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Antibiotic Resistance and Microbiome

The oral cavity is a port of entry to the digestive and respiratory tracts. Different sites in the aerodigestive tract are characterized by specific microbiomes, which also share several of the same microbial inhabitants. Among these are microorganisms which can lead to disease, especially if the balance in the normal microbiome is interrupted.

About our research

In high income countries, dentists stand for 6%-11% of antibiotic prescriptions in primary health care. The increase in antimicrobial resistance means that common procedures done today in dentistry and medicine, such as implants and use of prosthetic devices, may become too risky to be recommended in the near future.

Antimicrobial resistance is, according to the UN, one of the major threats to humanity. In our group, we are applying the experience acquired during years of research in oral microbiology to survey the impact of antimicrobials on the human microbiome. Our research focuses on the microbiome as a reservoir of antimicrobial resistance genes to pathogens, and in the potential of translating such knowledge into new diagnostic tools and vaccines.