Badra Hussain

• Hussain, Badra; Simm, Roger; Bueno, Jaime; Giannettou, Savvas; Naemi, Ali-Oddin & Lyngstadaas, Ståle Petter [Show all 7 contributors for this article] (2024). Biofouling on titanium implants: a novel formulation of poloxamer and peroxide for in situ removal of pellicle and multi-species oral biofilm. Regenerative Biomaterials. ISSN 2056-3426. 11. doi: 10.1093/rb/rbae014. Full text in Research Archive
• Sevgi, Usame; Johnsen, Gaute Floer; Hussain, Badra; Piasecki, Lucila; Parreiras Nogueira, Liebert & Haugen, Håvard Jostein (2023). Morphometric micro-CT study of contralateral mandibular incisors. Clinical Oral Investigations. ISSN 1432-6981. 28(1). doi: 10.1007/s00784-023-05419-y. Full text in Research Archive Show summary

  Objectives: This study aimed to determine the degree of similarity and symmetry in the anatomy of contralateral mandibular incisors. Three-dimensional (3D) models of extracted teeth were obtained from microtomography (micro-CT) scans. Qualitative and quantitative assessments of the morphology and comparison of contralateral pairs were made. The null hypothesis was that contralateral mandibular incisors could not be considered identical in simple morphometric measurements. Methods: Sixty pairs of mandibular incisors were extracted from 30 patients and scanned with micro-CT. Virtual models of the cemento-enamel junction to the root apex were rendered. Parameters such as length, canal width, dentinal thicknesses, tortuosity, centerline length, accessory canals, root canal configurations, and root canal orifice cross-sections were used to compare the teeth. Width and thickness comparisons between paired teeth in the same individual were made by paired t-test (Wilcoxon Signed Rank Test for variables not normally distributed). An online randomization tool generated randomized pairs (independent of the individual/patient). Subsequently, an unpaired t-test (or Mann-Whitney U test for non-normally distributed parameters) and a correlation analysis were conducted. Canal configurations were classified according to preexisting classification schemes. The number and location of accessory canals and apical foramina were registered and compared. Results: Utilizing advanced imaging techniques and quantitative analyses, our study establishes that contralateral mandibular incisors exhibit a remarkable degree of symmetry in multiple morphological parameters, including length, canal width, and dentinal thicknesses The apical third showed a high degree of inter-variability for the contralateral pairs. The rigorous statistical analysis of the normalized parameters by Z score showed no statistically significant differences between the contralateral mandibular incisors. Comparisons between central and lateral teeth revealed differences in root length but no significant disparity in the distribution of accessory canals. Central teeth, on average, were longer, while accessory canals were distributed relatively evenly between central and lateral teeth. Conclusions: The findings of this study further establish the significant similarities between contralateral mandibular incisors, reinforcing their suitability as a reliable substrate for root canal comparison studies. Clinical Relevance: The absence of statistically significant differences between contralateral pairs in normalized parameters underscores their potential as a reliable reference point for root canal comparison studies in clinical dentistry. Furthermore, our findings emphasize the importance of individualized treatment planning, considering the natural symmetry in mandibular incisors to enhance clinical decision-making. This research contributes valuable insights to the field of endodontics, offering a standardized approach to sample selection and enriching the understanding of dental anatomy

• Hussain, Badra; Khan, Sadia Nazir; Agger, Anne Eriksson; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Bueno, Jaime [Show all 7 contributors for this article] (2023). A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. Journal of Functional Biomaterials. ISSN 2079-4983. 14(8). doi: 10.3390/jfb14080394. Full text in Research Archive
• Haugen, Håvard Jostein; Makhtari, Soukayna; Ahmadi, Sara & Hussain, Badra (2022). The Antibacterial and Cytotoxic Effects of Silver Nanoparticles Coated Titanium Implants: A Narrative Review. Materials. ISSN 1996-1944. 15(14), p. 1–19. doi: 10.3390/ma15145025. Full text in Research Archive Show summary

  Nanotechnology has become an emerging research field with numerous biomedical scientific applications. Silver possesses bactericidal activities that have been harnessed for centuries; however, there is a concern about the toxic effects of silver nanoparticles. This paper aims to provide an overview of silver-treated dental implants and discuss their potential to reduce the prevalence of peri-implant diseases. An electronic search was performed using PubMed. After screening, data extraction was performed on the 45 remaining articles using inclusion and exclusion criteria. Most of the articles demonstrated that silver nanoparticles embedded in a coating layer and/or on surfacetreated titanium exhibit sound antibacterial effects and biocompatibility. Most of the reviewed studies revealed that silver nanoparticles on dental implant surfaces reduced cytotoxicity but provided a prolonged antibacterial effect. The cytotoxicity and antibacterial effect are closely linked to how the silver nanoparticles are released from the titanium surfaces, where a slower release increases cell viability and proliferation. However, to improve the clinical translation, there is still a need for more studies, especially evaluating the long-term systemic effects and studies recreating the conditions in the oral cavity.

• Hussain, Badra; Karaca, Ebru Ozkan; Kuru, Bahar Eren; Gursoy, Hare; Haugen, Håvard Jostein & Wohlfahrt, Johan Caspar (2021). Treatment of residual pockets using an oscillating chitosan device versus regular curettes alone—a randomized, feasibility parallel-arm clinical trial. Journal of Periodontology. ISSN 0022-3492. doi: 10.1002/JPER.21-0496. Full text in Research Archive
• Hussain, Badra; Haugen, Håvard Jostein; Aass, Anne Merete; Sanz Alonso, Mariano; Antonoglou, Georgios & Bouchard, Philippe [Show all 23 contributors for this article] (2021). Peri-Implant Health and the Knowing-Doing Gap—A Digital Survey on Procedures and Therapies. Frontiers in Dental Medicine. ISSN 2673-4915. 2(726607). doi: 10.3389/fdmed.2021.726607. Full text in Research Archive
• Hussain, Badra; Thieu, Minh Khai Le; Johnsen, Gaute Floer; Reseland, Janne Elin & Haugen, Håvard Jostein (2017). Can CAD/CAM resin blocks be considered as substitute for conventional resins? Dental Materials. ISSN 0109-5641. 33(12), p. 1362–1370. doi: 10.1016/j.dental.2017.09.003. Show summary

  Objective Dentists are facing a myriad of new CAD/CAM product for dental filling therapies. Are the new materials any worthwhile using? Are they succeeding the standard filling materials? Here we compare for the first time the new resin-composite blocks (RCBs) with conventional materials (Filtek Z250 and Tetric EvoCeram). Methods The material were tested for residual monomer elution by HPLC, thermogravimetric analysis (TG) was used to determine the percentage of fillers by weight, hardness was evaluated by Vickers method, morphology of fillers and distribution in the matrix were examined by scanning electron microscopy (SEM), elemental analysis for elemental determination of the filler particles was performed by energy-dispersive X-ray spectroscopy (EDX) cytotoxicity using human gingival fibroblasts and an epithelial cell line. Results The RBC outperformed conventional composite regarding mechanical characteristics (hardness) and monomer eluation, but showed some worrisome results regarding cytotoxicity. Significance The cost benefit is not in favour of RBCs in comparison to conventional composites, as the cytotoxicity was found higher for RBCs.

• Johnsen, Gaute Floer; Thieu, Minh Khai Le; Hussain, Badra; Pamula, Elzbieta; Reseland, Janne Elin & Lyngstadaas, Ståle Petter [Show all 7 contributors for this article] (2017). Own brand label restorative materials - A false bargain? Journal of Dentistry. ISSN 0300-5712. 56, p. 84–98. doi: 10.1016/j.jdent.2016.11.004. Show summary

  Objectives This study aims at evaluating and comparing mechanical, chemical, and cytotoxicological parameters of a commercial brand name composite material against two ‘own brand label' (OBL) composites. Methods Parameters included depth of cure, flexural strength, degree of conversion, polymerization shrinkage, filler particle morphology and elemental analyses, Vickers hardness, surface roughness parameters after abrasion, monomer elution, and cytotoxicity. Results The conventional composite outperformed the OBLS in terms of depth of cure (p < 0.001), degree of cure at the first and last time intervals (p < 0.001), hardness (p < 0.001), and post-abrasion roughness (p < 0.05). The polymerization volumetric shrinkage ranged from 2.86% to 4.13%, with the highest shrinkage seen among the OBLs. Both Monomer elution from the OBLs was statistically significantly higher (p<0.001). Statistically significantly higher cytotoxicity combined with altered morphology and loss of confluence was detected in the cells exposed to extracts from the OBLs. Conclusions The OBLs were in general outdone by the conventional composite. Clinical Significance: OBLs restorative materials have become pervasive in the dental market. Manufacturers often promise equal or better characteristics than existing brand-name composites, but at a lower price. Dentists are highly recommended to reconsider utilization of OBLs lacking sound scientific scrutiny, and our findings underscore this recommendation

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• Hussain, Badra; Simm, Roger; Bueno, Jaime; Giannettou, Savvas; Naemi, Ali-Oddin & Lyngstadaas, Ståle Petter [Show all 7 contributors for this article] (2023). Chemical decontamination strategies for treatment of peri-implant disease.
• Hussain, Badra; Simm, Roger; Lyngstadaas, Ståle Petter; Bueno, Jamie & Haugen, Håvard Jostein (2023). Chemical decontamination strategies for treatment of peri-implant disease: using an in vitro dental pellicle-, and a multispecies biofilm model.
• Haugen, Håvard Jostein; Hussain, Badra & Bjørkeng, Astrid Skiftesvik (2021). Er biomaterialer kroppens indre plaster? [Internet]. Universitetsplassen Podcast. Show summary

  Ting går i stykker. Også i kroppen. Men medisinsk forskning har gjort det mulig å erstatte noen ødelagte deler med biomaterialer. I denne podkasten forklarer forskerne Håvard Haugen og Badra Hussein hva biomaterialer er og hvordan de brukes - og ikke minst hvordan de forsker på nye biomaterialer for å lage nytt bein.

• Haugen, Håvard Jostein; Johnsen, Gaute Floer; Reseland, Janne Elin; Hussain, Badra & Thieu, Minh Khai Le (2017). Can CAD/CAM Resin Blocks be Considered as a Substitute to Conventional Resins?

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