Roger Gustav Simm

Head of Department - Institute of Oral Biology
Image of Roger Gustav Simm
Norwegian version of this page
Phone +47 22840337
Username
Visiting address Sognsvannsveien 10 Domus Odontologica 0372 Oslo
Postal address Postboks 1052 Blindern 0316 Oslo

Academic interests

The Research Group focuses on understanding the dynamics of bacterial host colonization and infection.  We are currently studying a number of mechanisms that determine bacterial persistence in different environments. Our research aims at understanding:

  • Development and spread of antimicrobial resistance in bacterial communities
  • Host-microbe and microbe-microbe interactions that determines bacterial colonization and pathogenicity
  • Regulation of bacterial biofilms and concomitant evolution of antimicrobial resistance.

The ultimate goal is to use the knowledge gained in our studies to develop novel therapeutics and treatment regimens that can prevent bacterial infections or reduce the damaging effects.

Teaching

http://www.uio.no/studier/emner/odont/tannlege/OD1100/index.html

http://www.uio.no/studier/emner/odont/tannlege/OD3100/index.html

http://www.uio.no/studier/emner/odont/tannlege/OD4100/index.html

http://www.uio.no/studier/emner/odont/tannpleie/TP1100/index.html

Higher education and employment history

2017 - present, Associate Professor, Institute of Oral Biology, UiO

2015 - 2017, Senior scientist, Norwegian Veterinary Institute

2011 - 2015, Post doc/Lab manager, Radiumhospitalet

2008 - 2011, Post doc, School of Pharmacy, UiO

2008, Scientist, GE Healthcare

2007 - 2008, Post doc, MTC, Karolinska Institutet

2003 - 2007, PhD, MTC, Karolinska Institutet

2001 - 2002, Teacher/Project Assistant, Karlstad University

2001, Biomedical Assistant, Centralsjukhuset

1995 - 2000, MSc in Biochemistry, Karlstad University

Tags: Biofilm, Antimicrobial resistance, Host-microbe interactions, Microbe-microbe interactions, Virulence, Molecular microbiology, c-di-GMP

Publications

  • Rørvik, Gro Herredsvela; Naemi, Ali-Oddin; Edvardsen, Per Kristian Thorén & Simm, Roger Gustav (2021). The c-di-AMP signaling system influences stress tolerance and biofilm formation of Streptococcus mitis. MicrobiologyOpen. ISSN 2045-8827. 10(4), p. 1–15. doi: 10.1002/mbo3.1203.
  • Kaspersen, Håkon; Fiskebeck, Eve Marie Louise Zeyl; Sekse, Camilla; Slettemeås, Jannice Schau; Urdahl, Anne Margrete & Norström, Madelaine [Show all 8 contributors for this article] (2020). Comparative genome analyses of wild type- and quinolone resistant Escherichia coli indicate dissemination of QREC in the Norwegian broiler breeding pyramid. Frontiers in Microbiology. ISSN 1664-302X. doi: 10.3389/fmicb.2020.00938.
  • Kaspersen, Håkon; Sekse, Camilla; Fiskebeck, Eve Marie Louise Zeyl; Slettemeås, Jannice Schau; Simm, Roger & Norström, Madelaine [Show all 8 contributors for this article] (2020). Dissemination of Quinolone-Resistant Escherichia coli in the Norwegian Broiler and Pig Production Chains and Possible Persistence in the Broiler Production Environment. Applied and Environmental Microbiology. ISSN 0099-2240. doi: 10.1128/AEM.02769-19. Full text in Research Archive
  • Vestby, Lene Karine; Grønseth, Torstein; Simm, Roger & Nesse, Live Lingaas (2020). Bacterial biofilm and its role in the pathogenesis of disease. Antibiotics. ISSN 2079-6382. 9:59(2), p. 1–29. doi: 10.3390/antibiotics9020059. Full text in Research Archive
  • Rørvik, Gro Herredsvela; Liskiewicz, Krystyna Anna; Kryuchkov, Fedor; Naemi, Ali-Oddin; aasheim, Hans-Christian & Petersen, Fernanda Cristina [Show all 8 contributors for this article] (2020). Cyclic di-adenosine monophosphate regulates metabolism and growth in the oral commensal streptococcus mitis. Microorganisms. ISSN 2076-2607. 8:1269(9), p. 1–21. doi: 10.3390/microorganisms8091269. Full text in Research Archive
  • Naemi, Ali-Oddin; Dey, Hymonti; Kiran, Nosheen; Sandvik, Sarah Torbergsen; Slettemeås, Jannice Schau & Nesse, Live Lingaas [Show all 7 contributors for this article] (2020). NarAB Is an ABC-Type Transporter That Confers Resistance to the Polyether Ionophores Narasin, Salinomycin, and Maduramicin, but Not Monensin. Frontiers in Microbiology. ISSN 1664-302X. 11:104, p. 1–9. doi: 10.3389/fmicb.2020.00104. Full text in Research Archive
  • Simm, Roger; Slettemeås, Jannice Schau; Norström, Madelaine; Dean, Katharine Rose; Kaldhusdal, Magne & Urdahl, Anne Margrete (2019). Significant reduction of vancomycin resistant E. faecium in the Norwegian broiler population coincided with measures taken by the broiler industry to reduce antimicrobial resistant bacteria. PLOS ONE. ISSN 1932-6203. 14(12). doi: 10.1371/journal.pone.0226101. Full text in Research Archive
  • Paulsen, Britt; Fredriksen, Kim Alex; Petersen, Dirk; Maes, Louis; Matheeussen, An & Naemi, Ali-Oddin [Show all 11 contributors for this article] (2019). Synthesis and antimicrobial activities of N6-hydroxyagelasine analogs and revision of the structure of ageloximes. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 27(4), p. 620–629. doi: 10.1016/j.bmc.2019.01.002. Full text in Research Archive
  • Enersen, Morten; Hultin, Margareta; Kønønen, Eija; Havemose Poulsen, Anne & Simm, Roger (2019). Antibiotics in the treatment of periodontal and peri-implant infections. Tandlægebladet. ISSN 0039-9353. 129(3), p. 224–235.
  • Nesse, Live Lingaas & Simm, Roger (2018). Biofilm: A Hotspot for Emerging Bacterial Genotypes. Advances in Applied Microbiology. ISSN 0065-2164. 103, p. 223–246. doi: 10.1016/bs.aambs.2018.01.003.
  • Kaspersen, Håkon; Urdahl, Anne Margrete; Simm, Roger; Slettemeås, Jannice Schau; Lagesen, Karin & Norström, Madelaine (2018). Occurrence of quinolone resistant E. coli originating from different animal species in Norway. Veterinary Microbiology. ISSN 0378-1135. 217, p. 25–31. doi: 10.1016/j.vetmic.2018.02.022. Full text in Research Archive
  • Simm, Roger; Kvalvaag, Audun Sverre Myrset; van Deurs, Bo; Lindback, Toril & Sandvig, Kirsten (2017). Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network. Experimental Cell Research. ISSN 0014-4827. 357(1), p. 67–78. doi: 10.1016/j.yexcr.2017.04.025.
  • Cimdins, Annika; Simm, Roger; Li, Fengyang; Lüthje, Petra; Thorell, Kaisa & Sjöling, Åsa [Show all 8 contributors for this article] (2017). Alterations of c-di-GMP turnover proteins modulate semi-constitutive rdar biofilm formation in commensal and uropathogenic Escherichia coli. MicrobiologyOpen. ISSN 2045-8827. 6(5). doi: 10.1002/mbo3.508.
  • Hassan, Karl A.; Fagerlund, Annette; Elbourne, Liam D.H.; Vörös, Aniko; Kroeger, Jasmin Kaori & Simm, Roger [Show all 12 contributors for this article] (2017). The putative drug efflux systems of the Bacillus cereus group. PLOS ONE. ISSN 1932-6203. 12(5), p. 1–25. doi: 10.1371/journal.pone.0176188. Full text in Research Archive
  • Lingelem, Anne Berit Dyve; Hjelseth, Ieva Ailte; Simm, Roger; Torgersen, Maria Lyngaas & Sandvig, Kirsten (2015). Geldanamycin enhances retrograde transport of Shiga toxin in HEp-2 cells. PLOS ONE. ISSN 1932-6203. 10:e0129214(5). doi: 10.1371/journal.pone.0129214.
  • Kroeger, Jasmin Kaori; Hassan, Karl; Vörös, Aniko; Simm, Roger; Saidijam, Massoud & Bettaney, Kim E. [Show all 10 contributors for this article] (2015). Bacillus cereus efflux protein BC3310 - A multidrug transporter of the unknown major facilitator family, UMF-2. Frontiers in Microbiology. ISSN 1664-302X. 6. doi: 10.3389/fmicb.2015.01063.
  • Le Guyon, Soazig; Simm, Roger; Rehn, Mikael & Römling, Ute (2015). Dissecting the cyclic di-guanylate monophosphate signalling network regulating motility in Salmonella enterica serovar Typhimurium. Environmental Microbiology. ISSN 1462-2912. 17(4), p. 1310–1320. doi: 10.1111/1462-2920.12580.
  • Kavaliauskiene, Simona; Skotland, Tore; Sylvänne, Tuulia; Simolin, Helena; Klokk, Tove Irene & Torgersen, Maria Lyngaas [Show all 10 contributors for this article] (2015). Novel actions of 2-deoxy-D-glucose: Protection against Shiga toxins and changes in cellular lipids. Biochemical Journal. ISSN 0264-6021. 470, p. 23–37. doi: 10.1042/BJ20141562.
  • Kymre, Linn Furebotten; Simm, Roger; Skotland, Tore & Sandvig, Kirsten (2015). Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells. Pathogens and Disease. ISSN 2049-632X. 73(9), p. 1–9. doi: 10.1093/femspd/ftv083.
  • Kavaliauskiene, Simona; Nymark, Carl-Martin; Bergan, Jonas; Simm, Roger; Sylvänne, Tuulia & Simolin, Helena [Show all 9 contributors for this article] (2014). Cell density-induced changes in lipid composition and intracellular trafficking. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71(6), p. 1097–1116. doi: 10.1007/s00018-013-1441-y.
  • Simm, Roger; Ahmad, Irfan; Rhen, Mikael; Guyon, Soazig Le & Römling, Ute (2014). Regulation of biofilm formation in Salmonella enterica serovar Typhimurium. Future Microbiology. ISSN 1746-0913. 9(11), p. 1261–1282. doi: 10.2217/fmb.14.88.
  • Bergan, Jonas; Skotland, Tore; Anne Berit Dyve, Lingelem; Simm, Roger; Spilsberg, Bjørn & Lindback, Toril [Show all 10 contributors for this article] (2014). The ether lipid precursor hexadecylglycerol protects against Shiga toxins. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71, p. 4285–4300. doi: 10.1007/s00018-014-1624-1.
  • Vörös, Aniko; Simm, Roger; Slamti, Leyla; McKay, Matthew J.; Hegna, Ida Kristin & Nielsen-Leroux, Christina [Show all 12 contributors for this article] (2014). SecDF as part of the sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PLOS ONE. ISSN 1932-6203. 9:e0103326(8). doi: 10.1371/journal.pone.0103326.
  • Vörös, Aniko; Simm, Roger; Kroeger, Jasmin Kaori & Kolstø, Anne-Brit (2013). Gene transcription from the linear plasmid pBClin15 leads to cell lysis and extracellular DNA-dependent aggregation of Bacillus cereus ATCC 14579 in response to quinolone-induced stress. Microbiology (Reading). ISSN 1350-0872. 159, p. 2283–2293. doi: 10.1099/mic.0.069674-0.
  • Backe, Paul Hoff; Simm, Roger; Lærdahl, Jon Kristen; Dalhus, Bjørn; Fagerlund, Annette & Økstad, Ole Andreas Løchen [Show all 10 contributors for this article] (2013). A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures. Journal of Structural Biology. ISSN 1047-8477. 183(1), p. 66–75. doi: 10.1016/j.jsb.2013.04.007. Full text in Research Archive
  • Kvalvaag, Audun Sverre Myrset; Pust, Sascha; Sundet, Kristine Ingrid; Simm, Roger; Sandvig, Kirsten & Engedal, Kim Nikolai (2013). The ERM Proteins Ezrin and Moesin Regulate Retrograde Shiga Toxin Transport. Traffic : the International Journal of Intracellular Transport. ISSN 1398-9219. 14(7), p. 839–852. doi: 10.1111/tra.12077.
  • Bergan, Jonas; Lingelem, Anne Berit Dyve; Simm, Roger; Skotland, Tore & Sandvig, Kirsten (2012). Shiga toxins. Toxicon. ISSN 0041-0101. 60(6), p. 1085–1107. doi: 10.1016/j.toxicon.2012.07.016.
  • Simm, Roger; Vörös, Aniko; Ekman, Jaakko V; Sødring, Marianne Sundt; Nes, Ingerid Veslemøy & Kroeger, Jasmin Kaori [Show all 11 contributors for this article] (2012). BC4707 Is a Major Facilitator Superfamily Multidrug Resistance Transport Protein from Bacillus cereus Implicated in Fluoroquinolone Tolerance. PLOS ONE. ISSN 1932-6203. 7(5). doi: 10.1371/journal.pone.0036720.

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  • Simm, Roger; Norström, Madelaine; Slettemeås, Jannice Schau & Urdahl, Anne Margrete (2019). No vancomycin resistant enterococci (VRE) detected in the Norwegian poultry Production for the first time since the monitoring started. In Simonsen, Gunnar Skov; Blix, Hege Salvesen; Grave, Kari & Urdahl, Anne Margrete (Ed.), NORM/NORM-VET 2018 Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway. NORM/NORM-VET. ISSN 1502-2307.
  • Kaspersen, Håkon; Sekse, Camilla; Slettemeås, Jannice Schau; Simm, Roger; Norström, Madelaine & Urdahl, Anne Margrete [Show all 7 contributors for this article] (2019). Low-resolution MLST as an initial analysis for deep characterization of quinolone resistant Escherichia coli.
  • Paulsen, Britt; Fredriksen, Kim Alex; Petersen, Dirk; Maes, Louis; Matheeussen, An & Naemi, Ali-Oddin [Show all 10 contributors for this article] (2019). Synthesis directed towards bioactive ent-Ageloxime D and analogues.
  • Paulsen, Britt; Fredriksen, Kim Alex; Petersen, Dirk; Maes, Louis; Matheeussen, An & Naemi, Ali-Oddin [Show all 11 contributors for this article] (2019). Synthesis directed towards bioactive ent-Ageloxime D and analogues.
  • Simm, Roger (2019). Biofilms and antibiotic resistance: a curse of modern medicine.
  • Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases.
  • Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases.
  • Kaspersen, Håkon; Sekse, Camilla; Slettemeås, Jannice Schau; Simm, Roger; Norström, Madelaine & Sørum, Henning [Show all 8 contributors for this article] (2018). Quinolone resistance mechanisms in E. coli from four animal species in Norway.
  • Kaspersen, Håkon; Urdahl, Anne Margrete; Slettemeås, Jannice Schau; Simm, Roger; Sørum, Henning & Lagesen, Karin [Show all 7 contributors for this article] (2017). Quinolone resistance despite low antimicrobial usage: comparison of occurrence in different species in Norway the last ten years .
  • Vörös, Aniko; Simm, Roger; Schleimer, Jasmin Kaori; Tourasse, Nicolas; Henderson, Peter J. F. & Kolstø, Anne-Brit (2009). Functional characterization of putative multidrug resistance transporters conserved in the Bacillus cereus group.
  • Sandvig, Kirsten; Simm, Roger & Kymre, LInn (2014). Structure-function relationship of Shiga toxins. Role of the A-subunit in complex stability and endocytosis. Reprosentralen, UIO.

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Published Apr. 5, 2017 10:46 AM - Last modified Sep. 18, 2020 1:49 PM