About the group

Synapses, connection points between neurons, are essential for signal transmission. We are particularly focused on synaptic plasticity, which refers to the ability of synapses to undergo structural, functional, or molecular changes. New synapses can form, old ones can disappear, and existing synapses can reorganize their structure. Additionally, synapses can modify the strength of signal transmission, making them more or less efficient. This dynamic process is central to how the brain stores information and adapts to experiences. Synapses are not passive connections, they are dynamic, highly intricate structures that function as molecular microprocessors.

Our research primarily focuses on how proteins and other cellular components influence synaptic and neural plasticity, and how these molecular structures impact cognitive functions like learning and memory. We also explore how disruptions in these processes contribute to various neurological and psychiatric disorders.

In addition, we investigate the role of glial cells in brain plasticity and their interactions with neurons. Once considered mere support cells, glial cells are now recognized as active participants in regulating synaptic function, signal transmission, and immune responses within the brain.

We employ a diverse range of advanced techniques, including:

  • Electrophysiology to measure synaptic activity and signal transmission.
  • Light microscopy, electron microscopy, and super-resolution microscopy to visualize synapses, neurons, glial cells, and proteins at various levels of detail.
  • Molecular biology methods such as PCR, Western blot and immunohistochemistry to examine gene and protein expression in both neurons and glial cells.
  • Cell culture models to study cellular processes, molecular mechanisms, and protein interactions in a controlled environment.
  • Imaging techniques such as functional magnetic resonance imaging (fMRI) to examine brain activity and functional connectivity in living organisms.
  • Behavioral testing in mice and rats to correlate molecular and cellular changes in neurons and glial cells with learning, behavior, and memory processes.

Through these experimental approaches, our goal is not only to identify novel therapeutic targets for treating brain disorders but also to gain a deeper understanding of how the brain, including the interplay between neurons and glial cells, functions and adapts to the ever-changing and dynamic environment.