Oral Physiology and Cancer Research Group (OPCG)
The overall aim of the group is to identify OC related biomarkers through comprehensive basic research on cancer cell lines and clinical material and to test and validate the identified biomarkers for future translational applications.
Hematoxylin and eosin stained picture of oral squamous cell carcinoma showing infiltrating cancer cells. Photo: Tine Søland, IOB/UiO.
Related projects at the Department of Oral Biology
- Sapkota's Lab - Dipak Sapkota
- Histopathological Diagnostic Service - Tine M. Søland
- Galtung’s lab - Hilde Galtung
- Haug’s lab - Trude M. Haug
About the group
OPCG consists of researchers, post-doctoral fellows, PhD candidates, master, bachelor, research line students and bioengineers who are involved in various aspects of basic and translational oral cancer (OC) research at the Department Institute of Oral Biology, University of Oslo. The group has expertise in the following laboratory methods/models:
- Profiling of mRNA, miRNA, protein from cells and tissue specimens.
- In vitro (monolayer and 3D organotypic co-culture) and in vivo (mouse and rat) models of oral carcinogenesis.
- Molecular profiling (immunohistochemistry, immunofluorescence, in situ hybridization) of fixed/frozen specimens of human oral cancer mucosa.
- Functional assays of carcinogenesis (cell proliferation, apoptosis assay, migration and invasion assays, etc).
- Models for microbiome induced carcinogenesis.
- Extracellular vesicle isolation, characterization and functionality.
- Electrophysiology and intracellular Ca2+ signaling.