Thesis summary
Bone fractures are a major cause of severe physical disability and impair the quality of life of many patients worldwide. Over the past few decades, treatment options relying on biomaterials and bone tissue engineering approaches have led to the development of several new strategies to stimulate tissue regeneration after bone damage resulting from trauma or loss of bone tissue caused by pathology or resorption.
After implantation into the human body, biomaterials induce a cascade of biological reactions known as foreign body responses (FBRs), which affect the success or failure of the implant. Studying FBRs towards different types of biomaterials is therefore of high importance. In Maryam's PhD thesis, bone tissue response to different metallic and composite bone implant materials was studied using various advanced 2D and 3D imaging techniques. Using different animal models, the material function and bone-to-implant interface could be studied in detail. The results obtained using the various different imaging techniques complimented each other and provided useful information about the biological responses occurring at the bone-biomaterial interface.
Evaluation committee
- Senior Lecturer Gavin Jell, University College London, UK
- Professor Pekka Vallittu, University of Turku, Finland
- Senior Researcher Hanne Scholz, University of Oslo
Supervisors
- Professor Håvard J Haugen
- Professor Thaqif El Khassawna
