Heidi Aarø Åmdal

• Shekhar, Sudhanshu; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2021). Vaccination With the Commensal Streptococcus mitis Expressing Pneumococcal Serotype 5 Capsule Elicits IgG/IgA and Th17 Responses Against Streptococcus pneumoniae. Frontiers in Immunology. ISSN 1664-3224. doi: 10.3389/fimmu.2021.676488. Full text in Research Archive
• Filho, Antonio Pedro Ricomini; Khan, Rabia; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2019). Conserved Pheromone Production, Response and Degradation by Streptococcus mutans. Frontiers in Microbiology. ISSN 1664-302X. 10. doi: 10.3389/fmicb.2019.02140. Full text in Research Archive
• Junges, Roger; Sturød, Kjersti; Salvadori, Gabriela ; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2019). Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae. Applied and Environmental Microbiology. ISSN 0099-2240. 85(2). doi: 10.1128/AEM.02297-18.
• Salvadori, Gabriela ; Junges, Roger; Åmdal, Heidi Aarø; Chen, T.; Morrison, D.A. & Petersen, Fernanda Cristina (2018). High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes. BMC Genomics. ISSN 1471-2164. 19(1). doi: 10.1186/s12864-018-4802-y. Full text in Research Archive
• Junges, Roger; Salvadori, Gabriela ; Shekhar, Sudhanshu; Åmdal, Heidi Aarø; Periselneris, Jimstan & Chen, Tsute [Show all 8 contributors for this article] (2017). A quorum-sensing system that regulates Streptococcus pneumoniae biofilm formation and surface polysaccharide production. mSphere. ISSN 2379-5042. 2(5), p. 1–18. doi: 10.1128/mSphere.00324-17. Full text in Research Archive
• Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2017). A positive feedback loop mediated by Sigma X enhances expression of the streptococcal regulator ComR. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-04768-5. Full text in Research Archive
• Junges, Roger; Khan, Rabia; Tovpeko, Yanina; Åmdal, Heidi Aarø; Petersen, Fernanda Cristina & Morrison, Donald (2017). Markerless genome editing in competent streptococci. Methods in molecular biology. ISSN 1064-3745. 1537, p. 233–247. doi: 10.1007/978-1-4939-6685-1_14. Full text in Research Archive
• Salvadori, Gabriela ; Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2017). Natural transformation of oral streptococci by use of synthetic pheromones. Methods in molecular biology. ISSN 1064-3745. p. 219–232. doi: 10.1007/978-1-4939-6685-1_13. Full text in Research Archive
• Khan, Rabia; Rukke, Håkon Valen; Høvik, Hedda; Åmdal, Heidi Aarø; Chen, T. & Morrison, Donald A. [Show all 7 contributors for this article] (2016). Comprehensive Transcriptome Profiles of Streptococcus mutans UA159 Map Core Streptococcal Competence Genes. mSystems. ISSN 2379-5077. 1(2). doi: 10.1128/mSystems.00038-15. Full text in Research Archive Show summary

  In Streptococcus mutans, an oral colonizer associated with dental caries, development of competence for natural genetic transformation is triggered by either of two types of peptide pheromones, competence-stimulating peptides (CSPs) (18 amino acids [aa]) or SigX-inducing peptides (XIPs) (7 aa). Competence induced by CSP is a late response to the pheromone that requires the response regulator ComE and the XIP-encoding gene comS. XIP binds to ComR to allow expression of the alternative sigma factor SigX and the effector genes it controls. While these regulatory links are established, the precise set of effectors controlled by each regulator is poorly defined. To improve the definition of all three regulons, we used a high-resolution tiling array to map global changes in gene expression in the early and late phases of the CSP response. The early phase of the CSP response was limited to increased gene expression at four loci associated with bacteriocin production and immunity. In the late phase, upregulated regions expanded to a total of 29 loci, including comS and genes required for DNA uptake and recombination. The results indicate that the entire late response to CSP depends on the expression of comS and that the immediate transcriptional response to CSP, mediated by ComE, is restricted to just four bacteriocin-related loci. Comparison of the new data with published transcriptome data permitted the identification of all of the operons in each regulon: 4 for ComE, 2 for ComR, and 21 for SigX. Finally, a core set of 27 panstreptococcal competence genes was identified within the SigX regulon by comparison of transcriptome data from diverse streptococcal species.

• Morrison, D.A.; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2015). Genome editing by natural genetic transformation in Streptococcus mutans. Journal of Microbiological Methods. ISSN 0167-7012. 119, p. 134–141. doi: 10.1016/j.mimet.2015.09.023.

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• Shekhar, Sudhanshu; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2021). Vaccination with the commensal Streptococcus mitis expressing pneumococcal serotype 5 capsule elicits IgG/IgA and Th17 responses against Streptococcus pneumoniae.
• Petersen, Fernanda Cristina; Dhariwal, Achal; Bråten, Lars Christian Haugli; Sturød, Kjersti; Junges, Roger & Salvadori, Gabriela [Show all 10 contributors for this article] (2021). Off-target impact of long-term amoxicillin treatment.
• Junges, Roger; Sturød, Kjersti; Salvadori, Gabriela ; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2018). Interspecies activation of a virulent pathway by an oral commensal.
• Salvadori, Gabriela ; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2018). Insights into regulatory pathways of competence development in Streptococcus mitis type strain and SK321 .
• Salvadori, Gabriela ; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2018). Molecular Characterization of Genetic Competence in Streptococcus mitis .
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Streptococcus mitis response to the competence pheromone.
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome analysis of Streptococcus mitis response to the competence pheromone.
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). A New Pheromone in Streptococcus mitis Enhances Biofilm Formation.
• Petersen, Fernanda Cristina; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Morrison, Donald A. (2015). A new link between the Streptococcus mutans XIP and CSP pheromone pathways revealed by directional RNA-sequencing.
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Characterization of an Rgg/SHP system in Streptococcus mitis that allows communication with Streptococcus pneumoniae.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptococcus mitis to the competence pheromone.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). A new link between two Streptococcus mutans pheromones.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptoccocus mutans to the sigX-inducing peptide (XIP).
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Identification of Streptococcus mitis competence pheromone responsive genes by transcriptome analysis.

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