Publications
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Shanbhag, Siddharth; Stødle, Ida Haukåen; Lie, Stein Atle; Alonso, Mariano Sanz & Verket, Anders
(2025).
Histological Outcomes of Root Coverage Procedures: A Systematic Review With Meta‐Analysis.
Journal of Periodontal Research.
ISSN 0022-3484.
61(1),
p. 9–29.
doi:
10.1111/jre.70043.
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Objective: To answer the focused PEOS question: In animals or humans with gingival recession defects (P) what are the histological outcomes (O) of different root coverage procedures (RCPs) (E) in preclinical or clinical studies (S)?
Methods: Electronic databases (MEDLINE, EMBASE, CENTRAL) were searched for eligible studies reporting histological outcomes of RCPs in large‐animal models or humans. Histomorphometric data from animal studies were summarized as pooled means (PM) for each RCP and compared between different RCPs using effect sizes (ES) based on random‐effects meta‐analyses.
Results: Overall, 41 preclinical (32 canine‐, 5 porcine‐, 4 primate‐models) and 43 clinical studies, mostly case reports/series, were included. The most frequently reported RCPs were coronally advanced flaps with or without connective tissue grafts or soft‐tissue substitutes. Biologicals, such as enamel matrix derivatives (EMD) or membranes, were sometimes used as adjuncts in RCPs. In human biopsies, healing following RCPs mostly occurred via the formation of long junctional epithelium (JE) and connective tissue (CT) adhesion. Some degree of periodontal regeneration was reported in half of the studies. In canine studies with experimentally created defects and limited observation times, PM of new bone, cementum, and CT attachment ranged from 0.17 to 0.50, 0.97 to 2.39, and 1.31 to 2.47, respectively. Meta‐analyses revealed significantly greater new cementum with inserting fibers when using biologicals, particularly EMD (ES 0.86–0.92), or membranes (ES 0.87) as adjuncts in RCPs.
Conclusion: Healing following RCPs is generally characterized by “repair” (long JE and CT adhesion). Based on animal studies, the adjunctive use of biologicals or membranes in RCPs may enhance periodontal regeneration at least in the short term.
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Stødle, Ida Haukåen; Imber, Jean-Claude; Shanbhag, Siddharth; Salvi, Giovanni E.; Verket, Anders & Stähli, Alexandra
(2025).
Methods for Clinical Assessment in Periodontal Diagnostics: A Systematic Review.
Journal of Clinical Periodontology.
ISSN 0303-6979.
52(29),
p. 58–73.
doi:
10.1111/jcpe.14145.
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Stødle, Ida Haukåen; Koldsland, Odd Carsten; Lukina, Polina; Andersen, Ina Lervåg; Mjønes, Patricia Gjertrud & Rønne, Elin
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(2024).
Undiagnosed Celiac Disease and Periodontal Bone Loss: A Cross-Sectional Radiological Assessment from the HUNT Study.
International Journal of Dentistry.
ISSN 1687-8728.
2024(1).
doi:
10.1155/2024/1952244.
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Objective. The objective was to assess radiographic periodontal bone loss in a population with previously undiagnosed celiac disease, and to compare it to a reference group without celiac disease. Background. Periodontitis and celiac disease are chronic inflammatory diseases with possible similar features related to immune reactions and microbial dysbiosis. The relationship between these two diseases is not clear. Methods. Clinical variables, blood samples, and answers to questionnaires were collected from participants in the fourth Trøndelag Health Study (HUNT4). Celiac disease was determined based on transglutaminase 2 (TG2), immunoglobulin A (IgA), and G (IgG) in serum samples. Seropositive individuals were invited to endoscopic examination and tissue sampling. Radiographically assessed bone loss caused by periodontitis in two different levels of severity was applied as outcome, that is, ≥15% and >33% of root length. Bone loss was determined in panoramic images in participants that had attended radiographic examination in the HUNT4 Oral Health Study or in the HUNT4 Coeliac Disease Study. The association between previously undiagnosed celiac disease and radiographic bone loss was estimated by adjusted Poisson regression models. Results. Radiographic assessment was completed in 485 individuals with celiac disease determined by positive serology and in 4,727 individuals with negative serology (without celiac disease). Compared to nonceliacs, seropositive participants were less likely to present with ≥15% radiographic bone loss (prevalence ratio (PR) 0.89 (95% CI 0.84–0.96). A similar association was also observed after histopathological confirmation of celiac disease (PR 0.89 (95% CI 0.82–0.98). No association between undiagnosed celiac disease and periodontal bone loss was observed when analyses were limited to individuals with severe bone loss (>33%). Conclusion. In this study of previously undiagnosed celiac disease and periodontal bone loss, newly diagnosed celiac disease was associated with less likelihood of presenting with ≥15% radiographic bone loss compared to a nonceliac reference group.
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Stødle, Ida Haukåen; Sen, Abhijit; Høvik, Hedda; Verket, Anders & Koldsland, Odd Carsten
(2023).
Association between periodontitis stages and self-reported diseases in a Norwegian population: the HUNT study.
BMC Oral Health.
23(1),
p. 1–10.
doi:
10.1186/s12903-023-03743-z.
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Background The relationships between periodontitis and non-communicable diseases (NCDs) have been investigated through several different case-definitions. The differences in methodology may have hindered the basis of comparison between these studies. The classification from the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions offers a unison platform that may facilitate future comparison of such research. The present study aimed to reproduce associations between periodontitis and other NCDs using the 2017 Classification, in the Trøndelag Health Study (HUNT). Material and methods The fourth HUNT-survey was carried out between 2017 and 2019. Clinical variables, blood samples and answers to questionnaires were collected from 4933 participants. Periodontal status was assessed based on the latest staging system, and its associations with NCDs were estimated by logistic regression models adjusted for potential confounders. Results Compared to no or Stage I periodontitis, participants with Stage III/IV periodontitis (radiographic bone loss exceeding 33%) were associated with cardiovascular disease, hyperglycemia in participants with diabetes and chronic obstructive pulmonary disease (COPD)/emphysema. Associations with hyperglycemia in participants with diabetes and COPD/emphysema were also observed in participants with Stage II periodontitis. The only observed association when considering never-smokers alone, was with COPD/emphysema. Conclusion Periodontitis Stage II and III/IV were associated with major NCDs. Effect sizes increased with increasing periodontitis stages, which implies greater occurrence of coincident comorbidities in patients with severe periodontitis.
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Stødle, Ida Haukåen; Verket, Anders; Høvik, Hedda; Sen, Abhijit & Koldsland, Odd Carsten
(2021).
Prevalence of periodontitis based on the 2017 classification in a Norwegian population. The HUNT Study.
Journal of Clinical Periodontology.
ISSN 0303-6979.
doi:
10.1111/jcpe.13507.
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Aim This cross-sectional study assesses the prevalence of periodontitis in a large Norwegian population, based on the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions. The prevalence of periodontitis was determined by bone loss recorded on radiographs (orthopantomogram [OPG] and bitewing [BW]) and by clinical examination. Materials and methods As part of a large population health study (The HUNT Study), 7347 participants aged 19 years and older were invited to the HUNT4 Oral Health Study. Radiographic bone loss (RBL) and periodontal stage and grade were assessed in 4863 participants. Results Periodontal examination was performed in 4863 participants. RBL and clinical registrations corresponding to periodontitis as defined were observed in 72.4%. The prevalence of periodontitis increased after 40 years of age, with severe forms occurring primarily after 60 years of age. Stage I was observed in 13.8%, Stage II in 41.1%, Stage III in 15.3%, and Stage IV in 2.3% of the population. Grade A, B, and C was observed in 5.7%, 60.2%, and 6.2%, respectively. Conclusion Periodontitis was frequently observed in the investigated population. The prevalence of periodontitis Stage III and Stage IV combined was observed in 17.6% of the study population.
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Published
Nov. 29, 2013 12:47 PM
- Last modified
Nov. 29, 2013 12:47 PM
