Satar Yousefiasl

• Seyedhamzeh, Mohammad; Falahi, Farzaneh; Kalantari-Hesari, Ali; Esmaeilzadeh, Kimia; Salarilak, Laleh & Bagheri, Hadi [Show all 11 contributors for this article] (2026). A novel copper-based nanosystem for augmented breast cancer photothermal and chemodynamic therapy. RSC Advances. 16(3), p. 2178–2178. doi: 10.1039/d5ra08100a. Full text in Research Archive Show summary

  This work develops and characterizes copper-cysteine nanoparticles as a multifunctional nanoplatform combining photothermal therapy and chemodynamic therapy to ablates primary tumors and inhibit metastatic breast cancer cells in tumor-bearing mice.

• Azizi, Rezvaneh; Kermanian, Mehraneh; Alinezhad, Vajihe; Kalantari-Hesari, Ali; Yousefiasl, Satar & Maeso, Lidia [Show all 12 contributors for this article] (2025). An intelligent ZIF-based nanoplatform for photothermal/chemodynamic-induced combination therapy with O2 evolution properties for improved infected wound regeneration. Journal of materials chemistry. B. ISSN 2050-750X. 13(30), p. 9242–9242. doi: 10.1039/d5tb00934k. Full text in Research Archive Show summary

  A multifunctional ZIF-based nanosystem incorporating Cu ions and a phytosterol showed excellent antibacterial and photothermal activities, making it a promising wound healing candidate.

• Yousefiasl, Satar; Ghovvati, Mahsa; Mirshafiei, Mojdeh; Hakimi, Fatemeh; Azadi, Amir & Moezzi, Seyed Mohammad Iman [Show all 11 contributors for this article] (2025). Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy. Coordination chemistry reviews. ISSN 0010-8545. 522, p. 216207–216207. doi: 10.1016/j.ccr.2024.216207. Full text in Research Archive
• Yousefiasl, Satar; Ghovvati, Mahsa; Alibakhshi, Abbas; Azizi, Mehdi; Samadi, Pouria & Kumar, Arun [Show all 12 contributors for this article] (2025). Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation. Small. ISSN 1613-6810. 21(7). doi: 10.1002/smll.202408898. Full text in Research Archive Show summary

  Abstract In cancer research and personalized medicine, mesoporous silica nanoparticles (MSNs) have emerged as a significant breakthrough in both cancer treatment and diagnosis. MSNs offer targeted drug delivery, enhancing therapeutic effectiveness while minimizing adverse effects on healthy cells. Due to their unique characteristics, MSNs provide targeted drug delivery, maximizing therapeutic effectiveness with minimal adverse effects on healthy cells. The review thoroughly investigates the role of MSNs as potent drug carriers, noted for their high drug‐loading capacity and controlled release, which significantly improves drug permeability and retention. Additionally, it discusses surface modification techniques that enable MSNs to target cancer cells precisely. The manuscript provides comprehensive insights into various MSN applications, including their role in cancer diagnosis, the design of advanced biosensors, and the development of both conventional and stimuli‐responsive drug delivery platforms. Special focus is given to stimuli‐triggered MSN systems, responsive to internal stimuli (e.g., pH, redox, enzyme) and external stimuli (e.g., temperature, magnetic field, light, ultrasound), highlighting the cutting‐edge progress in MSN technology. Additionally, the review delves into the immunogenicity and biosafety aspects of MSNs, underscoring their potential for clinical translation. Besides summarizing the current state of MSN research in oncology, this review also illuminates the path for future advancements and clinical applications.

• Sharifi, Esmaeel; Yousefiasl, Satar; Trovato, Maria; Sartorius, Rossella; Esmaeili, Yasaman & Goodarzi, Hamid [Show all 16 contributors for this article] (2023). Nanostructures for prevention, diagnosis, and treatment of viral respiratory infections: from influenza virus to SARS-CoV-2 variants. Journal of Nanobiotechnology. 21(1). doi: 10.1186/s12951-023-01938-8. Full text in Research Archive Show summary

  Abstract Viruses are a major cause of mortality and socio-economic downfall despite the plethora of biopharmaceuticals designed for their eradication. Conventional antiviral therapies are often ineffective. Live-attenuated vaccines can pose a safety risk due to the possibility of pathogen reversion, whereas inactivated viral vaccines and subunit vaccines do not generate robust and sustained immune responses. Recent studies have demonstrated the potential of strategies that combine nanotechnology concepts with the diagnosis, prevention, and treatment of viral infectious diseases. The present review provides a comprehensive introduction to the different strains of viruses involved in respiratory diseases and presents an overview of recent advances in the diagnosis and treatment of viral infections based on nanotechnology concepts and applications. Discussions in diagnostic/therapeutic nanotechnology-based approaches will be focused on H1N1 influenza, respiratory syncytial virus, human parainfluenza virus type 3 infections, as well as COVID-19 infections caused by the SARS-CoV-2 virus Delta variant and new emerging Omicron variant. Graphical Abstract

• Sharifi, Esmaeel; Yousefiasl, Satar; Laderian, Nilofar; Rabiee, Navid; Makvandi, Pooyan & Pourmotabed, Samiramis [Show all 9 contributors for this article] (2023). Cell-loaded genipin cross-linked collagen/gelatin skin substitute adorned with zinc-doped bioactive glass-ceramic for cutaneous wound regeneration. International Journal of Biological Macromolecules. ISSN 0141-8130. 251, p. 125898–125898. doi: 10.1016/j.ijbiomac.2023.125898. Full text in Research Archive
• Sharifi, Esmaeel; Reisi, Fatemeh; Yousefiasl, Satar; Elahian, Fatemeh; Barjui, Shahrbanou Parchami & Sartorius, Rossella [Show all 19 contributors for this article] (2023). Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluation. Advanced Composites and Hybrid Materials. ISSN 2522-0128. 6(6). doi: 10.1007/s42114-023-00768-4. Full text in Research Archive Show summary

  Abstract Cancer, as the leading cause of death worldwide, has been constantly increasing in mortality every year. Among several therapeutics, nanoscale compounds showed promising results in overcoming cancer diseases. There are numerous types of research on the paramagnetic nanoparticles of iron oxide, which cause apoptosis and cancer cell death. In this study, cobalt/zinc/ferrite nanoferrofluid composites (~ 39 nm) were synthesized and decorated with chitosan to enhance the cell entry for potential applications in cancer therapy. The neat and chitosan-adorned cobalt zinc ferrite nanoferrofluid composites (~ 94 nm) displayed superparamagnetic properties. The nanocomposite exhibited anti-cancer activity against WEHI164 cancer cells in a dose- and time-dependent manner. The chitosan-coated nanocomposite was found to induce oxidative stress in WEHI164 cancer cells, as indicated by reactive oxygen species (ROS) production. Furthermore, DNA damage was indicated in WEHI164 cancer cells after exposure to chitosan-coated nanocomposites. Chitosan-coated nanocomposites promoted dendritic cell maturation by inducing the release of interleukin-6 proinflammatory cytokines. According to the results and ancillary studies, superparamagnetic nanoparticles coated with chitosan can be considered an effective and promising treatment for the destruction of cancer cells. Graphical Abstract Summary: Chitosan decorated cobalt zinc ferrite nanoferrofluid composites was fabricated for potential cancer hyperthermia therapy with high biocompatibility.

• Shao, Minmin; Bigham, Ashkan; Yousefiasl, Satar; Yiu, Cynthia K. Y.; Girish, Yarabahally R. & Ghomi, Matineh [Show all 17 contributors for this article] (2023). Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect. Small. ISSN 1613-6810. 19(19). doi: 10.1002/smll.202207057. Full text in Research Archive Show summary

  Abstract Oxidative damage and infection can prevent or delay tissue repair. Moreover, infection reinforces reactive oxygen species (ROS) formation, which makes the wound's condition even worse. Therefore, the need for antioxidant and antibacterial agents is felt for tissue regeneration. There are emerging up‐and‐coming biomaterials that recapitulate both properties into a package, offering an effective solution to turn the wound back into a healing state. In this article, the principles of antioxidant and antibacterial activity are summarized. The review starts with biological aspects, getting the readers to familiarize themselves with tissue barriers against infection. This is followed by the chemistry and mechanism of action of antioxidant and antibacterial materials (dual function). Eventually, the outlook and challenges are underlined to provide where the dual‐function biomaterials are and where they are going in the future. It is expected that the present article inspires the designing of dual‐function biomaterials to more advanced levels by providing the fundamentals and comparative points of view and paving the clinical way for these materials.

• Yuan, Meng; Kermanian, Mehraneh; Agarwal, Tarun; Yang, Zhuang; Yousefiasl, Satar & Cheng, Ziyong [Show all 9 contributors for this article] (2023). Defect Engineering in Biomedical Sciences. Advanced Materials. ISSN 0935-9648. 35(38). doi: 10.1002/adma.202304176. Full text in Research Archive Show summary

  Abstract With the promotion of nanochemistry research, large numbers of nanomaterials have been applied in vivo to produce desirable cytotoxic substances in response to endogenous or exogenous stimuli for achieving disease‐specific therapy. However, the performance of nanomaterials is a critical issue that is difficult to improve and optimize under biological conditions. Defect‐engineered nanoparticles have become the most researched hot materials in biomedical applications recently due to their excellent physicochemical properties, such as optical properties and redox reaction capabilities. Importantly, the properties of nanomaterials can be easily adjusted by regulating the type and concentration of defects in the nanoparticles without requiring other complex designs. Therefore, this tutorial review focuses on biomedical defect engineering and briefly discusses defect classification, introduction strategies, and characterization techniques. Several representative defective nanomaterials are especially discussed in order to reveal the relationship between defects and properties. A series of disease treatment strategies based on defective engineered nanomaterials are summarized. By summarizing the design and application of defective engineered nanomaterials, a simple but effective methodology is provided for researchers to design and improve the therapeutic effects of nanomaterial‐based therapeutic platforms from a materials science perspective.

• Shao, Minmin; Lopes, Daniela; Lopes, Joana; Yousefiasl, Satar; Macário-Soares, Ana & Peixoto, Diana [Show all 13 contributors for this article] (2023). Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy. Matter. ISSN 2590-2393. 6(3), p. 799–799. doi: 10.1016/j.matt.2023.01.012. Full text in Research Archive
• Yousefiasl, Satar; Manoochehri, Hamed & Sharifi, Esmaeel (2023). Strontium‐doped mesoporous silica nanoparticles incorporated in chitosan/alginate biocomposite scaffolds for enhanced bone tissue regeneration. Polymers for Advanced Technologies. ISSN 1042-7147. 34(7), p. 2334–2334. doi: 10.1002/pat.6053. Full text in Research Archive Show summary

  Abstract Critical‐sized bone damage resulting from traumas, fractures, and tumors, impairs the bone tissues' inherent capacity for self‐repair. Conventional therapies could be associated with infection and pain besides demanding additional surgery while being costly. These limitations highlight the paucity of potential unique treatment strategies such as bone tissue engineering. In this study, strontium‐doped mesoporous silica nanoparticles (Sr‐MSN) were successfully synthesized and incorporated into the chitosan/alginate scaffolds which were then freeze‐dried and cross‐linked using CaCl 2 . The physicochemical characteristics of the fabricated scaffolds containing various Sr‐MSN contents were investigated using Fourier‐transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS). The hydrolytic degradation of the scaffolds was decreased with the increase in the Sr‐MSN content while maintaining their water uptake capacity. All fabricated scaffolds showed biocompatibility and Sr‐MSN‐containing scaffolds showed significantly increased Bone marrow mesenchymal stem cells (BMSCs) cell viability compared to chitosan/alginate scaffold after 72 h. The osteogenic differentiation potential investigations via mineralization assay and alkaline phosphatase enzyme activity indicated that the chitosan/alginate scaffold containing 20% Sr‐MSN showed the highest osteogenic differentiation capacity. Overall, bionanocomposite Cs/Alg/Sr‐MSN scaffolds integrated with desired physicochemical characteristics, biocompatibility, osteogenic differentiation capacity, and drug delivery potential show promising properties for attaining ideal results for bone repair and regeneration applications.

• Sharma, Preety; Kumar, Arun; Agarwal, Tarun; Dey, Asmita Deka; Moghaddam, Farnaz Dabbagh & Rahimmanesh, ILNAZ [Show all 13 contributors for this article] (2022). Nucleic acid-based therapeutics for dermal wound healing. International Journal of Biological Macromolecules. ISSN 0141-8130. 220, p. 933–933. doi: 10.1016/j.ijbiomac.2022.08.099. Full text in Research Archive
• Dey, Asmita Deka; Yousefiasl, Satar; Kumar, Arun; Moghaddam, Farnaz Dabbagh; Rahimmanesh, Ilnaz & Samandari, Mohamadmahdi [Show all 14 contributors for this article] (2022). <scp>miRNA</scp>‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers. Bioengineering & Translational Medicine. 8(1). doi: 10.1002/btm2.10343. Full text in Research Archive Show summary

  Abstract MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II‐derived noncoding RNAs act through post‐transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under‐healing or over‐healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA‐based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA‐based wound healing. Finally, challenges and opportunities for translation of miRNA‐based strategies into clinical applications are discussed.

• Ghasemii, Kousar; Darroudi, Mahdieh; Rahimmanesh, Ilnaz; Ghomi, Matineh; Hassanpour, Mahnaz & Sharifi, Esmaeel [Show all 13 contributors for this article] (2022). Advances in aptamer-based drug delivery vehicles for cancer therapy. Biomaterials Advances. ISSN 2772-9516. 140, p. 213077–213077. doi: 10.1016/j.bioadv.2022.213077. Full text in Research Archive
• Hajebi, Sakineh; Yousefiasl, Satar; Rahimmanesh, Ilnaz; Dahim, Alireza; Ahmadi, Sepideh & Kadumudi, Firoz Babu [Show all 16 contributors for this article] (2022). Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications. Advanced Healthcare Materials. ISSN 2192-2640. 11(20). doi: 10.1002/adhm.202201583. Full text in Research Archive Show summary

  Abstract Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a variety of biomedical applications such as therapeutics delivery, cancer therapy, and tissue engineering. Physiochemical nanoparticle assembly techniques involve the application of solvents and potentially harmful chemicals, commonly at high temperatures. Genetically engineered organisms have the potential to be used as promising candidates for greener, efficient, and more adaptable platforms for the synthesis and assembly of nanomaterials. Genetically engineered carriers are precisely designed and constructed in shape and size, enabling precise control over drug attachment sites. The high accuracy of these novel advanced materials, biocompatibility, and stimuli‐responsiveness, elucidate their emerging application in controlled drug delivery. The current article represents the research progress in developing various genetically engineered carriers. Organic‐based nanoparticles including cellulose, collagen, silk‐like polymers, elastin‐like protein, silk‐elastin‐like protein, and inorganic‐based nanoparticles are discussed in detail. Afterward, viral‐based carriers are classified, and their potential for targeted therapeutics delivery is highlighted. Finally, the challenges and prospects of these delivery systems are concluded.

• Dey, Asmita Deka; Bigham, Ashkan; Esmaeili, Yasaman; Ashrafizadeh, Milad; Moghaddam, Farnaz Dabbagh & Tan, Shing Cheng [Show all 16 contributors for this article] (2022). Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy. Seminars in Cancer Biology. ISSN 1044-579X. 86, p. 419–419. doi: 10.1016/j.semcancer.2022.06.003. Full text in Research Archive
• Ferreira-Faria, Inês; Yousefiasl, Satar; Macário-Soares, Ana; Pereira-Silva, Miguel; Peixoto, Diana & Zafar, Hajra [Show all 15 contributors for this article] (2022). Stem cell membrane-coated abiotic nanomaterials for biomedical applications. Journal of Controlled Release. ISSN 0168-3659. 351, p. 197–197. doi: 10.1016/j.jconrel.2022.09.012. Full text in Research Archive
• Jalilinejad, Negin; Rabiee, Mohammad; Baheiraei, Nafiseh; Ghahremanzadeh, Ramin; Salarian, Reza & Rabiee, Navid [Show all 14 contributors for this article] (2022). Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering. Bioengineering & Translational Medicine. 8(1). doi: 10.1002/btm2.10347. Full text in Research Archive Show summary

  Abstract A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon‐based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of protecting cells in biological media against attacking mechanisms. Nevertheless, their advantages and shortcoming in view of cellular behavior, toxicity, and targeted delivery depend on the tissue in which they are implanted or being used as a scaffold. This review seeks to address, summarize, classify, conceptualize, and discuss the use of carbon‐based nanoparticles in cardiac tissue engineering emphasizing their conductivity. We considered electrical conductivity as a key affecting the regeneration of cells. Correspondingly, we reviewed conductive polymers used in tissue engineering and specifically in cardiac repair as key biomaterials with high efficiency. We comprehensively classified and discussed the advantages of using conductive biomaterials in cardiac tissue engineering. An overall review of the open literature on electroactive substrates including carbon‐based biomaterials over the last decade was provided, tabulated, and thoroughly discussed. The most commonly used conductive substrates comprising graphene, graphene oxide, carbon nanotubes, and carbon nanofibers in cardiac repair were studied.

• Abadehie, Fatemeh Saniee; Dehkordi, Ali Hasanpour; Zafari, Mahdi; Bagheri, Mitra; Yousefiasl, Satar & Pourmotabed, Samiramis [Show all 13 contributors for this article] (2021). Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing. Engineered Regeneration. 2, p. 226–226. doi: 10.1016/j.engreg.2022.01.001. Full text in Research Archive
• Sharifi, Esmaeel; Bigham, Ashkan; Yousefiasl, Satar; Trovato, Maria; Ghomi, Matineh & Esmaeili, Yasaman [Show all 24 contributors for this article] (2021). Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation. Advanced Science. 9(2). doi: 10.1002/advs.202102678. Full text in Research Archive Show summary

  Abstract Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy‐to‐functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli‐responsive nanoplatforms), and immunological profile of MBG‐based nanodevices in reference to the development of novel cancer therapeutics.

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