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Brusevold, Ingvild Johnsen; Aasrum, Monica; Tveteraas, Ingun Heiene; Bryne, Magne & Christoffersen, Thoralf
(2011).
Signalling Mechanisms Mediating EGF- and HGF-induced Migration in Carcinoma Cells in Vitro.
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Brusevold, Ingvild Johnsen; Aasrum, Monica; Bryne, Magne & Christoffersen, Thoralf
(2011).
Signalmekanismer som medierer EGF- og HGF-indusert migrasjon i orale plateepitelkarsinomceller in vitro.
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Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete
(2010).
Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic.
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Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete
(2010).
Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic.
European Journal of Cancer.
ISSN 0959-8049.
8(5),
s. 149–149.
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Khuu, Cuong; Jevnaker, Anne Marthe; Sehic, Amer; Bryne, Magne & Osmundsen, Harald
(2010).
High levels of miR-363*inhibit proliferation of oral carcinoma cell line E10.
European Journal of Cancer.
ISSN 0959-8049.
8(5),
s. 140–141.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne
(2009).
Nuclear Met and p-p38 in oral squamous cell carcinoma and organotypic oral cancer model.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne
(2009).
Nuclear c-Met and p-p38 in oral sqamous cell carcinoma and organotypic oral cancer model.
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Søland, Tine Merete; Brusevold, Ingvild Johnsen; Koppang, Hanna Strømme; Schenck, Karl & Bryne, Magne
(2008).
p75NTR and pattern of invasion predict poor prognosis in oral squamous cell carcinomas.
European Journal of Cancer.
ISSN 0959-8049.
6,
s. 76–76.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong & Bryne, Magne
(2008).
Nuclear c-Met and p-p38 at the invasive front of oral squamous cell carcinomas.
European Journal of Cancer.
ISSN 0959-8049.
6,
s. 76–76.
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Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl & Bryne, Magne
(2008).
Manipulation of invasion in a 3D-co-culture organotypic oral cancer model.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne
(2008).
C-Met and p-p38 in oral cancer.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Khuu, Cuong; Christoffersen, Thoralf & Bryne, Magne
(2008).
Nuclear c-Met and p-p38 at the invasive front of oral squamous cell carcinoma (OSCC.
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Søland, Tine Merete; Brusevold, Ingvild Johnsen; Koppang, Hanna Strømme; Schenck, Karl & Bryne, Magne
(2008).
p75NTR and pattern of invasion predict poor prognosis in oral squamous cell carcinomas.
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Husvik, Camilla; Khuu, Cuong; Bryne, Magne & Halstensen, Trond Sundby
(2007).
Basal and EGF-induced PGE2 production in oral cancer cell lines is COX-2 dependent.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Husvik, Camilla; Khuu, Cuong & Bryne, Magne
(2007).
Nerve growth factor receptor (p75 NTR) in an organotypic oral cancer model.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete; Husvik, Camilla; Khuu, Cuong & Bryne, Magne
(2007).
Nerve growth factor receptor (p75 NTR) in an organotypic oral cancer model.
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Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Khuu, Cuong; Hayashi, Katsuhiko & Schenck, Karl
[Vis alle 7 forfattere av denne artikkelen]
(2007).
Nerve growth factor receptor (p75NTR)is a marker of poor prognosis in T1-T2 oral squamous cell carcinomas.
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Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Khuu, Cuong; Hayashi, Katsuhiko & Schenck, Karl
[Vis alle 7 forfattere av denne artikkelen]
(2007).
Nerve growth factor receptor (p75NTR) is a marker of poor prognosis in T1-T2 oral squamous cell carcinomas.
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Storesund, Trond; Hayashi, Katsuhiko; Kolltveit, Kristin Melkevik; Bryne, Magne & Schenck, Karl
(2007).
Salivary Trefoil Factor 3 (TFF3) enhances migration of oral keratinocytes.
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Brusevold, Ingvild Johnsen; Søland, Tine Merete & Bryne, Magne
(2006).
Hepatocyte growth factor receptor in oral cancer.
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Husvik, Camilla; Khuu, Ngoc Ky Cuong; Bryne, Magne & Halstensen, Trond Sundby
(2006).
EGF induced PGE2 production in OSCC cell lines is COX-2 dependent.
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Husvik, Camilla; Bryne, Magne & Halstensen, Trond Sundby
(2006).
EGFR signalling and COX-2 in oral cancer.
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Storesund, Trond; Hayashi, Katsuhiko; Bryne, Magne; Schenck, Karl; Helgeland, Kristen & Khuu, Cuong
(2006).
Salivary trefoil factor 3 enhances migration of oral keratinocytes.
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Husvik, Camilla; Bryne, Magne & Halstensen, Trond Sundby
(2006).
PGE2 production in OSCC cell lines is COX-2 dependent.
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Husvik, Camilla; Bryne, Magne & Halstensen, Trond Sundby
(2006).
EGFR signalling and COX-2 in oral cancer.
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Søland, Tine Merete; Husvik, Camilla; Koppang, Hanna Strømme; Boysen, Morten Ebbe; Sandvik, Leiv & Clausen, Ole Petter Fraas
[Vis alle 7 forfattere av denne artikkelen]
(2006).
Clinical importance of phosphorylated ERK1/2 MAPK and COX-2 at the invasive front of T1-T2 oral squamous cell carcinoma.
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Søland, Tine Merete; Husvik, Camilla; Kleinberg, Lilach; Koppang, Hanna Strømme; Boysen, Morten Ebbe & Davidson, Ben
[Vis alle 9 forfattere av denne artikkelen]
(2005).
Prognostic markers in the invasive front of of OSCC.
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Søland, Tine Merete; Husvik, Camilla; Koppang, Hanna Strømme; Boysen, Morten Ebbe; Sandvik, Leiv & Clausen, Ole Petter Fraas
[Vis alle 8 forfattere av denne artikkelen]
(2005).
Singel cell invasion in high risk patients.
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Sudbø, Jon & Bryne, Magne
(2005).
Nytt om munnhulekreft. Muligheter for tidlig behandling av en alvorlig sykdom?
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Husvik, Camilla; Karatsaidis, Andreas; Helgeland, Kristen; Schreurs, Olav; Khuu, Chuong & Søland, Tine
[Vis alle 7 forfattere av denne artikkelen]
(2004).
Reconstruction of human oral mucosa; three dimentional models of oral mucosa and oral squamous cell carcinoma.
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Bryne, Magne & Sudbø, Jon
(2004).
New treatment of oral cancer?
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Søland, Tine Merete; Schreurs, Olav; Husvik, Camilla; Clausen, Ole Petter; Boysen, Morten & Sudbø, Jon
[Vis alle 7 forfattere av denne artikkelen]
(2004).
Expression of COX-2, APC and β-catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
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Søland, Tine Merete; Schreurs, Olav; Husvik, Camilla; Clausen, Ole Petter; Boysen, Morten & Sudbø, Jon
[Vis alle 7 forfattere av denne artikkelen]
(2004).
Expression of COX-2, APC and β -catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
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Sudbø, Jon; Lippman, Scott M.; Lee, J. Jack; Kildal, Wanja; Sagen, Simone & Sudbø, Asle
[Vis alle 12 forfattere av denne artikkelen]
(2004).
Aneuploidy and the Risk of Mortality in Patients with Oral Leukoplakia.
Vis sammendrag
BACKGROUND
Standard treatment of oral leukoplakia varies from watchful waiting to complete resection. The value of this approach is unknown.
METHODS
We studied the relationships between cancer/mortality, resection, and ploidy status in 150 diploid (103), tetraploid (20), or aneuploid (27) dysplastic oral leukoplakia patients. New-cancer, cancer-specific mortality, and treatment data were obtained from The Cancer Registry of Norway, Statistics Norway, and from chart reviews.
RESULTS
Forty-seven (31 percent) of the 150 leukoplakia patients (5 with diploid, 16 with tetraploid, and 26 with aneuploid leukoplakia) developed primary oral carcinoma during a mean follow-up of 80 months (range, 4 to 237). The margin status of the initial leukoplakia resection had no impact on oral cancer development (P = 0.95). Twenty-six (55 percent) of the 47 cancer patients (4 with prior tetraploid, 22 with prior aneuploid lesions) had recurrences, which were more frequently multiple and distant (within the oral cavity) in the aneuploid than tetraploid or diploid patients. Standard surgery and radiation were given to all 47 and subsequent chemotherapy to the 26 recurring cancer patients. Only patients with aneuploid leukoplakia died of oral cancer, with a 72 percent 5-year cancer-specific mortality rate. Aneuploidy-related first carcinomas were later in stage (P = 0.03) and more lethal regardless of stage than were carcinomas originating from diploid or tetraploid leukoplakia.
CONCLUSIONS
Complete resection does not reduce the high risk of biologically aggressive carcinoma and mortality in aneuploid leukoplakia patients. These findings point to an unmet medical need in these patients.
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Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Clausen, Ole Petter Fraas; Boysen, Morten Ebbe & Sudbø, Jon
[Vis alle 7 forfattere av denne artikkelen]
(2004).
COX-2, APC and beta-catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
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Bryne, Magne; Søland, Tine Merete; Husvik, Camilla & Sudbø, Jon
(2004).
Concomitance of COX-2 up-regulation and genomic instability in precancers: a rationale for targeted use of coxibs to prevent oral cancer.
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Storesund, Trond; Bryne, Magne & Khan, Sadia
(2004).
Presence of COX-2 in normal, premalign and malign mucosa.
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Husvik, Camilla; Kolltveit, Kristin; Karatsaidis, Andreas; Søland, Tine; Helgeland, Kristen & Schreurs, Olav
[Vis alle 8 forfattere av denne artikkelen]
(2004).
Reconstruction of human oral mucosa-significance of number of divisions of fibroblasts.
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Storesund, Trond; Sudbø, Jon & Bryne, Magne
(2004).
Presence of COX-2 in normal, premalign and malign oral mucosa.
-
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da Silva, Daniele Pecharki Marques; Petersen, Fernanda Cristina; Bryne, Magne; Husvik, Camilla & Scheie, Anne Aamdal
(2003).
Streptococcus intermedius hyaluronidase: Role in adhesion to human cells.
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Bryne, Magne & Sudbø, Jon
(2003).
Nytt om munnhulekreft.
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Søland, Tine Merete; Sudbø, Jon; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne
(2003).
Selective COX-2 up-regulation in DNA aneuploid oral precancers: an opportunity for targeted preventive treatment of oral cancers?
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Husvik, Camilla; Karatsaidis, Andreas; Helgeland, Kristen & Bryne, Magne
(2003).
3-dimensjonal slimhinnemodell.
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Bryne, Magne; Husvik, Camilla; Søland, Tine Merete; Kolltveit, Kristin Melkevik & Sudbø, Jon
(2003).
The invasion of malignant oral keratinocytes is inhibited by a COX-2 inhibitor.
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Husvik, Camilla; Søland, Tine Merete; Kolltveit, Kristin Melkevik; Sudbø, Jon & Bryne, Magne
(2003).
Effect of COX-2 inhibitors on proliferation, invasion and migration of cell lines from oral squamous cell carcinoma.
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Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne
(2003).
Selective COX-2 up-regulation in DNA aneuploid oral precancers; an opportunity for targeted preventive treatment of oral cancer.
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Sudbø, Jon; Berner, Å.; Kildal, Wanja; Risberg, Bjørn; Bryne, Magne & Davidson, Ben
[Vis alle 7 forfattere av denne artikkelen]
(2003).
NON-INVASIVE IDENTIFICATION AND COUNSELLING OF PERSONS AT HIGH-RISK OF ORAL CANCER.
Vis sammendrag
Background: Prevention of oral cancer may be done through counselling, if high-risk persons can be identifed at an early stage of disease. Assessment of genomic instability predicts the risk of oral cancer, but there are no established screening methods for persons with clinically normal oral mucosa.
Methods: We undertook this prospective study to see if genomic instability could be detected in person with clinically normal oral mucosa, but with high-risk behaviour for head and neck cancer, and to see if information regarding early signs of malignant transformation could be used to guide counselling of such persons. Having confirmed that cytological specimens were equivalent to biopsies with respect to detecting markers of genomic instability, we prospectively analyzed DNA content from cytological specimens from 231 individuals with high-risk behaviour for oral cancer, but with clinically normal appearing oral mucosa. We then provided counselling on risk factors for oral cancer, as well as motivation to quit risk habits.
Results: Aneuploid lesions were found in 16 of the 231 patients (16/231, 6 percent) with high-risk behaviour but clinically normal oral mucosa. COX-2 was expressed in all cases with aneuploid lesions (16/16, 100 percent), but only expressed in 12 out of 215 diploid specimens (6/221, 5 percent)(P = 0.005). Compliance with counselling was excellent in all cases with markers of genomic instability. Thus, all 16 cases with high-risk lesions quit their tobacco habits after counselling, and 16/16 (100 %) have continued to do so during a median follow-up period of 27 months. Only 37 out of the 221 patients (12 percent) without markers of genomic instability quit their tobbacco habits. Of these, 16 (43 percent) have continued to do so during a median follow-up period of 26 months (P = 0.01)
Conclusions: High-risk lesions can be detected from clinically normal oral mucosa by non-invasive procedures. Information regarding individual high risk for oral cancer aids in counselling these patients to quit risk-habits. The close correlation between genomic instability and up-regulation of COX-2 indicates that individuals harbouring cells with genomic aberration in clinically normal mucosa may profit from chemopreventive measures targeting COX-2.
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Sudbø, Jon; Sondresen, Jan Erik; Ristimäki, Ari; Reith, Albrecht; Nesland, Jahn M & Bryne, Magne
(2002).
Chemoprevention of oral cancer.
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Sudbø, Jon; Sondresen, Jan Erik; Reith, Albrecht; Risberg, Bjørn & Bryne, Magne
(2002).
Cytological brushings can be used to identify high-risk lesions of the oral cavity, even in clinically normal oral mucosa.
Vis sammendrag
Emerging data indicate a link between genetic instability and up-regulation of cyclooxygenase-2 (COX-2). To see if individuals at high risk of oral cancer are candidates for treatment with selective COX-2 inhibitors (coxibs), levels of COX-2 expression in healthy, premalignant and cancerous oral mucosa were compared to the occurrence of DNA ploidy status as a genetic risk marker of oral cancer.
COX-2 gene product was detected immunohistochemically in 30 healthy persons, in 22 patients with dysplastic lesions without previous or concomitant carcinomas, and in 29 patients with oral carcinomas. The immunohistochemical findings were verified by in situ hybridization of COX-2 mRNA and Western blotting. COX-2 expression was correlated to DNA content as a genetic risk marker of oral cancer.
COX-2 was up-regulated from healthy to premalignant to cancerous oral mucosa. Thus, COX-2 expression was found in 1 case of healthy oral mucosa (3 percent). All specimens from healthy mucosa had a normal DNA content. In patients with premalignancies. In 29 patients with oral carcinomas, cyclooxygenase-2 expression was observed in 26 (88 percent), and aneuploidy was observed in 25 cases (94 percent, P = 0.04). Notably, Of 22 patients with dysplastic lesions, COX-2 was exclusively expressed in a subgroup of 9 patients (41 percent) identified to be at high risk of cancer by the aberrant DNA content of their lesions. Seven of these patients were followed for 5 years or more. An oral carcinoma developed in 6 of them (85 percent; P=0.02).
These findings emphasize the need to determine whether coxibs can reduce the risk of oral cancer in patients with high-risk precancerous lesions.
DNA ploidy distributions were compared in bioptic specimens and analyzed in cytological brushings. Cytological brushing were found to be equivalent to biopsies with respect to sensitivity and specificity in assessing DNA ploidy status in a pilot study of 50 patients. In another 131 persons with clinically normal oral mucosa, but with risk behaviour for oral cancer (tobacco and/or alcohol), 5 DNA aneuploid lesions were found by cytological brukshings. These were all verified by subsequent biopsies from the same sites as the original brushings had been obtained.
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Bryne, Magne
(2002).
The invasive front of oral carcinomas.
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Sudbø, Jon; Ristimäki, Ari; Nesland, Jahn M; Reith, Albrecht & Bryne, Magne
(2002).
Possible strategy for handling oral premalignancies in a targeted manner.
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Sudbø, Jon; Sondresen, Jan Erik; Reith, Albrecht & Bryne, Magne
(2002).
Risk targeting and strategy for chemoprevention of haad and neck cnacer.
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Sudbø, Jon; Sondresen, Jan Erik; Ristimäki, Ari; Nesland, Jahn M; Reith, Albrecht & Bryne, Magne
(2002).
Chemoprevention of oral cancer.
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Sudbø, Jon; Sondresen, Jan Erik; Ristimäki, Ari; Nesland, Jahn M; Reith, Albrecht & Bryne, Magne
(2002).
Identifying patients at high risk of oral cancer and treatment possibilities.
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Sudbø, Jon; Helvoirt, René van; Nesland, Jahn M; Bryne, Magne; Reith, Albrecht & Sudbø, Asle
(2002).
Texture analysis of resection margins as a tool for deciding on postoperative irradiation for early stage oral cancer.
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Sudbø, Jon; Ristimäki, Ari; Nesland, Jahn M; Reith, Albrecht & Bryne, Magne
(2002).
Cyclooxygenase-2 (COX-2) expression in patients having high-risk oral precancers.
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Sudbø, Jon; Kildal, Wanja; Sondresen, Jan Erik; Ristimäki, Ari; Nesland, Jahn M & Reith, Albrecht
[Vis alle 7 forfattere av denne artikkelen]
(2002).
Oral precancer - risk assessment in a chemopreventive perspective.
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Sudbø, Jon; Kildal, Wanja; Sondresen, Jan Erik; Ristimäki, Ari; Reith, Albrecht & Nesland, Jahn M
[Vis alle 7 forfattere av denne artikkelen]
(2002).
Oral precancer - risk assessment in a chemopreventive perspective.
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Sudbø, Jon; Sondresen, Jan Erik; Ristimäki, Ari; Nesland, Jahn M; Reith, Albrecht & Bryne, Magne
(2002).
Identification and possible treatment of patients at high risk of oral cancer.