Tanya Jeanette Franzen

• Rizk, Mumen Z.; Torgersbråten, Nina Ellen; Mohammed, Hisham; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska (2020). Stability of single-jaw vs two-jaw surgery following the correction of skeletal class III malocclusion: A systematic review and meta-analysis. Orthodontics & craniofacial research. ISSN 1601-6335. p. 1–14. doi: 10.1111/ocr.12456. Full text in Research Archive
• Rizk, Mumen Z.; Torgersbråten, Nina Ellen; Mohammed, Hisham; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska (2020). Stability of single-jaw vs two-jaw surgery following the correction of skeletal class III malocclusion: A systematic review and meta-analysis. Orthodontics & craniofacial research. ISSN 1601-6335. doi: 10.1111/ocr.12456. Full text in Research Archive
• Haugen, Sigrid; Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska [Show all 8 contributors for this article] (2017). Adiponectin prevents orthodontic tooth movement in rats. Archives of Oral Biology. ISSN 0003-9969. 83, p. 304–311. doi: 10.1016/j.archoralbio.2017.08.009. Full text in Research Archive Show summary

  Objective The objective was to examine the effects of repetitive local administration of adiponectin on experimental tooth movement in rats. Materials and methods The maxillary right first molar of male Wistar rats (n = 24) was moved mesially for 14 days, with local adiponectin injections (0.2 or 2 μg) every third day. Micro-computed tomography was performed at days 0, 6 and 14 and molar movement, bone density and bone volume fraction were calculated from the scans. Changes in extracellular matrix collagen and cell numbers in the periodontal ligament were analyzed histologically, and levels of circulating cytokines were measured by Luminex and ELISA. Results Adiponectin injections induced a reduction in tooth movement after 12 and 14 days compared to controls. No tooth movement was observed between days 3 and 14 in the group receiving the highest dosage (2 μg) of adiponectin. Differences in bone density and bone volume fractions between treatment and control groups were not identified. Relative size and morphology of collagen fibrils, and cell number in the periodontal region after adiponectin injections were unchanged compared to controls. Levels of circulating adiponectin or other selected factors in plasma were not influenced by the adiponectin injections. Conclusions Submucosal injections of adiponectin prevented experimental tooth movement in rats. The effect was dosage-dependent and local. Adiponectin injections caused no detectable changes in bone density, periodontal cell number or collagen content.

• Franzen, Tanya Jeanette; Zahra, Sherif; Kadi, A El & Vandevska-Radunovic, Vaska (2015). The influence of low-level laser on orthodontic relapse in rats. European Journal of Orthodontics. ISSN 0141-5387. 37(1), p. 111–117. doi: 10.1093/ejo/cju053. Full text in Research Archive
• Franzen, Tanya Jeanette; Monjo, Marta; Rubert, Marina & Vandevska-Radunovic, Vaska (2014). Expression of bone markers and micro-CT analysis of alveolar bone during orthodontic relapse. Orthodontics & craniofacial research. ISSN 1601-6335. 17(4), p. 249–258. doi: 10.1111/ocr.12050. Full text in Research Archive Show summary

  Structured Abstract Authors - Franzen T.J., Monjo M., Rubert M., Vandevska-Radunovic V. Objectives - To investigate biological changes of alveolar bone occurring during orthodontic relapse. Materials and Methods - Maxillary first rat molars were moved mesially for ten days. After orthodontic tooth movement (OTM) appliances were removed, and the molars were allowed to relapse for one, three, five, seven, 14 or 21 days. Changes in 3D morphometric parameters of bone located mesial to the first molars were evaluated by micro-CT. Total RNA was isolated from the same bone site and real-time RT-PCR was used to measure the expression of bone formation and resorption markers. Results - One day after appliance removal, the molars relapsed to a mean 73% of the achieved OTM, and then steadily relapsed to 93% at 21 days. Tissue mineral density and percent bone volume increased over the experimental period. Inversely, there was a decrease in total porosity. Gene expression of OCN, Coll-I and ALP decreased during OTM, and as the molars relapsed showed an increasing tendency. Gene expression of RANKL and TRAP increased during OTM. Changes in mRNA expression of H+-ATPase were minor. By 21 days post-appliance removal the remodelling process in rats appeared to have returned to control levels. Conclusions –Bone tissue reactions on a molecular level are similar during OTM and orthodontic relapse. These findings validate the importance of immediate retention following active OTM. Key words: bone remodelling; micro-CT; orthodontic relapse; Real-time RT-PCR; tooth movement.

• Franzen, Tanya Jeanette; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2013). Periodontal tissue reaction during orthodontic relapse in rat molars. European Journal of Orthodontics. ISSN 0141-5387. 35(2), p. 152–159. doi: 10.1093/ejo/cjr127. Full text in Research Archive Show summary

  Relapse after orthodontic tooth movement (OTM) is an undesirable outcome that involves a number of factors. This study investigated the remodelling of the alveolar bone and related periodontal structures during orthodontic relapse in rat molars. The maxillary right first molars of 35 Wistar rats were moved mesially by a fixed orthodontic appliance for 10 days and the contralateral molars served as controls. The appliances were removed and six animals killed. The molars were allowed to relapse, and the remaining animals were sacrificed at 1, 3, 5, 7, 14, and 21 days. The jaws were sectioned and stained with haematoxylin and eosin and tartrate-resistant acid phosphatase (TRAP). One day after appliance removal, the molars relapsed to a mean 62.5 per cent of the achieved OTM and then steadily relapsed to 86.1 per cent at 21 days. The number of osteoclasts situated along the alveolar bone of the first molars was highest at the end of active treatment and significantly decreased during the relapse period. In the OTM group, osteoclasts were most numerous in the pressure side of the periodontal ligament (PDL). As the molars relapsed over time, the osteoclast distribution shifted, and after 7 days of relapse, TRAP-positive cells were registered in previous pressure and tension sides of the first molars. After 21 days, these cells were concentrated in the distal parts of the PDL of all three maxillary right molars. These results indicate that orthodontic relapse in the rat model occurs rapidly and remodelling of the alveolar bone and PDL plays a central role in the relapse processes of both actively moved and adjacent teeth.

• Franzen, Tanya Jeanette; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2011). Periodontal tissue reaction during orthodontic relapse in rat molars. European Journal of Orthodontics. ISSN 0141-5387. doi: 10.1093/ejo/cjr127. Full text in Research Archive

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• Franzen, Tanya Jeanette; Monjo, Marta; Rubert, Marina; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2014). Alveolar bone remodelling during orthodontic relapse. Full text in Research Archive Show summary

  Aim: To examine the biological changes occurring in alveolar bone during orthodontic relapse. Materials and Method: Maxillary first rat molars were moved mesially for ten days, appliances were removed, and the molars allowed to relapse for 1, 3, 5, 7, 14 or 21 days. Maxillae of 35 rats were sectioned and stained with H&E and TRAP, whilst in 37 rats 3D morphometric parameters of bone sited mesial to the first molars were assessed by micro-CT, subsequently total RNA was isolated and real-time RT-PCR used to measure the expression of bone formation and resorption markers. Comparison among groups was assessed by t-tests or ANOVA, and correlations by Spearman’s rank correlation coefficient. Results: One day after appliance removal, the molars relapsed to 68.5% of the achieved OTM, and progressively relapsed to 90.6% at 21 days. Osteoclasts located along the alveolar bone of the first molars peaked at the end of active orthodontic tooth movement (OTM) and were most abundant in the pressure side of the PDL. Osteoclast numbers decreased significantly during relapse and their distribution shifted; after 7 days of relapse TRAP-positive cells were registered in previous pressure and tension sides of the first molars. After 21 days, these cells were concentrated in the distal sides of the PDL. In the bone mesial to the first molars tissue mineral density and percent bone volume increased whilst total porosity decreased over the experimental period. Gene expression of OCN, Coll-I and ALP decreased during OTM, and tended to increase as the molars relapsed. Gene expression of RANKL and TRAP increased during OTM. Changes in mRNA expression of H+-ATPase were minor. By 21 days the remodelling process appeared to have returned to control levels. Conclusion: The findings of this investigation indicate that orthodontic relapse in the rat model occurs rapidly and remodelling of the alveolar bone plays a central role in the relapse processes of both actively moved, and adjacent teeth.

• Franzen, Tanya Jeanette; Vandevska-Radunovic, Vaska; Zahra, Sherif & Elkadi, Abbadi (2014). The influence of Low-level laser therapy (LLLT) on orthodontic relapse. Full text in Research Archive
• Franzen, Tanya Jeanette; Vandevska-Radunovic, Vaska; Rubert, Marina & Monjo, Marta (2011). Expression of bone resorption and formation markers during orthodontic relapse. Full text in Research Archive Show summary

  Objectives: To investigate the mRNA levels of bone resorption and formation markers during orthodontic relapse of rat molars. Methods: Thirty-five maxillary right first rat molars were moved mesially (pressure side) by closed coil springs (0.5N force) whilst the contralateral maxillae served as internal controls. An additional non-treated control group (n=5) was used. Following ten days of orthodontic tooth movement (OTM) all appliances were removed, the amount of OTM registered and five animals were sacrificed. The molars of the remaining animals were allowed to relapse for one, three, five, seven, 14 and 21days. Orthodontic relapse was then measured and the animals sacrificed. RNA was isolated from bone removed from the mesial aspect of all maxillary first molars using a biopsy punch. Real-time PCR was performed for three housekeeping genes: 18S rRNA, glyceraldehyde-3-phosphate dehydrogenase and β-actin, and seven target genes: runx2, collagen type I (coll-I), alkaline phoshatase (ALP), osteocalcin, vacuolar type proton ATPase (H+-ATPase), tartrate-resistant acid phosphatase (TRAP) and receptor activator of nuclear factor kappa β ligand (RANKL). Results: One day after appliance removal, the molars relapsed to a mean 73% of the achieved OTM at ten days of active treatment, and then steadily relapsed to a mean 93% at 21 days. Levels of RANKL, TRAP and H+-ATPase were increased on the experimental side from the end of active OTM to 7 days relapse indicating bone resorption. They approached contralateral side levels at 14 and 21 days. Levels of bone formation markers coll-I, ALP, runx2 and osteocalcin showed little differences between the experimental and contralateral sides up to 14 days and then began to increase on the experimental side. Conclusions: On the former pressure side bone resorption continues during the early periods of orthodontic relapse, whilst bone formation does not occur until two weeks after the start of orthodontic relapse.

• Zahra, Sherif; Franzen, Tanya Jeanette; Kadi, A El & Vandevska-Radunovic, Vaska (2008). The effect of low level laser therapy on relapse processes in rat molars. Full text in Research Archive
• Franzen, Tanya Jeanette; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2006). Supporting dental tissue changes during orthodontic relapse in rat molars. European Journal of Orthodontics. ISSN 0141-5387. 28(6), p. e203–e203. Full text in Research Archive
• Brudvik, Pongsri; Vandevska-Radunovich, Vaska; Franzen, Tanya Jeanette & Greiner-simonsen, Rita (2005). Suppporting dental tissue changes during orthodontic relapse in rat molars. Full text in Research Archive

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