Linda Hildegard Bergersen

Professor - EM / ANAT
Image of Linda Hildegard Bergersen
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Phone +47 22840288
Mobile phone +47 97032049
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Visiting address Sognsvannsveien 10 Domus Odontologica 0372 Oslo
Postal address Postboks 1052 Blindern 0316 Oslo

Breaking News:  Why is physical exercise good for the brain?

In numerous investigations, physical exercise is the most effective measure against dementia, and is beneficial against normal aging and several brain diseases; how does information from muscles reach the brain? We just found out:

Active muscles deliver large quantities of lactate to the blood and thereby to the brain, where it hits a receptor protein, the lactate receptor HCAR1. The activated HCAR1 causes production of growth factors, such as VEGF, which stimulates nerve cells and causes formation of new capillaries – the thinnest blood vessels, where the vital substance exchange takes place. Seven weeks of high intensity interval training five days a week, or injections of lactate to reach similar blood lactate levels, caused increase of VEGF and capillaries in hippocampus in wild-type mice, but not in knockout mice lacking HCAR1.

This is the first time that a substance from exercising muscle has been shown to change the brain through an identified receptor. As impaired blood supply and nerve cell death are key problems in aging and neurodegenerative diseases, including Alzheimer’s disease, the findings open a new approach to treatment.

Other webpages

Education

PhD: Disputation date: 09.03.2001 Thesis title: “Monocarboxylate transporters in excitable tissues” Supervisor Professor Ole Petter Ottersen. Collaboration between University of Sport and Physical Activity and Faculty of Medicine/Department of Anatomy, University of Oslo, Norway

CURRENT AND PREVIOUS POSITIONS

Current

 

2015-           Head of Electron Microscopy Laboratory, Institute of Oral Biology (IOB), UiO, Norway

2013-           Professor in Physiology at the Faculty of Dentistry

2013-           Leader of the Brain and Muscle Energy Group at the IOB, Department of Oral Biology, University of Oslo, Norway 

2011-           Professor of Neurobiology of Aging at the Center of Healthy Aging (CEHA), Medical Faculty, University of Copenhagen, Denmark

Previous

2017- 2020         Dean of Research at the Faculty of Dentistry, UiO, Norway

2011-2013   Associate Professor and “Linjeleder” at the Synaptic Neurochemistry Laboratory (SN-Lab), Institute of Basic Medical Sciences (IMB), UiO

2009-2012   Leader of the SN-Lab, Department of Anatomy, IMB and Centre for Molecular Biology and Neuroscience (CMBN), UiO. 

2004-2013   Leader of the Brain and Muscle Energy Group at the SN-Lab, Department of Anatomy, IMB and CMBN, UiO (moved the group to IOB 2013) in the field of synaptic transmission and energy metabolism in brain and skeletal muscle

2002-2012   Researcher, Centre for Molecular Biology and Neuroscience (CMBN), a Norwegian Centre of Excellence, funded by the Nordic Centre of Excellence Program in Molecular Medicine

2002&2004 Post-Doctoral personal grant from the Research Council of Norway (RCN), Department of Anatomy and CMBN, UiO

2003            Post-Doctoral stay (personal grant RCN) one year abroad at the Institute of Physiology, University of Lausanne, Switzerland

FELLOWSHIPS, PRIZES AND AWARDS

Major grants include Research Council Norway FRMEDBIO (2012-2016)  3 postdocs and 1 PhD. FRIBIO ES460355 (2011-2014) 2 postdocs and 1 PhD. VELUX Foundation (2013-2015), University of Copenhagen (shared with M Kolko) 1 postdoc. Lundbeck Foundation (2012-2018) University of Copenhagen, 2 PhD and running cost. In addition, funding of PhD and postdoc positions has been provided by UiO

2013  The Norwegian Academy of Science and Letters, elected member

2012  The Medical Faculty equal opportunity award (University of Oslo

2011  Lundbeckfonden’s Visiting Professorship (University of Copenhagen)

2009  Centre for Molecular Biology and Neuroscience (CMBN) Career Development Award

2006  Professor Kristen Kjelsberg Osen Prize for Young Neuroscientists, University of Oslo

MOBILITY

2003            Post-Doctoral stay (RCN personal postdoc grant) one year abroad at the Institute of Physiology, University of Lausanne, Switzerland, 2003.

2011-           Professor in Neurobiology of Aging (10% position) at the Center for Neuroscience and Center for Healthy Aging.

SUPERVISION OF GRADUATE STUDENTS AND RESEARCH FELLOWS

2004-2017: main supervisor of 12 undergraduate students, 1 forskerlinje, 10 PhD students and 9 postdocs. I have provided external grant money to all my PhD students and postdocs (except from Rinholm).

PhD students & The Medical Student Research Program student

  • Ilaria Tonazzini (PhD 2004-2007) Marie Curie student from University of Pisa, Italy; now researcher at Institute of Nanoscience CNR, NEST (National Enterprise for nanoScience and nanoTechnology), Pisa
  • Simen Gylterud Owe (PhD 2006-2008) now head of Ortomedic Company – expert confocal microscopy
  • Johanne Egge Rinholm (PhD 2004-2010) current Associate Professor Medical faculty, UiO, Oslo Norway.
  • Fredrik Lauritzen (PhD 2008-2012) now leader Antidoping Norway
  • Chang Cheng (PhD 2009-2012) now Associate Professor, Zhengzhou University, China
  • Tirill Medin (PhD 2008-2013) now Associate professor from 2016 at the Oslo and Akershus University College of Applied Sciences expert on ADHD
  • Christine Elisabeth Regnell (PhD 2009-2014) spesialist i DNA/RNA - ekstraksjon NGS- labben
  • Signe Holm Hansen (PhD 2012-2017) Center of Healthy Ageing, Medical Faculty, University of Copenhagen, Denmark
  • Lauritz Kennedy ”The Medical Student Research Program” (2014- 2017) Medical Faculty, UiO,Oslo Norway
  • Elisabeth Holm Diget (PhD 2015-2019) Center of Healthy Ageing, Medical Faculty,  University of Copenhagen, Denmark 
  • Rupali Vohra (PhD 2015-2019) Medical Faculty, University of Copenhagen, Denmark 
  • Øyvind Pernell Haugen (PhD 2016-2020) delayed, IOB, Faculty of Dentistry, UiO Oslo, Norway
  • Krister Andersson (PhD 2014-2016) delayed  IMB, Faculty of Medicine, UiO, UiO, Oslo, Norway

Post-docs

  • Simen Gylterud Owe (2008-2009) see above
  • Max Larsson (2009-2010) now Researcher at Linkøping University, Sweeden
  • Fredrik Lauritzen (2012-2013) now leader Antidoping Norway
  • Knut Husø Lauritzen (2012-2015) current researcher Oslo University Hospital, Rikshospitalet
  • Maja Puchades (2011-2015); current researcher at Trygve Leergaard’s laboratory at the Medical Faculty, UiO
  • Johanne Egge Rinholm (2012-2015) now researcher at Magnar Bjørås’ laboratory, Oslo University Hospital Rikshospitalet; grant from Nasjonalforeningen on my research topic. Invited for an interview Accociate Professorship at the Medical Faculty, May 2017.
  • Tirill Medin (2013- 2016) see above
  • Liv Kleppa (2014-2016) 
  • Cecilie Morland (2012-2015) current Associate Professor, School of Pharmacy, UiO, from May 2017. Received ”Unge Forskertalenter” personal grant 2017-2020 from RCN on research topic HCAR1 

TEACHING ACTIVITIES  

I have one year of formal pedagogic education and have since 1994 taught at all levels of Academia (medicine, dentistry, science) with lectures in cell biology, physiology, anatomy and neuroscience. Histology course, work physiology course. I am also a founding faculty member of the Norwegian Research School in Neuroscience.

ORGANIZATION OF SCIENTIFIC MEETINGS

2008, 2010, 2012: Organized the Kavli Prize Symposium in Neuroscience, Oslo and Bergen

2009 Scandinavian Physiological Society symposium, Upsala, Sweden

2009 Transatlantic Science Week symposium Minneapolis MN, USA

2010 Career for female scientists - how to get to the top? Lysebu, Oslo

2011 The Healthy Brain: Aging and Brain Disease (Oslo University Hospital)

2012 Dopamine Discovery Day (Oslo University Hospital)

2012 Fourth Genome Dynamics in Neuroscience meeting (GDN4), Oslo

2013 Compete & Collaborate - How to prepare for the future science 'labour-market', DNVA, Oslo

2014 11th International Brain Energy Metabolism meeting, Copenhagen

2010- Academy of Science and Letters annually meeting 10th of October: Nansen Neuroscience Lectures

2018 Leader of the organizing committee for Virginia-Nordic Precision Neuroscience meeting: From discovery to translation and innovation, Oslo

INSTITUTIONAL RESPONSIBILITIES

2017-2021   Dean of Research, Faculty of Dentistry (25% position), University of Oslo

2010-2014   Member of the Medical Faculty of UiO, Equal Opportunity Commission; Leader 2010-2011

2006-2009   Member of the Med Faculty of UiO, Grant and Trust Fund Committee

2007-2017   Member of 10 PhD committees, UiO and Norwegian University of Science and Technology

                   PhD Dissertation leader (Acting Dean) at the Medical and Dentistry Faculties, UiO

                   Member evaluation committees for positions at the Faculty of Medicine, Univ Copenhagen

COMMISSIONS OF TRUST

2017-current     Dean of Research Faculty of Dentistry (25% position), University of Oslo, Norway

2015-current     Head of the Electron Microscopic Laboratory, Inst Oral Biology, UiO

2012-2016        Board member of the Nansen Neuroscience Network, Norway

2009-2016        Leader of the Synaptic Neurochemistry Lab, Dep of Anatomy, IMB, UiO

2004-current     Head of the Brain and Muscle Energy Group, UiO, Norway

2010-2014        Member of the Medical Faculty of UiO, Equal Opportunity Commission; Leader 2010-2011

2006-2009        Member of the Med Faculty of UiO, Grant and Trust Fund Committee

2003-current     Reviewer in leading journals, including Nature, Science, New Engl J Med, and J Neurosci

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2013-current        Elected member of “The Norwegian Academy of Science and Letters”

MAJOR COLLABORATIONS

National collaboration

Magnar Bjørås, Oslo University Hospital Rikshospitalet/Norwegian University of Science and Technology

Arne Klungland, Oslo University Hospital Rikshospitalet

Ulrik Wisløff, Norwegian University of Science and Technology Trondheim

 

Jon Storm-Mathisen, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo

Håvard Attramadal, Oslo University Hospital Rikshospitalet

Cecilie Morland, School of Pharmacy, University of Oslo

Johanne Egge Rinholm, Oslo University Hospital Rikshospitalet

Koen Vervaeke, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo

 

Vidar Gundersen, Oslo University Hospital Rikshospitalet

Tor Paaske Utheim, Oslo University Hospital Ullevål

Tirill Medin, Oslo and Akershus University College of Applied Sciences

International collaboration

  • David Attwell, University College London, UK
  • Tore Eid, Yale University, USA
  • Vilhelm Bohr, Natl Inst of Aging, Baltimore, USA
  • Stefan Offermanns, Max Planck Inst for Hearth and Lung research, Bad Neuheim, Germany
  • Andrea Volterra, Univ of Lausanne, Switzerland
  • Martin Lauritzen, Faculty of Medicine, University of Copenhagen, Denmark
  • Lene Juul Rasmussen, Center of Healthy Aging, Faculty of Medicine, University Copenhagen, Denmark
  • Miriam Kolko, Faculty of Medicine,  University of Copenhagen, Denmark
  • Karl Deisseroth, Stanford University, USA
  • Amy Arnsten, Yale University, USA
  • Robert Zorec, Lubliana University, Slovenia
  • Morten Scheibye-Knudsen, Centre of Healthy Ageing, Faculty of Medicine
  • Knut Røed, Faculty of Societal Sciences, University of Oslo, Oslo Norway

Total publications 83. Total citations: 4118 Google Scholar

Top 10 publications last ten years as main author

(supervised PhDs and Postdocs in bold).

My h-index is 32 from Google Scholar.

1) Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, Stølen T, Hennestad E, Moldestad O, Cai Y, Puchades M, Offermanns S, Vervaeke K, Bjørås M, Wisløff U, Storm-Mathisen J, Bergersen LH (2017) Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 Nat Commun doi: 10.1038/ncomms15557.[IF 11.3]

2) Lauritzen KH, Hasan-Olive MM,  Regnell CE, Liv Kleppa, Scheibye-Knudsen M,  Gjedde A, Klungland A, Bohr V, Storm-Mathisen J, Bergersen LH (2016) A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiol Aging [IF 5.1 ] Cited 1 time

3) Gundersen V, Storm-Mathisen J, Bergersen LH (2015) Neuroglial Transmission. Physiol Rev 95(3):695-726. [IF 27.5 ] Cited 38 times

4) Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH (2015) Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. Am J Physiol Heart Circ Physiol 309(3):H434-49. [IF 3.3 ] Cited 13 times

5) Bergersen LH (2015) Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction. J Cereb Blood Flow Metab 35(2):176-185. [IF 5,4] Cited 36 times

6) Lauritzen KH, Morland C, Puchades M, Holm-Hansen S, Hagelin EM, Lauritzen F, Attramadal H,  Storm-Mathisen J,  Gjedde A, Bergersen LH (2014) Lactate receptor sites link neurotransmission, neurovascular coupling, and  brain energy metabolism. Cereb Cortex 24(10):2784-2795 (accepted 15 April 2013) [IF 8.7]   Cited 77 times

7) Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjørås M, Bergersen LH (2012) Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells. Cell Rep 2:503-510. [IF 8.4]   Cited 39 times

8) Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH*, Klungland A* (2010) Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol 30:1357-1367. [IF 6.2]  *Correspondence, equal contribution. [IF 6.2]  Cited 43 times

9) Rinholm JE, Hamilton NB, Kessaris N, Richardson WD, Bergersen LH*, Attwell D* (2011) Regulation of oligodendrocyte development and myelination by glucose and lactate. J Neurosci 31:538-548. *Correspondence, equal contribution.  [IF 5.9] Cited 115 times.

10) Jourdain P*, Bergersen LH*, Bhaukaurally K, Bezzi P, Domercq M, Matute C, Tonello F, Gundersen V, Volterra A (2007) Glutamate exocytosis from astrocytes control synaptic strength. Nat Neurosci 10(3):331-339.  [IF 14.2] * These authors contributed equally. Cited 541 times 

 

INVITED SPEAKER AT INTERNATIONAL CONFERENCES AND INSTITUTIONS

I have been invited to speak at the most recognized conferences in the field (including Society for Neuroscience, FENS Forum, Internat Society for Neurochemistry, American Society for Neurochemistry, Internat Brain Research Organization, Internat Meeting in Brain Energy Metabolism), and at prestigious universities (e.g. Yale University, École Polytechnique Fédérale de Lausanne, Uppsala University, Karolinska Institute). Latest on the topic of a novel lactate receptor in the brain: 2015 International Society for Neurochemistry, Cairns, Australia; 2015 European Glia Meeting Bilbao, Spain; 2016 American Society for Neurochemistry, Denver CO, USA; 2016 FENS Forum, Copenhagen, Denmark; 2017 Exercise is Medicine, ACSM symposium: Neurobiological Effects of Physical Exercise, Denver CO, USA

MAJOR CONTRIBUTION TO EARLY CAREERS OF EXCELLENT RESEARCHERS

  • Cecilie Morland (previous postdoc). Just appointed Associate Professor School of Pharmacy (May 2017), personal young investigator grant from RCN 2017-2020.
  • Johanne Egge Rinholm (previous Master/PhD student/postdoc, I promoted her doctoral and postdoctoral training at University College London and Janelia Farm, USA). Invited for an interview May 2017 for a position as Associate Professor in Neuroscience at the IMB, Faculty of Medicine, UiO. Now researcher in the M Bjørås lab at OUS, Rikshospitalet on grant money from Nasjonalforeningen.
  • Tirill Medin (previous PhD and Postdoc in my group). Now Associate Professor Oslo and Akershus University College of Applied Sciences, December 2016.

LEADERSHIP IN RESEARCH                                                                                        

From 2004-2013 I was the leader of the Brain and Muscle Energy Group at the SN-Lab, IMB, UiO, where I organized meeting every Friday and team building events twice a year for all the members of SN-Lab. From 2013 I moved the group to the IOB, continuing weekly lab meetings and arranging Lactate Discovery Day twice a year. From 2015 I hold the position as Head of the Electron Microscopic Laboratory at the IOB where I lead a staff of 4 engineers and at present I am main supervisor of 3 PhD students and 1 postdoc. From 2011-2018 I am Leader of the Bergersen group at the Center of Healthy Aging (CEHA) (http://healthyaging.ku.dk), where I supervise 2 PhD students, one recently submitted her thesis. The Site Visit Committee for CEHA (report 12th February 2017) advised that a continued collaboration between CEHA and the Bergersen group (in Oslo) will strengthen the work on the biological basis of brain health considerably. From January 2017 I have been appointed Dean of Research at the Faculty of Dentistry, UiO (25% position). To further facilitate international cooperation in the Nordic countries, I have taken the initiative (Project Leader) to apply to the NordForsk call ‘New instrument for Nordic University Cooperation - Nordic University Hubs’ (duration 2018-2023): #86656 Nordic Hub of Brain and Cognitive Aging (NHBCA) comprising partners from Oslo/Trondheim, Göteborg, and Copenhagen, with the intention of including Finland and Iceland during the course of the project.

Courses taught

  • Medical curriculum, 4th Semester, Locomotion, Anatomy (in Norwegian only)
  • MBV4340 - Advanced neurobiology
  • MBV9340 - Advanced neurobiology

Other webpages

 

Tags: Brain and nervous system, Signal transmission in the nervous system, Brain metabolism, Physical activity and brain function

Publications

  • Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael & Muhl, Lars [Show all 33 contributors for this article] (2023). Molecular anatomy of adult mouse leptomeninges. Neuron. ISSN 0896-6273. 111, p. 3745–3764. doi: 10.1016/j.neuron.2023.09.002. Full text in Research Archive
  • Norevik, Cecilie Skarstad; Huuha, Aleksi Matias; Røsbjørgen, Ragnhild; Bergersen, Linda Hildegard; Jacobsen, Kamilla & Miguel dos Santos, Rodrigo [Show all 13 contributors for this article] (2023). Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain. Journal of Sport and Health Science. ISSN 2095-2546. doi: 10.1016/j.jshs.2023.07.003. Full text in Research Archive
  • Vohra, Rupali; Sanz-Morello, Berta; Tams, Anna Luna Mølgaard; Mouhammad, Zaynab Ahmad; Freude, Kristine Karla & Hannibal, Jens [Show all 9 contributors for this article] (2022). Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants. Cells. ISSN 2073-4409. 11(13). doi: 10.3390/cells11132098. Full text in Research Archive
  • Kennedy, Lauritz Hagen; Glesaaen, Emilie Rylund; Palibrk, Vuk; Pannone, Marco; Wang, Wei & Al-Jabri, Ali [Show all 13 contributors for this article] (2022). Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia. eLIFE. ISSN 2050-084X. 11. doi: 10.7554/eLife.76451. Full text in Research Archive
  • Haugen, Øyvind Pernell; Khuu, Cuong; Weidemann, Hanne Margrete; Utheim, Tor Paaske & Bergersen, Linda Hildegard (2022). Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells. Gene. ISSN 0378-1119. 822. doi: 10.1016/j.gene.2022.146346. Full text in Research Archive
  • Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Show all 13 contributors for this article] (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, p. 1–23. doi: 10.7554/ELIFE.59828. Full text in Research Archive
  • Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena & Haugen, Øyvind Pernell [Show all 10 contributors for this article] (2020). L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1. Acta Physiologica. ISSN 1748-1708. doi: 10.1111/apha.13587. Full text in Research Archive
  • Utheim, Tor Paaske; Chen, Xiangjun; Fricke, Otto; Bergersen, Linda Hildegard & Lagali, Neil Satish (2020). Microdot Accumulation in the Anterior Cornea with Aging–Quantitative Analysis with in Vivo Confocal Microscopy. Current Eye Research. ISSN 0271-3683. 45(9), p. 1058–1064. doi: 10.1080/02713683.2020.1725062.
  • Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma & Andrews, Zane B [Show all 27 contributors for this article] (2020). Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews Drug Discovery. ISSN 1474-1776. 19, p. 609–633. doi: 10.1038/s41573-020-0072-x. Full text in Research Archive
  • Hadzic, Alena; Nguyen, Teresa Dang; Hosoyamada, Makoto; Tomioka, Naoko H.; Bergersen, Linda Hildegard & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2020). The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle. International Journal of Molecular Sciences. ISSN 1661-6596. 21(18). doi: 10.3390/ijms21186457. Full text in Research Archive
  • Aman, Yahyah; Frank, Johannes; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming & Yang, Guang [Show all 13 contributors for this article] (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development. ISSN 0047-6374. 185, p. 1–11. doi: 10.1016/j.mad.2019.111194. Full text in Research Archive
  • Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie & Aman, Yahyah [Show all 18 contributors for this article] (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 186, p. 1–6. doi: 10.1016/j.mad.2020.111208. Full text in Research Archive
  • Haugen, Øyvind Pernell; Vallenari, Evan Michael; Belhaj, Imen; Småstuen, Milada Cvancarova; Storm-Mathisen, Jon & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2020). Blood lactate dynamics in awake and anaesthetized mice after intraperitoneal and subcutaneous injections of lactate—sex matters. PeerJ. ISSN 2167-8359. 2020(1). doi: 10.7717/peerj.8328. Full text in Research Archive
  • Fang, Fei; Nilsen, Hilde; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2019). NO-age in Norway. Translational Medicine of Aging. ISSN 2468-5011. 3, p. 37–39. doi: 10.1016/j.tma.2019.04.001.
  • Vohra, Rupali; Aldana, Blanca I; Bulli, Giorgia; Skytt, Dorte M.; Waagepetersen, Helle & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2019). Lactate-Mediated Protection of Retinal Ganglion Cells. Journal of Molecular Biology (JMB). ISSN 0022-2836. 431(9), p. 1878–1888. doi: 10.1016/j.jmb.2019.03.005.
  • Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2019). High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovascular Toxicology. ISSN 1530-7905. 19(5), p. 422–431. doi: 10.1007/s12012-019-09514-z. Full text in Research Archive
  • Vohra, Rupali; Aldana, Blanca I; Waagepetersen, Helle; Bergersen, Linda Hildegard & Kolko, Miriam (2019). Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation. Investigative Ophthalmology and Visual Science. ISSN 0146-0404. 60(4), p. 999–1008. doi: 10.1167/iovs.18-25458. Full text in Research Archive
  • Vohra, Rupali; Dalgaard, Line Marie; Vibæk, Jeppe; Langbøl, Mia Aggergaard; Bergersen, Linda Hildegard & Olsen, Niels Vidiendal [Show all 8 contributors for this article] (2019). Potential metabolic markers in glaucoma and their regulation in response to hypoxia. Acta Ophthalmologica. ISSN 1755-375X. p. 1–10. doi: 10.1111/aos.14021.
  • Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon & Bergersen, Linda Hildegard [Show all 11 contributors for this article] (2019). Are the Neuroprotective Effects of Exercise Training Systemically Mediated? Progress in cardiovascular diseases. ISSN 0033-0620. 62(2), p. 94–101. doi: 10.1016/j.pcad.2019.02.003. Full text in Research Archive
  • Medin, Tirill; Jensen, Vidar; Skare, Øivind; Storm-Mathisen, Jon; Hvalby, Øyvind Christian & Bergersen, Linda Hildegard (2019). Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD). Behavioural Brain Research. ISSN 0166-4328. 360, p. 209–215. doi: 10.1016/j.bbr.2018.12.028. Full text in Research Archive
  • Vohra, Rupali; Aldana, Blanca I; Skytt, Dorte M.; Freude, Kristine; Waagepetersen, Helle S. & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2018). Essential Roles of Lactate in Muller Cell Survival and Function. Molecular Neurobiology. ISSN 0893-7648. 55(12), p. 9108–9121. doi: 10.1007/s12035-018-1056-2.
  • Medin, Tirill; Medin, Hege; Hefte, Marita Brandsar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2018). Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment . Behavioural Brain Research. ISSN 0166-4328. 360, p. 279–285. doi: 10.1016/j.bbr.2018.12.023.
  • Hasan-Olive, Md Mahdi; Lauritzen, Knut Husø; Ali, Mohammad Abdulla; Rasmussen, Lene Juel; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2018). A ketogenic diet improves mitochondrial biogenesis and bioenergetics via the PGC1α-SIRT3-UCP2 axis. Neurochemical Research. ISSN 0364-3190. p. 1–16. doi: 10.1007/s11064-018-2588-6.
  • Thomsen, Kirsten; Yokota, Takashi; Hasan-Olive, Md Mahdi; Sherazi, Niloofar; Fakouri, Nima Borhan & Desler, Claus [Show all 12 contributors for this article] (2018). Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus. Neurobiology of Aging. ISSN 0197-4580. 61, p. 215–224. doi: 10.1016/j.neurobiolaging.2017.08.004.
  • Vardjan, Nina; Chowdhury, Helena H.; Horvat, Anemari; Velebit, Jelena; Malnar, Maja & Muhic, Marko [Show all 16 contributors for this article] (2018). Enhancement of astroglial aerobic glycolysis by extracellular lactate-mediated increase in cAMP. Frontiers in Molecular Neuroscience. ISSN 1662-5099. 11. doi: 10.3389/fnmol.2018.00148. Full text in Research Archive
  • Fakouri, Nima Borhan; Durhuus, Jon Ambæk; Regnell, Christine E; Angleys, Maria; Desler, Claus & Hasan-Olive, Md Mahdi [Show all 14 contributors for this article] (2017). Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-12662-3.
  • Vohra, Rupali; Gurubaran, I. S.; Henriksen, Ulrik; Bergersen, Linda Hildegard; Rasmussen, Lene Juel & Desler, Claus [Show all 8 contributors for this article] (2017). Disturbed mitochondrial function restricts glutamate uptake in the human Muller glia cell line, MIO-M1. Mitochondrion (Amsterdam. Print). ISSN 1567-7249. 36, p. 52–59. doi: 10.1016/j.mito.2017.02.003.
  • Jackson, Catherine; Reppe, Sjur; Eidet, Jon Roger; Eide, Lars; Tønseth, Kim Alexander & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2017). Optimization of storage temperature for Retention of Undifferentiated cell character of cultured human epidermal cell sheets. Scientific Reports. ISSN 2045-2322. 7:8206, p. 1–14. doi: 10.1038/s41598-017-08586-7.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications. ISSN 2041-1723. 8. doi: 10.1038/ncomms15557. Full text in Research Archive
  • Saeed, Muhammad; Rafiq, Sikander; Bergersen, Linda Hildegard & Deng, Liyuan (2017). Tailoring of water swollen PVA membrane for hosting carriers in CO2 facilitated transport membranes. Separation and Purification Technology. ISSN 1383-5866. 179, p. 550–560. doi: 10.1016/j.seppur.2017.02.022.
  • Hamilton, Nicola; Clarke, Laura E.; Arancibia-Carcamo, I. Lorena; Kougioumtzidou, Eleni; Matthey, Moritz & Karadottir, Ragnhildur [Show all 10 contributors for this article] (2017). Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internodelength. Glia. ISSN 0894-1491. 65(2), p. 309–321. doi: 10.1002/glia.23093. Full text in Research Archive
  • Skytt, D. M.; Toft-Kehler, A. K.; Brændstrup, C. T.; Cejvanovic, S.; Gurubaran, I. S. & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2016). Glia-neuron interactions in the retina can be studied in cocultures of Müller cells and retinal ganglion cells. BioMed Research International. ISSN 2314-6133. 2016. doi: 10.1155/2016/1087647. Full text in Research Archive
  • Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten & Gjedde, Albert [Show all 10 contributors for this article] (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging. ISSN 0197-4580. 48, p. 34–47. doi: 10.1016/j.neurobiolaging.2016.08.005.
  • Holm-Hansen, Signe; Low, J.K.; Zieba, J; Gjedde, A.; Bergersen, Linda Hildegard & Karl, Tim (2016). Behavioural effects of high fat diet in a mutant mouse model for the schizophrenia risk gene neuregulin 1. Genes, Brain and Behavior. ISSN 1601-1848. 15(3), p. 295–304. doi: 10.1111/gbb.12267.
  • Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan, Mahdi; Diget, Elisabeth Holm & Vohra, Rupali [Show all 13 contributors for this article] (2016). Lactate transport and receptor actions in retina: potential roles in retinal function and disease. Neurochemical Research. ISSN 0364-3190. 41(6), p. 1229–1236. doi: 10.1007/s11064-015-1792-x.
  • Rinholm, Johanne Egge; Vervaeke, Koen Gerard Alois; Tadross, Michael; Tkachuk, Ariana; Kopek, Benjamin & Brown, Timothy A [Show all 8 contributors for this article] (2016). Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths. Glia. ISSN 0894-1491. 64(5), p. 810–825. doi: 10.1002/glia.22965.
  • Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald & Haugen, Øyvind Pernell [Show all 12 contributors for this article] (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 309(3), p. H434–H449. doi: 10.1152/ajpheart.00253.2014.
  • Gundersen, Vidar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). Neuroglial transmission. Physiological Reviews. ISSN 0031-9333. 95(3), p. 695–726. doi: 10.1152/physrev.00024.2014.
  • Morland, Cecilie; Lauritzen, Knut Husø; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Andersson, Krister & Gjedde, Albert [Show all 9 contributors for this article] (2015). The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of Neuroscience Research. ISSN 0360-4012. 93(7), p. 1045–1055. doi: 10.1002/jnr.23593.
  • Bergersen, Linda Hildegard (2015). Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction . Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 35(2), p. 176–185. doi: 10.1038/jcbfm.2014.206.
  • Lauritzen, Fredrik; Eid, Tore & Bergersen, Linda Hildegard (2015). Monocarboxylate transporters in temporal lobe epilepsy: roles of lactate and ketogenic diet. Brain Structure and Function. ISSN 1863-2653. 220(1), p. 1–12. doi: 10.1007/s00429-013-0672-x.
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2014). Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex. Cerebral Cortex. ISSN 1047-3211. p. 2784–2795. doi: 10.1093/cercor/bht136.
  • Knudsen Scheibye, Morten; Mitchell, SJ; Fang, EF; Iyama, T; Ward, T. & Wang, J [Show all 22 contributors for this article] (2014). A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome . Cell Metabolism. ISSN 1550-4131. 20(5), p. 840–855. doi: 10.1016/j.cmet.2014.10.005.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 90(7), p. 527–537. doi: 10.3109/09553002.2014.906767.
  • Mariga, Shelton T.; Kolko, Miriam; Gjedde, Albert & Bergersen, Linda Hildegard (2014). Lactate transport and receptor actions in cerebral malaria. Frontiers in Neuroenergetics. ISSN 1662-6427. 6(MAY). doi: 10.3389/fnins.2014.00125. Full text in Research Archive
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2014). White matter lactate - Does it matter? Neuroscience. ISSN 0306-4522. 276, p. 109–116. doi: 10.1016/j.neuroscience.2013.10.002.
  • Rasmussen, Lene Juel; Shiloh, Y.; Bergersen, Linda Hildegard; Sander, Miriam; Bohr, Vilhelm A. & Tønjum, Tone (2013). DNA damage response, bioenergetics, and neurological disease: The challenge of maintaining brain health in an aging human population. Mechanisms of Ageing and Development. ISSN 0047-6374. 134(10), p. 427–433. doi: 10.1016/j.mad.2013.05.001.
  • Rodell, Anders; Rasmussen, Lene Juel; Bergersen, Linda Hildegard; Singh, KK & Gjedde, Albert (2013). Natural selection of mitochondria during somatic lifetime promotes healthy aging. Frontiers in Neuroenergetics. ISSN 1662-6427. doi: 10.3389/fnene.2013.00007.
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2013). Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bht136.
  • Nagelhus, Erlend Arnulf; Amiry-Moghaddam, Mahmood ; Bergersen, Linda Hildegard; Bjaalie, Jan G.; Eriksson, Jens & Gundersen, Vidar [Show all 12 contributors for this article] (2013). The glia doctrine: Addressing the role of glial cells in healthy brain ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 134(10), p. 449–459. doi: 10.1016/j.mad.2013.10.001.
  • Puchades, Maja Amedjkouh; Sogn, Carl Johan; Mæhlen, Jan; Bergersen, Linda Hildegard & Gundersen, Vidar (2013). Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease. Parkinson's Disease. ISSN 2090-8083. 3(3), p. 371–385. doi: 10.3233/JPD-130190.
  • Medin, Tirill; Rinholm, Johanne Egge; Owe, Simen Gylterud; Sagvolden, Terje; Gjedde, A. & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2013). LOW DOPAMINE D5 RECEPTOR DENSITY IN HIPPOCAMPUS IN AN ANIMAL MODEL OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD). Neuroscience. ISSN 0306-4522. 242, p. 11–20. doi: 10.1016/j.neuroscience.2013.03.036.
  • Bergersen, Linda Hildegard; Bramham, Clive R.; Hugdahl, Kenneth; Sander, Miriam & Storm-Mathisen, Jon (2013). The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. Neuroscience. ISSN 0306-4522. 247, p. 412–422. doi: 10.1016/j.neuroscience.2013.04.012.
  • Eid, Tore; Lee, Tih-Shih W.; Wang, Yue; Perez, Edgar; Drummond, Jana & Lauritzen, Fredrik [Show all 11 contributors for this article] (2013). Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy. Epilepsia. ISSN 0013-9580. 54(2), p. 228–238. doi: 10.1111/epi.12008.
  • Vafaee, Manouchehr S; Vang, Kim; Bergersen, Linda Hildegard & Gjedde, Albert (2012). Oxygen consumption and blood flow coupling in human motor cortex during intense finger tapping:implication for a role of lactate. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 32(10), p. 1859–1868. doi: 10.1038/jcbfm.2012.89.
  • Bergersen, Linda Hildegard & Gjedde, Albert (2012). Is lactate a volume transmitter of metabolic states of the brain? Frontiers in Neuroenergetics. ISSN 1662-6427. 5(4). doi: 10.3389/fnene.2012.00005. Full text in Research Archive
  • Lauritzen, Fredrik; Heuser, Kjell; de Lanerolle, Nihal C.; Lee, Tih-Shih W.; Spencer, Dennis D. & Kim, Jung H. [Show all 9 contributors for this article] (2012). Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. Glia. ISSN 0894-1491. 60(7), p. 1172–1181. doi: 10.1002/glia.22344.
  • Regnell, Christine E; Hildrestrand, Gunn Annette; Sejersted, Yngve; Medin, Tirill; Moldestad, Olve & Rolseth, Veslemøy [Show all 11 contributors for this article] (2012). Hippocampal Adult Neurogenesis Is Maintained by Neil3-Dependent Repair of Oxidative DNA Lesions in Neural Progenitor Cells. Cell reports. ISSN 2211-1247. 2(3), p. 503–510. doi: 10.1016/j.celrep.2012.08.008. Full text in Research Archive
  • Perez, Edgar L.; Lauritzen, Fredrik; Wang, Yue; Lee, Tih-Shih W.; Kang, Dewey & Zaveri, Hitten P. [Show all 10 contributors for this article] (2012). Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy. Neurobiology of Disease. ISSN 0969-9961. 47(3), p. 331–337. doi: 10.1016/j.nbd.2012.05.010.
  • Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Show all 10 contributors for this article] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), p. 217–227. doi: 10.1007/s13402-012-0081-9.
  • Lauritzen, Fredrik; Perez, Edgar L.; Melillo, Eric R.; Roh, Jung-Min; Zaveri, Hitten P. & Lee, Tih-Shih W. [Show all 9 contributors for this article] (2012). Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. Neurobiology of Disease. ISSN 0969-9961. 45(1), p. 165–176. doi: 10.1016/j.nbd.2011.08.001.
  • Ormel, Lasse; Stensrud, Mats Julius; Bergersen, Linda Hildegard & Gundersen, Vidar (2012). VGLUT1 is localized in astrocytic processes in several brain regions. Glia. ISSN 0894-1491. 60(2), p. 229–238. doi: 10.1002/glia.21258.
  • Bergersen, Linda Hildegard; Morland, Cecilie; Ormel, Lasse; Rinholm, Johanne Egge; Larsson, Max David & Wold, Johan Fredrik Hustad [Show all 13 contributors for this article] (2012). Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes. Cerebral Cortex. ISSN 1047-3211. 22(7), p. 1690–1697. doi: 10.1093/cercor/bhr254.
  • Medin, Tirill; Owe, Simen Gylterud; Rinholm, Johanne Egge; Larsson, Max; Sagvolden, Terje & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2011). Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus. Neuroscience. ISSN 0306-4522. 192, p. 164–171. doi: 10.1016/j.neuroscience.2011.06.056.
  • Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair. ISSN 1568-7864. 10(6), p. 639–653. doi: 10.1016/j.dnarep.2011.04.011.
  • Rinholm, Johanne Egge; Hamilton, Nicola; Kessaris, Nicoletta; Richardson, William D.; Bergersen, Linda Hildegard & Attwell, David (2011). Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate. Journal of Neuroscience. ISSN 0270-6474. 31(2), p. 538–548. doi: 10.1523/JNEUROSCI.3516-10.2011.
  • Lauritzen, Fredrik; de Lanerolle, Nihal; Lee, Tih-Shih W.; Spencer, Dennis D.; Kim, Jung H. & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2011). Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiology of Disease. ISSN 0969-9961. 41(2), p. 577–584. doi: 10.1016/j.nbd.2010.11.005.
  • Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute & Storm, Johan Frederik [Show all 9 contributors for this article] (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology. ISSN 0270-7306. 30(6), p. 1357–1367. doi: 10.1128/MCB.01149-09.
  • Raastad, Truls; Owe, Simen Gylterud; Paulsen, Gøran; Enns, Deborah; Overgaard, Kristian & Crameri, R [Show all 10 contributors for this article] (2010). Changes in Calpain Activity, Muscle Structure, and Function after Eccentric Exercise. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 42(1), p. 86–95. doi: 10.1249/MSS.0b013e3181ac7afa.
  • Lauritzen, Fredrik; Paulsen, Gøran; Raastad, Truls; Bergersen, Linda Hildegard & Owe, Simen Gylterud (2009). Gross ultrastructural changes and necrotic fiber segments in elbow flexor muscles after maximal voluntary eccentric action in humans. Journal of applied physiology. ISSN 8750-7587. 107(6), p. 1923–1934.
  • Paulsen, Gøran; Lauritzen, Fredrik; Bayer, Monica; Kalhovde, John Magne; Ugelstad, Ingrid & Owe, Simen Gylterud [Show all 9 contributors for this article] (2009). Subcellular movement and expression of HSP27, alpha beta-crystallin, and HSP70 after two bouts of eccentric exercise in humans. Journal of applied physiology. ISSN 8750-7587. 107(2), p. 570–582.
  • Jensen, Vidar; Rinholm, Johanne Egge; Johansen, Tine Jeanette; Medin, Tirill; Storm-Mathisen, Jon & Sagvolden, Terje [Show all 8 contributors for this article] (2009). N-methyl-d-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder. Neuroscience. ISSN 0306-4522. 158(1), p. 353–364. doi: 10.1016/j.neuroscience.2008.05.016.
  • Bergersen, Linda Hildegard & Gundersen, Vidar (2009). MORPHOLOGICAL EVIDENCE FOR VESICULAR GLUTAMATE RELEASE FROM ASTROCYTES. Neuroscience. ISSN 0306-4522. 158(1), p. 260–265. doi: 10.1016/j.neuroscience.2008.03.074.
  • Sagvolden, Terje; Johansen, Espen Borgå; Wøien, Grete; Walaas, S Ivar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard [Show all 14 contributors for this article] (2009). The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain. Neuropharmacology. ISSN 0028-3908. 57(7-8), p. 619–626. doi: 10.1016/j.neuropharm.2009.08.004.
  • Owe, Simen Gylterud; Jensen, Vidar; Evergren, E; Ruiz, A; Shupliakov, O & Kullmann, DM [Show all 10 contributors for this article] (2009). Synapsin- and Actin-Dependent Frequency Enhancement in Mouse Hippocampal Mossy Fiber Synapses. Cerebral Cortex. ISSN 1047-3211. 19(3), p. 511–523. doi: 10.1093/cercor/bhn101.
  • Paulsen, G; Lauritzen, Fredrik; Bayer, ML; Kalhovde, JM; Ugelstad, I & Owe, Simen Gylterud [Show all 9 contributors for this article] (2009). Subcellular movement and expression of HSP27, alpha beta-crystallin, and HSP70 after two bouts of eccentric exercise in humans. Journal of applied physiology. ISSN 8750-7587. 107(2), p. 570–582. doi: 10.1152/japplphysiol.00209.2009.
  • Lauritzen, Fredrik; Paulsen, Gøran; Raastad, T.; Bergersen, Linda Hildegard & Owe, Simen Gylterud (2009). Gross ultrastructural changes and necrotic fiber segments in elbow flexor muscles after maximal voluntary eccentric action in humans. Journal of applied physiology. ISSN 8750-7587. 107(6), p. 1923–1934. doi: 10.1152/japplphysiol.00148.2009.
  • Martinov, Vladimir Nikolkaev; Rizvi, Syed Mohammad H.; Sagave, Julia Fritzi; Bergersen, Linda Hildegard & Valen, Guro (2009). Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated perfused mouse hearts. Life Sciences. ISSN 0024-3205. 85, p. 379–385.
  • Sander, M; Bergersen, Linda & Storm-Mathisen, Jon (2009). Molecular approaches to understanding neural network plasticity and memory: the Kavli Prize Inaugural Symposium on Neuroscience. Neuroscience. ISSN 0306-4522. 163(4), p. 965–976. doi: 10.1016/j.neuroscience.2009.07.046.
  • Bergersen, Linda Hildegard; Storm-Mathisen, Jon & Gundersen, Vidar (2008). Immunogold quantification of amino acids and proteins in complex subcellular compartments. Nature Protocols. ISSN 1754-2189. 3. doi: 10.1038/nprot.2007.525.
  • Bergersen, Linda Hildegard (2007). Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience. ISSN 0306-4522. 145, p. 11–19. doi: 10.1016/j.neuroscience.2006.11.062.
  • Jourdain, P; Bergersen, Linda Hildegard; Bhaukaurally, K; Bezzi, P; Santello, M & Domercq, M [Show all 10 contributors for this article] (2007). Glutamate exocytosis from astrocytes controls synaptic strength. Nature Neuroscience. ISSN 1097-6256. 10, p. 331–339. doi: 10.1038/nn1849.
  • Rinholm, Johanne Egge; Slettaløkken, Gunnar; Marcaggi, Paikan; Skare, Øivind; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2007). Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents. Neuroscience. ISSN 0306-4522. 145. doi: 10.1016/j.neuroscience.2006.12.041.
  • Tonazzini, I; Trincavelli, ML; Storm-Mathisen, Jon; Martini, C & Bergersen, Linda Hildegard (2007). Co-localization and functional cross-talk between A(1) and P2Y(1) purine receptors in rat hippocampus. European Journal of Neuroscience. ISSN 0953-816X. 26, p. 890–902. doi: 10.1111/j.1460-9568.2007.05697.x.
  • Bergersen, Linda Hildegard; Thomas, M.J.; Johannsson, E; Wærhaug, Ola; Halestrap, A. & Andersen, K. [Show all 8 contributors for this article] (2006). Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle. Neuroscience. ISSN 0306-4522. 138(4), p. 1105–1113.
  • Bergersen, Linda Hildegard; Thomas, Marion J.; Johannsson, E; Johannsson, Erlingur S; Wærhaug, Ola & Halestrap, A [Show all 9 contributors for this article] (2006). Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle. Neuroscience. ISSN 0306-4522. 138, p. 1105–1113.
  • Bergersen, Linda Hildegard (2006). Laktat i hjernen - uten å surne. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 126(16), p. 2094–2097.
  • Bergersen, Linda Hildegard; Magistretti, PJ & Pellerin, L (2005). Selective postsynaptic co-localisation of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Cerebral Cortex. ISSN 1047-3211. 15(4), p. 361–370.
  • Gylterud, Simen; Bogen, Inger Lise; Walaas, Sven Ivar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2005). Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice. Neuroscience. ISSN 0306-4522. 136, p. 769–777.
  • Boulland, Jean-Luc; Qureshi, T.; Seal, R; Rafiki, A; Gundersen, Vidar & Bergersen, Linda Hildegard [Show all 10 contributors for this article] (2004). Expression of the vesicular glutamate transporters during development indicates the widespread co-release of multiple neurotransmitters. Journal of Comparative Neurology. ISSN 0021-9967. 480(3), p. 264–280.

View all works in Cristin

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  • Bergersen, Linda Hildegard; Petersen, Fernanda Cristina & Dahle, Ulf R (2020). Kort sagt, fredag 27. mars. [Newspaper]. Aftenposten.
  • Bergersen, Linda Hildegard; Bjorvand Bjørkøy, Aasta Marie; Fei Fang, Evandro; Gjelsvik, Olav; Hystad Hove, Lene & Liaaen Jensen, Janicke [Show all 12 contributors for this article] (2020). Vi må kunne tenke nytt om alderdom.
  • Fakouri, Nima Borhan; Durhuus, Jon Ambæk; Regnell, Christine E; Angleys, Maria; Desler, Claus & Hasan-Olive, Md Mahdi [Show all 14 contributors for this article] (2018). Erratum: Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD<sup>+</sup>-SIRT1-PGC1α axis (Scientific reports (2017) 7 1 (12480)). Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-20586-9.
  • Øverberg, Linda Thøring; Andersson, Krister Andreas; Lambertus, Marvin; Hadzic, Alena; Haugen, Øyvind Pernell & Storm-Mathisen, Jon [Show all 8 contributors for this article] (2018). Adult neurogenesis: A regulatory role of lactate through the lactate receptor HCAR1? .
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise benefits brain through the lactate receptor HCAR1, increasing VEGF and capillary density in hippocampus and cortex.
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Bergersen, Linda Hildegard & Storm-Mathisen, Jon (2017). Physical exercise promotes brain angiogenesis through a lactate receptor.
  • Jensen, Jørgen; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wærhaug, Ola; Samuelsen, Gunnar & Osen, Kirsten Kjelsberg (2017). Minneord: Hans A. Dahl. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137, p. 14–15. doi: 10.4045/tidsskr.17.0487.
  • Bergersen, Linda Hildegard (2016). Novel mechanism for exercise‐induced angiogenesis in the brain.
  • Bergersen, Linda Hildegard (2016). The lactate receptor is important for brain vascularization.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Hadzic, Alena; Andersson, Krister; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Stølen, Tomas & Wisløff, Ulrik [Show all 8 contributors for this article] (2016). Lactate receptor HCAR1 mediates synaptic plasticity.
  • Moretti, Laura; Stølen, Tomas; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Effects of intrinsic fitness level on mitochondria during exercise .
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Bergersen, Linda Hildegard (2016). Exercise induces brain VEGFA and angiogenesis through the lactate receptor.
  • Kolko, Miriam; Vosborg, Fia; Henriksen, Ulrik L.; Hasan-Olive, Md Mahdi; Diget, Elisabeth Holm & Vohra, Rupali [Show all 13 contributors for this article] (2016). Erratum to: Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease. Neurochemical Research. ISSN 0364-3190. 41(6), p. 1237–1237. doi: 10.1007/s11064-016-1916-y.
  • Bergersen, Linda Hildegard (2016). Hvor ligger forskningsfronten innen demens nå? Hva vet vi og hva vet vi ikke?
  • Bergersen, Linda Hildegard (2016). "Lactate transport and receptor action in the brain: rescue of cognitive decline” .
  • Bergersen, Linda Hildegard (2016). The brain has a lactate receptor.
  • Larsson, Max; Bergersen, Linda Hildegard & Gundersen, Vidar (2015). Immunogold electron microscopic quantification of small molecular compounds and proteins at synapses and other neural profiles. In Merighi, Adalberto & Lossi, Laura (Ed.), Immunocytochemistry and related techniques. Springer. ISSN 978-1-4939-2312-0. p. 281–297. doi: 10.1007/978-1-4939-2313-7_15.
  • Jackson, Catherine; Eidet, Jon Roger; Reppe, Sjur; Eide, Lars; Tønseth, Kim Aleksander & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2015). Storage of cultured skin cell sheets for treatment of limbal stem cell deficiency.
  • Bergersen, Linda Hildegard (2015). Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body-Brain Interaction.
  • Bergersen, Linda Hildegard (2015). Gir melkesyre bedre hjernehelse?
  • Bergersen, Linda Hildegard (2015). Clinical use of lactate monitoring in malaria.
  • Bergersen, Linda Hildegard (2015). Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction.
  • Bergersen, Linda Hildegard (2015). Monocarboxylate transporters and lactate receptor expression and function in the brain.
  • Bergersen, Linda Hildegard (2015). Lactate transport and receptor actions in cerebral malaria.
  • Bergersen, Linda Hildegard (2015). Exercise in healthy aging.
  • Bergersen, Linda Hildegard (2014). Professor i fysiologi, ekspert i sund aldring. [Internet]. iform.dk - advisory-board.
  • Bergersen, Linda Hildegard (2014). Professor i fysiologi och expert på sunt åldrande. [Internet]. iform.se - expertpanelen.
  • Bergersen, Linda Hildegard (2014). I FORM ekspert med spesiale: Sunn aldring. [Internet]. iFORM.nu.
  • Bergersen, Linda Hildegard (2014). Mutasjon i transportørgen kan gi ketoacidose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(23/24), p. 2257–2257. doi: 10.4045/tidsskr.14.1326.
  • Bergersen, Linda Hildegard (2014). Trening for et bedre og lengre liv - Hjerne og trening.
  • Bergersen, Linda Hildegard (2014). Trening for hjernehelse.
  • Bergersen, Linda Hildegard (2014). The brain lactate receptor – does it matter in cognitive impairment.
  • Bergersen, Linda Hildegard (2014). Lactate as messenger in the CNS.
  • Bergersen, Linda Hildegard (2014). A ketogenic diet accelerates neurodegeneration in forebrain neurons during mitochondrial DNA toxicity.
  • Bergersen, Linda Hildegard (2014). Lactate receptor in the brain.
  • Bergersen, Linda Hildegard & Eid, Tore (2014). Monocarboxylate transport matters. New England Journal of Medicine. ISSN 0028-4793. 371(20), p. 1931–1932. doi: 10.1056/NEJMe1411903.
  • Bergersen, Linda Hildegard (2013). Laktat har signalfunksjon i hjernen. [Business/trade/industry journal]. Tidsskrift for Den norske legeforening.
  • Bergersen, Linda Hildegard (2013). Lactate is a volume transmitter – 'New Deal' for understanding brain function and brain disease.
  • Bergersen, Linda Hildegard (2013). Melkesyre har en egen reseptor i hjernen- viktig for den aldrende hjernen?
  • Bergersen, Linda Hildegard (2013). Views from new research group Leader: how to succeed as leader and to build a new group?
  • Bergersen, Linda Hildegard (2013). Lactate receptor in the Brain.
  • Bergersen, Linda Hildegard (2013). How to implement brain research methods in exercise medicine? Lactate as a signal substance. How does physical exercise translate onto better brains?
  • Bergersen, Linda Hildegard; Lauritzen, Knut Husø; Lauritzen, Fredrik; Puchades, Maja Amedjkouh & Gjedde, Albert (2012). Lactate receptor locations link neurotransmission, neurovascular coupling, and brain energy metabolism. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 32, p. S183–S183.
  • Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng & Vollan, Hilde Synnøve [Show all 9 contributors for this article] (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2012). The wrap that feeds neurons. Nature. ISSN 0028-0836. 487(7408), p. 435–436. doi: 10.1038/487435a.
  • Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2012). Unikard oppstart - hjertet og hjernen.
  • Bergersen, Linda Hildegard & Storm-Mathisen, Jon (2012). Kavliprisvinnerne i nevrovitenskap 2012 (Cover illustration / story). NSB-nytt. 36(4), p. 6–8.
  • Bergersen, Linda Hildegard (2012). Lactate, a volume transmitter in the brain.
  • Bergersen, Linda Hildegard (2012). Mitochondrial DNA damage in hippocampus.
  • Gjedde, Albert; Kumakura, Yoshitaka & Bergersen, Linda Hildegard (2012). Modulation of brain activity by DOPAergic volume transmission. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 32, p. S93–S93.
  • Bergersen, Linda Hildegard; Sander, M. & Storm-Mathisen, Jon (2011). What the nose knows, what the eyes see, how we feel, how we learn, how we understand motor acts, why “YY” is essential for ion transport, how epigenetics meet neurobiology in Rett syndrome: seven topics at the 2010 Kavli Prize Symposium on Neuroscience. Neuroscience. ISSN 0306-4522. 190, p. 1–11. doi: 10.1016/j.neuroscience.2011.05.036.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina & Görlach, Agnes [Show all 8 contributors for this article] (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Ormel, Lasse; Volterra, A; Bergersen, Linda Hildegard & Gundersen, Vidar (2009). VGLUT1 IS PRESENT IN CORTICAL, HIPPOCAMPAL AND STRIATAL ASTROCYTES. Glia. ISSN 0894-1491. 57(13), p. S42–S42.
  • Rinholm, Johanne Egge; Hamilton, NB; Ianarelli, P; Kessaris, N; Richardson, WD & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2009). LACTATE TRANSPORTERS IN DEVELOPING OLIGODENDROCYTES. Glia. ISSN 0894-1491. 57(13), p. S113–S113.
  • Owe, Simen Gylterud; Jensen, Vidar; Evergren, Emma; Ruiz, Arnaud; Shupliakov, Oleg & Kullmann, Dimitri [Show all 10 contributors for this article] (2008). Facilitation of glutamate release at hippocampal mossy fibre synapses is dependent on synapsin and actin.

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Published June 24, 2013 11:16 AM - Last modified Sep. 13, 2023 2:46 PM