Sadia Nazir Khan

• Khan, Sadia Nazir; Koldsland, Odd Carsten; Tiainen, Hanna & Hjortsjö, Carl (2024). Anatomical three-dimensional model with peri-implant defect for in vitro assessment of dental implant decontamination. Clinical and Experimental Dental Research. 10(1). doi: 10.1002/cre2.841. Full text in Research Archive Show summary

  Abstract Objectives Access to the implant surface plays a significant role in effective mechanical biofilm removal in peri‐implantitis treatment. Mechanical decontamination may also alter the surface topography of the implant, potentially increasing susceptibility to bacterial recolonization. This in vitro study aimed to evaluate a newly developed, anatomically realistic, and adaptable three‐dimensional (3D)printed model with a peri‐implant bone defect to evaluate the accessibility and changes of dental implant surfaces after mechanical decontamination treatment. Material and Methods A split model of an advanced peri‐implant bone defect was prepared using 3D printing. The function of the model was tested by mechanical decontamination of the exposed surface of dental implants (Standard Implant Straumann AG) coated with a thin layer of colored occlusion spray. Two different instruments for mechanical decontamination were used. Following decontamination, the implants were removed from the split model and photographed. Image analysis and fluorescence spectroscopy were used to quantify the remaining occlusion spray both in terms of area and total amount, while scanning electron microscopy and optical profilometry were used to analyze alteration in the implant surface morphology. Results The 3D model allowed easy placement and removal of the dental implants without disturbing the implant surfaces. Qualitative and quantitative assessment of removal of the occlusion spray revealed differences in the mechanism of action and access to the implant surface between tested instruments. The model permitted surface topography analysis following the decontamination procedure. Conclusion The developed 3D model allowed a realistic simulation of decontamination of implant surfaces with colored occlusion spray in an advanced peri‐implant defect. 3D printing allows easy adaptation of the model in terms of the shape and location of the defect. The model presents a valuable tool for in vitro investigation of the accessibility and changes of the implant surface after mechanical and chemical decontamination.

• Khan, Sadia Nazir; Ribeiro-Vidal, Honorato; Virto, Leire; Bravo, Enrique; Nuevo, Paula & Koldsland, Odd Carsten [Show all 8 contributors for this article] (2024). The Decontamination Effect of an Oscillating Chitosan Brush Compared With an Ultrasonic PEEK-Tip: An In Vitro Study Using a Dynamic Biofilm Model. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14360. Full text in Research Archive
• Hussain, Badra; Khan, Sadia Nazir; Agger, Anne Eriksson; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Bueno, Jaime [Show all 7 contributors for this article] (2023). A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. Journal of Functional Biomaterials. 14(8). doi: 10.3390/jfb14080394. Full text in Research Archive Show summary

  Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBone®Clean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilised for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel®. Among the tested chemical decontamination candidates, NuBone®Clean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBone®Clean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomised clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in implant dentistry

• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Show all 9 contributors for this article] (2023). Non-surgical treatment of mild to moderate peri-implantitis with an oscillating chitosan brush or a titanium curette—12-month follow-up of a multicenter randomized clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14078. Full text in Research Archive
• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Show all 9 contributors for this article] (2022). Non-surgical treatment of mild to moderate peri-implantitis using an oscillating chitosan brush or a titanium curette—A randomized multicentre controlled clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14007. Full text in Research Archive Show summary

  Objectives This prospective, parallel-group, examiner-blinded, multicentre, randomized, controlled clinical trial aimed to assess the efficacy of an oscillating chitosan brush (OCB) versus titanium curettes (TC) on clinical parameters in the non-surgical treatment of peri-implantitis. Material and Methods In five dental specialist clinics, 39 patients with one implant with mild to moderate peri-implantitis, defined as 2–4 mm radiographic reduced bone level, bleeding index (BI) ≥ 2, and probing pocket depth (PPD) ≥ 4 mm were randomly allocated to test and control groups, receiving OCB or TC debridement, respectively. Treatment was performed at baseline and three months. PPD, BI, and Plaque index (PI) were measured at six sites per implant and recorded by five blinded examiners at baseline, one, three, and six month(s). Pus was recorded as present/not present. Changes in PPD and BI were compared between groups and analysed using multilevel partial ordinal and linear regression. Results Thirty-eight patients completed the study. Both groups showed significant reductions in PPD and BI at six months compared with baseline (p < .05). There was no statistically significant difference in PPD and BI changes between the groups. Eradication of peri-implant disease as defined was observed in 9.5% of cases in the OCB group and 5.9% in the TC group. Conclusions Within the limitations of this six-month multicentre clinical trial, non-surgical treatment of peri-implantitis with OCB and TC showed no difference between the interventions. Eradication of disease was not predictable for any of the groups.

• Khan, Sadia Nazir & Saxegaard, Erik (2015). Obstruktivt søvnapnésyndrom - hvordan kan tannlegen bidra i behandlingen? Den norske tannlegeforenings Tidende. ISSN 0029-2303. 125(9), p. 784–792. Full text in Research Archive
• Khan, Sadia Nazir; Skau, Irene; Grytten, Jostein Ivar & Saxegaard, Erik (2015). Obstruktivt søvnapnésyndrom - kunnskap og klinisk erfaring blant et utvalg norske tannleger. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 125(9), p. 794–798. Full text in Research Archive

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• Khan, Sadia Nazir; Koldsland, Odd Carsten & Hjortsjö, Carl (2019). Bacteriostatic effect of filling materials used in implant-abutment-screw-channel: A pilot study. Full text in Research Archive

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