Peter Ninkov

• Hol, Caroline; Eliassen, Morten; Hjortsjö, Carl; Larheim, Tore Arne; Ninkov, Peter & Arvidsson, Linda Zamoline (2026). Osteoarthritis Development After Surgical Treatment of Disc Displacement in the Temporomandibular Joints. A Systematic Review. Journal of Oral Rehabilitation. ISSN 0305-182X. 2026, p. 1–15. doi: 10.1111/joor.70302. Full text in Research Archive Show summary

  Background Temporomandibular joint (TMJ) discectomy and disc repositioning surgery (DRS) remain treatment options for disc displacement (DD) when conservative and minimally invasive treatments fail. DRS and discectomy with disc replacement are used, in part, to prevent osteoarthritis (OA) development. Objective To assess evidence for OA development after surgical treatment of TMJ DD by comparing OA development in surgically treated TMJs to OA development in conservatively treated patients with DD. Methods A systematic search (Medline, Embase and Cochrane up to 3 October 2024) was performed, and PRISMA was followed. A lack of effect sizes precluded meta-analysis; a descriptive statistical comparison between groups was made (Student's t-test, χ2 test, significance level p < 0.05). Results Eight observational studies, including discectomy of 117 TMJs (DD with/without reduction; without replacement), 206 comparison TMJs (DDwoR; observation) and one DRS study, met the eligibility criteria. An additional case report met the eligibility criteria but was not included in data synthesis. Heterogeneity in study designs, diagnostic methods and criteria, and mostly high Risk of Bias according to GRADE was found. OA and OA-related findings increased in all discectomy and comparison studies at follow-up. Conclusion A consistent trend of increasing TMJ OA frequency was observed across the included studies in both operated and unoperated TMJs with DD. Most studies provided evidence of very low certainty. This systematic review could therefore not reliably evaluate whether TMJ discectomy is itself responsible for OA development. Further research is needed to determine the influence of surgical treatments of TMJ DD on OA.

• Ignjatović, Nenad L.; Ninkov, Peter; Sabetrasekh, Roya; Lyngstadaas, Ståle Petter & Uskoković, Dragan P. (2014). In vitro evaluation of a multifunctional nano drug delivery system based on tigecycline-loaded calcium-phosphate/ poly-DL-lactide-co-glycolide. Bio-medical materials and engineering. ISSN 0959-2989. 24(4), p. 1647–1658. doi: 10.3233/BME-140978. Full text in Research Archive
• Ninkov, Peter; Svanæs, Dagfinn Beyer & Bjørnland, Tore (2011). Anatomical changes of the mandibular canal, displaced root fragment and neurosensory deficit after removal of a mandibular third molar: report of a case. Oral Surgery. ISSN 1752-2471. 4, p. 140–144. doi: 10.1111/j.1752-248X.2011.2011.01123.x. Full text in Research Archive
• Ingjatovic, Nenad L.; Ninkov, Peter; Sabetrasekh, Roya & Uskokovic, Dragan P. (2010). A novel nano drug delivery system based on tigecycline-loaded calciumphosphate coated with poly-dl-lactide-co-glycolide. Journal of Materials Science: Materials in Medicine. ISSN 0957-4530. 21(1), p. 231–239. doi: 10.1007/s10856-009-3854-6. Full text in Research Archive Show summary

  The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for controlled and systemic drug delivery with double effect. In the first step, a drug is released from bioresorbable polymer; in the second stage, after resorption of the polymer, non-bioresorbable calcium phosphate remains the chief part of the particle and takes the role of a filler, filling a bone defect. The obtained tigecycline-loaded calcium-phosphate(CP)/poly(dl-lactide-co-glycolide)(PLGA) nanoparticles contain calcium phosphate coated with bioresorbable polymer. The composite was analyzed by FT-IR, XRD and AFM methods. The average particle size of the nanocomposite ranges between 65 and 95 nm. Release profiles of tigecycline were obtained by UV–VIS spectroscopy in physiological solution at 37°C. Experimental results were analyzed using Peppas and Weibull mathematical models. Based on kinetic parameters, tigecycline release was defined as non-Fickian transport. The cytotoxicity of the nanocomposite was examined on standard cell lines of MC3T3-E1, in vitro. The obtained low values of lactate dehydrogenase (LDH) activity (under 37%) indicate low cytotoxicity level. The behaviour of the composite under real-life conditions was analyzed through implantation of the nanocomposite into living organisms, in vivo. The system with the lowest tigecycline content proved to be an adequate system for local and controlled release. Having in mind the registered antibiotics concentration in other tissues, delivery systems with a higher tigecycline content show both local and systemic effects.

View all works in NVA