Aina-Mari Lian

• Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni & Reseland, Janne Elin (2021). Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts. Bone Reports.  ISSN 2352-1872.  14:100750, s 1- 7 . doi: 10.1016/j.bonr.2021.100750 Full text in Research Archive. Show summary

  Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, the objective of this study was to evaluate the effects of the oral BP alendronate (ALN) and the PPI omeprazole (OME) alone and in combination on primary human osteoblasts and gingival fibroblasts in vitro. Methods: Human gingival fibroblasts and normal human osteoblasts were incubated with either 5 μM of ALN or 1 μM of OME, or ALN + OME for 1, 3, 7 or 14 days. Effect on viability was evaluated by the lactate dehydrogenase activity in the medium and on proliferation by quantifying 3H-thymidin incorporation. Multianalyte profiling of proteins in cell culture media was performed using the Luminex 200TM system to assess the effect on selected bone markers and cytokines. Results: The proliferation of osteoblasts and fibroblasts was reduced upon exposure to ALN + OME. ALN induced an early, temporary rise in markers of inflammation, and OME and ALN + OME promoted a transient decline. An initial increase in IL-13 occurred after exposure to all three options, whereas ALN + OME promoted IL-8 release after 7 days. OME and ALN + OME promoted a transient reduction in vascular endothelial growth factor (VEGF) from osteoblasts, whereas ALN and ALN + OME induced a late rise in VEGF from fibroblasts. Osteoprotegerin release was enhanced by ALN and suppressed by OME and ALN + OME. Conclusions: ALN + OME seemed to exaggerate the negative effects of each drug alone on human osteoblasts and gingival fibroblasts. The anti-proliferative effects, modulation of inflammation and impairment of angiogenesis, may induce unfavorable conditions in periodontal tissue facilitating development of osteonecrosis.

• Chahal, Aman S; Schweikle, Manuel; Lian, Aina-Mari; Reseland, Janne Elin; Haugen, Håvard Jostein & Tiainen, Hanna (2020). Osteogenic potential of poly(ethylene glycol)-amorphous calcium phosphate composites on human mesenchymal stem cells. Journal of Tissue Engineering.  ISSN 2041-7314.  11 . doi: 10.1177/2041731420926840 Full text in Research Archive.
• Schröder, Maria; Riksen, Elisabeth Aurstad; He, Jianying; Skallerud, Bjørn Helge; Møller, Mona Elisabeth; Lian, Aina-Mari; Syversen, Unni & Reseland, Janne Elin (2020). Vitamin K2 modulates vitamin D induced mechanical properties of human 3D bone spheroids in vitro. JBMR Plus.  ISSN 2473-4039.  4(9) . doi: 10.1002/jbm4.10394 Full text in Research Archive.
• Mann, Vivek; Grimm, Daniela; Corydon, Thomas J.; Krüger, Marcus; Wehland, Markus; Riwaldt, Stefan; Sahana, Jayashree; Kopp, Sascha; Bauer, Johan; Reseland, Janne Elin; Infanger, Manfred; Lian, Aina-Mari; Okoro, Elvis & Sundaresan, Alamelu (2019). Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering. International Journal of Molecular Sciences.  ISSN 1422-0067.  30(6) . doi: 10.3390/ijms20061357 Full text in Research Archive.
• Pullisaar, Helen; Colaianni, Graziana; Lian, Aina-Mari; Vandevska-Radunovic, Vaska; Grano, Maria & Reseland, Janne Elin (2019). Irisin promotes growth, migration and matrix formation in human periodontal ligament cells. Archives of Oral Biology.  ISSN 0003-9969. . doi: 10.1016/j.archoralbio.2019.104635 Full text in Research Archive.
• Stakkestad, Øystein; Heyward, Catherine Anne; Lyngstadaas, Ståle Petter; Medin, Tirill; Vondrasek, Jiri; Lian, Aina-Mari; Pezeshki, Gita & Reseland, Janne Elin (2018). An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon.  ISSN 2405-8440.  4(12) . doi: 10.1016/j.heliyon.2018.e01075 Full text in Research Archive.
• Fossmark, Reidar; Stunes, Astrid Kamilla; Petzold, Christiane; Waldum, Helge; Rubert, Marina; Lian, Aina-Mari; Reseland, Janne Elin & Syversen, Unni (2012). Decreased bone mineral density and reduced bone quality in H+/K+ ATPase beta-subunit deficient mice. Journal of Cellular Biochemistry.  ISSN 0730-2312.  113(1), s 141- 147 . doi: 10.1002/jcb.23337
• Aune, Guro; Lian, Aina-Mari; Tingulstad, Solveig; Torp, Sverre Helge; Forsmo, Siri; Reseland, Janne Elin; Stunes, Astrid Kamilla & Syversen, Unni (2011). Increased circulating hepatocyte growth factor (HGF): a marker of epithelial ovarian cancer and an indicator of poor prognosis. Gynecologic Oncology.  ISSN 0090-8258.  121(2), s 402- 406 . doi: 10.1016/j.ygyno.2010.12.355

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• Aune, Guro; Lian, Aina-Mari; Tingulstad, Solveig; Torp, Sverre Helge; Forsmo, Siri; Reseland, Janne Elin & Syversen, Unni (2015). Increased circulating hepatocyte growth factor (HGF): a marker of epithelial ovarian cancer and an indicator of poor prognosis.
• Wiig, Elisabeth; Tiainen, Hanna; Lian, Aina-Mari; Mann, Vivek; Sundaresan, Alamelu; Haugen, Håvard Jostein; Daniela, Grimm & Reseland, Janne Elin (2015). Effect of microgravity on bone cells in bioinspired ceramic TiO2 scaffolds.
• Aune, Guro; Lian, Aina-Mari; Tingulstad, Solveig; Torp, Sverre Helge; Forsmo, Siri; Reseland, Janne Elin & Syversen, Unni (2010). Increases in circulating hepatocyte growth factor (HGF): a marker of epithelial ovarian cancer and an indicator of poor prognosis.
• Aune, Guro; Lian, Aina-Mari; Tingulstad, Solveig; Torp, Sverre Helge; Forsmo, Siri; Stunes, Astrid Kamilla; Reseland, Janne Elin & Syversen, Unni (2010). Increased circulating HGF is an indicator of epithelial ovarian cancer and may indicate a poor prognosis.
• Kalvik, Anne; Riksen, Elisabeth Aurstad; Hynne, Astrid; Lian, Aina-Mari; Kvam, Britt-Mari; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2007). Effect of temperature and fluoride on ameloblasts in vitro. Calcified Tissue International.  ISSN 0171-967X.  80

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