Zlatko Dembic

Professor - Molekylær
Bilde av Zlatko Dembic
English version of this page
Telefon +47 22840330
Rom A1.M051
Brukernavn
Besøksadresse Domus Odontologica Sognsvannsveien 10 0372
Postadresse Postboks 1052 Blindern 0316 Oslo

Faglige interesser

Molekylærgenetikk - utviklingsstudier med fokus på kraniofaciale strukturer og immunsystemet

Gruppeleder: Professor Zlatko Dembic, dr.med.; Medlemmer: emeritus prof. Marie Wika, Cand.real., stipendiat Randi Krog Eftedal, cand odont.

   Vi undersøker genenes betydning for tidlige signaler i utviklingen av embryonale vev til strukturer i det kraniofaciale område - omfattende mucosa, spyttkjertler, tenner, knokler, ledd, tonsiller, beinmarg og nervevev. Vi undersøker også gener som kan predisponere for ulike sykdommer av immunologisk og/eller inflammatorisk karakter  og som kan føre til utvikling av kroniske sykdommer senere i et individs liv. Vi benytter ”case” (pasient) – kontroll studier for å bestemme frekvenser av genetiske markører i genetiske områder valgt ut fra kvalifisert gjetning eller knyttet til kraniofaciale områder der mikrochip profiler uttrykkes. Nylig er det gjort en undersøkelse på predisponerende faktorer for tuberkulose, bryst- og coloncancer såvel som primær oseoartritt i store ledd og i temporomandibulærleddet (kjeveleddet). Gener av interesse omfatter cytokinfamilimedlemmer som interferon-gamma  og interleukin-1 og Toll-lignende  receptor familiene 1,2,3,4,6,7 og 9, som er viktige for tidligaktivering av de spesifikke (adaptive) immunresponsene.

Emneord: 1. DNA, 2. Immungenetikk, 3. Respiratory infection, 4. Epitelial kreft, 5. Ledd inflammasjon, 6. Immunregulation, 7. RT PCR

 

Undervisning

http://www.uio.no/studier/program/odontologi/

http://www.uio.no/studier/program/medisin/

Bakgrunn

As a scientist with a medical background, it's natural that my research interests are placed at the crossroads of medicine and biology. Since the earliest days of my lab career I was attracted to molecular and cellular immunology. The more I learned, the more my interest evolved toward studying ontogeny and phylogeny of the immune system. The reason was simple: I wished to understand its function, and that is still my wish. During the last twenty years of the past century I've worked on important issues in immunology at the Max-Planck-Institute for Biology (Tubingen, Germany), the Basel Institute for Immunology (Switzerland; CH) and the Hoffman-La Roche AG (Basel, CH). We were the first to report the identification of genes underlying T-cell specificity and recognition (mouse T-cell receptor, in '86). Likewise, we led the research on molecular cloning of human cytokine receptors important for the effector phase of immunity such as the interferon-gamma receptor (IFNGR1; in '88) and the tumor necrosis factor receptor-2 (TNFR2; in '90). In 1995, I moved to the Institute of Immunology at the University of Oslo, Norway. Since then I broadened the scope of my research by working on T-cell development, cancer immunobiology, immunogenetics and susceptibility to cancer and infectious diseases. And, since 2002 I research and teach at the Department of Oral Biology, OF, UiO.

All of this would not have been possible without a substantial contribution from my academic collaborators and colleagues in Norway and Croatia. Some of these studies led me to propose a model about the workings of the immune system called the "integrity" model in the mid-nineties. It stresses that immunity is not only a defense system, but also a selector of potential symbionts and commensals. So far, my publication list has over 80 scientific contributions. Ten percent were published in top scientific journals (Nature and Cell) with myself as a prominent author (in half of them). I tend to take these achievements as evidence of the great fun and joy that basic research in immunology has given me over the past years. They are also the source of an unending motivation to study further what remains unknown - a progressively smaller part of human body.

Find more about biography here: http://folk.uio.no/zlatkod/index2.html and  http://folk.uio.no/zlatkod/index.html

Priser

The Hoffman-LaRoche prize (internal) for the first report on molecular cloning of the human Interferon gamma receptor molecule (1988)

Verv 

  • 2002 - Professor i cellebiology, immunologi og mikrobiologi ved Institutt for Oral Biologi (IOB) 

  • 2007 - Visiting professor i medisin ved Medisinsk fakultet, Universitetet i Rijeka (Kroatia) (privat; for videreutdanningskurs).

  • 2006 - Associate Editor - Scandinavian Journal of Immunology (Wiley)

Samarbeid

Medical Faculty, University of Oslo:

Centre for Immune Regulation (CiR) - Professor Bjarne Bogen 

Faculty of Medicine, University of Rijeka, Croatia:

Dept of Molecular Medicine and Biotechnology -  Professor dr med Sinisa Volarevic;

Clinic of Internal Medicine, Dept of Pulmology - Docent dr med Ljiljana Bulat-Kardum;

Department of Physiology and Immunology - Professor dr med Ines Mrakovcic-Sutic;

Faculty of medicine, University "Juraj Dobrila", Pula, Croatia:

Dean - Professor dr med Kresimir Pavelic; 

General Hospital, Clinic for Oncology - Professor dr med Damir Vrbanec;

Institute Rudjer Boskovic, Zagreb, Croatia:

Dept of Molecular Medicine - Dr Jelena Knezevic,

Dr Mariastefania Antica

Emneord: DNA, Immunogenetics, RT-PCR, Immunoregulation, Cranofacial biology, Respirasjons infekt, Epitelial kreft

Publikasjoner

 Here are some representative articles (-> click her for the complete list and TOP 20 cited articles ):

  • Dembic Z, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H and Steinmetz M: 
    Transfer of specificity by murine alpha- and beta-chain T-cell receptor genes.
     Nature 320, 232-238 (1986).
  • Dembic Z, Haas W, Zamoyska R, Parnes J, Steinmetz M and von Boehmer H: 
    Transfection of the CD8 gene enhances T cell recognition.
     Nature 326, 510-511 (1987).
  • Aguet M, Dembic Z and Merlin G: 
    Molecular cloning and expression of human IFN-gamma receptor.
     Cell 55, 273-276 (1988).
  • Vidovic D, Roglic M, McKune K, Guerder S, Mackay C, and Dembic Z: 
    Qa-1 restricted recognition of foreign antigen by a gamma/delta T cell hybridoma.
     Nature 340, 646-650 (1989).
  • Dembic Z, Schenck K, and Bogen B: 
    Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.
     Proc Natl Acad Sci USA 97, 2697-2702 (2000).
  • Dembic Z, Røttingen J-A, Dellacasagrande J, Schenck K and Bogen B. 
    Phagocytic dendritic cells purified from myelomas activate tumor-specific T cells at a single cell level. Blood 97, 2808-14 (2001).
  • Dembic Z     Pharmaco-therapeutic challenges in cancer biology with focus on the immune-system related risk factors. Curr Pharm Des 20(42):6652-9 (2014). 
  • Gardar Sveinbjornsson, et al. ... Zlatko Dembic,... Ingileif Jonsdottir, & Kari Stefansson: 
    HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature Genetics 48, 318-322 (2016)
  • Vrgoc Goran, Vrbanec Jurica, Eftedal Randi K., Lederer Dembic Petra, Balen Sanja, Dembic Zlatko, and Jotanovic Zdravko:
    Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis.
    J Orthop Res. Epub Nov 30 (2017)

 

  • Eftedal, Randi Krog; Jotanovic, Zdravko; Balen, Sanja & Dembic, Zlatko (2020). TNFA Genetic Polymorphism is Associated with Risk for Developing Hip but not Knee Osteoarthritis in Croatian Population. EC Gastroenterology and Digestive System. ISSN 2276-1209. Fulltekst i vitenarkiv
  • Oršolić, Ines; Bursać, Slađana; Jurada, Deana; Drmić Hofman, Irena; Dembic, Zlatko & Bartek, Jiri [Vis alle 8 forfattere av denne artikkelen] (2020). Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint. Oncogene. ISSN 0950-9232. 39(17), s. 3443–3457. doi: 10.1038/s41388-020-1231-6.
  • Dembic, Zlatko (2020). Antitumor Drugs and Their Targets. Molecules. ISSN 1420-3049. 25(23). doi: 10.3390/molecules25235776. Fulltekst i vitenarkiv
  • Dembic, Zlatko (2019). On integrity in immunity during ontogeny or how thymic regulatory T cells work. Scandinavian Journal of Immunology. ISSN 0300-9475. s. 1–12. doi: 10.1111/sji.12806. Fulltekst i vitenarkiv
  • Cohn, Melvin; Anderson, Colin C. & Dembic, Zlatko (2019). The case for allele-specific recognition by the TCR. Scandinavian Journal of Immunology. ISSN 0300-9475. 90(2). doi: 10.1111/sji.12790. Fulltekst i vitenarkiv
  • Eftedal, Randi Krog; Vrgoc, Goran; Jotanovic, Zdravko & Dembic, Zlatko (2019). Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research. ISSN 0736-0266. 37(9), s. 1972–1978. doi: 10.1002/jor.24334. Fulltekst i vitenarkiv
  • Vrgoc, Goran; Vrbanec, Jurica; Eftedal, Randi Krog; Dembic, Petra L.; Balen, Sanja & Dembic, Zlatko [Vis alle 7 forfattere av denne artikkelen] (2018). Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research. ISSN 0736-0266. 36(6), s. 1684–1693. doi: 10.1002/jor.23823.
  • Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Vis alle 7 forfattere av denne artikkelen] (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(4), s. 242–250. doi: 10.1111/sji.12525.
  • Teofilović, Natalija Knežević; Bihi, Mahjoub; Stojković, Marijana Radić; Tumir, Lidija M.; Ester, Katja & Kralj, Marijeta [Vis alle 17 forfattere av denne artikkelen] (2017). 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 27(7), s. 1530–1537. doi: 10.1016/j.bmcl.2017.02.048.
  • Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Vis alle 7 forfattere av denne artikkelen] (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), s. 84–94. doi: 10.1111/sji.12500.
  • Vrbanec, Jurica; Lederer-Dembic, Petra; Bulat-Kardum, Ljiljana; Balen, Sanja; Eftedal, Randi Krog & Dembic, Zlatko (2016). Genetic Risk of Tuberculosis is Spread within the Hallmarks of the Disease. Immunotherapy: Open Access. ISSN 2471-9552. 2(2), s. 117–122. doi: 10.4172/2471-9552.1000117. Fulltekst i vitenarkiv
  • Sveinbjornsson, Gardar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Kristinsson, Karl G.; Gottfredsson, Magnus & Barrett, Jeffrey C. [Vis alle 30 forfattere av denne artikkelen] (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nature Genetics. ISSN 1061-4036. 48(3), s. 318–322. doi: 10.1038/ng.3498.
  • Armingohar, Zahra; Jørgensen, Jørgen J.; Kristoffersen, Anne Karin; Schenck, Karl & Dembic, Zlatko (2015). Polymorphisms in the interleukin-10 gene and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. Journal of Oral Microbiology. ISSN 2000-2297. 7(1), s. 1–8. doi: 10.3402/jom.v7.26051. Fulltekst i vitenarkiv
  • Jotanovic, Zdravko; Mihelic, Radovan; Gulan, Gordan; Sestan, Branko & Dembic, Zlatko (2015). Osteoarthritis of the hip: An overview. Periodicum biologorum. ISSN 0031-5362. 117(1), s. 95–108.
  • Bulat-Kardum, Ljiljana; Etokebe, Godfrey; Lederer, Petra; Balen, S & Dembic, Zlatko (2015). Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F Genes Differently Affect the Risk for Tuberculosis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 82(1), s. 63–69. doi: 10.1111/sji.12300.
  • Etokebe, Godfrey; Jotanovic, Zdravko; Mihelic, Radovan; Mulac-Jericevic, Biserka; Nikolic, Tamara & Balen, Sanja [Vis alle 8 forfattere av denne artikkelen] (2015). Susceptibility to Large-Joint Osteoarthritis (Hip and Knee) is Associated with BAG6 rs3117582 SNP and the VNTR Polymorphism in the Second Exon of the FAM46A Gene on Chromosome 6. Journal of Orthopaedic Research. ISSN 0736-0266. 33(1), s. 56–62. doi: 10.1002/jor.22738.
  • Etokebe, Godfrey; Zienolddiny, Shanbeh; Kupanovac, Zeljko; Enersen, Morten; Balen, Sanja & Flego, Velkjo [Vis alle 12 forfattere av denne artikkelen] (2015). Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations. PLOS ONE. ISSN 1932-6203. 10(4). doi: 10.1371/journal.pone.0122651. Fulltekst i vitenarkiv
  • Etokebe, Godfrey; Bulat-Kardum, Ljiljana; Munthe, Ludvig Andre; Balen, Sanja & Dembic, Zlatko (2014). Association of variable number of tandem repeats in the coding region of the FAM46A gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with susceptibility to tuberculosis. PLOS ONE. ISSN 1932-6203. 9(3). doi: 10.1371/journal.pone.0091385. Fulltekst i vitenarkiv
  • Dembic, Zlatko (2014). Pharmaco-therapeutic challenges in cancer biology with focus on the immune- system related risk factors. Current pharmaceutical design. ISSN 1381-6128. 20(42), s. 6652–6659. doi: 10.2174/1381612820666140826154147.
  • Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg & Hofgaard, Peter Olaf [Vis alle 11 forfattere av denne artikkelen] (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules? Frontiers in Immunology. ISSN 1664-3224. 5:174. doi: 10.3389/fimmu.2014.00174. Fulltekst i vitenarkiv
  • Jotanovic, Zdravko; Mihelic, Radovan; Sestan, Branko & Dembic, Zlatko (2014). Emerging pathways and promising agents with possible disease modifying effect in osteoarthritis treatment. Current Drug Targets. ISSN 1389-4501. 15(6), s. 635–661. doi: 10.2174/1389450115666140306153115.
  • Armingohar, Zahra; Jørgensen, Jørgen J.; Kristoffersen, Anne Karin; Schenck, Karl & Dembic, Zlatko (2014). Polymorphisms in the interleukin-1 gene locus and chronic periodontitis in patients with atherosclerotic and aortic aneurysmal vascular diseases. Scandinavian Journal of Immunology. ISSN 0300-9475. 79(5), s. 338–345. doi: 10.1111/sji.12166.
  • Dembic, Zlatko (2013). On recognizing 'shades-of-gray' (Self-nonself discrimination) or 'colour' (Integrity model) by the immune system. Scandinavian Journal of Immunology. ISSN 0300-9475. 78(4), s. 325–338. doi: 10.1111/sji.12090.
  • Kårvatn, Marikken; Jotanovic, Zdravko; Mihelic, Radovan; Etokebe, Godfrey; Mulac-Jericevic, Biserka & Tijanic, Tamara [Vis alle 9 forfattere av denne artikkelen] (2013). Associations of the Interleukin-1 Gene Locus Polymorphisms with Risk to Hip and Knee Osteoarthritis: Gender and Subpopulation Differences. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(2), s. 151–161. doi: 10.1111/sji.12016.
  • Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Kårvatn, Marikken; Mulac-Jericevic, Biserka & Tijanic, Tamara [Vis alle 9 forfattere av denne artikkelen] (2012). IL1B-511(G > A) and IL1RN (VNTR) allelic polymorphisms and susceptibility to knee osteoarthritis in Croatian population. Rheumatology International. ISSN 0172-8172. 32(7), s. 2135–2141. doi: 10.1007/s00296-011-1946-3.
  • Knezevic, Jelena; Pavlinic, Dinko; Rose II, William A.; Leifer, Cynthia A; Bendelja, Kreso & Gabrilovac, Jelka [Vis alle 16 forfattere av denne artikkelen] (2012). Heterozygous Carriage of a Dysfunctional Toll-like Receptor 9 Allele Affects CpG Oligonucleotide Responses in B Cells. Journal of Biological Chemistry. ISSN 0021-9258. 287(29), s. 24544–24553. doi: 10.1074/jbc.M111.337477.
  • Kårvatn, Marikken; Vrbanec, Jurica; Kulic, Ana; Knezević, Jelena; Petricevic, Branka & Balen, Sanja [Vis alle 8 forfattere av denne artikkelen] (2012). Single Nucleotide Polymorphism in the Interleukin 12B Gene is Associated with Risk for Breast Cancer Development. Scandinavian Journal of Immunology. ISSN 0300-9475. 76(3), s. 329–335. doi: 10.1111/j.1365-3083.2012.02736.x.
  • Jotanovic, Zdravko; Mihelic, Radovan; Sestan, Branko & Dembic, Zlatko (2012). Role of Interleukin-1 Inhibitors in Osteoarthritis An Evidence-Based Review. Drugs & Aging. ISSN 1170-229X. 29(5), s. 343–358. doi: 10.2165/11599350-000000000-00000.
  • Dzumhur, A; Zibar, L; Wagner, J; Simundic, T; Dembic, Zlatko & Barbic, J (2012). Association Studies of Gene Polymorphisms in Toll-Like Receptors 2 and 4 in Croatian Patients with Acute Myocardial Infarction. Scandinavian Journal of Immunology. ISSN 0300-9475. 75(5), s. 517–523. doi: 10.1111/j.1365-3083.2012.02681.x.
  • Kaarvatn, Marikken Heiland; Eftedal, Randi Krog; Vrbanec, Jurica; Jotanovic, Zdravko; Etokebe, Godfrey & Sanja, Balen [Vis alle 8 forfattere av denne artikkelen] (2012). Interleukin-1 Gene Locus Polymorphisms are Associated with Risk to Breast Cancer in Croatian Population. Periodicum biologorum. ISSN 0031-5362. 114(4), s. 497–503. Fulltekst i vitenarkiv
  • Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Kårvatn, Marikken; Mulac-Jericevic, Biserka & Tijanic, Tamara [Vis alle 9 forfattere av denne artikkelen] (2011). Hip Osteoarthritis Susceptibility Is Associated with IL1B-511(G > A) and IL1 RN (VNTR) Genotypic Polymorphisms in Croatian Caucasian Population. Journal of Orthopaedic Research. ISSN 0736-0266. 29(8), s. 1137–1144. doi: 10.1002/jor.21378.
  • Etokebe, GE; Skjeldal, F; Nilsen, Nadra; Rodionov, Dmitrii; Knezevic, Jelena & Bulat-Kardum, Ljiljana [Vis alle 9 forfattere av denne artikkelen] (2010). Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(5), s. 369–381. doi: 10.1111/j.1365-3083.2010.02379.x. Fulltekst i vitenarkiv
  • Etokebe, Godfrey; Kuchler, Axel Matthias; Haraldsen, Guttorm; Landin, Maria Augusta Dos S Silva; Osmundsen, Harald & Dembic, Zlatko (2009). Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds. Archives of Oral Biology. ISSN 0003-9969. 54(11), s. 1002–1007. doi: 10.1016/j.archoralbio.2009.08.005.
  • Etokebe, Godfrey; Knezević, Jelena; Petricević, Branka; Pavelić, Jasminka; Vrbanec, Damir & Dembic, Zlatko (2009). Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. Genetic Testing and Molecular Biomarkers. ISSN 1945-0265. 13(6), s. 729–734. doi: 10.1089/gtmb.2009.0045.
  • Etokebe, Godfrey; Axellson, Stefan; Svaerd, Niels Henrik; Storhaug, Kari & Dembic, Zlatko (2008). Detection of Hemizygous Chromosomal Copy Number Variants in Williams-Beuren Syndrome (WBS) by Duplex Quantitative PCR Array: An Unusual Type of WBS Genetic Defect. International Journal of Biomedical Science. ISSN 1550-9702. 4(3), s. 161–170. Fulltekst i vitenarkiv
  • Etokebe, Godfrey; Bulat-Kardum, L; Johansen, MS; Knezevic, J; Balen, S & Matakovic-Mileusnic, N [Vis alle 11 forfattere av denne artikkelen] (2006). Interferon-gamma gene (T874A and G2109A) polymorphisms are associated with microscopy-positive tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 63, s. 136–141.
  • Bulat-Kardum, L; Etokebe, Godfrey; Knezevic, J; Balen, S; Matakovic-Mileusnic, N & Zaputovic, L [Vis alle 9 forfattere av denne artikkelen] (2006). Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 63.
  • Dembic, Zlatko (2005). The Function of Toll-like Receptors. I Rich, Tina (Red.), Toll and Toll-Like Receptors: An Immunologic Perspective. Landes Bioscience / Eurekah.com and Kluwer Academic / Plenum Publishers. s. 18–55.
  • Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias & Dembic, Zlatko [Vis alle 7 forfattere av denne artikkelen] (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, s. 759–769.
  • Dai, Kezheng; Johansen, Finn Eirik; Kolltveit, Kristin Melkevik; Aasheim, Hans-Christian; Dembic, Zlatko & Vartdal, Frode [Vis alle 7 forfattere av denne artikkelen] (2004). Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter. Journal of Immunology. ISSN 0022-1767. 172, s. 6144–6151.
  • Dembic, Zlatko; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2004). Anti-class II antibodies, but not cytotoxic T-lymphocyte antigen 4-immunoglobulin hybrid molecules, prevent rejection of major histocompatibility complex class II-negative myeloma in T-cell receptor-transgenic mice. Scandinavian Journal of Immunology. ISSN 0300-9475. 60, s. 143–152.
  • Dai, Ke-Zheng; Johansen, Finn-Eirik; Kolltveit, Kristin Melkevik; Åsheim, Hans-Christian; Dembic, Zlatko & Vartdal, Frode [Vis alle 7 forfattere av denne artikkelen] (2004). Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter. Journal of Immunology. ISSN 0022-1767. doi: 10.4049/jimmunol.172.10.6144.
  • Dellacasagrande, Jerome; Schreurs, Olav Joseph F; Hofgaard, Peter Olaf; Omholt, Hilde; Steinsvoll, Svein E B & Schenck, Karl [Vis alle 8 forfattere av denne artikkelen] (2003). Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scandinavian Journal of Immunology. ISSN 0300-9475. 57(6), s. 534–544.
  • Fraser, D. A.; Loos, Bruno G.; Boman, U; Winkelhoff, Arie J Van; Velden, U van der & Schenck, Karl [Vis alle 7 forfattere av denne artikkelen] (2003). Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitits. Acta Odontologica Scandinavica. ISSN 0001-6357. 61(5), s. 297–302.
  • Dembic, Zlatko (2003). Critical elements in case-control studies in predisposition to tuberculosis. Scandinavian Journal of Immunology. ISSN 0300-9475. 58.
  • Fraser, D. A.; Bulat-Kardum, L; Knezevic, J; Babarovic, Z; Matakovic-Mileusnic, N.* & Dellacasagrande, Jerome [Vis alle 10 forfattere av denne artikkelen] (2003). Interferon-gamma receptor-1 gene polymorphism in tuberculosis patients from Croatia. Scandinavian Journal of Immunology. ISSN 0300-9475. 57(5), s. 480–484.
  • Fraser, DA; Loos, BG; Boman, U; van Winkelhoff, AJ; van der Velden, U & Schenck, Karl [Vis alle 7 forfattere av denne artikkelen] (2003). Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis. Acta Odontologica Scandinavica. ISSN 0001-6357. 61, s. 297–302.
  • Dembic, Zlatko; Rottingen, John-Arne; Dellacasagrande, Jerome; Schenck, Karl & Bogen, Bjarne (2001). Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood. ISSN 0006-4971. 97(9), s. 2808–14.
  • Dembic, Zlatko; Røttingen, John-Arne; Dellacasagrande, Jerome; Schenck, Karl & Bogen, Bjarne (2001). Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood. ISSN 0006-4971. 97, s. 2808–2814.
  • Dembic, Zlatko; Schenck, Karl & Bogen, Bjarne (2000). Dendritic cells purified from myeoloma are spontaneously primed with tumor-specific antigen (idiotype) and activate CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 97, s. 2697–2702.
  • Bogen, Bjarne; Schenck, Karl; Munthe, Ludvig Andre & Dembic, Zlatko (2000). Deletion of Idiotype(Id)-specific T cells in multiple myeloma. Acta Oncologica. ISSN 0284-186X. 39, s. 783–788.
  • Dembic, Zlatko; Munthe, Ludvig Andre; Schenck, Karl; Mueller, Christopher & Bogen, Bjarne (1998). Transient overexpression of CD4 enhances allelic exclusion of T cell receptor (TCR) chains and promotes positive selection of class II-restricted TCR-transgenic thymmocytes. Molecular Immunology. ISSN 0161-5890. 35, s. 23–38.
  • Dembic, Zlatko; Munthe, Ludvig Andre; Schenck, Karl; Mueller, C. & Bogen, Bjarne (1998). Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) a chains and promotes positive selection of class II-restricted TCR-transgenetic thymocytes. Molecular Immunology. ISSN 0161-5890. s. 23–38.
  • Bogen, Bjarne; Weiss, S. & Dembic, Zlatko (1997). Idiotypes and T cell selection. In Handbook of Immune Modulating Agents. I Kresina, T. (Red.), Marcel Decker. New York.
  • Schreurs, Olav Joseph F; Halstensen, Trond Sundby; Dembic, Zlatko; Bogen, Bjarne & Schenck, Karl (1997). TUNEL combined with staining for epithelial cellmarker permits unambiguous localization of apoptic cells in murine thymus. Biochemica. ISSN 0946-1310. 4, s. 19–21.
  • Merlin, G.; Leede, B. J. M. van der ; McKune, K.; Bannwarth, W.; Romquin, N. & Viegas-Pequignot, E. [Vis alle 8 forfattere av denne artikkelen] (1997). The gene for the ligand binding chain of the human interferon gamma receptor. Immunogenetics. ISSN 0093-7711. 45, s. 413–421.
  • Munthe, Ludvig Andre; Blichfeldt, E.; Sollien, Anders; Dembic, Zlatko & Bogen, Bjarne (1996). T cells with two TCR_b chains and reactivity to both MHC/idiotypic peptide and superantigen. Cellular Immunology. ISSN 0008-8749. 170, s. 283–290.
  • Magyar, JP; Martini, R; Ruelicke, T; Aguzzi, A; Adlkofer, K & Dembic, Zlatko [Vis alle 8 forfattere av denne artikkelen] (1996). Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. Journal of Neuroscience. ISSN 0270-6474. 16, s. 5351–5360.
  • Ebensperger, C; Muthukumaran, G; Lembo, D; Donnely, RJ; Pestka, S & Dembic, Zlatko (1996). Genomic organization and promotor analysis of the gene ifngr2 encoding the second chain of the mouse interferon-g-receptor. Scandinavian Journal of Immunology. ISSN 0300-9475. 44, s. 599–606.
  • Rhee, S; Ebensperger, C; Dembic, Zlatko & Pestka, S (1996). The structure of the gene for the second chain of the human interferon gamma receptor. Journal of Biological Chemistry. ISSN 0021-9258. 271, s. 28947–28952.
  • Muthukumaran, G; Donnely, RJ; Ebensperger, C; Mariano, TM; Garotta, G & Dembic, Zlatko [Vis alle 8 forfattere av denne artikkelen] (1996). The intracellular domain of the second chain of the interferon-gamma-receptor is interchangeable between species. Journal of Interferon and Cytokine Research. ISSN 1079-9907. 16, s. 1039–1045.

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  • Dembic, Zlatko (2015). The Cytokines of the Immune System. Academic Press. ISBN 978-0-12-419998-9. 310 s.
  • Bogen, Bjarne; Dembic, Zlatko & Weiss, S. (1998). Book chapter "Idiotypes and T cell selection" in "Immune Modulating Agents". Marcel Dekker Inc., NY, Basel, Hong Kong. 19 s.

Se alle arbeider i Cristin

  • Dembic, Zlatko (2012). The Immune System Maintains Integrity of an Organism. Fulltekst i vitenarkiv
  • Jodal, Henriette Cecilie; Hofgaard, Peter Olaf; Dembic, Zlatko & Bogen, Bjarne (2011). A New Mouse Model for Multiple Myeloma. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 388–388.
  • Kårvatn, Marikken; Jotanovic, Zdravko; Etokebe, Godfrey; Mihelic, Radovan; Mulac-Jericevic, Biserka & Tijanic, Tamara [Vis alle 9 forfattere av denne artikkelen] (2011). Interleukin-1(IL-1)A, IL-1B and IL-1 Receptor Antagonist Gene Polymorphisms in Predisposition to Hip and Knee Osteoarthritis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s. 370–371.
  • Kaarvatn, MH; Jotanovic, Z; Etokebe, Godfrey; Mihelic, NN; Mulac-Jericevic, NN & Tijanic, T [Vis alle 9 forfattere av denne artikkelen] (2010). Polymorphisms in the Interleukin-1B And IL-1 Receptor Antagonist Genes in Predisposition to Hip and Knee Osteoarthritis in Croatian Population. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(6), s. 482–482.
  • Dembic, Zlatko (2008). Beginning of the end of (understanding) the immune response. Scandinavian Journal of Immunology. ISSN 0300-9475. 68(4), s. 381–382. doi: 10.1111/j.1365-3083.2008.02159.x.
  • Dembic, Zlatko (2004). Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms. Scandinavian Journal of Immunology. ISSN 0300-9475. 60, s. 3–5.
  • Dembic, Zlatko; Fraser, David; Loos, Bruno G.; Velden, Ubele van der & Schenck, Karl (2004). Genetic Polymorphism in Periodontal Disease.
  • Dembic, Zlatko (2004). Immunosurveillance of malign tumors.
  • Dai, Ke-Zheng; Johansen, Finn-Eirik; Kolltveit, Kristin Melkevik; Aasheim, Hans-Christian; Dembic, Zlatko & Vartdal, Frode [Vis alle 7 forfattere av denne artikkelen] (2003). Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5� monophosphate responsive element in the proximal SH2D2A promoter.
  • Loos, Bruno G.; Schreiber, S.; Scholtz, C.; Jebsen, S.; Groessner-Schreiber, B. & Dembic, Zlatko [Vis alle 7 forfattere av denne artikkelen] (2003). CARD4 and CARD15 gene polymorphysms in relation to aggressive periodontitis.
  • Dembic, Zlatko; Røttingen, John-Arne; Dellacasagrande, Jerome & Schenck, Karl (2001). Isolated phagocytic dendritic cells from myeloma activate tumor-specific T cells at a single cell level.
  • Dembic, Zlatko; Røttingen, John-Arne; Dellacasagrande, Jerome; Schenck, Karl & Bogen, Bjarne (2001). Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level.
  • Bogen, Bjarne; Dembic, Zlatko; Røttingen, John-Arne & Schenck, Karl (1999). Professional APC in plasmacytomas are primed with myeloma protein idiotype (Id) and are able to introduce activation of class II restricted Id-specific CD4+ cells.
  • Dembic, Zlatko (1996). Do we need integrity? Scandinavian Journal of Immunology. ISSN 0300-9475. 44, s. 549–550.

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Publisert 1. nov. 2010 13:35 - Sist endret 4. sep. 2020 14:47