Jan Eirik Ellingsen

• Jamous, Reem; Nysæther, Ingvild; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Fredriksson, Malin Vestin & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2026). Multi-Scale Assessment of Scaffold-Guided Regeneration in Human Extraction Sockets Using an Ultra-Porous TiO₂ Biomaterial. Acta Biomaterialia. ISSN 1742-7061. doi: 10.1016/j.actbio.2026.08.041. Full text in Research Archive Show summary

  Ultra-porous TiO₂ scaffolds are architected non-degradable ceramic graft substitutes, but human evidence relating their structural integration to local tissue maturation remains limited. This exploratory study assessed scaffold-associated healing in a prospective clinical cohort registered at ClinicalTrials.gov (NCT06269497; 10 patients, 11 treated sites). Cone-beam computed tomography (CBCT)-based segmentation at baseline and follow-up was used to quantify changes in bone volume, radiographic low-density/non-mineralized volume, and radiographically detectable scaffold volume. Eleven scaffold-associated specimens were examined using non-decalcified histology, histomorphometry, and immunohistochemistry; nine were retrieved at approximately 6 months, one at 4 months, and one at 9 months. CBCT showed within-site increases in bone and total tissue volume and a reduction in radiographically detectable scaffold volume. Histology showed extensive pore colonization by osteoid-rich tissue, localized mineralization, and limited residual cartilage, consistent with ongoing but incomplete matrix maturation. Normalized RunX2 showed a positive exploratory association with absolute bone volume change, whereas associations with osteocalcin were uncertain and endpoint-dependent. CD206/CD68 and the vessel-to-osteoid ratio were more closely associated with low-density/non-mineralized volume outcomes than with bone-volume change. Osteoclast-associated variables were evaluable in only four sites and were interpreted descriptively. These findings are exploratory and do not establish causality or comparative efficacy, but they characterize tissue-scaffold interactions during human extraction-socket healing.

• Lauretis, Angela De; Santacroce, Marco; Wang, Qiang; Ramirez, Manuel; Ma, Qianli & Lyngstadaas, Ståle Petter [Show all 9 contributors for this article] (2026). Combined Chemical and Mechanical Debridement Enhances Salivary Protein Removal from Titanium while Maintaining Biological Properties. ACS Biomaterials Science and Engineering. doi: 10.1021/acsbiomaterials.5c01973. Full text in Research Archive Show summary

  Effective decontamination of dental implants is essential for managing peri-implant diseases, yet its impact on the salivary pellicle and cell response remains unclear. As the pellicle mediates bacterial and host cell interactions, investigating how decontamination alters its composition is key to understanding the effects on biological outcomes. Accordingly, we examined how a Poloxamer 407 (P407) hydrogel, a P407 + hydrogen peroxide (H2O2) hydrogel, a titanium brush, and their combinations influence the adsorbed salivary proteins and cell adhesion on OsseoSpeed-like titanium surfaces. Surfaces with salivary proteins were treated with different decontamination methods and re-exposed to saliva. Protein quantity was measured using the BCA assay, while the proteomic composition and molecular functions of the adsorbed proteins were determined by liquid chromatography-mass spectrometry and gene ontology analysis. Human bone marrow mesenchymal stem cell (hBMMSC) adhesion was assessed on the surfaces, and cytotoxicity was evaluated using an LDH assay. Protein-coated and protein-free surfaces served as controls. Although protein levels were consistent across groups after either decontamination or recontamination, each treatment produced a different proteomic profile. Mechanical decontamination, alone or combined with chemicals, enhanced protein removal efficiency. Combined treatments yielded reduced protein diversity following recontamination and enriched adhesion-related proteins. None of the treatments compromised hBMMSC adhesion nor made the surface cytotoxic. Decontamination methods selectively modify the proteomic profile. Combined chemical and mechanical decontamination promotes the removal of salivary proteins and limits their readsorption while preserving cytocompatibility, supporting their relevance to peri-implant health.

• Lauretis, Angela De; Wang, Qiang; Santacroce, Marco; Thiede, Bernd; Ma, Qianli & Lyngstadaas, Ståle Petter [Show all 9 contributors for this article] (2025). A Comparative Study of the Impact of Chemical Debridement Products on the Proteomic Profile of the Salivary Pellicle and Cell Adhesion on OsseoSpeed Titanium Dental Implant Surfaces. ACS Applied Materials & Interfaces. ISSN 1944-8244. 17(39), p. 54592–54592. doi: 10.1021/acsami.5c14570. Full text in Research Archive
• Nysæther, Ingvild; Haugen, Håvard Jostein; Khassawna, Thaqif El; Jamous, Reem; Afnan, Shoresh & Santacroce, Marco [Show all 10 contributors for this article] (2025). Clinical Performance of Ultra‐Porous TiO2 Scaffold as Bone Graft Substitute in Human Alveolar Ridge Preservation—A Feasibility Study. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.70074. Full text in Research Archive Show summary

  Objectives This study evaluates the safety and osteoconductive potential of a ceramic TiO2 scaffold in human alveolar bone, hypothesising that placement in human extraction sockets is safe, supports bone ingrowth and preserves ridge dimensions. Material and Methods Nine subjects requiring the extraction of ≥ 1 premolar or molar tooth were enrolled. Full-thickness mucoperiosteal flaps were elevated. Following tooth extraction, porous ceramic TiO2 scaffolds were adjusted chair-side, placed into the extraction socket and covered by a resorbable collagen membrane. After 6 months of healing, before dental implant placement, a biopsy was performed at the site where the scaffold had been placed. Histomorphometric and micro-CT analyses were made. CBCT images were made at baseline and at 6 months to assess alveolar ridge dimensional changes. Implants placed in regenerated bone were followed for 21 months. Results Scaffold customisation with chairside adjustment was straightforward. No serious adverse events were observed during the 6 months following scaffold implantation. One scaffold was removed due to an early exposure, while the remaining 9 scaffolds successfully integrated. Two sites presented with minor soft tissue dehiscences at 1–2 weeks, which healed spontaneously. Micro-CT and histology confirmed new bone formation. Soft tissue healing was favourable, with no adverse reactions. Dimensional analysis revealed minimal changes in alveolar ridge width and height, indicating effective preservation of volume. Conclusions This clinical study confirms that TiO2 scaffolds are a safe and effective option for promoting bone regrowth and preserving volume in human alveolar bone, thereby facilitating bone formation and maintaining ridge dimensions post-extraction.

• Lauretis, Angela de; Wang, Qiang; Santacroce, Marco; Thiede, Bernd; Ma, Qianli & Lyngstadaas, Ståle Petter [Show all 9 contributors for this article] (2025). A Comparative Study of the Impact of Chemical Debridement Products on the Proteomic Profile of the Salivary Pellicle and Cell Adhesion on OsseoSpeed Titanium Dental Implant Surfaces. ACS Applied Materials & Interfaces. ISSN 1944-8244. 17, p. 54579–54592. doi: 10.1021/acsami.5c14570. Full text in Research Archive Show summary

  Background and objectives: Dental implants are commonly used for tooth replacement, with excellent success rates over 10 years. However, exposure to oral cavity bacteria makes them susceptible to biofilm accumulation, which can lead to peri-implant diseases. The salivary pellicle, a protein-rich layer formed on implant surfaces, mediates bacterial adhesion and cell attachment. Effective decontamination is essential for managing bacterial infections, yet no consensus exists on the best chemical agent. Understanding how chemical agents affect the pellicle proteomic profile may guide the selection of optimal treatments. Methods: We investigate the impact of chemical decontamination agents on the salivary pellicle on OsseoSpeed-like titanium dental implant surfaces using a BCA assay and proteomics, and on cell adhesion using human gingival fibroblasts (HGF) and human bone marrow mesenchymal stem cells (hBMSC). We compare the effects of hydrogen peroxide (H2O2), Poloxamer 407 (P407), P407 + H2O2 and sodium hypochlorite + amino acids (NaOCl + AA) using the salivary pellicle and a clean titanium surface as controls. By quantifying and identifying proteins on titanium surfaces after decontamination, this study reveals how chemical agents affect the salivary pellicle. Results: All products reduced the total protein on the surfaces, with the P407 + H2O2 hydrogel demonstrating lower protein variety and superior effectiveness in preventing surface recontamination. Not all proteins were removed during decontamination procedures, and unique proteins were detected in each experimental condition, suggesting protein readsorption depends on surface chemistry. P407 + H2O2 shows the highest enrichment in integrin- and cadherin-binding proteins upon recontamination. P407 and P407 + H2O2 promoted HGFs and hBMSCs attachment. Conversely, NaOCl + AA and H2O2 showed lower HGFs and hBMSCs counts. Conclusion: The P407 + H2O2 hydrogel had the strongest decontamination effect and limited surface recontamination. Each chemical agent produced a distinct proteomic profile. P407 and P407 + H2O2 promoted initial cell adhesion.

• Lauretis, Angela de; Agger, Anne Eriksson; Pal, Antara; Pedersen, Jan Skov; Szostak, Szymon Mikolaj & Lund, Reidar [Show all 10 contributors for this article] (2025). Balancing sterilization and functional properties in Poloxamer 407 hydrogels: comparing heat and radiation techniques. Regenerative Biomaterials. 12. doi: 10.1093/rb/rbaf005. Full text in Research Archive Show summary

  Poloxamer 407, also known as Pluronic® F127, is gaining interest in the cosmetic, biomedical, and pharmaceutical fields for its biocompatibility, safety, and thermosensitive properties. Ensuring sterility is critical in clinical applications, and sterilization is often preferred over aseptic processing. However, sterilization can impact the hydrogel's functional properties. In this study, we investigate the effects of steam heat (121°C, 20 min), dry heat (160°C, 1 h), gamma irradiation (25 kGy), and electron beam (e-beam) irradiation (15 kGy and 25 kGy) on a 30%w/v Poloxamer 407 hydrogel formulation. Our analysis encompasses gelling properties, pH, Fourier-transform infrared (FTIR) spectroscopy, Gel Permeation Chromatography (GPC), Small-angle X-ray scattering (SAXS), rheology, swelling, degradation by-products, and lactate dehydrogenase (LDH) release of the sterilised hydrogels, comparing them to a non-sterile counterpart. We demonstrated that heat sterilisation alters the hydrogel’s gelling and structural properties due to water evaporation and oxidation under harsh temperature conditions, especially when applying the dry heat method. Gamma irradiation proved unsuitable, resulting in an acidic and cytotoxic hydrogel due to oxidative degradation. In contrast, e-beam irradiation preserves the hydrogel's elasticity, gelling, and structural properties while enhancing mechanical resilience and moderating swelling. Therefore, e-beam irradiation within the 15 – 25 kGy range appears to be the most suitable method for sterilizing a 30%w/v Poloxamer 407 hydrogel.

• Lauretis, Angela de; Santacroce, Marco; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter; Linke, Dirk & Haugen, Håvard Jostein (2025). Surface-specific outcomes of mechanical debridement with titanium, chitosan and nitinol brushes on titanium dental implant surfaces. Journal of Dentistry. ISSN 0300-5712. doi: 10.1016/j.jdent.2025.106010. Full text in Research Archive Show summary

  Objectives Dental implants are susceptible to peri‑implant inflammation caused by bacterial biofilms, with surface properties playing a key role in bacterial adhesion and osseointegration. While mechanical debridement is essential for biofilm removal, consensus on the optimal tool remains limited. In this study, we evaluate the impact of a titanium, a chitosan and a nitinol brush on the surface properties of four titanium dental implant surfaces: OsseoSpeed®-like, SLActive®-like, machined, and polished. Methods Profilometry, contact angle measurements, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) were used to assess the surface properties and chemistry. Results SEM and profilometry revealed that the titanium and nitinol brushes altered the morphology and topography of the rough OsseoSpeed®-like and SLActive®-like surfaces, while these effects were less pronounced on machined surfaces. Conversely, the chitosan brush caused minimal changes, but its bristles wore down quickly by physical abrasion, increasing surface carbon as detected by EDX and identified by XPS as organic material. Conversely, XPS confirmed that carbon contamination in samples treated with metal brushes was primarily environmental. The increased hydrophobicity observed across all groups was linked to carbon contamination. Polished surfaces remained unaffected by mechanical debridement. Conclusions The chitosan brush showed minimal surface alterations, but the rapid bristle wear left organic residues that increased hydrophobicity. The titanium and nitinol brushes caused more pronounced surface changes, while contributing to increased hydrophobicity through environmental carbon contamination during debridement. Clinical significance Dental implant surface properties, including topography, morphology, wettability, and surface chemistry, play a critical role in bacterial adhesion and osseointegration. Selecting an optimal mechanical debridement instrument requires balancing the effective removal of biofilm with the impact on the implant surface properties.

• Stanford, Clark M.; Chvartszaid, David; Saito, Hanae; Estafanous, Emad; Ellingsen, Jan Eirik & Osswald, Martin (2024). How Long Does It Take for Implant Success to Be Truly Successful? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(3), p. 337–341. Full text in Research Archive
• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Osswald, Martin; Saito, Hanae & Stanford, Clark (2024). Implant Fracture: An Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(6), p. 809–814. Full text in Research Archive
• Estafanous, Emad; Stanford, Clark; Chvartszaid, David; Oates, Thomas & Ellingsen, Jan Eirik (2024). Clinical performance of dental implants. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(2), p. 201–205. Full text in Research Archive
• Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Oates, Thomas & Osswald, Martin (2024). Prosthetic complications in implant restorations. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(1), p. 14–17. Full text in Research Archive
• Ellingsen, Jan Eirik; Stanford, Clark M.; Chvartszaid, David; Saito, Hanae; Estafanous, Emad & Osswald, Martin (2024). All-Ceramic Implant-Supported Single Crowns (SCs) and Fixed Dental Prostheses (FDPs): How Good Are They? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(4), p. 501–505. Full text in Research Archive
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Ellingsen, Jan Eirik & Tiainen, Hanna (2023). Backscatter from therapeutic doses of ionizing irradiation does not impair cell migration on titanium implants in vitro. Clinical Oral Investigations. ISSN 1432-6981. doi: 10.1007/s00784-023-05128-6. Full text in Research Archive Show summary

  Objective The influence of radiation backscatter from titanium on DNA damage and migration capacity of human osteoblasts (OBs) and mesenchymal stem cells (MSCs) may be critical for the osseointegration of dental implants placed prior to radiotherapy. In order to evaluate effects of radiation backscatter, the immediate DNA damage and migration capacity of OBs and MSCs cultured on titanium or plastic were compared after exposure to ionizing irradiation. Materials and methods Human OBs and MSCs were seeded on machined titanium, moderately rough fluoride-modified titanium, or tissue culture polystyrene, and irradiated with nominal doses of 2, 6, 10, or 14 Gy. Comet assay was performed immediately after irradiation, while a scratch wound healing assay was initiated 24 h post-irradiation. Fluorescent live cell imaging documented the migration. Results DNA damage increased with higher dose and with backscatter from titanium, and MSCs were significantly more affected than OBs. All doses of radiation accelerated the cell migration on plastic, while only the highest dose of 10 Gy inhibited the migration of both cell types on titanium. Conclusions High doses (10 Gy) of radiation inhibited the migration capacity of both cell types on titanium, whereas lower doses (2 and 6 Gy) did not affect the migration of either OBs or MSCs. Clinical relevance Fractionated doses of 2 Gy/day, as distributed in conventional radiotherapy, appear not to cause severe DNA damage or disturb the migration of OBs or MSCs during osseointegration of dental implants.

• Hussain, Badra; Khan, Sadia Nazir; Agger, Anne Eriksson; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Bueno, Jaime [Show all 7 contributors for this article] (2023). A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. Journal of Functional Biomaterials. 14(8). doi: 10.3390/jfb14080394. Full text in Research Archive Show summary

  Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBone®Clean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilised for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel®. Among the tested chemical decontamination candidates, NuBone®Clean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBone®Clean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomised clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in implant dentistry

• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2023). The Reoccurring Issue of Peri-implantitis: What Have We Learned So Far? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(1), p. 15–17. Full text in Research Archive
• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2023). Implant Placement in Bony Defects of Variable Sizes. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(2), p. 215–217. Full text in Research Archive
• Chvartszaid, David; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). Implant care in frail, dependent, and institutionalized elders. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(4), p. 640–642. Full text in Research Archive
• Oates, Thomas; Ellingsen, Jan Eirik; Estafanous, Emad; Osswald, Martin; Chvartszaid, David & Stanford, Clark (2023). What guidance do we need? A look at the accuracy of guided surgical approaches to implant placement. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(3), p. 410–414. doi: 10.11607/jomi.2023.3.tar. Full text in Research Archive
• Ellingsen, Jan Eirik; Chvartszaid, David; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). The use of short dental implants: Where are we today? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(5), p. 842–846. Full text in Research Archive
• Chvartszaid, David; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). Socket shield technique: A new way to deal with an old problem. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(6), p. 1078–1082. Full text in Research Archive
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Tiainen, Hanna & Ellingsen, Jan Eirik (2023). The dose-dependent impact of γ-radiation reinforced with backscatter from titanium on primary human osteoblasts. Biomaterial Investigations in Dentistry. 10(1). doi: 10.1080/26415275.2023.2209116. Full text in Research Archive Show summary

  In head and neck cancer patients receiving dental implants prior to radiotherapy, backscatter from titanium increases the radiation dose close to the surface, and may affect the osseointegration. The dose-dependent effects of ionizing radiation on human osteoblasts (hOBs) were investigated. The hOBs were seeded on machined titanium, moderately rough fluoride-modified titanium, and tissue culture polystyrene, and cultured in growth- or osteoblastic differentiation medium (DM). The hOBs were exposed to ionizing γ-irradiation in single doses of 2, 6 or 10 Gy. Twenty-one days post-irradiation, cell nuclei and collagen production were quantified. Cytotoxicity and indicators of differentiation were measured and compared to unirradiated controls. Radiation with backscatter from titanium significantly reduced the number of hOBs but increased the alkaline phosphatase activity in both types of medium when adjusted to the relative cell number on day 21. Irradiated hOBs on the TiF-surface produced similar amounts of collagen as unirradiated controls when cultured in DM. The majority of osteogenic biomarkers significantly increased on day 21 when the hOBs had been exposed to 10 Gy, while the opposite or no effect was observed after lower doses. High doses reinforced with backscatter from titanium resulted in smaller but seemingly more differentiated subpopulations of osteoblasts.

• Thieu, Minh Khai Le; Stoetzel, Sabine; Rahmati, Maryam; Khassawna, Thaqif El; Verket, Anders & Sanz-Esporrin, Javier [Show all 9 contributors for this article] (2022). Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO<inf>2</inf> block or a xenogeneic graft in chronic alveolar defects. Clinical Implant Dentistry and Related Research. ISSN 1523-0899. doi: 10.1111/cid.13143. Full text in Research Archive Show summary

  Objectives To evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic non-contained bone defects using a non-resorbable TiO2 block. Material and methods Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomisation: TiO2 block: TiO2-scaffold and a collagen membrane, DBBM particulates: Deproteinised bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha smooth muscle actin (α-SMA), osteopontin, osteocalcin, tartrate-resistant acid phosphatase and collagen type I. Histomorphometry was performed on Movat Pentachrome and Von Kossa/Van Gieson stained sections. Stereolithographic models were used to compare alveolar profile changes. Results The percentage of α-SMA and osteopontin increased in TiO2 group after 12 weeks of healing at the bone-scaffold interface, while collagen type I increased in the empty control group. In the defect area, α-SMA decreased in the empty control group, while collagen type I increased in the DBBM group. All groups maintained alveolar profile from 4 to 12 weeks, but TiO2 group demonstrated the widest soft tissue contour profile. Conclusions The present findings suggested contact osteogenesis when GBR is performed with a TiO2 block or DBBM particulates. The increase in osteopontin indicated a potential for bone formation beyond 12 weeks. The alveolar profile data indicated a sustained lateral increase in lateral bone augmentation using a TiO2 block and a collagen membrane, as compared to DBBM and a collagen membrane or a collagen membrane alone.

• Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W.; Chvartszaid, David & Stanford, Clark M. (2022). Dental Implant Success: Systematic Reviews and Clinical Outcomes. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(2), p. 231–234. Full text in Research Archive
• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2022). Strategies for the Treatment of Peri-implantitis—Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(4), p. 634–637. Full text in Research Archive
• Stanford, Clark M.; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad W.; Oates, Thomas W. & Osswald, Martin (2022). Zirconia Implants—A 2022 Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(1), p. 16–18. Full text in Research Archive
• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2022). What’s Happening in the Nanoverse? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(5), p. 855–857. Full text in Research Archive
• Osswald, Martin; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2021). Digital Planning and Surgical Guidance: Planning Perfection, Achieving Excellence. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 366(5), p. 847–849. Full text in Research Archive
• Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2021). Use of zygoma-anchored implants for oral rehabilitation. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(2), p. 213–217. Full text in Research Archive
• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2021). Single Implants in the Anterior Maxilla. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(6), p. 1058–1063. Full text in Research Archive
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Osswald, Martin [Show all 7 contributors for this article] (2021). It’s a Brave New World: How Should We Use Antibiotics? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(3), p. 417–421. Full text in Research Archive
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2021). The implant-supported dental fixed prosthesis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(1), p. 15–19. Full text in Research Archive
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2021). Short Implants: Documentation for Clinical Use in Rehabilitation of Edentulous Posterior Arches. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(4), p. 625–630. Full text in Research Archive
• Thieu, Minh Khai Le; Homayouni, Amin; Hæren, Lena Ringsby; Tiainen, Hanna; Verket, Anders & Ellingsen, Jan Eirik [Show all 13 contributors for this article] (2021). Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomaterials Research. ISSN 1226-4601. 25(43). doi: 10.1186/s40824-021-00245-3. Full text in Research Archive Show summary

  Background Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthetic TiO2 block scaffold was placed in circumferential peri-implant defects with buccal fenestrations. Methods The mandibular premolars were extracted and the alveolar bone left to heal for 4 weeks prior to implant placement in six minipigs. Two cylindrical defects were created in each hemi-mandible and were subsequent to implant placement allocated to treatment with either TiO2 scaffold or sham in a split mouth design. After 12 weeks of healing time, the samples were harvested. Microcomputed tomography (MicroCT) was used to investigate defect fill and integrity of the block scaffold. Distances from implant to bone in vertical and horizontal directions, percentage of bone to implant contact and defect fill were analysed by histology. Results MicroCT analysis demonstrated no differences between the groups for defect fill. Three of twelve scaffolds were partly fractured. At the buccal sites, histomorphometric analysis demonstrated higher bone fraction, higher percentage bone to implant contact and shorter distance from implant top to bone 0.5 mm lateral to implant surface in sham group as compared to the TiO2 group. Conclusions This study demonstrated less bone formation with the use of TiO2 scaffold block in combination with implant placement in cylindrical defects with buccal bone fenestrations, as compared to sham sites.

• Osswald, Martin; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2020). "The lucky fibula 2.0". International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(5), p. 875–877. Full text in Research Archive
• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2020). Dental student implant education. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(6), p. 1072–1075. Full text in Research Archive
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Estafanous, Emad & Osswald, Martin [Show all 7 contributors for this article] (2020). Enhancing Implant Stability with Osseodensification: Remember That Biology Happens! International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(3), p. 457–460. Full text in Research Archive
• Huynh-Ba, Guy; Estafanous, Emad; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin & Chvartszaid, David [Show all 7 contributors for this article] (2020). Antibiotics and Implant Therapy Revisited. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(2), p. 244–247. Full text in Research Archive
• Estafanous, Emad; Chvartszaid, David; Ellingsen, Jan Eirik; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2020). Effect of Medications/Chemotherapy on Osseointegration. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(1), p. 15–21. Full text in Research Archive
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2020). Impact of Tobacco Smoking on Peri-implantitis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(4), p. 671–673. Full text in Research Archive
• Skjerven, Henrik; Olsen-Bergem, Heming; Rønold, Hans Jacob; Riis, Ulf Harald & Ellingsen, Jan Eirik (2019). Comparison of postoperative intraoral scan versus cone beam computerised tomography to measure accuracy of guided implant placement—A prospective clinical study. Clinical Oral Implants Research. ISSN 0905-7161. 30(6), p. 531–541. doi: 10.1111/clr.13438. Full text in Research Archive
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Osswald, Martin [Show all 7 contributors for this article] (2019). Understanding the Role of Titanium Particles and Corrosion in Peri-implantitis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(3), p. 561–564. Full text in Research Archive
• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2019). Oral Implants Made of Zirconia: An Update for 2019. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(2), p. 307–310. Full text in Research Archive
• Sanz, Mariano; Dahlin, Christer; Apatzidou, Danae; Artzi, Zvi; Bozic, Darco & Calciolari, Elena [Show all 19 contributors for this article] (2019). Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology. ISSN 0303-6979. 46(21), p. 82–91. doi: 10.1111/jcpe.13123. Full text in Research Archive Show summary

  Background and Aims To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies. Material and Methods Four background review publications served to elaborate this consensus report. Results and Conclusions Biomaterials used as bone grafts must meet specific requirements: biocompatibility, porosity, osteoconductivity, osteoinductivity, surface properties, biodegradability, mechanical properties, angiogenicity, handling and manufacturing processes. Currently used biomaterials have demonstrated advantages and limitations based on the fulfilment of these requirements. Similarly, membranes for guided bone regeneration (GBR ) must fulfil specific properties and potential biological mechanisms to improve their clinical applicability. Pre‐clinical and clinical studies have evaluated the added effect of bone morphogenetic proteins (mainly BMP ‐2) and autologous platelet concentrates (APC s) when used as bioactive agents to enhance bone regeneration. Three main approaches using cell therapies to enhance bone regeneration have been evaluated: (a) “minimally manipulated” whole tissue fractions; (b) ex vivo expanded “uncommitted” stem/progenitor cells; and (c) ex vivo expanded “committed” bone‐/periosteum‐derived cells. Based on the evidence from clinical trials, transplantation of cells, most commonly whole bone marrow aspirates (BMA ) or bone marrow aspirate concentrations (BMAC ), in combination with biomaterial scaffolds has demonstrated an additional effect in sinus augmentation and horizontal ridge augmentation, and comparable bone regeneration to autogenous bone in alveolar cleft repair.

• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2019). Factors Associated with Oral Implant Failures. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(1), p. 17–21. Full text in Research Archive
• Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein; Rinna, Alessandra; Ellingsen, Jan Eirik & Reseland, Janne Elin (2019). Hydrofluoric acid treatment of titanium surfaces enhance the proliferation of human gingival fibroblasts. Journal of Tissue Engineering. 10. doi: 10.1177/2041731419828950. Full text in Research Archive Show summary

  The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts (HGF). HGF cells were exposed to hydrofluoric acid (HF) modified Ti coins (Ti-F) for 1, 3, 7, 14 and 21d, and untreated coins were used as controls. A 5-6 fold increase in the proliferation of HGF on Ti-F compared to Ti surfaces was observed. Enhanced gene expression of IL-6 and OPG was found at 7 d. Increased levels of sclerostin, IL- 6 and OPG in the media from HGF cultured on Ti-F coins were found compared to controls. Our results confirm that HF modified surface may indirectly enhance the firm attachment of implant surface to junction epithelium, soft tissue epithelium, which would give protection for underlying osseous structures making osseointegration of the dental implant possible.

• Skjerven, Henrik; Riis, Ulf Harald; Herlofson, Bente Brokstad & Ellingsen, Jan Eirik (2019). In Vivo Accuracy of Implant Placement Using a Full Digital Planning Modality and Stereolithographic Guides. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(1), p. 124–132. doi: 10.11607/JOMI.6939. Full text in Research Archive
• Ellingsen, Jan Eirik; Stanford, Clark; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2019). Ceramic Implant-Supported Single Crowns and Fixed Dental Prostheses: A Real Alternative to Metal-Ceramic? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(4), p. 804–808. Full text in Research Archive
• Stanford, Clark M.; Estafanous, Emad W.; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Huynh-Ba, Guy [Show all 7 contributors for this article] (2019). THEMATIC. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(1), p. 17–21. Full text in Research Archive
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences. ISSN 0909-8836. 127(6), p. 500–507. doi: 10.1111/eos.12654. Full text in Research Archive Show summary

  Radiotherapy to the head and neck region negatively influences the osseointegration and survival of dental implants. The effects of cobalt 60 (60Co) ionizing radiation and the impact of backscatter rays were investigated on human mesenchymal stem cells cultured on titanium surfaces. Bone marrow‐derived human mesenchymal stem cells were seeded on titanium (Ti), fluoride‐modified titanium (TiF), and tissue culture plastic. Cells were exposed to ionizing γ ‐radiation in single doses of 2, 6, or 10 Gy using a 60Co source. Density and distribution of cells were evaluated using confocal laser‐scanning microscopy, 21 d post‐irradiation. Lactate dehydrogenase concentration and the levels of total protein and cytokines/chemokines were measured in the cell‐culture medium on days 1, 3, 7, 14, and 21 post‐irradiation. Unirradiated cells were used as the control. Irradiation had no effect on cell viability, collagen and actin expression, or cell distribution, but induced an initial increase in the secretion of interleukin (IL )‐6, IL ‐8, monocyte chemotactic protein 1 (MCP ‐1), and vascular endothelial growth factor (VEGF ), followed by a decrease in secretion after 3 or 7 d. Irradiation resulted in secretion of a lower amount of all analytes examined compared with controls on day 21, irrespective of radiation dose and growth surface. Backscattering from titanium did not influence the cell response significantly, suggesting a clinical potential for achieving successful osseointegration of dental implants placed before radiotherapy.

• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2018). Complications With Zygomatic Implant Treatment. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(6), p. 1193–1197. Full text in Research Archive
• Sailer, Irena; Muhlemann, Sven; Kohal, Ralf J.; Spies, Benedikt C.; Pjetursson, Bjarni E. & Lang, Niklaus P. [Show all 15 contributors for this article] (2018). Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018. Clinical Oral Implants Research. ISSN 0905-7161. 29(Oct), p. 239–242. doi: 10.1111/clr.13302. Full text in Research Archive Show summary

  Objectives: The tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all‐ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions. Methods: Four reviews were available analyzing the current literature on the respective topics. One review dealt with the efficiency and efficacy of digital and conventional fabrication workflows. Two reviews analyzed the outcomes of all‐ceramic fixed implant reconstructions, one focusing on single‐implant reconstructions and the other evaluating multiple‐unit implant fixed dental prostheses (FDPs). The fourth review evaluated the clinical outcome on external, respectively, internal implant‐abutment connections. These reviews were the basis for the discussions within the group and at the plenary sessions. Results: The present consensus report gives the consensus statements, the clinical recommendations, and the implications for future research as discussed and approved by the plenum of the consensus conference. The four manuscripts by Mühlemann et al., Rabel et al., Pieralli et al., and Pjetursson et al. are published as part of the journal supplement of the present EAO consensus conference.

• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2018). Considerations for Implant-Supported Cemented Restorations. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(2), p. 253–256. Full text in Research Archive
• Stanford, Clark; Chvartszaid, David; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Oates, Thomas & Estafanous, Emad [Show all 7 contributors for this article] (2018). Implant-Retained Removable Partial Dentures: A Reliable Alternative Line of Treatment. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(1), p. 17–20. Full text in Research Archive
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Osswald, Martin [Show all 7 contributors for this article] (2018). The Implant-Abutment-Soft Tissue Interface: Change is Hard! International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(3), p. 497–500. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2018). Use of Oral Implants for Cancer Reconstruction: The Role of the Approach to Vascular Flaps in Implant Outcomes. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(5), p. 959–961. Full text in Research Archive
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Show all 7 contributors for this article] (2018). Dental Implant Treatment of Atrophic Arches With or Without Augmentation. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(4), p. 735–739. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2017). Challenging paradigms: Update on the use of dental implant therapy for patients With diabetes mellitus. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(3), p. 477–479. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2017). Dental Implants in the Posterior Mandible: Complications and Management. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(1), p. 20–22. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2017). Immediate Implant Placement and Restoration: An Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(2), p. 245–248. Full text in Research Archive
• Chvartszaid, David; Stanford, Clark; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2017). Implants and the Spectrum of Aging. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(5), p. 965–968. Full text in Research Archive
• Osswald, Martin; Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad & Huynh-Ba, Guy [Show all 7 contributors for this article] (2017). The Lucky Fibula. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(6), p. 1215–1217. Full text in Research Archive
• Ellingsen, Jan Eirik; Stanford, Clark; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2017). Implantoplasty: A Valuable Method for the Management of Peri-implantitis? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(4), p. 711–714. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2016). Do We Get Improved Precision of Implant Fixed Dental Prostheses with Digital Scanners and Computer-Aided Design/Computer-Assisted Manufacture? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(4), p. 743–747. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2016). Antibiotics and implant therapy. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(2), p. 273–277. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2016). Implant therapy: When are we helping Our patients? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(3), p. 513–515. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2016). The Jedi dark side of implant therapy? Peri implant disease(s: Recent updates on prevalence and etiology. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(1), p. 17–22. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2016). The Issue with Tissue: How to Treat Peri-implantitis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(5), p. 989–996. Full text in Research Archive
• Chvartszaid, David; Stanford, Clark; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2016). Implant Failure. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(6), p. 1233–1236. Full text in Research Archive
• Verket, Anders; Müller, Benjamin; Wohlfahrt, Johan Caspar; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein [Show all 7 contributors for this article] (2016). TiO2 scaffolds in peri-implant dehiscence defects: an experimental pilot study. Clinical Oral Implants Research. ISSN 0905-7161. 27(10), p. 1200–1206. doi: 10.1111/clr.12725. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2015). Update: Diabetes mellitus and outcomes of oral implant therapy. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 30(1), p. 17–19. doi: 10.11607/jomi.2015.1.tar. Full text in Research Archive
• Xing, Rui; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik; Taxt-Lamolle, Sebastien Francis Michel & Haugen, Håvard Jostein (2015). The influence of surface nanoroughness, texture and chemistry of TiZr implant abutment on oral biofilm accumulation. Clinical Oral Implants Research. ISSN 0905-7161. 26(6), p. 649–656. doi: 10.1111/clr.12354. Full text in Research Archive Show summary

  Objectives The aim of the study was to examine surface nanoroughness, texture and chemistry of dental implant abutment and to investigate how these parameters influence oral biofilm formation in healthy subjects. Materials and methods Eight different nanorough TiZr surfaces were produced by polishing, machining, cathodic polarization and acid etching. Surface topography was examined using field emission scanning electron microscope and a blue light laser profilometer. Surface chemistry was analyzed by secondary ion mass spectrometry and X-ray photoelectron spectroscopy. Surface hydrophilicity was tested by measuring contact angle on the surfaces. A human in vivo study using a splint model was employed to evaluate oral biofilm accumulation on these surfaces. Results Different surface textures (flat, grooved and irregular) were created with nanoroughness from 29 to 214 nm. Some test surfaces were incorporated with hydrogen by cathodic polarization and/or acid etching with HCl/H2SO4. Nanoroughness (Sa) positively correlated with microbial adhesion. Biofilm accumulation was less pronounced on flat and grooved than on irregular surfaces. No significant association between hydrogen content or hydrophilicity of the surface and biofilm accumulation was observed. Conclusions Nanoroughness (< 214 nm) and surface texture influence oral biofilm accumulation independent of surface chemistry and hydrophilicity. Surface hydrogen, which has previously been shown to promote fibroblast growth, does not affect biofilm formation

• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2015). Understanding Peri-implantitis Through the Lens of the Oral Microbiome. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 30(3), p. 503–506. Full text in Research Archive
• Osswald, Martin; Stanford, Clark; Estafanous, Emad; Oates, Thomas; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2015). Nanotechnology and Oral Implants: An Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 30(5), p. 995–997. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2015). Crown-to-Implant Ration: What is the latest? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 30(2), p. 259–261. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Ellingsen, Jan Eirik; Osswald, Martin; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2015). Radiotherapy and Oral Implants. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 30(4), p. 745–747. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Ellingsen, Jan Eirik; Osswald, Martin; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2014). Do implants really help? A look at how implants enhance the quality of life of our patients. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29, p. 542–545. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Ellingsen, Jan Eirik; Osswald, Martin; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2014). "All-on-four": Where are we now? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29(2), p. 285–288. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2014). Dental implants and a rising demand to immediately improve patient`s oral function and esthetics: Is Research conclusive? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29(6), p. 1254–1258. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Ellingsen, Jan Eirik; Osswald, Martin; Huynh-Ba, Guy & Oates, Thomas [Show all 7 contributors for this article] (2014). ORONet and an approach to understanding patient-oriented outcomes relative to oral implant therapy. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29, p. 25–27. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2014). Dental implants are contraindicated in... International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29(5), p. 1024–1027. Full text in Research Archive
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Show all 7 contributors for this article] (2014). Zirconia oral implants - Do we have scientific documentation for general clinical use? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 29(4), p. 777–780. Full text in Research Archive
• Pham, Thi Ngoc Maria Huong; Landin, Maria Augusta Dos S Silva; Tiainen, Hanna; Reseland, Janne Elin; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2014). The effect of hydrofluoric acid treatment of titanium and titanium dioxide surface on primary human osteoblasts. Clinical Oral Implants Research. ISSN 0905-7161. 25(3), p. 385–394. doi: 10.1111/clr.12150. Full text in Research Archive Show summary

  Abstract Objective The aim of the study was to investigate solely the effect of fluoride on the surface chemistry of polycrystalline ceramic titanium dioxide (TiO2) and metallic titanium (Ti) and its effect on proliferation and differentiation of primary human osteoblasts (NHO). Materials and methods The NHO cells were exposed to fluoride-modified and unmodified samples for 1, 3, 7, 14 and 21 days. The fluoride effect on the mRNA expression was quantified and measured. The secretion of cytokines and interleukins in the cell culture medium was measured by Luminex, gene expression by RT-PCR, and compared with untreated controls. The effect on cell growth after 1 and 3 days in culture was measured using [3H]-thymidine incorporation. Fluoride release was measured using an ion-selective electrode. The surfaces were examined by X-ray photoelectron spectroscopy and profilometry. Results The fluoride release study detected that fluoride content easily washed off in TiO2 coins when compared with Ti coins. No increase in cell proliferation was found among fluoride-modified TiO2 surfaces compared with controls, except for washed Ti coins with fluoride modification. The cell differentiation with regard to gene expression showed no significant differences in both fluoride-modified and unmodified samples and less effect on protein release for all groups. Conclusions The fluoride from hydrofluoric acid treatment on Ti and TiO2 surfaces gave no specific effect on primary human osteoblast cells. The study indicates that the released fluoride is not the unique factor for the bioactivity of Ti and TiO2 surfaces.

• Ellingsen, Jan Eirik; Stanford, Clark; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Estafanous, Emad (2013). Short implants - a valuable alternative in patients With reduced bone height? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 28(4), p. 950–953. Full text in Research Archive
• Oates, Thomas; Stanford, Clark; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Osswald, Martin & Estafanous, Emad (2013). Bisphosphonates: A hindrance or a help? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 28(3), p. 655–657. Full text in Research Archive
• Oates, Thomas; Stanford, Clark; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Osswald, Martin & Estafanous, Emad (2013). Peri-implantitis: "Tsunami" or Marginal Problem? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 28(2), p. 333–337. Full text in Research Archive
• Stanford, Clark; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas & Osswald, Martin (2013). Mini-implants and overdenture therapy? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 28(1), p. 25–27. Full text in Research Archive

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• Lauretis, Angela de; Santacroce, Marco; Hussain, Badra; Ma, Qianli; Ellingsen, Jan Eirik & Lyngstadaas, Ståle Petter [Show all 8 contributors for this article] (2025). A poloxamer-peroxide forumulation effectively removes pellicle and limits recontamination. Full text in Research Archive
• Lauretis, Angela de; Hussain, Badra; Ma, Qianli; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2024). A comparative evaluation of chemical decontamination products on the cleanliness of dental implant surfaces using a dental pellicle model. Full text in Research Archive Show summary

  Dental implants are widely employed for tooth replacement, but complications such as peri-implant infections may arise due to bacterial adhesion and biofilm formation, facilitated by the protein-rich salivary pellicle formed on the implant surface. Ensuring the cleanliness of the implant surface is crucial for long-term success and maintenance of peri-implant health.

• Lauretis, Angela de; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2024). Decontamination dental implant surfaces using a dental pellicle mode. Full text in Research Archive
• Lauretis, Angela De; Hussain, Badra; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2024). A comparative evaluation of chemical decontamination products on the cleanliness of dental implant surfaces using a dental pellicle model. Full text in Research Archive
• Hussain, Badra; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2024). A Comparative Investigation Of Chemical Decontamination Methods For In Situ Cleaning Of Dental Implant Surfaces. Full text in Research Archive
• Pham, Thi Ngoc Maria Huong; Rinna, Alessandra; Ellingsen, Jan Eirik; Haugen, Håvard Jostein & Reseland, Janne Elin (2015). Enhanced In Vitro HGF Proliferation and Differentiation on Surface Modified Hydrofluoric Acid treated TiO₂. Full text in Research Archive
• Ellingsen, Jan Eirik; Monjo, Marta & Ramis, Joana Maria (2015). Development of a novel fluoride-modified implant surface for clinical use. In Wennerberg, Ann; Albrektsson, Tomas & Jimbo, Ryo (Ed.), Implant surfaces and their biological and clinical impact. Springer. ISSN 9783662453780. p. 45–64. doi: 10.1007/78-3-662-45379-7. Full text in Research Archive
• Rønold, Hans Jacob; Saxegaard, Erik & Ellingsen, Jan Eirik (2015). Hvordan sikre en god start på en vellykket tannbehandling? Den norske tannlegeforenings Tidende. ISSN 0029-2303. 125(2), p. 162–167. Full text in Research Archive
• Grytten, Jostein Ivar; Aass, Anne Merete; Lyngstadaas, Ståle Petter; Brodin, Pål; Ellingsen, Jan Eirik & Barkvoll, Pål (2015). Kompetansesentrenes forsvarsskrift - en korreksjon til deres realitetsorientering. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 125(5), p. 459–462. Full text in Research Archive
• Pham, Thi Ngoc Maria Huong; Rinna, Alessandra; Haugen, Håvard Jostein; Ellingsen, Jan Eirik & Reseland, Janne Elin (2015). Enhanced In Vitro HGF Proliferation and Differentiation on Surface Modified Hydrofluoric Acid treated TiO₂. Full text in Research Archive
• Ellingsen, Jan Eirik (2014). Development and performance of the Osseospeed dental implant. Full text in Research Archive
• Ellingsen, Jan Eirik (2014). Development and performance of the Osseospeed dental implant. Full text in Research Archive
• Ellingsen, Jan Eirik (2014). Development and performance of the Osseospeed Dental Implant. Full text in Research Archive
• Skjerven, Henrik; Herlofson, Bente Brokstad; Wohlfahrt, Johan Caspar; Rønold, Hans Jacob & Ellingsen, Jan Eirik (2014). Evaluation of the Precision of implant placement using stereolithographic guides. Full text in Research Archive

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