Roger Junges

• Dhariwal, Achal; Junges, Roger; Chen, Tsute & Petersen, Fernanda Cristina (2020). ResistoXplorer: a web-based tool for visual, statistical and exploratory data analysis of resistome data. BioRxiv.  ISSN 0362-4331. . doi: https://doi.org/10.1101/2020.08.14.250837
• Celeste, Roger K.; Oliveira, Sara C. & Junges, Roger (2019). Threshold-effect of income on periodontitis and interactions with race/ethnicity and education. Revista Brasileira de Epidemiologia.  ISSN 1415-790X.  22 . doi: 10.1590/1980-549720190001
• Junges, Roger; Maienschein-Cline, Mark; Morrison, Donald A. & Petersen, Fernanda Cristina (2019). Complete Genome Sequence of Streptococcus pneumoniae Serotype 19F Strain EF3030. Microbiology Resource Announcements (MRA).  ISSN 2169-8287.  8(19), s 1- 3 . doi: 10.1128/MRA.00198-19
• Junges, Roger; Salvadori, Gabriela; Chen, Tsute; Morrison, Donald A. & Petersen, Fernanda Cristina (2019). Hidden Gems in the Transcriptome Maps of Competent Streptococci. Frontiers in Molecular Biosciences.  ISSN 2296-889X.  5, s 1- 7 . doi: 10.3389/fmolb.2018.00116 Full text in Research Archive.
• Junges, Roger; Sturød, Kjersti; Salvadori, Gabriela; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2019). Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae. Applied and Environmental Microbiology.  ISSN 0099-2240.  85(2) . doi: 10.1128/AEM.02297-18
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2019). Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications. Frontiers in Cellular and Infection Microbiology.  ISSN 2235-2988.  9:94, s 1- 8 . doi: 10.3389/fcimb.2019.00094 Full text in Research Archive.
• Lauren A., Cowley; Petersen, Fernanda Cristina; Junges, Roger; Jimenez, M; Morrison, Donald A. & Hanage, WP (2018). Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae. PLoS Genetics.  ISSN 1553-7390.  14(6) . doi: 10.1371/journal.pgen.1007410 Full text in Research Archive.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, T.; Morrison, D.A. & Petersen, Fernanda Cristina (2018). High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes. BMC Genomics.  ISSN 1471-2164.  19(1) . doi: 10.1186/s12864-018-4802-y Full text in Research Archive.
• Sturød, Kjersti; Salvadori, Gabriela; Junges, Roger & Petersen, Fernanda Cristina (2018). Antibiotics alter the window of competence for natural transformation in streptococci. Molecular Oral Microbiology.  ISSN 2041-1006.  33(5), s 378- 387 . doi: 10.1111/omi.12240
• Junges, Roger; Khan, Rabia; Tovpeko, Yanina; Åmdal, Heidi Aarø; Petersen, Fernanda Cristina & Morrison, Donald (2017). Markerless genome editing in competent streptococci. Methods in molecular biology.  ISSN 1064-3745.  1537, s 233- 247 . doi: 10.1007/978-1-4939-6685-1_14 Full text in Research Archive.
• Junges, Roger; Salvadori, Gabriela; Shekhar, Sudhanshu; Åmdal, Heidi Aarø; Periselneris, Jimstan; Chen, Tsute; Brown, Jeremy S. & Petersen, Fernanda Cristina (2017). A quorum-sensing system that regulates Streptococcus pneumoniae biofilm formation and surface polysaccharide production. mSphere.  ISSN 2379-5042.  2(5), s 1- 18 . doi: 10.1128/mSphere.00324-17 Full text in Research Archive.
• Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2017). A positive feedback loop mediated by Sigma X enhances expression of the streptococcal regulator ComR. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-04768-5 Full text in Research Archive.
• Praveen K., Gajendrareddy; Junges, Roger; Cygan, G; Zhao, Y; Marucha, Phillip T. & Engeland, Cristopher G. (2017). Increased oxygen exposure alters collagen expression and tissue architecture during ligature-induced periodontitis. Journal of Periodontal Research.  ISSN 0022-3484.  52(3), s 644- 649 . doi: 10.1111/jre.12408
• Salvadori, Gabriela; Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2017). Natural transformation of oral streptococci by use of synthetic pheromones. Methods in molecular biology.  ISSN 1064-3745.  s 219- 232 . doi: 10.1007/978-1-4939-6685-1_13 Full text in Research Archive.
• Engeland, C. G.; Hugo, F. N.; Hilgert, J. B.; Nascimento, G. G.; Junges, Roger; Lim, H. J.; Marucha, P. T. & Bosch, J. A. (2016). Psychological distress and salivary secretory immunity. Brain, behavior, and immunity.  ISSN 0889-1591.  52, s 11- 17 . doi: 10.1016/j.bbi.2015.08.017
• Engeland, Christopher G.; Hugo, Fernando N.; Hilgert, Juliana B.; Nascimento, Gustavo G.; Junges, Roger; Lim, HJ; Marucha, Phillip T. & Bosch, Jos A. (2016). The effects of psychological distress on salivary secretory immunity. Brain, behavior, and immunity.  ISSN 0889-1591.  52, s 11- 17 . doi: 10.1016/j.bbi.2015
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Overcoming the barrier of low efficiency during Genetic transformation of Streptococcus mitis. Frontiers in Microbiology.  ISSN 1664-302X.  7 . doi: 10.3389/fmicb.2016.01009 Full text in Research Archive.
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Overcoming the barrier of low efficiency during natural transformation of Streptococcus mitis. Frontiers in Microbiology.  ISSN 1664-302X. . doi: 10.3389/fmicb.2016.01009
• Morrison, D.A.; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2015). Genome editing by natural genetic transformation in Streptococcus mutans. Journal of Microbiological Methods.  ISSN 0167-7012.  119, s 134- 141 . doi: 10.1016/j.mimet.2015.09.023
• Junges, Roger; Celeste, RK; Pizzatto, LN; Gatti, FDS; Abegg, C & Samuel, SMW (2014). Elementary schoolteachers’ knowledge and decision making regarding dental trauma.. Oral Health & Preventive Dentistry.  ISSN 1602-1622.
• Rösing, CK; Junges, Roger & Haas, AN (2014). Publication rates of editorial board members in oral health journals.. Brazilian Oral Research.  ISSN 1806-8324. . doi: 10.1590/1807-3107BOR-2014.vol28.0042
• Gajendrareddy, PK; Engeland, CG; Junges, Roger; Horan, MP; Rojas, IG & Marucha, PT (2013). MMP-8 overexpression and persistence of neutrophils relate to stress-impaired healing and poor collagen architecture in mice.. Brain, behavior, and immunity.  ISSN 0889-1591.
• Junges, Roger; Zitzmann, NU; Walter, C & Rösing, CK (2013). Dental care providers' decision making regarding maintenance of compromised teeth and implant therapy indication: an analysis of gender and enrollment in teaching positions. Clinical Oral Implants Research.  ISSN 0905-7161. . doi: 10.1111/clr.12206
• Junges, Roger; Moraes, VB & Rösing, CK (2012). Association between gingival recession and dentin hypersensitivity. Perionews.  ISSN 1981-2922.
• Junges, Roger; Portella, FF; Hugo, FN; Padilha, DM & Samuel, SMW (2012). Caregivers' attitudes regarding oral health in a long-term care institution in Brazil.. Gerodontology.  ISSN 0734-0664.
• Slawski, EG; Moreira, IB; Junges, Roger & Rösing, CK (2012). The participation of dentists in multidisciplinary teams in Intensive Care Units (ICUs). Perionews.  ISSN 1981-2922.
• Junges, Roger; Stello, RS; Portella, FF; Rösing, CK & Samuel, SMW (2011). Impact of the implantation of a new curriculum in the process of learning in a Faculty of Dentistry in Brazil.. Brazilian Oral Research.  ISSN 1806-8324.
• Moreira, IB; Slawski, EG; Junges, Roger & Rösing, CK (2011). Oral health care in surgical and hospitalized patients in Porto Alegre. Perionews.  ISSN 1981-2922.

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• Dhariwal, Achal; Junges, Roger & Petersen, Fernanda Cristina (2019). Exploratory analysis and Visualization of resistome data. Show summary

  Abstract: Recently, antimicrobial resistance (AMR) has gained everybody’s attention at a global level due to its impact on public health. Nation-wide surveillance efforts have been going on for characterization of these resistance determinants responsible for AMR. Due to advancements in metagenomics, comprehensive databases have been already established providing hierarchical information such as class, group and mechanism of these antibiotic resistance genes (ARGs). Additionally, some recently developed tools are also able to quantify the abundance of these ARGs present in any metagenomic sample. However, it is still challenging to perform bioinformatics analysis and interpretation of such data. Further, there is no such specific tool developed to support comprehensive downstream analysis and visualization from resistome data. As a result, we are aiming to develop ResistoAnalyst, a user-friendly web-based tool that integrates recent advancements in visualization and statistics techniques, integrated with several comprehensive databases, to enable comprehensive analysis of resistome data generated from metagenomics studies. Development of such tool will enable most clinicians, bench researchers to better understand, and generate hypothesis from their own data in real time. Additionally, ResistoAnalyst will be a valuable resource for sequence-based surveillance and monitoring of antibiotic usage and resistome development.

• Junges, Roger (2019). A ComRS-like regulator system in the mitis group of streptococci that regulates bacteriocin production. Show summary

  Abstract: Streptococci are particularly abundant in the oral cavity. Species in this genus trigger the natural transformation system, which enables them to acquire exogenous DNA and recombine, through the products of different gene clusters: comCDE and comRS. While members of the mitis groups of streptococci present the activation via comCDE, here we investigated the presence and functionality of comRS-like systems in these species. Homology search indicated the presence of putative ComRS systems in the mitis group, including Streptococcus mitis and Streptococcus gordonii. One of the S. mitis candidates was selected for mechanistic studies. Downstream of the ComR regulator gene, a comS-like gene coding for a putative pheromone was identified, and it contained a double-tryptophan as traditionally found in type II XIPs (sigX-inducing peptide). However, no conserved ComR-box was identified upstream of sigX, which encodes the master regulator of competence for natural transformation, indicating that the ComRS system was not involved in competence activation. Induction of the system using the synthetic XIP-like peptide revealed that the system promoted activation of a bacteriocin cluster. Altogether, we have identified a ComRS-like system in the mitis group that regulates bacteriocin production. This is the first description of a ComRS-like system that does not seem to regulate competence. In addition, the target of the bacteriocin produced by this oral bacterium poses as an interesting target for further studies.

• Junges, Roger (2019). Antimicrobial stewardship in oral health care: are we doing our part?.
• Junges, Roger (2019). ComRS systems in the mitis group of streptococci.
• Junges, Roger (2019). Exciting research stay at the University of Illinois of Chicago (UIC).
• Junges, Roger (2019). Identification of a ComRS-like regulator system in the mitis group of streptococci.
• Junges, Roger (2019). Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation.
• Junges, Roger; Salvadori, Gabriela; Chen, Tsute & Petersen, Fernanda Cristina (2019). Identification of a ComRS-like regulator system in the mitis group of streptococci.
• Pagotto, LL; Junges, Roger; Salvadori, Gabriela; Petersen, Fernanda Cristina & Ricomini Filho, AP (2019). Inhibition of Streptococcus mutans competence by chlorhexidine gluconate.
• Pagotto, LL; Junges, Roger; Salvadori, Gabriela; Petersen, Fernanda Cristina & Ricomoni Filho, Antonio Pedro (2019). Inhibition of Streptococcus mutans competence by chlorhexidine gluconate.
• Junges, Roger & Petersen, Fernanda Cristina (2018). Eavesdropping on bacterial conversations: what are they doing and do they understand each other?.
• Junges, Roger & Petersen, Fernanda Cristina (2018). Interspecies cell-to-cell communication in the mitis group of streptococci.
• Junges, Roger & Petersen, Fernanda Cristina (2018). Rgg/SHP cross-communication in the mitis group of streptococci.
• Junges, Roger; Petersen, Fernanda Cristina; Egija, Zaura; Lemos, José A. & Merritt, Justin (2018). Environmental and antibiotic stress on oral bacteria: a target for new therapies.
• Junges, Roger; Sturød, Kjersti; Salvadori, Gabriela; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2018). Interspecies activation of a virulent pathway by an oral commensal.
• Morrison, Donald A.; Jimenez, Med; Cowley, Lauren A.; Junges, Roger; Petersen, Fernanda Cristina & Hanage, William P. (2018). Genomic signature of natural genetic transformation shared by S. pneumoniae and S. pyogenes.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2018). Insights into regulatory pathways of competence development in Streptococcus mitis type strain and SK321.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2018). Molecular Characterization of Genetic Competence in Streptococcus mitis.
• Sturød, Kjersti; Salvadori, Gabriela; Junges, Roger & Petersen, Fernanda Cristina (2018). Antibiotic Induced Streptococcal Competence Not Always Correlate with Transformability.
• Cowley, Lauren A.; Petersen, Fernanda Cristina; Junges, Roger; Hanage, William P & Morrison, Donald A. (2017). Co-culture of S. pneumoniae strains fosters large recombination events.
• Cowley, Lauren A.; Petersen, Fernanda Cristina; Junges, Roger; Hanage, William P & Morrison, Donald A. (2017). Large recombination events readily occurring in biofilm cultures of Streptococcus pneumoniae.
• Junges, Roger; Salvadori, Gabriela; Chen, Tsute; Åmdal, Heidi A.; Jimstan N., Periselneris; Jeremy S., Brown & Petersen, Fernanda Cristina (2017). A bacterial pheromone system regulates biofilm formation and colonization..
• Junges, Roger; Salvadori, Gabriela; Sudhanshu, Shekhar; Åmdal, Heidi A.; Jimstan N., Periselneris; Chen, Tsute; Jeremy S., Brown & Petersen, Fernanda Cristina (2017). An Rgg/SHP quorum sensing system reduces virulence and fitness in Streptococcus pneumoniae.
• Salvadori, Gabriela; Junges, Roger & Petersen, Fernanda Cristina (2017). A Competence-Induced Bacteriocin Reduces Growth of Oral Pathogenic Bacteria.
• Salvadori, Gabriela; Junges, Roger; Chen, Tsute & Petersen, Fernanda Cristina (2017). A Competence-Induced Bacteriocin Reduces Growth of Oral Pathogenic Bacteria..
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2017). High efficiency genetic transformation in encapsulated pneumococcus.
• Junges, Roger (2016). Overcoming barriers to genome editing of oral streptococci.
• Junges, Roger (2016). Overcoming barriers to genome editing of oral streptococci.
• Junges, Roger (2016). Rgg-type regulators in streptococci.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi A.; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Markerless Genome Editing in Oral Streptococci.
• Junges, Roger; Salvadori, Gabriela; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). High efficiency genetic transformation in Streptococcus Mitis.
• Junges, Roger; Salvadori, Gabriela; Åmdal, Heidi A.; Morrison, Donald A.; Chen, Tsute & Petersen, Fernanda Cristina (2016). Global response of Streptococcus mitis to the competence-stimulating peptide.
• Salvadori, Gabriela; Junges, Roger; Chen, Tsute; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). High-resolution profiles of the CSP signaling pathway in Streptococcus mitis SK321 and NCTC12261T..
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi A.; Chen, Tsute & Petersen, Fernanda Cristina (2016). Transcriptome response of Streptococcus mitis to the competence pheromone (Hatton Award representation).
• Celeste, Roger K.; Junges, Roger & Oliveira, Sara C. (2015). Higher income levels and household assets are related to better periodontal condition up to a certain threshold.
• Junges, Roger (2015). Markerless genome editing in streptococci.
• Junges, Roger (2015). Microbiology and Immunology.
• Junges, Roger (2015). Rgg/SHP pheromone system in S. pneumoniae and S. mitis.
• Junges, Roger (2015). Understanding cell-to-cell communication in bacteria.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). A new link between two Streptococcus mutans pheromones.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptoccocus mutans to the sigX-inducing peptide (XIP).
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). A New Pheromone in Streptococcus mitis Enhances Biofilm Formation.
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Characterization of an Rgg/SHP system in Streptococcus mitis that allows communication with Streptococcus pneumoniae.
• Petersen, Fernanda Cristina; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Morrison, Donald A. (2015). A new link between the Streptococcus mutans XIP and CSP pheromone pathways revealed by directional RNA-sequencing.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Identification of Streptococcus mitis competence pheromone responsive genes by transcriptome analysis.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptococcus mitis to the competence pheromone.
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Streptococcus mitis response to the competence pheromone.
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome analysis of Streptococcus mitis response to the competence pheromone.
• Junges, Roger (2014). Host-microbe interactions.
• Junges, Roger (2014). Streptococcus mitis transcriptome changes in response to a novel pheromone.
• Junges, Roger; Rukke, HV; Åmdal, HA; Chen, Tsute & Petersen, Fernanda Cristina (2014). Streptococcus mitis transcriptome changes in response to a novel pheromone.

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