The effect of fluoride modified TiO2 scaffolds on bone cells and in vivo bone regeneration (completed)
About the project
In the present project titanium dioxide (TiO2) has been chosen as bone- graft substitute material. This material has proven to fulfil many of the demands for a bone- graft substitute material. TiO2 has shown to be biocompatible, enhance bone and vascular ingrowth and to have a certain degree of bacteriostatic effect. One of the major obstacles with a bone- graft substitute is its function as load bearing device, so also with TiO2 bone- graft substitutes.
However, initial testing in our laboratory with the so- called polymer sponge method has shown that it is possible to produce porous structures with this material, where porous bone- graft materials have had compressive strength above 2 MPa. We are interested in the effect of fluoride modified TiO2 scaffolds on bone cells and in vivo bone regeneration.