Zlatko Dembic

Professor - Molekylær
Image of Zlatko Dembic
Norwegian version of this page
Phone +47 22840330
Mobile phone 92228251
Room Rikshospitalet, A1.M051
Username
Visiting address Domus Odontologica Sognsvannsveien 10 0372
Postal address Postboks 1052 Blindern 0316 Oslo

Academic Interests

Molecular genetics

Group leader: Professor Zlatko Dembic, dr. Med.; Past members: Assoc. professor M. Wika, Randi Krogh Eftedal, dr. odont.

   We research the genes important for giving early signals to embryonic tissues during development to differentiate into structures in the craniofacial area comprising oral mucosa, salivary glands, teeth, bones, joints, tonsils, bone marrow and neural tissue. We also investigate genes that may predispose to various diseases of immunologic and inflammatory character and can lead to the development of chronic diseases or cancer later on in the life of an individual. We use case (disease) - control studies to determine markers' frequencies in genetic areas selected by educated guess or linked to craniofacial region by microchip expression profiling. We have recently investigated predisposing genetic factors in tuberculosis, breast and colon cancer, as well as primary osteoarthritis of large joints, including the temporomandibular joint. Genes of interest comprise various cytokine family members like interferon-gamma and interleukin-1 and Toll-like receptor families 1,2,3,4,6,7, and 9, which are important for early activating the specific (adaptive) immune responses.

Keywords: 1. DNA, 2. Immunogenetics, 3. Respiratory infection, 4. Epithelial cancer, 5. Joint inflammasjon (large joints), 6. Immunoregulation, 7. RT PCR

Teaching

Higher education and employment history

    As a scientist with a medical background, it's natural that my research interests are placed at the crossroads of medicine and biology. Since the earliest days of my lab career, I have been attracted to molecular and cellular immunology. The more I learned, the more my interest evolved toward studying ontogeny and phylogeny of the immune system. The reason was simple: I wished to understand its function, which is still my wish. During the last twenty years of the past century, I worked on important issues in immunology at the Max-Planck-Institute for Biology (Tubingen, Germany), the Basel Institute for Immunology (Switzerland; CH) and the Hoffman-La Roche AG (Basel, CH). We were the first to report the identification of genes underlying T-cell specificity and recognition (mouse T-cell receptor, in '86). Likewise, we led the research on molecular cloning of human cytokine receptors important for the effector phase of immunity, such as the interferon-gamma receptor (IFNGR1; in '88) and the tumor necrosis factor receptor-2 (TNFR2; in '90). 1995, I moved to the Institute of Immunology at the University of Oslo, Norway. Since then, I have broadened the scope of my research by working on T-cell development, cancer immunobiology, immunogenetics, and susceptibility to cancer and infectious diseases. 

This was only possible with a substantial contribution from my academic collaborators and colleagues in Norway and Croatia. Some of these studies led me to propose a model about the workings of the immune system called the "integrity" model in the mid-nineties. It stresses that immunity is a defense system, an active protector of own tissues, and a selector of microbiome, including commensals. So far, my publications comprise over 100 scientific contributions and a monograph entitled "Cytokines of the Immune System" (Academic Press, Elsevier, 2015). About one-tenth were published in top scientific journals (like Nature and Cell). I take these achievements as evidence of the joy that basic research in immunology has given me over the past years. They are also the source of an unending motivation to study further what remains unknown - a progressively smaller part of the human body.

CURRICULUM VITAE

Researcher unique identifiers: ORCID ID: 0000-0002-9970-6497

EDUCATION

1977             Dr. med., (M.D.) Medical Faculty, University in Rijeka (UiR), Croatia.

1980             Mr. Sc. in biomedicine, University in Zagreb (UiZ), Croatia.

1987             Dr. sc. in medicine (Ph.D. equivalent), UiR.

CURRENT POSITIONS

2002 – present:  Professor I (professor in cell biology, immunology and microbiology), University of Oslo (UiO).

2007 – present:  Professor (visiting; in medicine (biomedicine; for postgraduate studies), Medical Faculty, University in Rijeka (UiR), Croatia, EU. (Since 2013, re-instated, tenured).

PREVIOUS POSITIONS

1977 - 1980      Assistant, Department of Physiology, Medical Faculty (MF), UiZ.

1980 - 1984      Research Assistant and Lecturer, Department of Physiology, MF, UiZ, Croatia.

1982 - 1984      Postdoctoral research fellow, Max-Planck Institut für Biologie, Abt. Immungenetik, Tübingen, Germany.

1984 - 1986      Member, Basel Institute for Immunology, Basel, Switzerland.

1986 - 1989      Staff Scientist, Hoffmann-La Roche Ltd, Basel, Switzerland.

1989 - 1995      Senior Scientist, Hoffmann-La Roche Ltd, Basel, Switzerland.

1991 - 2002      Visiting Lecturer, Medical Faculty, University in Rijeka, Croatia.

1995 - 1996      Guest Scientist, Institute for General and Rheumatologic Immunology (IGRI), The National Hospital (Rikshospitalet), Oslo, Norway.

1997 - 2002      Senior Scientist (Forsker, Den Norske Kreftforening), IGRI / Institute of Immunology, The National Hospital (Rikshospitalet), Oslo, Norway.

2002 - 2007      Visiting Associate Professor in medicine (biomedicine), Medical Faculty, UiR, Rijeka, Croatia.

INSTITUTIONAL RESPONSIBILITIES

2002 - present: Course leader: “Cranio-facial developmental biology“, a postgraduate course in the core curriculum of specialists’ education at the Faculty of Dentistry, UiO, Norway.

2012 - 2015: 3rd-semester leader, Faculties of Medicine, Dentistry and Nutrition, UiO.

2017:          Course leader: “Basics of Tumor Immunotherapy “, a postgraduate course as a part of the Medical Oncology study for postgraduates and specialists in medicine, at the University of Zagreb, Croatia.

2001 - 2008: Course leader: “Cytokines and disease“, postgraduate course (bi-annual) in “Biomedicine” at the Medical School, University of Rijeka, Croatia.

COMMISSIONS OF TRUST

2001 – 2006: Editor-in-chief, Scandinavian Journal of Immunology; publisher: Blackwell, UK.

2006 – 2021: Associate Editor, Scandinavian Journal of Immunology; publisher: Blackwell Science, Wiley, UK.

2022 – present: Associate Editor for Cancer Immunity and Immunotherapy, a research section with articles appearing in the Frontiers in Immunology and Frontiers in Oncology online journals, published by Frontiers Media SA (International).

MEMBERSHIP IN SCIENTIFIC SOCIETIES

2008 – 2010: President of the Norwegian Society for Immunology

GRANTED PATENTS

Several patents filed in Switzerland, in European Union and the USA dealing with Cytokines’ receptors and their potential use as hybrid molecules with immunoglobulins:

1. Inventor (with R. Gentz and G. Garotta) of the patent "Chimeric Human Interferon-gamma Receptor - Immunoglobulin Polypeptides" filed by ROCHE, on Mar 1993 (EU);

2. Co-inventor of the US patents "Human TNF Receptor" (US 8,163,522 B1) and “Human TNF Receptor Fusion Proteins” (US 8,063,182 B1) filed by ROCHE, May 19, 1995, of which the latter describes a product known as etanercept. It is a successful biological called Enbrel (Amgen), currently used to treat autoimmune diseases like rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, polyarticular juvenile arthritis and ankylosing spondylitis.

Cooperations  - Collaborations 

Medical Faculty, University of Oslo:

Centre for Immune Regulation (CiR) - Professor Bjarne Bogen;

Medical Faculty in Rijeka, University of Rijeka, Croatia:

Dept of Molecular Medicine and Biotechnology -  Professor Sinisa Volarevic;

Clinic of Internal Medicine, Dept of Pulmonology - Doc Ljiljana Bulat-Kardum;

Dept. of Physiology - Professor Ines Mrakovčić Šutić

Clinic of Orthopaedics, Lovran - Professor Zdravko Jotanović

Medical Faculty in Pula, University Juraj Dobrila, Pula, Croatia:

General Hospital Pula, Clinic for Oncology - Professor Damir Vrbanec;

Institute Rudjer Boskovic, Zagreb, Croatia:

Dept of Molecular Medicine - Dr Jelena Knezevic

Tags: DNA, Immunogenetics, Immunoregulation, Craniofacial biology, Respiratory infection, Epithelial cancer, RT-PCR

Publications

 Some representative articles:

  • Dembic Z, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H and Steinmetz M: 
    Transfer of specificity by murine alpha- and beta-chain T-cell receptor genes.
     Nature 320, 232-238 (1986).
  • Dembic Z, Haas W, Zamoyska R, Parnes J, Steinmetz M and von Boehmer H: 
    Transfection of the CD8 gene enhances T cell recognition.
     Nature 326, 510-511 (1987).
  • Aguet M, Dembic Z and Merlin G: 
    Molecular cloning and expression of human IFN-gamma receptor.
     Cell 55, 273-276 (1988).
  • Vidovic D, Roglic M, McKune K, Guerder S, Mackay C, and Dembic Z: 
    Qa-1 restricted recognition of foreign antigen by a gamma/delta T cell hybridoma.
     Nature 340, 646-650 (1989).
  • Dembic Z, Schenck K, and Bogen B: 
    Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.
     Proc Natl Acad Sci USA 97, 2697-2702 (2000).
  • Dembic Z, Røttingen J-A, Dellacasagrande J, Schenck K and Bogen B. 
    Phagocytic dendritic cells purified from myelomas activate tumor-specific T cells at a single cell level. Blood 97, 2808-14 (2001).
  • Sveinbjornsson et al. HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature Genetics 48, 318-322 (2016).

  • Dembic, Z., Antitumor Drugs and Their Targets. Molecules 2020, 25, (23).

  • Dembic, Z., Cytokines in Innate Immunity. Chapter in Encyclopedia of Infection and Immunity, 2022; pp 170-192.

  • Dembic, Z., Defending and integrating an organism by the immune system. Scand J Immunol 2022, 95, (5), e13172.

  • Tudor, Karlo; Baranasic, Jurica; Knezevic, Jelena; Serer Vicevic, Marta; Sutic, Maja & Dembic, Zlatko [Show all 7 contributors for this article] (2024). Indirect influence of microRNA-146a on the association of IL-6 and TNF-α genetic polymorphisms with the increased risk of hip osteoarthritis. Journal of Orthopaedic Research. ISSN 0736-0266. doi: 10.1002/jor.25804.
  • Simunic-Briski, Nina; Vrgoc, Goran; Knjaz, Damir; Jankovic, Sasa; Dembic, Zlatko & Lauc, Gordan (2023). MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes. Journal of Orthopaedic Research. ISSN 0736-0266. doi: 10.1002/jor.25663.
  • Dembic, Zlatko (2022). Cytokines in Innate Immunity. In Rezaei, Nima (Eds.), Encyclopedia of Infection and Immunity. Elsevier. ISSN 978-0-323-90303-5. p. 170–192. doi: 10.1016/B978-0-12-818731-9.00090-2.
  • Dembic, Zlatko (2022). Defending and integrating an organism by the immune system. Scandinavian Journal of Immunology. ISSN 0300-9475. 95(5). doi: 10.1111/sji.13172. Full text in Research Archive
  • Eftedal, Randi Krog; Jotanovic, Zdravko; Balen, Sanja & Dembic, Zlatko (2020). TNFA Genetic Polymorphism is Associated with Risk for Developing Hip but not Knee Osteoarthritis in Croatian Population. EC Gastroenterology and Digestive System. ISSN 2276-1209. Full text in Research Archive
  • Oršolić, Ines; Bursać, Slađana; Jurada, Deana; Drmić Hofman, Irena; Dembic, Zlatko & Bartek, Jiri [Show all 8 contributors for this article] (2020). Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint. Oncogene. ISSN 0950-9232. 39(17), p. 3443–3457. doi: 10.1038/s41388-020-1231-6.
  • Dembic, Zlatko (2020). Antitumor Drugs and Their Targets. Molecules. ISSN 1431-5157. 25(23). doi: 10.3390/molecules25235776. Full text in Research Archive
  • Dembic, Zlatko (2019). On integrity in immunity during ontogeny or how thymic regulatory T cells work. Scandinavian Journal of Immunology. ISSN 0300-9475. p. 1–12. doi: 10.1111/sji.12806. Full text in Research Archive
  • Cohn, Melvin; Anderson, Colin C. & Dembic, Zlatko (2019). The case for allele-specific recognition by the TCR. Scandinavian Journal of Immunology. ISSN 0300-9475. 90(2). doi: 10.1111/sji.12790. Full text in Research Archive
  • Eftedal, Randi Krog; Vrgoc, Goran; Jotanovic, Zdravko & Dembic, Zlatko (2019). Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research. ISSN 0736-0266. 37(9), p. 1972–1978. doi: 10.1002/jor.24334. Full text in Research Archive
  • Vrgoc, Goran; Vrbanec, Jurica; Eftedal, Randi Krog; Dembic, Petra L.; Balen, Sanja & Dembic, Zlatko [Show all 7 contributors for this article] (2018). Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research. ISSN 0736-0266. 36(6), p. 1684–1693. doi: 10.1002/jor.23823.
  • Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(4), p. 242–250. doi: 10.1111/sji.12525.
  • Teofilović, Natalija Knežević; Bihi, Mahjoub; Stojković, Marijana Radić; Tumir, Lidija M.; Ester, Katja & Kralj, Marijeta [Show all 17 contributors for this article] (2017). 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 27(7), p. 1530–1537. doi: 10.1016/j.bmcl.2017.02.048.
  • Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), p. 84–94. doi: 10.1111/sji.12500.
  • Vrbanec, Jurica; Lederer-Dembic, Petra; Bulat-Kardum, Ljiljana; Balen, Sanja; Eftedal, Randi Krog & Dembic, Zlatko (2016). Genetic Risk of Tuberculosis is Spread within the Hallmarks of the Disease. Immunotherapy: Open Access. ISSN 2471-9552. 2(2), p. 117–122. doi: 10.4172/2471-9552.1000117. Full text in Research Archive
  • Sveinbjornsson, Gardar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Kristinsson, Karl G.; Gottfredsson, Magnus & Barrett, Jeffrey C. [Show all 30 contributors for this article] (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature Genetics. ISSN 1061-4036. 48(3), p. 318–322. doi: 10.1038/ng.3498.
  • Armingohar, Zahra; Jørgensen, Jørgen J.; Kristoffersen, Anne Karin; Schenck, Karl & Dembic, Zlatko (2015). Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. Journal of Oral Microbiology. ISSN 2000-2297. 7(1), p. 1–8. doi: 10.3402/jom.v7.26051. Full text in Research Archive
  • Jotanovic, Zdravko; Mihelic, Radovan; Gulan, Gordan; Sestan, Branko & Dembic, Zlatko (2015). Osteoarthritis of the hip: An overview. Periodicum biologorum. ISSN 0031-5362. 117(1), p. 95–108.
  • Bulat-Kardum, Ljiljana; Etokebe, Godfrey; Lederer, Petra; Balen, S & Dembic, Zlatko (2015). Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F Genes Differently Affect the Risk for Tuberculosis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 82(1), p. 63–69. doi: 10.1111/sji.12300.
  • Etokebe, Godfrey; Jotanovic, Zdravko; Mihelic, Radovan; Mulac-Jericevic, Biserka; Nikolic, Tamara & Balen, Sanja [Show all 8 contributors for this article] (2015). Susceptibility to Large-Joint Osteoarthritis (Hip and Knee) is Associated with BAG6 rs3117582 SNP and the VNTR Polymorphism in the Second Exon of the FAM46A Gene on Chromosome 6. Journal of Orthopaedic Research. ISSN 0736-0266. 33(1), p. 56–62. doi: 10.1002/jor.22738.
  • Etokebe, Godfrey; Zienolddiny, Shanbeh; Kupanovac, Zeljko; Enersen, Morten; Balen, Sanja & Flego, Velkjo [Show all 12 contributors for this article] (2015). Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations. PLOS ONE. ISSN 1932-6203. 10(4). doi: 10.1371/journal.pone.0122651. Full text in Research Archive
  • Etokebe, Godfrey; Bulat-Kardum, Ljiljana; Munthe, Ludvig Andre; Balen, Sanja & Dembic, Zlatko (2014). Association of variable number of tandem repeats in the coding region of the FAM46A gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with susceptibility to tuberculosis. PLOS ONE. ISSN 1932-6203. 9(3). doi: 10.1371/journal.pone.0091385. Full text in Research Archive
  • Dembic, Zlatko (2014). Pharmaco-therapeutic challenges in cancer biology with focus on the immune- system related risk factors. Current pharmaceutical design. ISSN 1381-6128. 20(42), p. 6652–6659. doi: 10.2174/1381612820666140826154147.
  • Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg & Hofgaard, Peter Olaf [Show all 11 contributors for this article] (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules? Frontiers in Immunology. ISSN 1664-3224. 5:174. doi: 10.3389/fimmu.2014.00174. Full text in Research Archive
  • Jotanovic, Zdravko; Mihelic, Radovan; Sestan, Branko & Dembic, Zlatko (2014). Emerging pathways and promising agents with possible disease modifying effect in osteoarthritis treatment. Current Drug Targets. ISSN 1389-4501. 15(6), p. 635–661. doi: 10.2174/1389450115666140306153115.
  • Armingohar, Zahra; Jørgensen, Jørgen J.; Kristoffersen, Anne Karin; Schenck, Karl & Dembic, Zlatko (2014). Polymorphisms in the interleukin-1 gene locus and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. Scandinavian Journal of Immunology. ISSN 0300-9475. 79(5), p. 338–345. doi: 10.1111/sji.12166.
  • Dembic, Zlatko (2013). On recognizing 'shades-of-gray' (Self-nonself discrimination) or 'colour' (Integrity model) by the immune system. Scandinavian Journal of Immunology. ISSN 0300-9475. 78(4), p. 325–338. doi: 10.1111/sji.12090.
  • Kårvatn, Marikken; Jotanovic, Zdravko; Mihelic, Radovan; Etokebe, Godfrey; Mulac-Jericevic, Biserka & Tijanic, Tamara [Show all 9 contributors for this article] (2013). Associations of the Interleukin-1 Gene Locus Polymorphisms with Risk to Hip and Knee Osteoarthritis: Gender and Subpopulation Differences. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(2), p. 151–161. doi: 10.1111/sji.12016.
  • Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Kårvatn, Marikken; Mulac-Jericevic, Biserka & Tijanic, Tamara [Show all 9 contributors for this article] (2012). IL1B-511(G > A) and IL1RN (VNTR) allelic polymorphisms and susceptibility to knee osteoarthritis in Croatian population. Rheumatology International. ISSN 0172-8172. 32(7), p. 2135–2141. doi: 10.1007/s00296-011-1946-3.
  • Knezevic, Jelena; Pavlinic, Dinko; Rose II, William A.; Leifer, Cynthia A; Bendelja, Kreso & Gabrilovac, Jelka [Show all 16 contributors for this article] (2012). Heterozygous Carriage of a Dysfunctional Toll-like Receptor 9 Allele Affects CpG Oligonucleotide Responses in B Cells. Journal of Biological Chemistry. ISSN 0021-9258. 287(29), p. 24544–24553. doi: 10.1074/jbc.M111.337477.
  • Kårvatn, Marikken; Vrbanec, Jurica; Kulic, Ana; Knezević, Jelena; Petricevic, Branka & Balen, Sanja [Show all 8 contributors for this article] (2012). Single Nucleotide Polymorphism in the Interleukin 12B Gene is Associated with Risk for Breast Cancer Development. Scandinavian Journal of Immunology. ISSN 0300-9475. 76(3), p. 329–335. doi: 10.1111/j.1365-3083.2012.02736.x.
  • Jotanovic, Zdravko; Mihelic, Radovan; Sestan, Branko & Dembic, Zlatko (2012). Role of Interleukin-1 Inhibitors in Osteoarthritis An Evidence-Based Review. Drugs & Aging. ISSN 1170-229X. 29(5), p. 343–358. doi: 10.2165/11599350-000000000-00000.
  • Dzumhur, A; Zibar, L; Wagner, J; Simundic, T; Dembic, Zlatko & Barbic, J (2012). Association Studies of Gene Polymorphisms in Toll-Like Receptors 2 and 4 in Croatian Patients with Acute Myocardial Infarction. Scandinavian Journal of Immunology. ISSN 0300-9475. 75(5), p. 517–523. doi: 10.1111/j.1365-3083.2012.02681.x.
  • Kaarvatn, Marikken Heiland; Eftedal, Randi Krog; Vrbanec, Jurica; Jotanovic, Zdravko; Etokebe, Godfrey & Sanja, Balen [Show all 8 contributors for this article] (2012). Interleukin-1 Gene Locus Polymorphisms are Associated with Risk to Breast Cancer in Croatian Population. Periodicum biologorum. ISSN 0031-5362. 114(4), p. 497–503. Full text in Research Archive
  • Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Kårvatn, Marikken; Mulac-Jericevic, Biserka & Tijanic, Tamara [Show all 9 contributors for this article] (2011). Hip Osteoarthritis Susceptibility Is Associated with IL1B-511(G > A) and IL1 RN (VNTR) Genotypic Polymorphisms in Croatian Caucasian Population. Journal of Orthopaedic Research. ISSN 0736-0266. 29(8), p. 1137–1144. doi: 10.1002/jor.21378.
  • Etokebe, GE; Skjeldal, F; Nilsen, Nadra; Rodionov, Dmitrii; Knezevic, Jelena & Bulat-Kardum, Ljiljana [Show all 9 contributors for this article] (2010). Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(5), p. 369–381. doi: 10.1111/j.1365-3083.2010.02379.x. Full text in Research Archive
  • Etokebe, Godfrey; Kuchler, Axel Matthias; Haraldsen, Guttorm; Landin, Maria Augusta Dos S Silva; Osmundsen, Harald & Dembic, Zlatko (2009). Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds. Archives of Oral Biology. ISSN 0003-9969. 54(11), p. 1002–1007. doi: 10.1016/j.archoralbio.2009.08.005.
  • Etokebe, Godfrey; Knezević, Jelena; Petricević, Branka; Pavelić, Jasminka; Vrbanec, Damir & Dembic, Zlatko (2009). Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Genetic Testing and Molecular Biomarkers. ISSN 1945-0265. 13(6), p. 729–734. doi: 10.1089/gtmb.2009.0045.
  • Etokebe, Godfrey; Axellson, Stefan; Svaerd, Niels Henrik; Storhaug, Kari & Dembic, Zlatko (2008). Detection of Hemizygous Chromosomal Copy Number Variants in Williams-Beuren Syndrome (WBS) by Duplex Quantitative PCR Array: An Unusual Type of WBS Genetic Defect. International Journal of Biomedical Science. ISSN 1550-9702. 4(3), p. 161–170. Full text in Research Archive
  • Etokebe, Godfrey; Bulat-Kardum, L; Johansen, MS; Knezevic, J; Balen, S & Matakovic-Mileusnic, N [Show all 11 contributors for this article] (2006). Interferon-gamma gene (T874A and G2109A) polymorphisms are associated with microscopy-positive tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 63, p. 136–141.
  • Bulat-Kardum, L; Etokebe, Godfrey; Knezevic, J; Balen, S; Matakovic-Mileusnic, N & Zaputovic, L [Show all 9 contributors for this article] (2006). Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 63.
  • Dembic, Zlatko (2005). The Function of Toll-like Receptors. In Rich, Tina (Eds.), Toll and Toll-Like Receptors: An Immunologic Perspective. Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers. p. 18–55.
  • Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias & Dembic, Zlatko [Show all 7 contributors for this article] (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, p. 759–769.
  • Dai, Kezheng; Johansen, Finn Eirik; Kolltveit, Kristin Melkevik; Aasheim, Hans-Christian; Dembic, Zlatko & Vartdal, Frode [Show all 7 contributors for this article] (2004). Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter. Journal of Immunology. ISSN 0022-1767. 172, p. 6144–6151.
  • Dembic, Zlatko; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2004). Anti-class II antibodies, but not cytotoxic T-lymphocyte antigen 4-immunoglobulin hybrid molecules, prevent rejection of major histocompatibility complex class II-negative myeloma in T-cell receptor-transgenic mice. Scandinavian Journal of Immunology. ISSN 0300-9475. 60, p. 143–152.
  • Dellacasagrande, Jerome; Schreurs, Olav Joseph F; Hofgaard, Peter Olaf; Omholt, Hilde; Steinsvoll, Svein E B & Schenck, Karl [Show all 8 contributors for this article] (2003). Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scandinavian Journal of Immunology. ISSN 0300-9475. 57(6), p. 534–544.
  • Fraser, D. A.; Loos, Bruno G.; Boman, U; Winkelhoff, Arie J Van; Velden, U van der & Schenck, Karl [Show all 7 contributors for this article] (2003). Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitits. Acta Odontologica Scandinavica. ISSN 0001-6357. 61(5), p. 297–302.
  • Dembic, Zlatko (2003). Critical elements in case-control studies in predisposition to tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 58.
  • Fraser, D. A.; Bulat-Kardum, L; Knezevic, J; Babarovic, Z; Matakovic-Mileusnic, N.* & Dellacasagrande, Jerome [Show all 10 contributors for this article] (2003). Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia. Scandinavian Journal of Immunology. ISSN 0300-9475. 57(5), p. 480–484.
  • Fraser, DA; Loos, BG; Boman, U; van Winkelhoff, AJ; van der Velden, U & Schenck, Karl [Show all 7 contributors for this article] (2003). Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis. Acta Odontologica Scandinavica. ISSN 0001-6357. 61, p. 297–302.
  • Dembic, Zlatko; Rottingen, John-Arne; Dellacasagrande, Jerome; Schenck, Karl & Bogen, Bjarne (2001). Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood. ISSN 0006-4971. 97(9), p. 2808–14.
  • Dembic, Zlatko; Schenck, Karl & Bogen, Bjarne (2000). Dendritic cells purified from myeoloma are spontaneously primed with tumor-specific antigen (idiotype) and activate CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 97, p. 2697–2702.
  • Bogen, Bjarne; Schenck, Karl; Munthe, Ludvig Andre & Dembic, Zlatko (2000). Deletion of Idiotype(Id)-specific T cells in multiple myeloma. Acta Oncologica. ISSN 0284-186X. 39, p. 783–788.
  • Dembic, Zlatko; Munthe, Ludvig Andre; Schenck, Karl; Mueller, C. & Bogen, Bjarne (1998). Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) a chains and promotes positive selection of class II-restricted TCR-transgenetic thymocytes. Molecular Immunology. ISSN 0161-5890. p. 23–38.
  • Bogen, Bjarne; Weiss, S. & Dembic, Zlatko (1997). Idiotypes and T cell selection. In Handbook of Immune Modulating Agents. In Kresina, T. (Eds.), Marcel Decker. New York.
  • Schreurs, Olav Joseph F; Halstensen, Trond Sundby; Dembic, Zlatko; Bogen, Bjarne & Schenck, Karl (1997). TUNEL combined with staining for epithelial cellmarker permits unambiguous localization of apoptic cells in murine thymus. Biochemica. ISSN 0946-1310. 4, p. 19–21.
  • Merlin, G.; Leede, B. J. M. van der ; McKune, K.; Bannwarth, W.; Romquin, N. & Viegas-Pequignot, E. [Show all 8 contributors for this article] (1997). The gene for the ligand binding chain of the human interferon gamma receptor. Immunogenetics. ISSN 0093-7711. 45, p. 413–421.
  • Munthe, Ludvig Andre; Blichfeldt, E.; Sollien, Anders; Dembic, Zlatko & Bogen, Bjarne (1996). T cells with two TCR_b chains and reactivity to both MHC/idiotypic peptide and superantigen. Cellular Immunology. ISSN 0008-8749. 170, p. 283–290.
  • Magyar, JP; Martini, R; Ruelicke, T; Aguzzi, A; Adlkofer, K & Dembic, Zlatko [Show all 8 contributors for this article] (1996). Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. Journal of Neuroscience. ISSN 0270-6474. 16, p. 5351–5360.
  • Ebensperger, C; Muthukumaran, G; Lembo, D; Donnely, RJ; Pestka, S & Dembic, Zlatko (1996). Genomic organization and promotor analysis of the gene ifngr2 encoding the second chain of the mouse interferon-g-receptor. Scandinavian Journal of Immunology. ISSN 0300-9475. 44, p. 599–606.
  • Rhee, S; Ebensperger, C; Dembic, Zlatko & Pestka, S (1996). The structure of the gene for the second chain of the human interferon gamma receptor. Journal of Biological Chemistry. ISSN 0021-9258. 271, p. 28947–28952.
  • Muthukumaran, G; Donnely, RJ; Ebensperger, C; Mariano, TM; Garotta, G & Dembic, Zlatko [Show all 8 contributors for this article] (1996). The intracellular domain of the second chain of the interferon-gamma-receptor is interchangeable between species. Journal of Interferon and Cytokine Research. ISSN 1079-9907. 16, p. 1039–1045.

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  • Dembic, Zlatko (2015). The Cytokines of the Immune System. Academic Press. ISBN 978-0-12-419998-9. 310 p.

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  • Dembic, Zlatko (2012). The Immune System Maintains Integrity of an Organism. Full text in Research Archive
  • Jodal, Henriette Cecilie; Hofgaard, Peter Olaf; Dembic, Zlatko & Bogen, Bjarne (2011). A New Mouse Model for Multiple Myeloma. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 388–388.
  • Kårvatn, Marikken; Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Mulac-Jericevic, Biserka & Tijanic, Tamara [Show all 9 contributors for this article] (2011). Interleukin-1(IL-1)A, IL-1B and IL-1 Receptor Antagonist Gene Polymorphisms in Predisposition to Hip and Knee Osteoarthritis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 370–371.
  • Kaarvatn, MH; Jotanovic, Z; Etokebe, Godfrey; Mihelic, NN; Mulac-Jericevic, NN & Tijanic, T [Show all 9 contributors for this article] (2010). Polymorphisms in the Interleukin-1B And IL-1 Receptor Antagonist Genes in Predisposition to Hip and Knee Osteoarthritis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(6), p. 482–482.
  • Dembic, Zlatko (2008). Beginning of the end of (understanding) the immune response. Scandinavian Journal of Immunology. ISSN 0300-9475. 68(4), p. 381–382. doi: 10.1111/j.1365-3083.2008.02159.x.
  • Dembic, Zlatko (2004). Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms. Scandinavian Journal of Immunology. ISSN 0300-9475. 60, p. 3–5.
  • Dembic, Zlatko; Fraser, David; Loos, Bruno G.; Velden, Ubele van der & Schenck, Karl (2004). Genetic Polymorphism in Periodontal Disease.
  • Dembic, Zlatko (2004). Immunosurveillance of malign tumors.
  • Dai, Ke-Zheng; Johansen, Finn-Eirik; Kolltveit, Kristin Melkevik; Aasheim, Hans-Christian; Dembic, Zlatko & Vartdal, Frode [Show all 7 contributors for this article] (2003). Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5� monophosphate responsive element in the proximal SH2D2A promoter.
  • Loos, Bruno G.; Schreiber, S.; Scholtz, C.; Jebsen, S.; Groessner-Schreiber, B. & Dembic, Zlatko [Show all 7 contributors for this article] (2003). CARD4 and CARD15 gene polymorphysms in relation to aggressive periodontitis.
  • Dembic, Zlatko; Røttingen, John-Arne; Dellacasagrande, Jerome & Schenck, Karl (2001). Isolated phagocytic dendritic cells from myeloma activate tumor-specific T cells at a single cell level.
  • Dembic, Zlatko; Røttingen, John-Arne; Dellacasagrande, Jerome; Schenck, Karl & Bogen, Bjarne (2001). Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level.
  • Bogen, Bjarne; Dembic, Zlatko; Røttingen, John-Arne & Schenck, Karl (1999). Professional APC in plasmacytomas are primed with myeloma protein idiotype (Id) and are able to introduce activation of class II restricted Id-specific CD4+ cells.
  • Dembic, Zlatko (1996). Do we need integrity? Scandinavian Journal of Immunology. ISSN 0300-9475. 44, p. 549–550.

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Published Nov. 1, 2010 4:05 PM - Last modified Nov. 17, 2023 9:44 AM

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