Zlatko Dembic

Professor - Molekylær
Bilde av Zlatko Dembic
English version of this page
Telefon +47 22840330
Rom A1.M051
Brukernavn
Besøksadresse Domus Odontologica Sognsvannsveien 10 0372
Andre tilknytninger Institutt for oral biologi

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Molekylærgenetikk - utviklingsstudier med fokus på kraniofaciale strukturer og immunsystemet

Gruppeleder: Professor Zlatko Dembic, dr.med.; Medlemmer: emeritus prof. Marie Wika, Cand.real., stipendiat Randi Krog Eftedal, cand odont.

   Vi undersøker genenes betydning for tidlige signaler i utviklingen av embryonale vev til strukturer i det kraniofaciale område - omfattende mucosa, spyttkjertler, tenner, knokler, ledd, tonsiller, beinmarg og nervevev. Vi undersøker også gener som kan predisponere for ulike sykdommer av immunologisk og/eller inflammatorisk karakter  og som kan føre til utvikling av kroniske sykdommer senere i et individs liv. Vi benytter ”case” (pasient) – kontroll studier for å bestemme frekvenser av genetiske markører i genetiske områder valgt ut fra kvalifisert gjetning eller knyttet til kraniofaciale områder der mikrochip profiler uttrykkes. Nylig er det gjort en undersøkelse på predisponerende faktorer for tuberkulose, bryst- og coloncancer såvel som primær oseoartritt i store ledd og i temporomandibulærleddet (kjeveleddet). Gener av interesse omfatter cytokinfamilimedlemmer som interferon-gamma  og interleukin-1 og Toll-lignende  receptor familiene 1,2,3,4,6,7 og 9, som er viktige for tidligaktivering av de spesifikke (adaptive) immunresponsene.

Emneord: 1. DNA, 2. Immungenetikk, 3. Respiratory infection, 4. Epitelial kreft, 5. Ledd inflammasjon, 6. Immunregulation, 7. RT PCR

 

Undervisning

http://www.uio.no/studier/program/odontologi/

http://www.uio.no/studier/program/medisin/

Bakgrunn

As a scientist with a medical background, it's natural that my research interests are placed at the crossroads of medicine and biology. Since the earliest days of my lab career I was attracted to molecular and cellular immunology. The more I learned, the more my interest evolved toward studying ontogeny and phylogeny of the immune system. The reason was simple: I wished to understand its function, and that is still my wish. During the last twenty years of the past century I've worked on important issues in immunology at the Max-Planck-Institute for Biology (Tubingen, Germany), the Basel Institute for Immunology (Switzerland; CH) and the Hoffman-La Roche AG (Basel, CH). We were the first to report the identification of genes underlying T-cell specificity and recognition (mouse T-cell receptor, in '86). Likewise, we led the research on molecular cloning of human cytokine receptors important for the effector phase of immunity such as the interferon-gamma receptor (IFNGR1; in '88) and the tumor necrosis factor receptor-2 (TNFR2; in '90). In 1995, I moved to the Institute of Immunology at the University of Oslo, Norway. Since then I broadened the scope of my research by working on T-cell development, cancer immunobiology, immunogenetics and susceptibility to cancer and infectious diseases. And, since 2002 I research and teach at the Department of Oral Biology, OF, UiO.

All of this would not have been possible without a substantial contribution from my academic collaborators and colleagues in Norway and Croatia. Some of these studies led me to propose a model about the workings of the immune system called the "integrity" model in the mid-nineties. It stresses that immunity is not only a defense system, but also a selector of potential symbionts and commensals. So far, my publication list has over 80 scientific contributions. Ten percent were published in top scientific journals (Nature and Cell) with myself as a prominent author (in half of them). I tend to take these achievements as evidence of the great fun and joy that basic research in immunology has given me over the past years. They are also the source of an unending motivation to study further what remains unknown - a progressively smaller part of human body.

Find more about biography here: http://folk.uio.no/zlatkod/index2.html and  http://folk.uio.no/zlatkod/index.html

Priser

The Hoffman-LaRoche prize (internal) for the first report on molecular cloning of the human Interferon gamma receptor molecule (1988)

Verv 

  • 2002 - Professor i cellebiology, immunologi og mikrobiologi ved Institutt for Oral Biologi (IOB) 

  • 2007 - Visiting professor i medisin ved Medisinsk fakultet, Universitetet i Rijeka (Kroatia) (privat; for videreutdanningskurs).

  • 2006 - Associate Editor - Scandinavian Journal of Immunology (Wiley)

Samarbeid

Medical Faculty, University of Oslo:

Centre for Immune Regulation (CiR) - Professor Bjarne Bogen 

Faculty of Medicine, University of Rijeka, Croatia:

Dept of Molecular Medicine and Biotechnology -  Professor dr med Sinisa Volarevic;

Clinic of Internal Medicine, Dept of Pulmology - Docent dr med Ljiljana Bulat-Kardum;

Department of Physiology and Immunology - Professor dr med Ines Mrakovcic-Sutic;

Faculty of medicine, University "Juraj Dobrila", Pula, Croatia:

Dean - Professor dr med Kresimir Pavelic; 

General Hospital, Clinic for Oncology - Professor dr med Damir Vrbanec;

Institute Rudjer Boskovic, Zagreb, Croatia:

Dept of Molecular Medicine - Dr Jelena Knezevic,

Dr Mariastefania Antica

Emneord: DNA, Immunogenetics, RT-PCR, Immunoregulation, Cranofacial biology, Respirasjons infekt, Epitelial kreft
Publisert 1. nov. 2010 13:35 - Sist endret 4. sep. 2020 14:47