Most recent publications

• Arqub, Sarah Abu; Venugopal, Adith; Dellinger, Aron; Varghese, Joseph; Cornelis, Marie A. & Fleming, Padhraig S. [Show all 12 contributors for this article] (2026). World Federation of Orthodontists Global Guidance on patient instructions and emergency protocols: A consensus framework for safe, patient-centered orthodontic care. Journal of the World Federation of Orthodontists. ISSN 2212-4438. p. 1–14. doi: 10.1016/j.ejwf.2026.07.002.
• Vårum, Vegard Berg; Vandevska-Radunovic, Vaska & Pullisaar, Helen (2026). Orthodontic emergencies in a postgraduate clinic: a retrospective analysis. Acta Odontologica Scandinavica. ISSN 0001-6357. 85, p. 574–574. doi: 10.2340/aos.v85.46620. Full text in Research Archive Show summary

  Objective: This retrospective study aimed to investigate the frequency, causes, and temporal distribution of orthodontic emergencies at the Department of Orthodontics, University of Oslo. Methods: All appointments coded as emergencies from 2015 to 2022 were reviewed and manually screened. Emergencies were classified into three categories: (1) during active treatment, (2) during retention, and (3) miscellaneous. A negative binomial generalized linear regression model was used to assess annual and monthly variations. Chi-square tests for independence were applied to analyze relationships between age group and year, gender and year, and reason for emergency. The significance level was set at p < 0.05. Results: Out of 7206 records screened, 3592 met the inclusion criteria, involving 1657 patients – 685 males (41.3%) and 972 females (58.7%). The mean number of emergencies per patient was 2.2, with no significant year-to-year variation in gender distribution. The most common age groups were 10–14 years and over 20 years. Annual emergency numbers ranged from 313 in 2015 to 638 in 2022, with statistically significant variation. Monthly variation was also significant, with July consistently having the fewest emergencies (p < 0.001). Most emergencies occurred during active treatment (n = 2021), followed by the retention phase (n = 1353), and miscellaneous reasons (n = 218). The most frequent causes were issues related to full fixed appliances and fixed retainers. Conclusions: No consistent pattern of orthodontic emergencies was observed, indicating that operator experience, the stage of postgraduate training, and seasonal fluctuations are likely the key influencing factors

• Vandevska-Radunovic, Vaska (2026). Periodontal and pulpal tissue reactions after tooth transplantation: A narrative review. Seminars in orthodontics. ISSN 1073-8746. doi: 10.1053/j.sodo.2026.07.003. Full text in Research Archive Show summary

  Tooth autotransplantation is a biologically based and cost-effective surgical procedure in which a tooth is repositioned within the same individual, offering a valuable alternative to prosthetics or implants, particularly in growing patients. Modern protocols, developed through advances in surgical techniques, imaging, and case selection, have significantly improved predictability and success rates. This narrative review aims to synthesize current knowledge on periodontal and pulpal healing following autotransplantation, with emphasis on biological mechanisms and factors influencing clinical outcomes. Periodontal healing depends largely on preservation of periodontal ligament vitality and stem cells, enabling regeneration and functional integration. Revascularization, increased dentin formation and obliteration of the pulp are favourable for survival of the transplant, although complete histological restoration is rare. In general, immature teeth demonstrate superior regenerative capacity compared to mature teeth, but complications such as root resorption and ankylosis remain challenges in both instances. Radiographic evaluation provides limited insight during early healing stages, highlighting discrepancies with histological findings. In conclusion, successful autotransplantation relies on careful case selection, atraumatic technique, and biological preservation, though further human-based research is needed to clarify healing mechanisms and optimize long-term results.

• Pullisaar, Helen & Vandevska-Radunovic, Vaska (2026). Fixed or Removable? An Evidence-based Narrative Review of Orthodontic Retainer Selection and Clinical Considerations. Seminars in orthodontics. ISSN 1073-8746. doi: 10.1053/j.sodo.2026.06.006. Full text in Research Archive
• Martina Žigante; Vandevska-Radunovic, Vaska & Špalj, Stjepan (2026). Protocols and trends in maintaining the stability of orthodontic treatment outcomes in Croatia over 10 years: A repeated cross-sectional study. Acta Stomatologica Croatica. ISSN 0001-7019. 60(2), p. 184–196. doi: 10.15644/asc60/2/3. Full text in Research Archive Show summary

  Objectives: The aim was to analyze current orthodontic retention protocols in Croatia and their trend over a 10-year period. Subjects and Methods: In a repeated cross-sectional survey, questionnaires were distributed to 150 orthodontists in Croatia in 2013 and 185 of them in 2023 (representing 69% and 85% of practicing orthodontists with response rates of 61% and 75%). Results: Significant changes in retainer types across different malocclusions and treatment protocols were observed over a 10-year period. There was an increase in the use of VFR and a decrease in acrylic retention plates in both jaws (p≤0.001). Over the decade, the use of only fixed retention in the mandible declined from 20% to 7% (p=0.007), and the combination of fixed and removable retention in the maxilla dropped from 29% to 17% (p≤0.033). Increased use of removable retainers was noted in cases involving rotations, open bites, and extractions. Conversely, fixed-removable retainers were more frequently used in spacing cases (p≤0.001). There was a trend toward fewer check-ups (p=0.001) and toward increased patient self-monitoring (p=0.021). Personal experience as the primary reason for choosing a retention protocol increased from 39% to 62% (p<0.001). Additionally, the use of written information on retention rose from 39% to 69% (p<0.001). Conclusion: Retention practices in Croatia have evolved over the past decade, characterized by increased use of VFRs, more frequent implementation of dual retention in the mandible, and greater provision of written retention information. Additionally, follow-up protocols have shifted toward fewer scheduled visits, with increased emphasis on patient self-monitoring.

• Yang, Yang; Pullisaar, Helen; Reseland, Janne Elin & Ma, Jingzhi (2025). Molecular insights into irisin’s role in the regulation of programmed cell death: mechanisms and therapeutic potential. Journal of Molecular Medicine. ISSN 0946-2716. 104(1). doi: 10.1007/s00109-025-02623-z. Full text in Research Archive
• Arntsen, Torill Gürtner; Axelsson, Anders Stefan; Sun, Yi-Qian; Nordgarden, Hilde & Vandevska-Radunovic, Vaska (2025). Orthodontic Treatment of Patients With Disabilities in Norway: A Survey Among Orthodontists. Special Care in Dentistry: managing special patients, settings, and situations. ISSN 0275-1879. 45(1). doi: 10.1111/scd.70003. Full text in Research Archive
• Færøvig, Maria Lucete Martinho; Bjørnland, Tore; Magnusson, Anders; Lindsten, Rune; Pandis, Nikolaos & Bjerklin, Krister [Show all 7 contributors for this article] (2025). Closed vs open surgical exposure of palatally displaced canines: Patients’ perceptions of recovery, operating time, and complications—A 2-center randomized controlled trial. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 167(4), p. 382–398. doi: 10.1016/j.ajodo.2024.11.014. Full text in Research Archive
• Færøvig, Maria Lucete Martinho; Pandis, Nikolaos; Johal, Ama & Vandevska-Radunovic, Vaska (2024). Mandibular second molar extraction: A retrospective cohort study of spontaneous occlusal changes in adolescent patients. Orthodontics & craniofacial research. ISSN 1601-6335. doi: 10.1111/ocr.12772. Full text in Research Archive Show summary

  Abstract Objectives Evaluate long‐term spontaneous occlusal changes following L7 extraction in adolescent patients. Materials and Methods Study models of 144 participants (63 males, 81 females) retrospectively assessed prior to L7 extraction (9–16 years old; T1) and following L8 eruption (14–25 years old; T2). All received upper fixed appliances. A sub‐group (n = 86) received no lower fixed appliances and acted as controls. Occlusal changes were compared between treatment (lower fixed appliance) and control (no lower fixed appliance) groups using PAR index. At T2, L8 occlusal outcome was assessed using ABO grading system. Results Mean follow‐up period 6 (SD 2) years. At T1, lower scores observed in control group for Lower Anterior ( P  &lt; .001), Midline ( P  = .033) and Lateral Segments ( P  = .040) components. At T2, lower scores continued being observed in control group for Midline ( P  &lt; .001) and Lateral segment ( P  = .019) components. Higher decrease in Lower Anterior PAR scores observed in treatment group (&lt;.001) with comparable scores between groups at T2 ( P  = .057). Similar PAR score changes between groups for Lateral Segments, Overjet and Overbite components. At T2, no significant difference observed in Total PAR score reduction between control (83%) and treatment (82%) groups. Good‐to‐acceptable occlusal outcome of the L8 observed in 81.55% of cases at T2 with no difference between groups. Conclusion In growing patients with mild mandibular crowding, extraction of L7 followed by upper fixed appliance therapy, leads to favourable occlusal changes over a 6‐year follow‐up period, with or without lower fixed appliance therapy, being an alternative extraction protocol where lower fixed appliance therapy is not recommended.

• Papageorgiou, Spyridon; Giannakopoulou, Theodora; Eliades, Theodore & Vandevska-Radunovic, Vaska (2024). Occlusal outcome of orthodontic treatment: A systematic review with meta-analyses of randomized trials. European Journal of Orthodontics. ISSN 0141-5387. 46(6). doi: 10.1093/ejo/cjae060. Full text in Research Archive Show summary

  Background Several appliances or treatment protocols are marketed to either patients or orthodontists as being associated with improved orthodontic outcomes. However, clinical decision-making should be based on robust scientific evidence and not marketing claims or anecdotal evidence. Objective To identify appliances/protocols being associated with improved outcomes of fixed appliance treatment. Search methods Unrestricted literature searches in seven databases/registers for human studies until March 2024. Selection criteria Randomized or quasi-randomized clinical trials on human patients of any age, sex, or ethnicity receiving comprehensive orthodontic treatment with fixed appliances and assessing occlusal outcome with either the Peer Assessment Rating (PAR) or the American Board of Orthodontics-Objective Grading System (ABO-OGS) index. Data collection and analysis Duplicate/independent study selection, data extraction, and risk of bias assessment with the Cochrane RoB 2 tool. Random-effects meta-analyses of averages or mean differences with their 95% Confidence Intervals (CI), followed by meta-regression/subgroup/sensitivity analyses and assessment of the quality of clinical recommendations with the Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results Data from 20 small- to moderately-sized trials covering 1470 patients indicated that orthodontic treatment with fixed appliances is effective and results on average in a final PAR score of 6.0 points (95% CI 3.9–8.2 points), an absolute PAR reduction of 23.0 points (95% CI 15.6–30.4 points), a % PAR reduction of 82.6% (95% CI 70.8%–94.4%), and an absolute ABO-OGS score of 18.9 points (95% CI 11.7–26.2 points). However, very high between-study heterogeneity (I2 > 75%) was seen for both PAR and ABO-OGS. Extraction treatment was associated with significantly better occlusal outcome than non-extraction treatment with ABO-OGS (12.9 versus 16.6 points; P = .02). There was no statistically significant difference in occlusal outcome with (i) 0.018″-slot or 0.022″-slot brackets; (ii) customized or prefabricated brackets; (iii) anchorage reinforcement with temporary anchorage devices; (iv) use of vibrational adjuncts; and (v) aligners or fixed appliances (P > .05 in all instances), while small benefits were seen with indirectly bonded brackets. Conclusions Considerable between-study heterogeneity exists in the reported occlusal outcome of fixed appliance treatment, and different appliances or adjuncts have little effect on this. Standardization and/or automatization of the scoring procedures for PAR and ABO-OGS might help to improve consistency and reliability of outcome measurement in orthodontic trials.

• Pullisaar, Helen; Cattaneo, Paolo M.; Gera, Arwa; Sankiewicz, Monika; Bilińska, Małgorzata & Vandevska-Radunovic, Vaska [Show all 7 contributors for this article] (2024). Stability, survival, patient satisfaction, and cost-minimization of CAD/CAM versus conventional multistranded fixed retainers in orthodontic patients: a 2-year follow-up of a two-centre randomized controlled trial. European Journal of Orthodontics. ISSN 0141-5387. 46(2). doi: 10.1093/ejo/cjae006. Full text in Research Archive Show summary

  Background CAD/CAM (computer-aided design/computer-aided manufacturing) fixed retainers (FRs) as an alternative to multistranded FRs to maintain orthodontic treatment outcome. Objectives The primary aim was to compare CAD/CAM versus conventional multistranded FRs in terms of stability until 2 years. Secondary outcomes were failure rates, patient satisfaction, and cost-minimization. Trial design 2-arm parallel, two-centre randomized controlled trial. Methods Patients were randomized to CAD/CAM or conventional FRs in both arches, in a 1:1 ratio and blocks of four. Allocation concealment was secured by using sequentially numbered envelopes. Patients were blinded. FRs were bonded at the end of treatment, and patients were recalled after 12 and 24 months. First-time retainer failures were recorded and digital impressions were taken. Arch widths and lengths, as well as Little’s Irregularity Index (LII), were measured. Additionally, patients answered satisfaction questionnaires. Linear mixed models were applied for measurements and patient satisfaction. Survival analyses were estimated with Kaplan–Meier curves, along with Cox-regression modelling. Cost-minimization analysis was undertaken. Results One hundred and eighty-one patients were randomized (98 in Centre 1, and 83 in Centre 2): 90 in CAD/CAM and 91 in conventional group. One hundred and fifty three patients attended T24 follow-up. There were no significant differences in LII and arch dimensions between groups for failure-free patients. Within 24 months, 34% maxillary CAD/CAM FRs and 38% maxillary conventional FRs failed, along with 42% mandibular CAD/CAM FRs and 40% mandibular conventional FRs, with no significant difference in survival between groups (hazard ratios conventional to CAD/CAM: maxillary arch: 1.20 [P = 0.46], mandibular arch: 0.98 [P = 0.94]). There were no significant differences in patient satisfaction between groups. No harms were observed. Cost-minimization analysis showed that CAD/CAM FRs were slightly cheaper than conventional FRs. Conclusions There were no clinically significant differences in LII, arch widths, and lengths between CAD/CAM and conventional FRs after 24 months. There were no differences in failures and patient satisfaction between groups. CAD/CAM FRs were slightly cheaper than conventional FRs.

• Namura, Yasuhiro; Pullisaar, Helen; Holm, Heidi Vanessa; Syverud, Morten; Mulic, Aida Gacic & Vandevska-Radunovic, Vaska (2023). Elemental composition, corrosion resistance and mechanical properties of computer-aided design and computer-aided manufacturing fixed retainers versus conventional fixed retainers. Journal of Oral Science. ISSN 1343-4934. 66(2), p. 107–110. doi: 10.2334/josnusd.23-0303. Full text in Research Archive
• Yang, Yang; Geng, Tianxiang; Samara, Athina; Olstad, Ole Kristoffer; He, Jianying & Agger, Anne Eriksson [Show all 11 contributors for this article] (2023). Recombinant irisin enhances the extracellular matrix formation, remodeling potential, and differentiation of human periodontal ligament cells cultured in 3D. Journal of Periodontal Research. ISSN 0022-3484. 58(2), p. 336–349. doi: 10.1111/jre.13094. Full text in Research Archive Show summary

  Abstract Background Irisin is expressed in human periodontal ligament (hPDL), and its administration enhances growth, migration and matrix deposition in hPDL cells cultured in monolayers in vitro. Objectives To identify whether irisin affects the gene expression patterns directing the morphology, mechanical properties, extracellular matrix (ECM) formation, osteogenic activity and angiogenic potential in hPDL cell spheroids cultured in 3D. Materials and Methods Spheroids of primary human hPDL cells were generated in a rotational 3D culture system and treated with or without irisin. The gene expression patterns were evaluated by Affymetrix microarrays. The morphology of the spheroids was characterized using histological staining. Mechanical properties were quantified by nanoindentation. The osteogenic and angiogenic potential of spheroids were assessed through immunofluorescence staining for collagen type I, periostin fibronectin and von Willebrand factor (vWF), and mRNA expression of osteogenic markers. The secretion of multiple myokines was evaluated using Luminex immunoassays. Results Approximately 1000 genes were differentially expressed between control and irisin-treated groups by Affymetrix. Several genes related to ECM organization were differentially expressed, and multiple deubiquitinating enzymes were upregulated in the irisin-exposed samples analyzed. These represent cellular and molecular mechanisms indicative of a role for irisin in tissue remodeling. Irisin induced a rim-like structure on the outer region of the hPDL spheroids, ECM-related protein expression and the stiffness of the spheroids were enhanced by irisin. The expression of osteogenic and angiogenetic markers was increased by irisin. Conclusions Irisin altered the morphology in primary hPDL cell-derived spheroids, enhanced its ECM deposition, mechanical properties, differentiation and remodeling potential.

• Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Nogueira, Liebert Parreiras; Syversen, Unni & Reseland, Janne Elin (2023). Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament. European Journal of Orthodontics. ISSN 0141-5387. 45(6), p. 842–853. doi: 10.1093/ejo/cjad021. Full text in Research Archive Show summary

  Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in vivo. Materials and methods The maxillary right first molars of male Wistar rats (n = 21) were moved mesially for 14 days, with submucosal injection of two dosages of irisin (0.1 or 1 μg) or phosphate-buffered saline (control) every third day. OTM was recorded by feeler gauge and micro-computed tomography (μCT). Alveolar bone and root volume were analysed using μCT, and plasma irisin levels by ELISA. Histological characteristics of PDL tissues were examined, and the expression of collagen type I, periostin, osteocalcin (OCN), von Willebrand factor (vWF) and fibronectin type III domain-containing protein 5 (FNDC5) in PDL was evaluated by immunofluorescence staining. Results Repeated 1 μg irisin injections suppressed OTM on days 6, 9, and 12. No significant differences were observed in OTM in the 0.1 μg irisin group, or in bone morphometric parameters, root volume or plasma irisin, compared to control. Resorption lacunae and hyalinization were found at the PDL-bone interface on the compression side in the control, whereas they were scarce after irisin administration. The expression of collagen type I, periostin, OCN, vWF, and FNDC5 in PDL was enhanced by irisin administration. Limitations The feeler gauge method may overestimate OTM. Conclusions Submucosal irisin injection reduced OTM by enhancing osteogenic potential of PDL, and this effect was more significant on the compression side.

• Gera, Arwa; Pullisaar, Helen; Cattaneo, Paolo M.; Gera, Shadi; Vandevska-Radunovic, Vaska & Cornelis, Marie (2022). Stability, survival, and patient satisfaction with CAD/CAM versus conventional multistranded fixed retainers in orthodontic patients: a 6-month follow-up of a two-centre randomized controlled clinical trial. European Journal of Orthodontics. ISSN 0141-5387. 45(1), p. 58–67. doi: 10.1093/ejo/cjac042. Full text in Research Archive Show summary

  Abstract Objectives The primary aim of this two-arm parallel two-centre randomized controlled trial was to compare computer-aided design and computer-aided manufacturing (CAD/CAM) versus conventional multistranded fixed retainers (FRs) in terms of stability over 6 months. Secondary outcomes were failure rates and patient satisfaction. Methods Patients were randomized to CAD/CAM or conventional FRs in both arches, in 1:1 ratio and blocks of four. Allocation concealment was secured by using sequentially numbered envelopes. Patients were blinded. Retainers were bonded at the end of orthodontic treatment (T0), and patients were recalled after 1 (T1), 3 (T3), and 6 (T6) months. First-time retainer failures were recorded and digital impressions were taken. Arch widths and lengths, as well as Little’s Irregularity Index (LII), were measured. Additionally, patients answered satisfaction questionnaires. Linear mixed models were applied for measurements and patient satisfaction. Survival analyses were estimated with Kaplan-Meier curves, along with Cox-regression modelling. Results One hundred and eighty-one patients were randomized (98 in Centre 1, and 83 in Centre 2): Ninety in the CAD/CAM group and 91 in the conventional group. Three subjects dropped out at baseline, as they did not attend any of the follow-up appointments.168 patients attended the T6 visit. There were no significant differences in arch dimensions between T0 and T6, whilst the LII was different only in the CAD/CAM group (mean difference: 0.2 mm; 95% confidence interval: 0.1 to 0.4; P &amp;lt; 0.001). Within 6 months, 39 upper retainers (19 out of 88 CAD/CAM and 20 out of 90 conventional retainers) and 52 lower retainers failed (26 out of 88 CAD/CAM and 26 out of 90 conventional retainers), with no significant difference between the survival of both types of retainers (hazard ratios conventional to CAD/CAM: upper arch: 0.99 [P =0.99], lower arch: 0.93 [P = 0.80]). There were no significant changes in patient satisfaction between the groups. No harms were observed. Conclusions There were no clinically significant differences in LII, arch widths and lengths between CAD/CAM and conventional retainers after 6 months. There was no difference in failures and in patient satisfaction between both types of FRs. Registration ClinicalTrials.gov NCT04389879.

• Hamran, Tord; Cergic, Emina; Aiyar, Akila & Vandevska-Radunovic, Vaska (2022). Survey on retention procedures and use of thermoplastic retainers among orthodontists in Norway, Sweden, and Denmark. Journal of the World Federation of Orthodontists. ISSN 2212-4438. 11(4), p. 114–119. doi: 10.1016/j.ejwf.2022.05.002. Full text in Research Archive Show summary

  Background Orthodontic retention is the most important factor after successful orthodontic treatment. The use of thermoplastic retainers has increased in recent years, but information is lacking about the product materials and orthodontists’ awareness of the products they use. The aim of this survey was to map the retention protocols among Scandinavian orthodontists, particularly their use of thermoplastic retainers. Furthermore, the aim was to investigate their knowledge of thermoplastic materials and record any possible adverse effects. Methods An online questionnaire was prepared, and 667 orthodontists in Norway, Sweden, and Denmark were invited to take the survey. The survey was sent to all members of the national orthodontic associations using Nettskjema in Norway and Microsoft Forms in Sweden and Denmark. Data were collected anonymously and analyzed using chi-square and correlation coefficients. Results Of the 667 orthodontists, 432 (64%) responded (59% female). The most common retention protocol (51%) was fixed retainer in both maxilla and mandible and thermoplastic retainer in the maxilla. Two-thirds of the orthodontists were unaware of the thermoplastic material used, and 58% did not acquire knowledge of the materials. Only 1% of the respondents had registered adverse reactions to thermoplastic retainers, and none were aware of the type of material that was used. Conclusions Scandinavian orthodontists use similar retention protocols, with the most common being fixed retainer in the mandible and dual retention, fixed, and thermoplastic retainer in the maxilla. Orthodontists’ knowledge about thermoplastic materials was insufficient, but adverse effects related to thermoplastic retainer use were rare.

• Mohamed, Ahmed; Wafaie, Khaled; Mohammed, Hisham; Mohamed, Abdelrahman Ma; Xinrui, Wang & Vandevska-Radunovic, Vaska [Show all 7 contributors for this article] (2022). Effect of chlorhexidine mouthwash on gingival health around orthodontic miniscrew implants: A pilot placebo-controlled randomized trial. Orthodontics & craniofacial research. ISSN 1601-6335. doi: 10.1111/ocr.12596. Full text in Research Archive Show summary

  Objective This randomized controlled trial (RCT) aims to investigate the short-term effects of chlorhexidine mouthwash (MW) on gingival health surrounding orthodontic miniscrew implants (OMIs) and their overall survivability. Materials and Methods Thirty-two participants (mean age, 22.8 years) undergoing fixed orthodontic appliance treatment after maxillary premolar extraction were randomly allocated in a parallel fashion to either receive (1) MW with an active component of chlorhexidine or (2) a placebo. Each participant received two maxillary buccal OMIs for anchorage reinforcement purposes. Participants were assessed for their gingival oral health status around all inserted OMIs and had their OMI survivability recorded at three time points; T1 = 1 month, T2 = 3 months, and T3 = 6 months after OMI placement. A Kaplan-Meier plot was used to estimate the survival function of OMIs. Results All randomized participants completed the follow-up period. In terms of gingival oral health, there were no statistically significant differences at any time point between the chlorhexidine MW group and the placebo-controlled group (P > .05). One OMI was lost in the chlorhexidine MW group and another two OMIs in the control group. There was no significant difference between both groups in terms of survivability (P = .585). Conclusion The use of chlorhexidine MW does not seem to have a significant clinical impact on gingival health around OMIs or their survivability in this pilot study.

• Salvesen, Barbro Fostad; Grytten, Jostein Ivar; Rongen, Gunnar & Vandevska-Radunovic, Vaska (2022). Patient‐reported outcome measures on oral hygiene, periodontal health, and treatment satisfaction of orthodontic retention patients up to ten years after treatment—A cross‐sectional study. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 19(8), p. 1–10. doi: 10.3390/ijerph19084843. Full text in Research Archive Show summary

  Background: This cross-sectional study evaluated patient-reported outcome measures (PROMs) on (1) oral hygiene, (2) periodontal health, (3) retainer failure, (4) orthodontic treatment satisfaction, and (5) outcome satisfaction in orthodontic retention patients. The purpose of the study was to evaluate whether orthodontic retention treatment is associated with patient-reported outcome measures on oral hygiene, periodontal health, and treatment satisfaction. Methods: A ten-item questionnaire on the five PROMs was conducted among 211 consecutive retention patients up to ten years following orthodontic treatment. Linear regression models were computed to detect possible associations between the PROMs and retention treatment or patient characteristics. Results: The presence of a fixed lingual retainer was not associated with the reduced ability to perform oral hygiene, self-perceived periodontal health, or orthodontic outcome satisfaction. Older patients were more content with the orthodontic treatment result (p &lt; 0.05). Patients with fixed lingual retainers in the mandible were less satisfied with the course of orthodontic treatment (p &lt; 0.05). Smokers more often reported gingival bleeding (p &lt; 0.05). Females reported increased gingival recessions (p &lt; 0.05) and perceived their teeth as longer than before treatment (p &lt; 0.05). Longer orthodontic treatment duration corresponded to retainer failure (p &lt; 0.05). Conclusions: In general, long-term orthodontic retention patients were satisfied with orthodontic treatment. These patients reported the satisfactory ability to perform adequate oral hygiene and periodontal health, and they communicated a high degree of treatment and outcome contentment. However, patients with a retainer in the mandible were less satisfied with orthodontic treatment.

• Zigante, Martina; Pavlic, Andrej; Morelato, Luka; Vandevska-Radunovic, Vaska & Špalj, Stjepan (2021). Presence and maturation dynamics of mandibular third molars and their influence on late mandibular incisor crowding: A longitudinal study. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. 18(19). doi: 10.3390/ijerph181910070. Full text in Research Archive Show summary

  The objective of this study was to investigate the relationship between the absence, presence and dynamics of mandibular third molar development and the occurrence and amount of late mandibular incisor crowding. Dental plaster casts and panoramic radiographs of 72 orthodontically untreated subjects from the Nittedal growth study, Norway were analyzed. The subjects were recalled for a checkup at 12, 15, 18 and 21 years of age. Mandibular incisor crowding was assessed using Little’s irregularity index and dental maturation of the third molars by the Cameriere’s index. The majority of the subjects (64%) had ≥1 mm increase in irregularity; 22% experienced an increase of 0.1–0.9 mm and 14% had unchanged or decreased irregularity. Incisor irregularity increased with age, regardless of absence or presence of third molars. The amount of change in incisor irregularity from 12 to 21 years did not differ significantly between subjects with hypodontia of third molars, extraction and those with third molars present. No differences were observed between erupted, unerupted or impacted third molars. No correlation was found between the amount of change in irregularity and maturation of the third molars. In conclusion, occurrence and amount of mandibular late incisor crowding is not significantly influenced by the presence of mandibular third molars or their development dynamics.

• Miloš, Danira; Pavlic, Andrej; Vandevska-Radunovic, Vaska; Zigante, Martina; Matthewson, Alana & Špalj, Stjepan (2021). Craniofacial Growth in Adolescence and its Influence on the Mandibular Incisor Crowding. Acta Stomatologica Croatica. ISSN 0001-7019. 55(1), p. 38–45. doi: 10.15644/asc55/1/5. Full text in Research Archive
• Yang, Yang; Pullisaar, Helen; Landin, Maria Augusta Dos S Silva; Heyward, Catherine Anne; Schröder, Maria & Geng, Tianxiang [Show all 8 contributors for this article] (2021). FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2021.105061. Full text in Research Archive Show summary

  Objective To examine the expression and regulation of fibronectin type III domain-containing protein 5/irisin (FNDC5/irisin) in primary human periodontal ligament (hPDL) cells, dental pulp stem cells (hDPCs) and osteoblasts (hOBs). Methods FNDC5/irisin was identified in sections of paraffin embedded rat maxillae, cryo-sections of 3D cultured spheroids hPDL cells, hDPCs and hOBs, 2D cultured hPDL cells, hDPCs and hOBs by immunohistochemistry. The expression of FNDC5/irisin was identified by qPCR, followed by sequencing of the qPCR product. Regulation of FNDC5/irisin expression in hPDL cells, hDPCs and hOBs were evaluated after administration of different concentrations of irisin and all-trans retinoic acid (ATRA). qPCR and ELISA were used to identify expression and secretion of FNDC5/irisin in odontoblast-like differentiation of hDPCs. Results FNDC5/irisin was confirmed to be present in rat periodontium and dental pulp regions, as well as in 2D and 3D cultured hPDL cells, hDPCs and hOBs. BLAST analyses verified the generated nucleotide alignments matched human FNDC5/irisin. FNDC5/irisin gene expression was enhanced during odontoblast-like differentiation of hDPCs whereas the secretion of the protein was decreased compared to control. The protein signals in rat periodontal and pulpal tissues were higher than that of alveolar bone, and the expression of FNDC5/irisin was differently regulated by recombinant irisin and ATRA in hPDL cells and hDPCs compared to hOBs. Conclusions FNDC5/irisin expression was verified in rodent periodontium and dental pulp, and in hPDL cells, hDPCs and hOBs. The FNDC5/irisin expression was regulated by recombinant irisin and ATRA. Finally, expression and secretion of FNDC5/irisin were affected during odontoblast-like differentiation of hDPCs.

• Papageorgiou, Spyridon; Tilen, Raphael; Vandevska-Radunovic, Vaska & Eliades, Theodore (2021). Occlusal outcome after orthodontic treatment with preadjusted straight-wire and standard edgewise appliances A retrospective cohort study. Journal of Orofacial Orthopedics. ISSN 1434-5293. doi: 10.1007/s00056-020-00273-z. Full text in Research Archive Show summary

  Abstract Purpose Orthodontic fixed appliances have been proven to be effective in treating a wide variety of malocclusions, and different types of appliances have emerged during recent decades. However, the comparative effects of different appliances have not been adequately assessed. Thus, the aim was to assess the occlusal outcome of orthodontic treatment with preadjusted straight-wire (SWIRE) and standard edgewise (SEDGE) appliances. Methods In all, 56 patients (mean age: 13.5 years; 45% male) receiving extraction-based treatment with either SWIRE or SEDGE appliances were included. Between-group differences in the occlusal outcome assessed with the American Board of Orthodontists Objective Grading System (ABO-OGS) and treatment duration were analyzed statistically at the 5% level. Results The average ABO-OGS score was 31.3 ± 7.2 points and 34.0 ± 10.4 points in the SWIRE and SEDGE groups with no statistically significant difference between groups ( P  = 0.26). Treatment duration was significantly shorter in the SWIRE group compared to the SEDGE group, with an average difference of −6.8 months (95% confidence interval [95% CI] = −9.6 to −4.0 months; P  &lt; 0.001). Likewise, fewer visits were needed with SWIRE compared to SEDGE appliances with an average difference of −7.2 visits (95% CI = −10.3 to −4.2 visits; P  &lt; 0.001). Adjusting for the influence of any potential confounders did not considerably impact the results. Conclusion Similar treatment outcomes were observed after premolar extraction treatment with SWIRE and SEDGE appliances. On the other hand, SEDGE appliances were associated with prolonged treatment duration and more visits needed to complete treatment compared to SWIRE appliances.

• Papageorgiou, Spyridon; Cassina, Chiara; Vandevska-Radunovic, Vaska & Eliades, Theodore (2021). Incisor and profile alterations in extraction cases treated with standard Edgewise and pre-adjusted appliances: A controlled before-and-after study. Journal of the World Federation of Orthodontists. ISSN 2212-4438. 14. doi: 10.1016/j.ejwf.2021.04.001. Full text in Research Archive Show summary

  Background Even though treatment of Class II malocclusion with premolar extractions and incisor retraction might affect incisor inclination and soft tissue profile, the effects of bracket prescription on this have not been thoroughly assessed. Methods Fifty patients (mean age: 13.6 years; 34% male) receiving extraction-based treatment with either standard Edgewise or pre-adjusted appliances were included. Between-group differences in the incisor inclination assessed with lateral cephalograms were analyzed statistically with linear/logistic regression at 5%. Results Treatment-induced changes included retroclination of the upper/lower incisors (−3.0° and −2.0°, respectively), retraction of the upper/lower incisors (−3.4 mm and −1.5 mm, respectively), retraction of the upper/lower lip (−2.1 mm and −2.0 mm, respectively), and enlargement of the nasolabial angle (+1.6°). Analysis of the data adjusting for confounders indicated that the pre-adjusted group, after treatment, had larger inclination of the upper or lower incisors (+3.2° and +4.5°, respectively), more prominent upper incisors relative to the facial plane (+1.3 mm), and smaller interincisal angle (−7.3 or −7.7°). Post-treatment upper incisor inclination fell within the cephalometric norm significantly more in the pre-adjusted than in the standard Edgewise group (odds ratio 4.3; 95% confidence interval 1.1–16.6). No differences were found in lower incisor prominence, upper/lower lip prominence, or nasolabial angle. Conclusions Pre-adjusted appliances were associated with increased inclination of the upper and lower incisors, with more prominent upper incisors, and with more acute interincisal angle after retraction compared with standard Edgewise appliances. However, such differences did not translate in greater retraction of the upper/lower lips and greater nasolabial angle.

• Kazmierczak, Stanislaw; Juszka, Zofia; Vandevska-Radunovic, Vaska; Maal, Thomas J.J.; Fudalej, Piotr & Mandziuk, Jacek (2021). Prediction of the Facial Growth Direction is Challenging. In Mantoro, Teddy; Lee, Minho; Ayu, Media Anugerah; Wong, Kok Wai & Hidayanto, Achmad Nizar (Ed.), Neural Information Processing. Springer. ISSN 9783030923099. p. 665–673. doi: 10.1007/978-3-030-92310-5_77. Full text in Research Archive
• Salvesen, Barbro Fostad; Grytten, Jostein; Rongen, Gunnar; Koldsland, Odd Carsten & Vandevska-Radunovic, Vaska (2021). Periodontal status in long-term orthodontic retention patients up to 10 years after treatment – a cross-sectional study. Acta Odontologica Scandinavica. ISSN 0001-6357. 79(8), p. 623–629. doi: 10.1080/00016357.2021.1921842. Full text in Research Archive Show summary

  Objective To assess periodontal status in long-term orthodontic retention patients and investigate possible risk indicators. Materials and Methods Plaque index (PI), gingival index (GI), probing pocket depth (PPD), gingival recessions (GR) and calculus were recorded in 211 patients with or without fixed retainers. Results Periodontal parameters were within the limits of clinically healthy periodontium. The use of fixed retainers was associated with higher PI in the maxilla (ß = 1.10 [0.37]; p <.05). Older age was associated with higher PI in the mandible (ß = 0.27 [0.11]; p <.05). Smoking was associated with gingival bleeding on both palatal (ß = 0.63 [0.16]; p < .01) and labial sides in the maxilla (ß = 0.46 [0.20]; p <.05). Smoking was also associated with increased prevalence of GR in the mandible (ß = 0.24 [0.07]; p <.01), while use of snuff had similar effect on the labial side in the maxilla (ß = 0.35 [0.08]; p <.01). Higher age (ß = 0.05 [0.02]; p <.05) and the presence of a retainer (ß = 0.23 [0.07]; p < .05) were associated with calculus accumulation on the lingual side in the mandible. Conclusion The present observational study suggest that long-term fixed retainers alone have no detrimental effect on the periodontium. Additional factors may increase the risk of plaque deposits and increased probing pocket depths. Further prosepective studies are needed to confirm the present outcome.

• Torgersbråten, Nina Ellen; Stenvik, Arild & Espeland, Lisen Vivienne (2020). Patient satisfaction after orthognathic surgery: a 3 year follow-up of 60 high-angle Class II individuals. European Journal of Orthodontics. ISSN 0141-5387. doi: 10.1093/ejo/cjaa038. Full text in Research Archive Show summary

  Summary Background and objectives High-angle Class II malocclusion is considered challenging to treat to a stable result and, although studies report treatment outcome in terms of morphology, patient satisfaction has not been addressed. The objectives of the present study were to examine patients’ motives for treatment and satisfaction with the results. Material and methods A structured questionnaire was distributed 3 years post-operatively to 93 consecutively treated patients with an initial diagnosis of mandibular-plane angle (ML/NSL) ≥34.0 degrees and ANB angle ≥4.0 degrees. Three surgical subsamples were defined: one-piece Le Fort I, bilateral sagittal split osteotomy, or a combination of the two (Bimax). Lateral cephalometric radiographs were used to assess morphological characteristics and post-treatment changes. Results Questionnaire participation was 69.8 per cent. The most frequently reported motives for seeking treatment were to improve oral function (85.0 per cent) and dental appearance (71.7 per cent). Thirty per cent were very satisfied, 53.3 per cent were satisfied, and 16.7 per cent were dissatisfied with the overall treatment result. Dissatisfaction was associated with a persisting post-treatment anterior open bite (AOB), horizontal relapse at B point, and with sensory impairment. Conclusions and implications A higher rate of dissatisfaction was found than what has usually been reported for othognathic surgical patients, and this was associated with a persisting AOB. In addition, mandibular relapse and impaired sensory function were related to dissatisfaction and are associated with mandibular surgery. Prospective high-angle Class II patients should be comprehensively informed about the unpredictability of treatment outcomes in terms of occlusion and facial appearance.

• Rizk, Mumen Z.; Torgersbråten, Nina Ellen; Mohammed, Hisham; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska (2020). Stability of single-jaw vs two-jaw surgery following the correction of skeletal class III malocclusion: A systematic review and meta-analysis. Orthodontics & craniofacial research. ISSN 1601-6335. p. 1–14. doi: 10.1111/ocr.12456. Full text in Research Archive
• Rizk, Mumen Z.; Torgersbråten, Nina Ellen; Mohammed, Hisham; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska (2020). Stability of single-jaw vs two-jaw surgery following the correction of skeletal class III malocclusion: A systematic review and meta-analysis. Orthodontics & craniofacial research. ISSN 1601-6335. doi: 10.1111/ocr.12456. Full text in Research Archive
• Hamran, Tord & Vandevska-Radunovic, Vaska (2020). Bruk av skinner innen tannregulering. Aktuell Nordisk odontologi. ISSN 1902-3545. 45, p. 153–165. doi: 10.18261/ISSN.2058-7538-2020-01-13. Full text in Research Archive
• Wiechmann, Dirk; Bantleon, Hans-Peter; Melsen, Birte; Zachrisson, Bjørn Uddo; Hägg, Urban & Canal, Pierre [Show all 17 contributors for this article] (2020). Incorrect measurements and misleading conclusions in the article "comparison of the efficacy of tooth alignment among lingual and labial brackets: An in vitro study". Head & Face Medicine. 16(1). doi: 10.1186/s13005-020-00221-7. Full text in Research Archive Show summary

  Background/objective To reproduce the methods and results of the study by Alobeid et al. (2018) in which the efficacy of tooth alignment using conventional labial and lingual orthodontic bracket systems was assessed. Materials/methods We used the identical experimental protocol and tested (i) regular twin bracket (GAC-Twin [Dentsply]) and lingual twin bracket systems (Incognito [3M]), (ii) together with NiTi 0.014” wires (RMO), and (iii) a simulated malocclusion with a displaced maxillary central incisor in the x-axis (2 mm gingivally) and in the z-axis (2 mm labially). Results The method described by Alobeid et al. (2018) is not reproducible, and cannot be used to assess the efficacy of tooth alignment in labial or lingual orthodontic treatment. Major flaws concern the anteroposterior return of the Thermaloy-NiTi wire ligated with stainless steel ligatures. The reproduced experimental setting showed that a deflected Thermaloy-NiTi wire DOES NOT move back at all to its initial stage (= 0 per cent correction) because of friction and binding (see supplemented video), neither with the tested labial nor with the lingual brackets. Furthermore, an overcorrection of up to 138 per cent, which the authors indicate for some labial bracket-wire combinations and which deserves the characterization “irreal”, stresses the inappropriateness of the method of measurement.Further flaws include: a) incorrect interpretation of the measurement results, where a tooth tripping around (overcorrection) is interpreted as a better outcome than a perfect 100 per cent correction; b) using a statistical test in an inappropriate and misleading way; c) uncritical copying of text passages from older publications to describe the method, which do not correspond to this experimental protocol and lead to calculation errors; d) wrong citations; e)differences in table and bar graph values of the same variable; f) using a lingual mushroom shaped 0.013” Thermaloy-NiTi wire which does not exist; g) drawing uncritical conclusions of so called "clinical relevance" from a very limited in vitro testing. Conclusions Clinical recommendations based on in vitro measurements using the Orthodontic Measurement and Simulation System (OMSS) should be read with caution.

• Torgersbråten, Nina Ellen; Stenvik, Arild & Espeland, Lisen Vivienne (2020). Bimaxillary surgery to correct high-angle class II malocclusion: Does a simultaneous genioplasty affect long-term stability? European Journal of Orthodontics. ISSN 0141-5387. 42(4), p. 426–433. doi: 10.1093/ejo/cjz055. Full text in Research Archive
• Torgersbråten, Nina Ellen; Stenvik, Arild & Espeland, Lisen Vivienne (2020). A comparison of Class II open bite correction by maxillary or mandibular surgery. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 157(5), p. 631–640. doi: 10.1016/j.ajodo.2019.05.018. Full text in Research Archive
• Hvaring, Christina & Birkeland, Kari (2020). The long-term fate of persisting deciduous molars and canines in 42 patients with severe hypodontia: A 12-year follow-up. European Journal of Orthodontics. ISSN 0141-5387. 42(6), p. 581–586. doi: 10.1093/ejo/cjz090. Full text in Research Archive
• Henriksson, Ingrid Christina Heuck; Andersson, Els-Marie & Møystad, Anne (2019). Hypodontia and retention of third molars in Norwegian medieval skeletons: dental radiography in osteoarchaeology. Acta Odontologica Scandinavica. ISSN 0001-6357. p. 1–5. doi: 10.1080/00016357.2018.1549749. Full text in Research Archive
• Pullisaar, Helen; Colaianni, Graziana; Lian, Aina-Mari; Vandevska-Radunovic, Vaska; Grano, Maria & Reseland, Janne Elin (2019). Irisin promotes growth, migration and matrix formation in human periodontal ligament cells. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2019.104635. Full text in Research Archive Show summary

  Objective The objective of the study was to examine the effect of irisin on human periodontal ligament cells (hPDLCs) growth, migration and osteogenic behaviour in vitro. Materials and methods Primary hPDLCs and human osteoblasts (hOBs), used as positive controls, were cultured with irisin (10 and 100 ng/ml), and effect on cell proliferation was evaluated with 5-bromo-2`-deoxyuridine incorporation at 1, 2, and 3 days, and on migration capacity was investigated by scratch assay at 2, 6, and 24 h. Osteogenic behaviour was assessed with alkaline phosphatase activity, immunoassay at 3, 7, 14, and 21 days, and confocal laser scanning microscopy at 21 days. Mineralization was examined by Alizarin red staining at 21 days. Data were compared group wise using ANOVA tests. Results Irisin induced increased proliferation of primary hPDLCs and hOBs at all time points compared to untreated controls. This was confirmed by scratch assay where irisin enhanced migration of both hPDLCs and hOBs after 6 and 24 h compared to controls. Irisin treatment promoted osteogenic behaviour of both cell types by enhancement of extracellular matrix formation. In hPDLCs irisin increased expression of type I collagen, secretion of osteoblastogenesis related proteins osteocalcin and leptin, and calcium deposition/mineralization compared to controls at 21 days. In addition, to enhance calcium deposition/mineralization in hOBs, irisin increased expression of periostin, and secretion of osteoblastogenesis related proteins osteopontin, alkaline phosphatase and osteocalcin, as compared to controls at 21 days. Conclusions Primary hPDLCs responded to irisin treatment with enhanced cell growth, migration, and matrix formation in vitro.

• Gamage, Thilini Hansamali Gamage Yaddehi; Lengle, Emma; Gunnes, Gjermund; Pullisaar, Helen; Holmgren, Asbjørn & Reseland, Janne Elin [Show all 16 contributors for this article] (2019). STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone. Cell Calcium. ISSN 0143-4160. 85. doi: 10.1016/j.ceca.2019.102110. Full text in Research Archive
• Mandal, Emeline; Filip, Charles; Andersson, Els-Marie & Øgaard, Bjørn Andreas (2019). Eighteen-Year Follow-Up of 160 Consecutive Individuals Born With Unilateral Cleft Lip or Cleft Lip and Alveolus Treated by the Oslo Cleft Lip and Palate Team. The Cleft Palate-Craniofacial Journal. ISSN 1055-6656. 56(7), p. 853–859. doi: 10.1177/1055665618820753. Full text in Research Archive
• Bjering, Ragnar & Vandevska-Radunovic, Vaska (2018). Occlusal changes during a 10-year posttreatment period and the effect of fixed retention on anterior tooth alignment. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 154(4), p. 487–494. doi: 10.1016/j.ajodo.2017.12.015. Full text in Research Archive
• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2018). Local facial atrophy and permanent anesthesia of right upper lip following subcutaneous extrusion of chlorhexidine digluconate. Oral and Maxillofacial Surgery Cases. 5(1). doi: 10.1016/j.omsc.2018.10.009. Full text in Research Archive Show summary

  Endodontic therapy is a well-established treatment modality with a high success rate [1]. The aim of endodontic therapy is to prevent or treat periapical inflammatory lesions [2] by removal of connective tissue and microorganisms found in infected root canal [3]. In addition, it seeks an effective seal in order to prevent recolonization of the root canal system with bacteria [4]. Irrigation plays a major role in successful endodontic therapy, and it is used to remove debris from the root canal, eliminate microorganisms, and serve as a lubricant during instrumentation. Therefore, an “ideal” irrigation solution should be efficient as an antimicrobial agent but not toxic to the surrounding tissues [5]. Sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA) and in the recent years chlorhexidine (CHX) gluconate are commonly used root canal irrigants [6]. Negative adverse effects and complications following accidental extrusion of irrigation solutions are well known in the literature for NaOCl [7,8], hydrogen peroxide [9,10] and sulfuric acid [11]. CHX has been advocated to be antimicrobial effective without having the inflammatory disadvantages of NaOCl [12,13]. To our knowledge, there have been no reports of severe tissue damage caused by 2% CHX digluconate during the course of endodontic therapy. Unique to this case report is also the unusual form of harm persistence in the aftermath of injury.

• Peanchitlertkajorn, Supakit; Mercado, Ana; Daskalogiannakis, John; Hathaway, Ronald; Russell, Kathleen & Semb, Gunvor [Show all 10 contributors for this article] (2018). An Intercenter Comparison of Nasolabial Appearance Including a Center Using Nasoalveolar Molding. The Cleft Palate-Craniofacial Journal. ISSN 1055-6656. 55(5), p. 655–663. doi: 10.1177/1055665618754947. Full text in Research Archive
• Haugland, Linn; Kristensen, Kasper Dahl; Lie, Stein Atle & Vandevska-Radunovic, Vaska (2018). The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis. European Journal of Orthodontics. ISSN 0141-5387. 40(3), p. 326–336. doi: 10.1093/ejo/cjy003. Full text in Research Archive
• Peanchitlertkajorn, Supakit; Mercado, Ana; Daskalogiannakis, John; Hathaway, Ronald; Russell, Kathleen & Semb, Gunvor [Show all 10 contributors for this article] (2018). An Intercenter Comparison of Dental Arch Relationships and Craniofacial Form Including a Center Using Nasoalveolar Molding. The Cleft Palate-Craniofacial Journal. ISSN 1055-6656. 55(6), p. 821–829. doi: 10.1597/16-018. Full text in Research Archive
• Bjering, Ragnar; Sandvik, Leiv; Midtbø, Marit & Vandevska-Radunovic, Vaska (2017). Stability of anterior tooth alignment 10 years out of retention [Stabilitat der Ausformung im Frontzahnbereich 10 Jahre nach Beendigung der Retention]. Journal of Orofacial Orthopedics. ISSN 1434-5293. 78(4), p. 275–283. doi: 10.1007/s00056-017-0084-2. Full text in Research Archive
• Papageorgiou, Spyridon; Keilig, Ludger; Vandevska-Radunovic, Vaska; Eliades, Theodore & Bourauel, Christoph (2017). Torque differences due to the material variation of the orthodontic appliance: a finite element study. Progress in Orthodontics. ISSN 1723-7785. 18(1). doi: 10.1186/s40510-017-0161-5. Full text in Research Archive Show summary

  Background: Torque of the maxillary incisors is crucial to occlusal relationship and esthetics and can be influenced by many factors. The aim of this study was to assess the relative influence of the material of the orthodontic appliance (adhesive, bracket, ligature, and wire) on tooth displacements and developed stresses/strains after torque application. Methods: A three-dimensional upper right central incisor with its periodontal ligament (PDL) and alveolus was modeled. A 0.018-in. slot discovery® (Dentaurum, Ispringen, Germany) bracket with a rectangular 0.018 x 0.025-in. wire was generated. The orthodontic appliance varied in the material of its components: adhesive (composite resin or resin-modified glass ionomer cement), bracket (titanium, steel, or ceramic), wire (beta-titanium or steel), and ligature (elastomeric or steel). A total of 24 models were generated, and a palatal root torque of 5° was applied. Afterwards, crown and apex displacement, strains in the PDL, and stresses in the bracket were calculated and analyzed. Results: The labial crown displacement and the palatal root displacement of the tooth were mainly influenced by the material of the wire (up to 150% variation), followed by the material of the bracket (up to 19% variation). The magnitude of strains developed in the PDL was primarily influenced by the material of the wire (up to 127% variation), followed by the material of the bracket (up to 30% variation) and the ligature (up to 13% variation). Finally, stresses developed at the bracket were mainly influenced by the material of the wire (up to 118% variation) and the bracket (up to 59% variation). Conclusions: The material properties of the orthodontic appliance and all its components should be considered during torque application. However, these in silico results need to be validated in vivo before they can be clinically extrapolated.

• Haugen, Sigrid; Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska [Show all 8 contributors for this article] (2017). Adiponectin prevents orthodontic tooth movement in rats. Archives of Oral Biology. ISSN 0003-9969. 83, p. 304–311. doi: 10.1016/j.archoralbio.2017.08.009. Full text in Research Archive Show summary

  Objective The objective was to examine the effects of repetitive local administration of adiponectin on experimental tooth movement in rats. Materials and methods The maxillary right first molar of male Wistar rats (n = 24) was moved mesially for 14 days, with local adiponectin injections (0.2 or 2 μg) every third day. Micro-computed tomography was performed at days 0, 6 and 14 and molar movement, bone density and bone volume fraction were calculated from the scans. Changes in extracellular matrix collagen and cell numbers in the periodontal ligament were analyzed histologically, and levels of circulating cytokines were measured by Luminex and ELISA. Results Adiponectin injections induced a reduction in tooth movement after 12 and 14 days compared to controls. No tooth movement was observed between days 3 and 14 in the group receiving the highest dosage (2 μg) of adiponectin. Differences in bone density and bone volume fractions between treatment and control groups were not identified. Relative size and morphology of collagen fibrils, and cell number in the periodontal region after adiponectin injections were unchanged compared to controls. Levels of circulating adiponectin or other selected factors in plasma were not influenced by the adiponectin injections. Conclusions Submucosal injections of adiponectin prevented experimental tooth movement in rats. The effect was dosage-dependent and local. Adiponectin injections caused no detectable changes in bone density, periodontal cell number or collagen content.

• Špalj, Stjepan; Tranesen, Kate Mroz; Birkeland, Kari; Katic, Visnja; Pavlić, Andrej & Vandevska-Radunovic, Vaska (2017). Comparison of activator-headgear and twin block treatment approaches in class II division 1 malocclusion. BioMed Research International. ISSN 2314-6133. 2017:4861924, p. 1–9. doi: 10.1155/2017/4861924. Full text in Research Archive Show summary

  The purpose was to compare the treatment effects of functional appliances activator-headgear (AH) and Twin Block (TB) on skeletal, dental, and soft-tissue structures in class II division 1 malocclusion with normal growth changes in untreated subjects. The sample included 50 subjects (56% females) aged 8–13 years with class II division 1 malocclusion treated with either AH () or TB () appliances. Pre- and posttreatment lateral cephalograms were evaluated and compared to 50 untreated class II division 1 cases matched by age, gender, ANB angle, and skeletal maturity. A paired sample, independent samples tests and discriminant analysis were performed for intra- and intergroup analysis. Treatment with both appliances resulted in significant reduction of skeletal and soft-tissue facial convexity, the overjet, and the prominence of the upper lip in comparison to untreated individuals (). Retroclination of maxillary incisors and proclination of mandibular incisors were seen, the latter being significantly more evident in the TB group (). Increase of effective mandibular length was more pronounced in the TB group. In conclusion, both AH and TB appliances contributed successfully to the correction of class II division 1 malocclusion when compared to the untreated subjects with predominantly dentoalveolar changes.

• Rosa, Marco; Lucchi, Patrizia; Ferrari, Simona; Zachrisson, Bjørn Uddo & Caprioglio, Alberto (2016). Congenitally missing maxillary lateral incisors: Long-term periodontal and functional evaluation after orthodontic space closure with first premolar intrusion and canine extrusion. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 149(3), p. 339–348. doi: 10.1016/j.ajodo.2015.08.016. Full text in Research Archive
• Breugem, Corstiaan C.; Evans, Kelly N.; Poets, Christian F.; Suri, Sunjay; Picard, Arnaud & Filip, Charles [Show all 24 contributors for this article] (2016). Best practices for the diagnosis and evaluation of infantswith robin sequence a clinical consensus report. JAMA pediatrics. ISSN 2168-6203. 170(9), p. 894–902. doi: 10.1001/jamapediatrics.2016.0796. Full text in Research Archive
• Andersson, Els-Marie; Axelsson, Stefan & Katsaris, Kristoffer Panag (2016). Malocclusion and the need for orthodontic treatment in 8-year-old children with Down syndrome: a cross-sectional population-based study. Special Care in Dentistry: managing special patients, settings, and situations. ISSN 0275-1879. 36(4), p. 194–200. doi: 10.1111/scd.12160. Full text in Research Archive
• Hvaring, Christina; Øgaard, Bjørn Andreas & Birkeland, Kari (2016). Tooth replacements in young adults with severe hypodontia: orthodontic space closure, dental implants and tooth-supported fixed dental prostheses. A follow-up study. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 150(4), p. 620–626. doi: 10.1016/j.ajodo.2016.03.023. Full text in Research Archive
• Bondevik, Olav; Espeland, Lisen Vivienne & Stenvik, Arild (2015). Dental arch changes from 22 to 43 years of age: are they different in individuals with high versus low mandibular plane angle? European Journal of Orthodontics. ISSN 0141-5387. 37(4), p. 367–372. doi: 10.1093/ejo/cju054. Full text in Research Archive
• Bondevik, Olav (2015). A longitudinal study of dental arches and occlusal changes in adults from 22 to 33, and 33 to 43 years of age. Journal of Orofacial Orthopedics. ISSN 1434-5293. 76(1), p. 79–89. doi: 10.1007/s00056-014-0230-z. Full text in Research Archive
• Zachrisson, Bjørn Uddo (2015). Multistranded wire bonded retainers: From start to success. American Journal of Orthodontics and Dentofacial Orthopedics. ISSN 0889-5406. 148(5), p. 724–727. doi: 10.1016/j.ajodo.2015.07.015. Full text in Research Archive
• Bjering, Ragnar; Birkeland, Kari & Vandevska-Radunovic, Vaska (2015). Anterior tooth alignment. A comparison of orthodontic retention regimens 5 years posttreatment. Angle orthodontist. ISSN 0003-3219. 85(3), p. 353–359. doi: 10.2319/051414-349.1. Full text in Research Archive
• Peltomäki, Timo; Kreiborg, Sven; Pedersen, Thomas Klit & Øgaard, Bjørn Andreas (2015). Craniofacial Groth and dento-alveolar development in juvenile idiopathic arthritis patients. Seminars in orthodontics. ISSN 1073-8746. 21(2), p. 84–93. doi: 10.1053/j.sodo.2015.02.004. Full text in Research Archive
• Andersson, Els-Marie; Feragen, Kristin Judith Billaud; Mikalsen, Daniel; Kaul, Juli; Holla, Thomas Mogstad & Filip, Charles (2015). Bilateral hypodontia in adolescents with pierre robin sequence. The Cleft Palate-Craniofacial Journal. ISSN 1055-6656. 52(4), p. 452–457. doi: 10.1597/AAID-JOI-D-11-00190. Full text in Research Archive
• Leone, Angelo; Volponi, Ana Angelova; Uzzo, ML; Spatola, GF; Jurjus, A & Vandevska-Radunovic, Vaska (2015). Dental pulp in mature replanted human teeth: morphological alterations and metalloproteineses-2 and -9, Annexin-5, BCL-2 and iNOS modulation. Journal of Biological Regulators and Homeostatic Agents. ISSN 0393-974X. 29(4), p. 961–967. Full text in Research Archive
• Franzen, Tanya Jeanette; Zahra, Sherif; Kadi, A El & Vandevska-Radunovic, Vaska (2015). The influence of low-level laser on orthodontic relapse in rats. European Journal of Orthodontics. ISSN 0141-5387. 37(1), p. 111–117. doi: 10.1093/ejo/cju053. Full text in Research Archive
• Alzahawi, Kawa; Færøvig, Espen; Brudvik, Pongsri; Bøe, Olav Egil & Mavragani, Maria (2014). Root resorption after leveling with super-elastic and conventional steel arch wires: a prospective study. Progress in Orthodontics. ISSN 1723-7785. 15(1). doi: 10.1186/s40510-014-0035-z. Full text in Research Archive Show summary

  Background: The aim of this prospective study was to compare root resorption after the leveling phase of treatment, performed by either super-elastic or conventional multi-stranded stainless steel arch wires. Methods: From a total of 156 future orthodontic patients in a private clinic, 82 were included in the study after excluding those who earlier had orthodontic or endodontic treatment or signs of resorption. Patients were equally arbitrary allocated into two groups, where leveling was performed either with super-elastic heat-activated or conventional multi-stranded stainless steel arch wires. Root length loss was calculated using pre-treatment and post-leveling periapical radiographs. Results: The use of super-elastic arch wires did not significantly increase the severity of root resorption, except for tooth 31, while it reduced leveling time compared to conventional stainless steel wires. Crossbite of maxillary lateral incisors seemed to be a risk factor for resorption. Conclusion: Incisor root resorption after leveling did not differ significantly between patients treated with super-elastic and conventional stainless steel arch wires, except for a mandibular incisor.

• Fjeld, Morten; Birkeland, Kari; Arvidsson, Linda Zamoline; Stabrun, Anne Elisabeth; Larheim, Tore Arne & Øgaard, Bjørn (2014). Dento-alveolar Changes and Need of Orthodontic Treatment in JIA Patients.Followed from Childhood to Adulthood. Dentistry. doi: 10.4172/2161-1122.S2-003. Full text in Research Archive
• Franzen, Tanya Jeanette; Monjo, Marta; Rubert, Marina & Vandevska-Radunovic, Vaska (2014). Expression of bone markers and micro-CT analysis of alveolar bone during orthodontic relapse. Orthodontics & craniofacial research. ISSN 1601-6335. 17(4), p. 249–258. doi: 10.1111/ocr.12050. Full text in Research Archive Show summary

  Structured Abstract Authors - Franzen T.J., Monjo M., Rubert M., Vandevska-Radunovic V. Objectives - To investigate biological changes of alveolar bone occurring during orthodontic relapse. Materials and Methods - Maxillary first rat molars were moved mesially for ten days. After orthodontic tooth movement (OTM) appliances were removed, and the molars were allowed to relapse for one, three, five, seven, 14 or 21 days. Changes in 3D morphometric parameters of bone located mesial to the first molars were evaluated by micro-CT. Total RNA was isolated from the same bone site and real-time RT-PCR was used to measure the expression of bone formation and resorption markers. Results - One day after appliance removal, the molars relapsed to a mean 73% of the achieved OTM, and then steadily relapsed to 93% at 21 days. Tissue mineral density and percent bone volume increased over the experimental period. Inversely, there was a decrease in total porosity. Gene expression of OCN, Coll-I and ALP decreased during OTM, and as the molars relapsed showed an increasing tendency. Gene expression of RANKL and TRAP increased during OTM. Changes in mRNA expression of H+-ATPase were minor. By 21 days post-appliance removal the remodelling process in rats appeared to have returned to control levels. Conclusions –Bone tissue reactions on a molecular level are similar during OTM and orthodontic relapse. These findings validate the importance of immediate retention following active OTM. Key words: bone remodelling; micro-CT; orthodontic relapse; Real-time RT-PCR; tooth movement.

• Fiane, Jon Egil Tønnevold; Breivik, Martin & Vandevska-Radunovic, Vaska (2014). A histomorphometric and radiographic study of replanted human premolars. European Journal of Orthodontics. ISSN 0141-5387. 36(6), p. 641–648. doi: 10.1093/ejo/cjt088. Full text in Research Archive Show summary

  Objectives:The purpose of this study was to investigate time-related dental tissue reactions to tooth replantation in mature and immature human premolars by histomorphometric and radiographic methods.Material and methods:Sixty premolars were extracted, immediately replanted (T0), and left without intervention for 1, 2, 3, 6, 12, and 24 weeks before re-extraction (T1). Periapical radiographs were taken at T0 and T1 in all groups except for the 24 week group. Paraffin-embedded teeth were sectioned buccolingually at 5 µm, stained with haematoxylin-eosin, and prepared for histological analysis. Root resorption, tertiary dentine, and root and crown length were recorded and compared on both radiographs and paraffin sections.Results:Initial degeneration of the odontoblast layer and disturbance of vasculature and normal architecture of the pulp were seen in both mature and immature teeth within the first 3 weeks. Revascularization and tertiary dentine formation was visible on histological sections in immature teeth at 6 weeks. After 24 weeks, most immature teeth had pulps partly or completely obliterated. Abundant tertiary dentine observed on histological slides was not easily seen on periapical radiographs. Likewise, surface root resorption found in both immature and mature teeth was not visible on the radiographs up to 6 weeks after replantation.Conclusion:Within the limits of this study it can be concluded that the dental pulp of immature teeth has the ability to regenerate and produce tertiary dentine after replantation. Root resorptions and tertiary dentine seen on histological sections are not visible on corresponding radiographs 6 and 12 weeks after replantation.

• HÅGENSLI, NIELS FREDRIK; Stenvik, Arild & Espeland, Lisen Vivienne (2014). Asymmetric mandibular prognathism: Outcome, stability and patient satisfaction after BSSO surgery. A retrospective study. Journal of Cranio-Maxillofacial Surgery. ISSN 1010-5182. 42(8), p. 1735–1741. doi: 10.1016/j.jcms.2014.06.008. Full text in Research Archive
• Kanavakis, Georgios; Ludwig, Björn; Rosa, Marco; Zachrisson, Bjørn Uddo & Hourfar, Jan (2014). Clinical outcomes of cases with missing lateral incisors treated with the 'T'-Mesialslider. Journal of orthodontics. ISSN 1465-3125. 41, p. S33–S38. doi: 10.1179/1465313314Y.0000000103. Full text in Research Archive
• HÅGENSLI, NIELS FREDRIK; Stenvik, Arild & Espeland, Lisen Vivienne (2014). Patients offered orthognathic surgery: Why do many refrain from treatment? Journal of Cranio-Maxillofacial Surgery. ISSN 1010-5182. 42(5), p. e296–e300. doi: 10.1016/j.jcms.2013.10.009. Full text in Research Archive Show summary

  AIM: To examine factors associated with patients' decision to decline surgery. MATERIAL/METHODS: Of 470 consecutive patients referred to the University of Oslo from 2007 to 2009, a sample of 160 subjects who had not undergone surgery was identified and contacted. 236 operated patients from the same period served as a comparison group. Morphology was assessed from cephalograms and photographs, and the individuals' opinions were recorded using questionnaires. RESULTS: Dentofacial morphology represented normative treatment need and was generally similar except for a higher rate of severe negative overjet in the operated group (p < 0.001). The most prevalent reasons for declining surgery were risks of side effects, the burden of care, and a general reluctance to undergo surgery. Many un-operated subjects were dissatisfied with their masticatory function and dentofacial appearance. CONCLUSION: Informed consent to orthognathic surgery represents a challenge both to the patient and the professional. The findings imply that patients' motives and fears should be explored during consultation and that the information provided should be adapted to the potential risks and benefits related to the actual treatment.

• Hvaring, Christina; Birkeland, Kari & Åstrøm, Anne Nordrehaug (2014). Discriminative ability of the generic and condition specific Oral Impact on Daily Performance (OIDP) among adolescents with and without hypodontia. BMC Oral Health. 14(1:57). doi: 10.1186/1472-6831-14-57. Full text in Research Archive Show summary

  Background: The aims of this study were to (1) investigate to what extent the generic and condition specific (CS) forms of the oral impact of daily performance (OIDP) inventory discriminate between a group of patients with hypodontia and a group of patients having malocclusion, (2) assess the association of the generic and CS OIDP with severity and localisation of hypodontia, whilst adjusting for patients’ age and sex. Methods: A total of 163 patients aged 10–17 years were included in a cross-sectional study. Two groups were investigated: 62 patients with non-syndromic hypodontia and 101 non-hypodontia patients. Both groups had a malocclusion of similar treatment need. All patients underwent a clinical and radiographic examination and completed a Norwegian version of the generic and the CS OIDP inventory. CS scores were established for impacts attributed to hypodontia. Results: The mean number of missing teeth in the hypodontia group was 6.2. The prevalence of generic and CS oral impacts in the hypodontia group were 64% and 30%, and the corresponding rates in the non-hypodontia group were 62% and 10%. The generic OIDP did not discriminate between the two groups with respect to overall scores. The CS OIDP discriminated strongly between patients with and without hypodontia regarding problems with emotional status, showing teeth, social contact, speaking and carrying out work. Compared to the non-hypodontia group, patients with hypodontia, with severe hypodontia (≥ 6 missing teeth) and upper anterior hypodontia were respectively 3.4, 2.5 and 7.0 times more likely to report any oral impact attributed to small teeth, gaps between teeth and missing teeth. Conclusions: Hypodontia and malocclusion patients report a considerable burden of oral impacts. The CS-OIDP measure discriminated most effectively between patients with and without hypodontia and was related to severity and upper anterior localisation of hypodontia.

• Færøvig, Espen (2014). Root resorption after levelling with super-elastic and conventional steel arch wires. Progress in Orthodontics. ISSN 1723-7785. 15. Full text in Research Archive
• Andersson, Els-Marie; Axelsson, Stefan; Austeng, Marit Erna; Øverland, Britt; Valen, Ingrid Ekroll & Jensen, Terese Agustin [Show all 7 contributors for this article] (2014). Bilateral hypodontia is more common than unilateral hypodontia in children with Down syndrome: A prospective population-based study. European Journal of Orthodontics. ISSN 0141-5387. 36(4), p. 414–418. doi: 10.1093/ejo/cjt063. Full text in Research Archive
• Franzen, Tanya Jeanette; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2013). Periodontal tissue reaction during orthodontic relapse in rat molars. European Journal of Orthodontics. ISSN 0141-5387. 35(2), p. 152–159. doi: 10.1093/ejo/cjr127. Full text in Research Archive Show summary

  Relapse after orthodontic tooth movement (OTM) is an undesirable outcome that involves a number of factors. This study investigated the remodelling of the alveolar bone and related periodontal structures during orthodontic relapse in rat molars. The maxillary right first molars of 35 Wistar rats were moved mesially by a fixed orthodontic appliance for 10 days and the contralateral molars served as controls. The appliances were removed and six animals killed. The molars were allowed to relapse, and the remaining animals were sacrificed at 1, 3, 5, 7, 14, and 21 days. The jaws were sectioned and stained with haematoxylin and eosin and tartrate-resistant acid phosphatase (TRAP). One day after appliance removal, the molars relapsed to a mean 62.5 per cent of the achieved OTM and then steadily relapsed to 86.1 per cent at 21 days. The number of osteoclasts situated along the alveolar bone of the first molars was highest at the end of active treatment and significantly decreased during the relapse period. In the OTM group, osteoclasts were most numerous in the pressure side of the periodontal ligament (PDL). As the molars relapsed over time, the osteoclast distribution shifted, and after 7 days of relapse, TRAP-positive cells were registered in previous pressure and tension sides of the first molars. After 21 days, these cells were concentrated in the distal parts of the PDL of all three maxillary right molars. These results indicate that orthodontic relapse in the rat model occurs rapidly and remodelling of the alveolar bone and PDL plays a central role in the relapse processes of both actively moved and adjacent teeth.

• Andersson, Els-Marie; Axelsson, Stefan; Gjølstad, Lars-Fredrik & Storhaug, Kari (2013). Taurodontism: A minor diagnostic criterion in Laurence-Moon/Bardet-Biedl syndromes. Acta Odontologica Scandinavica. ISSN 0001-6357. 71(6), p. 1671–1674. doi: 10.3109/00016357.2013.794389. Full text in Research Archive
• Jakobsone, Gundega; Stenvik, Arild & Espeland, Lisen Vivienne (2013). Soft tissue response after Class III bimaxillary surgery Impact of surgical change in face height and long-term skeletal relapse. Angle orthodontist. ISSN 0003-3219. 83(3), p. 533–539. doi: 10.2319/043012-356.1. Full text in Research Archive

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• Pullisaar, Helen; Cattaneo, Paolo M.; Gera, Arwa; Sankiewicz, Monika; Bilińska, Małgorzata & Vandevska-Radunovic, Vaska [Show all 7 contributors for this article] (2024). Retainere etter kjeveortopedisk behandling fremstilt med CAD⁄CAM viser likeverdige kliniske egenskaper som konvensjonelle retainere men til en lavere kostnad. Norsk tannlegeforening Tidende. doi: 10.56373/2024-9-8. Full text in Research Archive
• Fernandez, Lucete Færøvig; Vandevska-Radunovic, Vaska; Bjørnland, Tore; Magnusson, Anders & Bjerklin, Krister (2023). CLOSED VS OPEN SURGICAL EXPOSURE OF PALATALLY DISPLACED CANINES: OPERATING TIME, COMPLICATIONS AND PATIENT`S PERCEPTIONS OF RECOVERY: A RANDOMIZED CONTROLLED TRIAL. Full text in Research Archive
• Vandevska-Radunovic, Vaska (2023). Treatment options for dental traumas. Full text in Research Archive
• Hamran, Tord; Kopperud, Hilde M.; Valen, Håkon & Vandevska-Radunovic, Vaska (2023). ORTHODONTIC THERMOPLASTIC MATERIALS; AN IN VITRO STUDY OF LEACHATES, MICRO-HARDNESS AND SIMULATED WEAR. Full text in Research Archive
• Vasconcelos, Gisela Mafalda Sa Pereira de & Åsten, Pamela (2022). LONG - TERM FOLLOW - UP OF THE DEVELOPMENT OF DENTITION AND OROFACIAL FUNCTIONS IN CHILDREN WITH BECKWITH - WIEDEMANN SYNDROME. Full text in Research Archive Show summary

  Aim(s): should be clearly stated. Beckwith - Wiedemann syndrome (BWS) is a rare paediatric overgrowth syndrome with distinct genetic and clinical features. Clinical findings are variable and include characteristic facial appearance, macroglossia, hemihypertrophy, anterior abdominal wall defects and gigantism. Macroglossia is present in most of the cases. The problems caused by the enlarged tongue comprise difficulties with feeding, distorted speech and increased drooling. The position of the teeth and lower jaw are often altered. Respiratory difficulties may occur due to tongue obstruction. The presence of hemi-hypertrophy can lead to asymmetric overgrowth of the head and face. Tongue reduction surgery is a treatment option. Based on systematically collected data, the development of the dentition and orofacial functions of 8 patients with BWS from childhood to adolescence is described. Methods: With sufficient detail of sampling, interventions and main outcome measures A Norwegian model for standardized long - term follow - up of the development of dentition, facial growth and orofacial functions was outlined by the TAKO - centre and the National Craniofacial Team in order to validate the quality of care of children and adolescents with Beckwith-Wiedemann syndrome (BWS). Examinations by a specialist in orthodontics, paediatric dentist, speech and language pathologist, otolaryngologist surgeon and plastic surgeon are performed at key ages in order to identify treatment needs and to provide coordinated care. This protocol includes follow - up of persons with BWS both with and without tongue reduction surgery. Results: should give the most important findings and always include both numbers and percentages All individuals in this study had a macroglossia and in two of them a tongue reduction was performed. A commom found was anterior open bite in the primary dentition. In the transition from mixed to permanent dentition a reduction of the anterior open bite was registered with dento - alveolar compensation. The orofacial functions such as speech, chewing and swallowing also improved from childhood to adolescence in most individuals. Conclusions: should highlight the most important finding(s) and be based on the observed results. This study may provide useful information for clinical guidelines and improve multiprofessional evidence based practice for Beckwith - Wiedemann syndrome.

• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2020). Lokal blødtvævsatrofi i kinden og sensibilitetstab i højre side af overlæben efter subkutan ekstrusion af klorhexidindiglukonat i forbindelse med endodontisk behandling. Tandlægebladet. ISSN 0039-9353. Full text in Research Archive
• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2019). Lokal bløtvevsatrofi i kinn og tap av følelse i høyre overleppe etter subkutan ekstrusjon av klorheksidindiglukonat i forbindelse med endodontisk behandling. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 129, p. 706–710. Full text in Research Archive
• Øgaard, Bjørn Andreas (2018). UiO-forskarar på verdstoppen i siteringar i kjeveortopedi. [Journal]. Uniforum. Full text in Research Archive
• Shadnazar, Shervin; Bergman, Axel & Birkeland, Kari (2018). Outcome of orthodontic space-closure and autotransplantation replacing a missing maxillary central incisor. Full text in Research Archive
• Kristensen, Trond Anders; Hovland, Katrine; Birkeland, Kari & Vandevska-Radunovic, Vaska (2018). Third molar eruption after orthodontic treatment wirh and without premolar extraction: A retrospective study. Full text in Research Archive
• Espeland, Lisen Vivienne; Birkeland, Kari; Haanæs, Hans Reidar & Stenvik, Arild (2016). Amelogenesis imperfecta: Behandling ved retensjon og resorpsjon av tenner. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 126(11), p. 890–892. Full text in Research Archive
• Vandevska-Radunovic, Vaska (2016). Retention - Necessity or Burden. Full text in Research Archive
• Vandevska-Radunovic, Vaska (2016). Tooth transplantation as a viable option for orthodontic problems. Full text in Research Archive
• Juloski, Jovana; Glisic, Branislav & Vandevska-Radunovic, Vaska (2016). LONG-TERM INFLUENCE OF FIXED LINGUAL RETAINERS ON THE DEVELOPMENT OF MANDIBULAR GINGIVAL RECESSIONS. Full text in Research Archive
• Vandevska-Radunovic, Vaska (2016). Histological and immunohistochemical pulpal tissue changes in replanted human premolars. Full text in Research Archive
• Haugland, Linn; Kristensen, Kasper Dahl; Midtbø, Marit & Vandevska-Radunovic, Vaska (2016). Systemic factors effects on orthodontically induced inflammatory root resorption (OIIRR) in human patients and animals: A systematic review and meta-analysis. Full text in Research Archive
• Øgaard, Bjørn Andreas (2016). Kjeveortopedisk diagnostikk og henvisning. Full text in Research Archive
• Maltha, Jaap; Vandevska-Radunovic, Vaska & Kuijpers-Jagtman, Anne Marie (2015). The biological background of relapse of orthodontic tooth movement. In Krishnan, Vinod & Davidovitch, Ze'ev (Ed.), Biological mechanisms of tooth movement. John Wiley & Sons. ISSN 9781118688878. p. 248–259. Full text in Research Archive
• Øgaard, Bjørn Andreas (2015). Diagnostikk og henvisning til kjeveortoped. Full text in Research Archive
• Øgaard, Bjørn Andreas (2015). Introduction. In: Juvenile idiopathic arthritis and temporomandibular joint involvement: an interdisciplinary approach. Seminars in orthodontics. ISSN 1073-8746. 21(2), p. 71–71. doi: 10.1053/j.sodo.2015.02.001. Full text in Research Archive
• Gulino, A; Belmonte, B; Guarnotta, C; Cancila, V; Volponi, Ana Angelova & Vandevska-Radunovic, Vaska [Show all 8 contributors for this article] (2015). Vascular and neural dental pulp histological alterations during orthodontic treatment. Full text in Research Archive
• Vandevska-Radunovic, Vaska (2015). Tooth transplantation and orthodontics. Full text in Research Archive
• Hvaring, Christina; Åstrøm, Anne Nordrehaug & Birkeland, Kari (2014). Oral impacts on daily performance in children and adolescents with and without hypodontia. Full text in Research Archive
• Enersen, Silje; Gjestrum, Lars Johan; Hjulstad, Bror-Eric; Birkeland, Kari & Vandevska-Radunovic, Vaska (2014). Orthodontic treatment with extraction of second molars and its influence on dentofacial structures and third molar eruption. Full text in Research Archive
• Bjering, Ragnar; Midtbø, Marit; Birkeland, Kari & Vandevska-Radunovic, Vaska (2014). Stability of non-extraction versus four premolar extraction treatment 10 years out of retention. Full text in Research Archive
• Franzen, Tanya Jeanette; Monjo, Marta; Rubert, Marina; Brudvik, Pongsri & Vandevska-Radunovic, Vaska (2014). Alveolar bone remodelling during orthodontic relapse. Full text in Research Archive Show summary

  Aim: To examine the biological changes occurring in alveolar bone during orthodontic relapse. Materials and Method: Maxillary first rat molars were moved mesially for ten days, appliances were removed, and the molars allowed to relapse for 1, 3, 5, 7, 14 or 21 days. Maxillae of 35 rats were sectioned and stained with H&E and TRAP, whilst in 37 rats 3D morphometric parameters of bone sited mesial to the first molars were assessed by micro-CT, subsequently total RNA was isolated and real-time RT-PCR used to measure the expression of bone formation and resorption markers. Comparison among groups was assessed by t-tests or ANOVA, and correlations by Spearman’s rank correlation coefficient. Results: One day after appliance removal, the molars relapsed to 68.5% of the achieved OTM, and progressively relapsed to 90.6% at 21 days. Osteoclasts located along the alveolar bone of the first molars peaked at the end of active orthodontic tooth movement (OTM) and were most abundant in the pressure side of the PDL. Osteoclast numbers decreased significantly during relapse and their distribution shifted; after 7 days of relapse TRAP-positive cells were registered in previous pressure and tension sides of the first molars. After 21 days, these cells were concentrated in the distal sides of the PDL. In the bone mesial to the first molars tissue mineral density and percent bone volume increased whilst total porosity decreased over the experimental period. Gene expression of OCN, Coll-I and ALP decreased during OTM, and tended to increase as the molars relapsed. Gene expression of RANKL and TRAP increased during OTM. Changes in mRNA expression of H+-ATPase were minor. By 21 days the remodelling process appeared to have returned to control levels. Conclusion: The findings of this investigation indicate that orthodontic relapse in the rat model occurs rapidly and remodelling of the alveolar bone plays a central role in the relapse processes of both actively moved, and adjacent teeth.

• Franzen, Tanya Jeanette; Vandevska-Radunovic, Vaska; Zahra, Sherif & Elkadi, Abbadi (2014). The influence of Low-level laser therapy (LLLT) on orthodontic relapse. Full text in Research Archive
• Fjeld, Morten; Birkeland, Kari; Stabrun, Anne Elisabeth; Arvidsson, Linda Zamoline & Øgaard, Bjørn (2013). Malocclusion and need for orthodontic treatment in young juvenile idiopathic arthritis patients. Full text in Research Archive
• Hvaring, Christina; Birkeland, Kari & Øgaard, Bjørn (2013). Hypodontia: An interdisciplinary approach to treatment of children and adolescents. Full text in Research Archive

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