TBUT) of 2 s and five from patients with a TBUT of 10 s. Tear fluid EV-RNA was isolated using a Qiagen exoRNeasy Midi Kit, and the RNA was characterized using Affymetrix ClariomTM D microarrays. The mean signal values of the two groups were compared using a one-way ANOVA. A total of 26,639 different RNA transcripts were identified, comprising both mRNA and ncRNA subtypes. Approximately 6% of transcripts showed statistically significant differential abundance between the two groups. The mRNA sodium channel modifier 1 (SCNM1) was detected at a level 3.8 times lower, and the immature microRNA-130b was detected at a level 1.5 times higher in the group with TBUT 2 s compared to the group with TBUT 10 s. This study demonstrates the potential for using tear fluid EV-RNA in DED diagnostics.

• Vrkoslav, Vladimir; Smeringaiova, Ingrida; Smorodinova, Natalia; Svobodova, Alzbeta; Strnad, Stepan & Jackson, Catherine Joan [Show all 8 contributors for this article] (2023). Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane. Bioengineering. ISSN 2306-5354. 10(6). doi: 10.3390/bioengineering10060740. Full text in Research Archive
• Jackson, Catherine Joan; Naqvi, Maria; Gundersen, Kjell Gunnar & Utheim, Tor Paaske (2022). Role of stem cells in regenerative treatment of dry eye disease caused by lacrimal gland dysfunction. Acta Ophthalmologica. ISSN 1755-375X. doi: 10.1111/aos.15629. Full text in Research Archive Show summary

  An ageing population and increased screen use in younger people have contributed to a rise in incidence of dry eye disease (DED). Quality of life can be significantly affected by DED, with patients experiencing eye dryness, burning, pain and sensitivity to light. If left untreated, DED may progress to cause lasting damage to the delicate cell layers of the ocular surface. The aqueous-deficient form of DED is characterized by decreased tear volume. This can occur through underlying disease or damage to the lacrimal gland (LG), which results in increased inflammation at the ocular surface and decreased tear secretion. Regenerative therapy for treatment of aqueous-deficient DED would ideally restore LG function without causing adverse side effects and be feasible in terms of cost, production and practical application in the clinic. In this review, we evaluate research directed at the development of clinical procedures for regeneration of the LG using various stem cell types and their products. We also discuss work identifying potential therapeutic targets that may alter pathways to effect healing and ameliorate development of DED. Finally, we discuss shortcomings and recommend future avenues for research. These include determination of the best tissue of origin for mesenchymal cells and transference of knowledge gleaned from animal studies to clinical investigations.

• Vernhardsdottir, Ragnheidur Ravnaas; Magnø, Morten Schjerven; Hynnekleiv, Leif; Lagali, Neil Satish; Dartt, Darlene A. & Vehof, Jelle [Show all 8 contributors for this article] (2022). Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review. The ocular surface. ISSN 1542-0124. 26, p. 211–221. doi: 10.1016/j.jtos.2022.08.010. Full text in Research Archive Show summary

  Dry eye disease (DED) is among the most prevalent ophthalmic conditions but is often underdiagnosed and mistreated. Antibiotics are regularly used to treat DED caused by meibomian gland dysfunction (MGD) or blepharitis, but their use has been questioned. Objective To critically evaluate the use of oral and topical antibiotics in DED management. Methods A literature search was conducted on November 15th, 2021, in the PubMed database. The search terms were: (antibiotics OR azithromycin OR doxycycline OR minocycline) AND (dry eye disease OR meibomian gland OR blepharitis anterior OR blepharitis posterior OR chronic blepharitis) . All relevant original articles with English full-text were included. Case reports and review articles were excluded. Results The search provided 619 articles, of which 22 met the inclusion criteria. Oral and topical antibiotics appeared to have short-term positive effects on signs and symptoms of blepharitis- or MGD-related DED. However, these improvements often reverted upon cessation of treatment. The need for repeated treatments and mild adverse events were common. Conclusions Current evidence suggests that patients with blepharitis- or MGD-related DED experience short-term benefits of antibiotics. However, evidence for lasting improvement after completed treatment was lacking. Given the unclear long-term benefits, common side effects, and increasing antibiotic resistance seen globally, the existing literature is not sufficient to conclude that antibiotics are useful in long-term MGD management. A survival-analysis of a single round of antibiotics, in addition to the effects of repeated rounds of treatment, on DED parameters could provide useful insights.

• Bakken, Ingvild Mygland; Jackson, Catherine Joan; Utheim, Tor Paaske; Villani, Edoardo; Hamrah, Pedram & Kheirkhah, Ahmad [Show all 9 contributors for this article] (2022). The use of in vivo confocal microscopy in fungal keratitis – Progress and challenges. The ocular surface. ISSN 1542-0124. 24, p. 103–118. doi: 10.1016/j.jtos.2022.03.002. Full text in Research Archive Show summary

  Fungal keratitis (FK) is a serious and sight-threatening corneal infection with global reach. The need for prompt diagnosis is paramount, as a delay in initiation of treatment could lead to irreversible vision loss. Current “gold standard” diagnostic methods, namely corneal smear and culture, have limitations due to diagnostic insensitivity and their time-consuming nature. PCR is a newer, complementary method used in the diagnosis of fungal keratitis, whose results are also sample-dependent. In vivo confocal microscopy (IVCM) is a promising complementary diagnostic method of increasing importance as it allows non-invasive real-time direct visualization of potential fungal pathogens and manifesting infection directly in the patient’s cornea. In numerous articles and case reports, FK diagnosis by IVCM has been evaluated, and different features, approaches, sensitivity/specificity, and limitations have been noted. Here, we provide an up-to-date, comprehensive review of the current literature and present the authors’ combined recommendations for fungal identification in IVCM images, while also looking to the future of FK assessment by IVCM using artificial intelligence methods.

• Cotsworth, Shawn; Jackson, Catherine Joan; Hallson, Graham; Fitzpatrick, Kathleen A.; Syrzycka, Monika & Coulthard, Alistair B. [Show all 15 contributors for this article] (2022). Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate‐Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster. Cells. ISSN 2073-4409. 11(3). doi: 10.3390/cells11030448. Full text in Research Archive Show summary

  The zeppelin (zep) locus is known for its essential role in the development of the embryonic cuticle of Drosophila melanogaster. We show here that zep encodes Gfat1 (Glutamine: Fructose-6-Phosphate Aminotransferase 1; CG12449), the enzyme that catalyzes the rate-limiting step in the hexosamine biosynthesis pathway (HBP). This conserved pathway diverts 2%–5% of cellular glucose from glycolysis and is a nexus of sugar (fructose-6-phosphate), amino acid (glutamine), fatty acid [acetyl-coenzymeA (CoA)], and nucleotide/energy (UDP) metabolism. We also describe the isolation and characterization of lethal mutants in the euchromatic paralog, Gfat2 (CG1345), and demonstrate that ubiquitous expression of Gfat1+ or Gfat2+ transgenes can rescue lethal mutations in either gene. Gfat1 and Gfat2 show differences in mRNA and protein expression during embryogenesis and in essential tissue-specific requirements for Gfat1 and Gfat2, suggesting a degree of functional evolutionary divergence. An evolutionary, cytogenetic analysis of the two genes in six Drosophila species revealed Gfat2 to be located within euchromatin in all six species. Gfat1 localizes to heterochromatin in three melanogaster-group species, and to euchromatin in the more distantly related species. We have also found that the pattern of flanking-gene microsynteny is highly conserved for Gfat1 and somewhat less conserved for Gfat2.

• Jackson, Catherine Joan; Gundersen, Kjell Gunnar; Tong, Louis & Utheim, Tor Paaske (2022). Dry eye disease and proteomics. The ocular surface. ISSN 1542-0124. 24, p. 119–128. doi: 10.1016/j.jtos.2022.03.001. Show summary

  Dry eye disease (DED) is a highly prevalent disease worldwide mostly associated with age, though other factors such as screen use and contact lens wear explain why it is increasingly diagnosed in younger people. DED also disproportionately affects women. Symptoms include eye dryness, burning, pain and sensitivity to light that can significantly affect quality of life. This condition may progress to cause lasting damage to the ocular surface if left untreated. Currently, diagnosis is through assessment of signs and symptoms determined by clinical tests and questionnaires. However, there is considerable overlap between normal and DED result distributions of currently available metrics as signs and symptoms fluctuate over time and with disease severity. Importantly, the non-targeted approach of proteomics means that significant changes in novel proteins may be discovered. Proteomics is a powerful tool that has been applied to the field of DED to understand changes at a biochemical level, uncover new disease biomarkers and determine the success of clinical interventions. While individual proteins may not be sensitive enough when used as single biomarkers, proteomics opens the possibility to uncover several relevant proteins that may be combined in a panel to provide more accurate diagnostic value i.e. parallel testing. In this review we discuss the use of proteomics in DED research and the potential for application of proteomic results in the clinic. We also identify shortcomings and future avenues for research.

• Storås, Andrea; Strumke, Inga; Riegler, Michael Alexander; Grauslund, Jakob; Hammer, Hugo Lewi & Yazidi, Anis [Show all 10 contributors for this article] (2021). Artificial intelligence in dry eye disease. The ocular surface. ISSN 1542-0124. 23, p. 74–86. doi: 10.1016/j.jtos.2021.11.004. Show summary

  Dry eye disease (DED) has a prevalence of between 5 and 50%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests used in the diagnosis of DED rely on an experienced observer for image interpretation, which may be considered subjective and result in variation in diagnosis. Since artificial intelligence (AI) systems are capable of advanced problem solving, use of such techniques could lead to more objective diagnosis. Although the term ‘AI’ is commonly used, recent success in its applications to medicine is mainly due to advancements in the sub-field of machine learning, which has been used to automatically classify images and predict medical outcomes. Powerful machine learning techniques have been harnessed to understand nuances in patient data and medical images, aiming for consistent diagnosis and stratification of disease severity. This is the first literature review on the use of AI in DED. We provide a brief introduction to AI, report its current use in DED research and its potential for application in the clinic. Our review found that AI has been employed in a wide range of DED clinical tests and research applications, primarily for interpretation of interferometry, slit-lamp and meibography images. While initial results are promising, much work is still needed on model development, clinical testing and standardisation.

• Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine Joan; Tønseth, Kim Alexander & Eidet, Jon Roger (2021). Concise Review: Considering Optimal Temperature for Short-Term Storage of Epithelial Cells. Frontiers in medicine. ISSN 2296-858X. 8. doi: 10.3389/fmed.2021.686774. Full text in Research Archive
• Jackson, Catherine; Pasovic, Lara; Ræder, Sten; Sehic, Amer; Roald, Borghild & de la Paz, Maria Fideliz [Show all 7 contributors for this article] (2020). Optisol-GS storage of cultured human limbal epithelial cells at ambient temperature Is superior to hypothermic storage. Current Eye Research. ISSN 0271-3683. 45(12), p. 1497–1503. doi: 10.1080/02713683.2020.1770295.
• Cabral, Joao Victor; Jackson, Catherine; Utheim, Tor Paaske & Jirsova, Katerina (2020). Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review. Stem Cell Research & Therapy. ISSN 1757-6512. 11:301, p. 1–13. doi: 10.1186/s13287-020-01783-8. Full text in Research Archive
• Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Utheim, Tor Paaske; Reppe, Sjur; Sapkota, Dipak & Olstad, Ole Kristoffer [Show all 8 contributors for this article] (2020). Sericin-induced melanogenesis in cultured retinal pigment epithelial cells is associated with elevated levels of hydrogen peroxide and inflammatory proteins. Molecules. ISSN 1431-5157. 25(19), p. 1–20. doi: 10.3390/molecules25194395. Full text in Research Archive
• Ringstad, Håkon; Reppe, Sjur; Schøyen, Tine Hiorth; Tønseth, Kim Alexander; Utheim, Tor Paaske & Jackson, Catherine (2020). Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C. PLOS ONE. ISSN 1932-6203. 15(5), p. 1–20. doi: 10.1371/journal.pone.0232270. Full text in Research Archive Show summary

  Transplantation of cultured epidermal cell sheets (CES) can be life-saving for patients with large area burns. CES have also been successfully used to regenerate eye and urethral epithelia in animal models. Short-term storage aims to extend the transplantation window, offers flexibility in timing surgery and allows testing of CES quality, phenotype and sterility. This study investigated extended CES storage and explored the effect of additional re-incubation recovery time following storage. The proliferative quality of stored confluent versus pre-confluent CES was also investigated using functional testing. CES were stored at 12°C and results compared to non-stored control CES. Investigation of timepoints during 15 days storage revealed that viability began to deteriorate by day 11 and was associated with increased lactate in the storage medium. The percentage of apoptotic cells also significantly increased by day 11. Flow cytometry analysis of integrin β1 expression and cell size indicated best retention of stem cells at 7 days of storage. Functional testing of pre-confluent and confluent cells following 7 days storage showed that pre-confluent cells responded well to 1-day re-incubation after storage; they became highly prolific, increasing in number by ~67%. Conversely, proliferation in stored confluent cells declined by ~50% with 1-day re-incubation. Pre-confluent stored CES also had far superior stem cell colony forming efficiency (CFE) performance compared to the confluent group. Re-incubation improved CFE in both groups, but the pre-confluent group again out-performed the confluent group with significantly more colonies. In conclusion, a maximum storage period of 7 days is recommended. Use of pre-confluent cells and one day recovery incubation greatly improves viability, colony-forming ability and proliferation of cells stored for 7 days at 12°C. Thus, these recommendations should be considered under culture and storage of high-quality CES for clinical use.

• Jackson, Catherine; Ernø, Inger Thea Myklebust; Ringstad, Håkon; Tønseth, Kim Alexander; Dartt, Darlene Ann & Utheim, Tor Paaske (2019). Simple limbal epithelial transplantation: Current status and future perspectives: Concise review. Stem Cells Translational Medicine. ISSN 2157-6564. p. 1–13. doi: 10.1002/sctm.19-0203. Full text in Research Archive
• Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine & Utheim, Tor Paaske (2019). A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy. Bioengineering. ISSN 2306-5354. 6(4), p. 1–17. doi: 10.3390/bioengineering6040097. Full text in Research Archive
• Yazdani, Mazyar; Shahdafar, Aboulghassem; Jackson, Catherine & Utheim, Tor Paaske (2019). Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review. Cells. ISSN 2073-4409. 8(3), p. 1–12. doi: 10.3390/cells8030245. Full text in Research Archive
• Skraastad, Bendixen Berit; Knudsen, Cathrine Wold; Jackson, Catherine; Utheim, Tor Paaske; Pripp, Are Hugo & Tønseth, Kim Alexander (2019). Quality of life, patient satisfaction and cosmetic outcome after delayed breast reconstruction using DIEP flap: a 10 years' follow-up survey. Journal of Plastic Surgery and Hand Surgery. ISSN 2000-656X. 53(2), p. 119–124. doi: 10.1080/2000656X.2018.1562459.
• Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø & Eidet, Jon Roger [Show all 7 contributors for this article] (2018). High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets. Stem Cells International. ISSN 1687-966X. doi: 10.1155/2018/6545876. Full text in Research Archive
• Lång, Emma Helena; Polec, Anna; Lång, Anna Ulrika; Valk, Marijke; Blicher, Pernille & Rowe, Alexander D. [Show all 12 contributors for this article] (2018). Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding. Nature Communications. ISSN 2041-1723. 9(1), p. 1–15. doi: 10.1038/s41467-018-05578-7. Full text in Research Archive
• Utheim, Tor Paaske; Utheim, Øygunn Aass; Salvanos, Panagiotis; Jackson, Catherine; Schrader, Stefan & Geerling, Gerd [Show all 7 contributors for this article] (2018). Concise review: Altered versus unaltered amniotic membrane as a substrate for limbal epithelial cells. Stem Cells Translational Medicine. ISSN 2157-6564. 7(5), p. 415–427. doi: 10.1002/sctm.17-0257. Full text in Research Archive
• Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine & Thiede, Bernd [Show all 8 contributors for this article] (2018). Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-24121-8. Full text in Research Archive
• Jackson, Catherine; Reppe, Sjur; Eidet, Jon Roger; Eide, Lars; Tønseth, Kim Alexander & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2017). Optimization of storage temperature for Retention of Undifferentiated cell character of cultured human epidermal cell sheets. Scientific Reports. ISSN 2045-2322. 7:8206, p. 1–14. doi: 10.1038/s41598-017-08586-7.
• Jackson, Catherine; Tønseth, Kim Alexander & Utheim, Tor Paaske (2017). Cultured epidermal stem cells in regenerative medicine. Stem Cell Research & Therapy. ISSN 1757-6512. 8:155, p. 1–7. doi: 10.1186/s13287-017-0587-1. Full text in Research Archive
• Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine; Reppe, Sjur; Lyberg, Torstein & Eidet, Jon Roger (2016). Nucleus Morphometry in Cultured Epithelial Cells Correlates with Phenotype. Microscopy and Microanalysis. ISSN 1431-9276. 22(3), p. 612–620. doi: 10.1017/S1431927616000830. Show summary

  Phenotype of cultured ocular epithelial transplants has been shown to affect clinical success rates following transplantation to the cornea. The purpose of this study was to evaluate the relationship between cell nucleus morphometry and phenotype in three types of cultured epithelial cells. This study provides knowledge for the development of a non-invasive method of determining the phenotype of cultured epithelium before transplantation. Cultured human conjunctival epithelial cells (HCjE), human epidermal keratinocytes (HEK), and human retinal pigment epithelial cells (HRPE) were analyzed by quantitative immunofluorescence. Assessments of nucleus morphometry and nucleus-to-cytoplasm ratio (N/C ratio) were performed using ImageJ. Spearman’s correlation coefficient was employed for statistical analysis. Levels of the proliferation marker PCNA in HCjE, HEK, and HRPE correlated positively with nuclear area. Nuclear area correlated significantly with levels of the undifferentiated cell marker ABCG2 in HCjE. Bmi1 levels, but not p63α levels, correlated significantly with nuclear area in HEK. The N/C ratio did not correlate significantly with any of the immunomarkers in HCjE (ABCG2, CK7, and PCNA) and HRPE (PCNA). In HEK, however, the N/C ratio was negatively correlated with levels of the undifferentiated cell marker CK14 and positively correlated with Bmi1 expression. The size of the nuclear area correlated positively with proliferation markers in all three epithelia. Morphometric indicators of phenotype in cultured epithelia can be identified using ImageJ. Conversely, the N/C ratio did not show a uniform relationship with phenotype in HCjE, HEK, or HRPE. N/C ratio therefore, may not be a useful morphometric marker for in vitro assessment of phenotype in these three epithelia.

• Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Aass, Hans Christian; Tønseth, Kim Aleksander & Roald, Borghild [Show all 8 contributors for this article] (2016). Effect of Storage Temperature on the Phenotype of Cultured Epidermal Cells Stored in Xenobiotic-Free Medium. Current Eye Research. ISSN 0271-3683. 41(6), p. 757–768. doi: 10.3109/02713683.2015.1062113.
• Islam, Rakibul; Jackson, Catherine; Eidet, Jon Roger; Messelt, Edvard Berger; Corroya, Rima Maria & Lyberg, Torstein [Show all 9 contributors for this article] (2015). Effect of storage temperature on structure and function of cultured human oral keratinocytes. PLOS ONE. ISSN 1932-6203. 10:e0128306(6). doi: 10.1371/journal.pone.0128306. Full text in Research Archive
• Jackson, Catherine; Aabel, Peder; Eidet, Jon Roger; Messelt, Edvard Berger; Lyberg, Torstein & Von Unge, Magnus [Show all 7 contributors for this article] (2014). Effect of storage temperature on cultured epidermal cell sheets stored in xenobiotic-free medium. PLOS ONE. ISSN 1932-6203. 9(8). doi: 10.1371/journal.pone.0105808. Full text in Research Archive
• Eidet, Jon Roger; Pasovic, Lara; Maria, Rima; Jackson, Catherine & Utheim, Tor Paaske (2014). Objective assessment of changes in nuclear morphology and cell distribution following induction of apoptosis. Diagnostic Pathology. ISSN 1746-1596. 9(1). doi: 10.1186/1746-1596-9-92.
• Treweek, Shaun; Lockhart, Pauline; Pitkethly, Marie; Cook, Jonathan A.; Kjeldstrøm, Monica & Johansen, Marit [Show all 12 contributors for this article] (2013). Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open. ISSN 2044-6055. 3(2:e002360). doi: 10.1136/bmjopen-2012-002360.

View all works in Cristin

• Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine Joan; Tønseth, Kim Alexander & Eidet, Jon Roger (2021). Corrigendum: Concise Review: Considering Optimal Temperature for Short-Term Storage of Epithelial Cells (Front. Med., (2021), 8, (686774), 10.3389/fmed.2021.686774). Frontiers in medicine. ISSN 2296-858X. 8. doi: 10.3389/fmed.2021.775351.
• Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø & Eidet, Jon Roger [Show all 7 contributors for this article] (2018). Factorial design in regenerative medicine–high throughput screening of additives to promote survival of stored undifferentiated epidermal cells. Investigative Ophthalmology and Visual Science. ISSN 0146-0404. 59(9), p. 3865–3865.
• Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø & Eidet, Jon Roger [Show all 7 contributors for this article] (2018). Factorial design in regenerative medicine–high throughput screening of additives to promote survival of stored undifferentiated epidermal cells.
• Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Reppe, Sjur; Utheim, Tor Paaske; Olstad, Ole Kristoffer & Thiede, Bernd [Show all 7 contributors for this article] (2018). Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelium is Associated with Elevated Levels of Hydrogen Peroxide.
• Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Eide, Lars; Tønseth, Kim Aleksander & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2015). Storage of cultured skin cell sheets for treatment of limbal stem cell deficiency.
• Utheim, Tor Paaske; wendel, johan; Jackson, Catherine; Islam, Rakibul; Ræder, Sten & Sehic, Amer [Show all 7 contributors for this article] (2015). Innovative strategies for treating stem cell deficiency of the ocular surface.
• Utheim, Tor Paaske; Utheim, Øygunn Aass; Eidet, Jon Roger; Ræder, Sten; Jackson, Catherine & Sehic, Amer (2015). Transplantasjon av hud til øyets overflate. Hva er status 122 år etter første transplantasjon? Oftalmolog. ISSN 0108-5344.
• Jackson, Catherine; Eidet, Jon Roger; Tønseth, Kim Aleksander; Eide, Lars; Messelt, Edward B. & Utheim, Tor Paaske (2015). 12oC is the Optimal Storage Temperature for Retention of Viability and Undifferentiated Cell Character of Cultured Epidermal Cells.
• Jackson, Catherine; Aabel, Peder; Eidet, Jon Roger; Messelt, Edvard Berger; Lyberg, Torstein & Utheim, Tor Paaske (2014). The effect of temperature on the viability, morphology and phenotype of epidermal cell sheets after 14 days of storage.
• Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine; Reppe, Sjur; Lyberg, Torstein & Eidet, Jon Roger (2014). Cell Nucleus Morphology in Cultured Epithelial Correlates with Phenotype.
• Utheim, Tor Paaske; Jackson, Catherine; Eidet, Jon Roger; Messelt, Edward B.; Maria, Rima & Lyberg, Torstein [Show all 9 contributors for this article] (2014). Effect of Storage Temperature on the Viability, Phenotype, Metabolism and Morphology of Cultured Human Oral Keratinocytes.
• Utheim, Tor Paaske; Utheim, Øygunn Aass; Raeder, Sten; Lyberg, Torstein; Messelt, Edward B. & Jackson, Catherine [Show all 8 contributors for this article] (2014). Stem Cell Therapy of the Ocular Surface – Current Possibilities and Limitations.
• Khan, Ayyad Ahmad Zartasht; Utheim, Tor Paaske; Jackson, Catherine; Reppe, Sjur; Lyberg, Torstein & Eidet, Jon Roger (2014). Cell Nucleus Morphometry in Cultured Epithelia Correlates with Phenotype.
• Jackson, Catherine; Aabel, Peder; Eidet, Jon Roger; Messelt, Edvard Berger; Lyberg, Torstein & Utheim, Tor Paaske (2014). Xenobiotic Free Storage of Cultured Epidermal Cell Sheets for 14 Days – the Effects of Temperature on Viability, Morphology, Phenotype and Metabolic status. Investigative Ophthalmology and Visual Science. ISSN 0146-0404.

View all works in Cristin