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Herlofson, Bente Brokstad
(2023).
Kjevebenspatologi og benmodulerende behandling -
Betydning for pasienter med myelomatose?
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Herlofson, Bente Brokstad
(2023).
Munnhelse og kreft - Fokus på pasienter med myelomatose.
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Herlofson, Bente Brokstad & Langeland, Øystein
(2023).
Autotransplantasjon av tenner - Nytt fra kirurgens ståsted?
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Herlofson, Bente Brokstad; Vang, Kjersti & Berstad, Johanna Elisabeth Rykke
(2023).
Oral fokussanering i forbindelse med strålebehandling for hode-/halskreft.
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Herlofson, Bente Brokstad; Tingvoll, Dag Petter Nilsen & Giltvedt, Karen Marie
(2023).
The Scandinavian ONJ Cohort Study, an 8-years research collaboration - Focus on the Norwegian study results.
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Herlofson, Bente Brokstad
(2023).
Kjevebenspatologi - Antiresorptiv behandling og MRONJ med fokus på pasienter med osteoporose.
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Herlofson, Bente Brokstad
(2022).
Oral helse og kreft - Dagens er fremtidens utfordringer.
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Herlofson, Bente Brokstad
(2022).
MRONJ - collaboration projects - International, national and single center ONJ studies.
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Herlofson, Bente Brokstad & Westgaard, Kristine Løken
(2022).
The Oral Health Subproject - part of the Late toxicity and long-term quality of life study in head and neck cancer survivors .
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Herlofson, Bente Brokstad
(2022).
Tann-og munnhelseutfordringer - ansvar og økonomi .
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Herlofson, Bente Brokstad
(2022).
The Scandinavian ONJ Cohort Study - ONJ collaboration projects.
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Herlofson, Bente Brokstad
(2022).
Oral helse og kreft - Tverrfaglige utfordringer .
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Monsen, Ragnhild Elisabeth; Nordgarden, Hilde; Gay, Caryl; Lerdal, Anners & Herlofson, Bente Brokstad
(2022).
Munntørrhet - et manglende symptom i Edmonton Symptom Assessment System?
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Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad
[Show all 10 contributors for this article]
(2022).
Orale soppinfeksjoner - mer enn Candida albicans: mikrobiologiske analyser av prøver fra alvorlig syke pasienter med kreft .
Show summary
Bakgrunn
Pasienter med alvorlig kreftsykdom er utsatte for orale soppinfeksjoner, grunnet sykdommen, kreftbehandling og/eller svekket immunforsvar. Orale soppinfeksjon påvirker pasienters matlyst, ernæringstilstand og livskvalitet. Candida albicans er en vanlig soppart i munnhulen, men forekomst av non-albicans Candida-arter, og i kombinasjon med C. albicans, er økende. Artene har varierende toleranse for antimykotiske midler, det kan gi behandlingsutfordringer.
Hensikten med studien var å identifisere og resistensteste Candida sopparter i munnhulen til alvorlig syke pasienter med kreft.
Metode
Sopprøver tatt under studien Oral Health in Advanced Cancer i perioden 2014 – 2016, ble analysert høsten 2020. Pasientprøvene ble re-dyrket ved Institutt for oral biologi, Universitetet i Oslo. Soppartene ble identifisert biokjemisk og ved DNA sekvensering, og resistenstestet for antimykotiske legemidler: fluconazole, amphotericin B, anidulafungin og nystatin.
Resultat
Vi analyserte totalt 56 isolater fra 45 pasienter og identifiserte syv Candida arter og en Saccharomyces. Til sammen hadde 36 pasienter oppvekst av én soppart, og 9 pasienter hadde 2 til 3 ulike sopparter i munnhulen. Av C. albicans artene var 39 av 40 følsomme for fluconazole. To Candida parapsilosis og en Candida tropicalis var resistent mot anidulafungin. En C. tropicalis var resistent mot anidulafungin. En Candida glabrata var resistent mot fluconazole.
Konklusjon
Studien viste at forskjellige Candida arter forekommer både i monoinfeksjoner og blandingsinfeksjoner. C. albicans var dominerende med høy følsomhet for antimykotiske midler. Blandingsinfeksjoner kan komplisere behandlingen og forårsake gjentagende infeksjoner. Mikrobiologiske prøver og analyser med identifisering og resistenstesting, bør være en del av utredningen hos pasienter med alvorlig og tilbakevendende orale soppinfeksjoner.
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Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad
[Show all 10 contributors for this article]
(2022).
Oral candidiasis in advanced cancer – identification and susceptibility testing of detected Candida species.
Show summary
Introduction: Candida albicans is the most common fungal species in the oral cavity. Increased prevalence of non-C. albicans are detected, and co-infection with C. albicans may have implications for treatment, due to antifungal resistance. The aim of the study was to assess the diversity and susceptibility of oral yeasts in patients with advanced cancer.
Methods: Clinical fungal isolates were sampled in 2014-2016 from 45 patients in a hospice unit. Totally 56 isolates were grown on chromID Candida plates, prepared for biochemical identification, and controlled with DNA sequencing. E-test was performed with the antifungal agents fluconazole, amphotericin B, anidulafungin and nystatin were tested.
Results: A total of 56 isolates were identified. Candida species was dominated by C. albicans at 71%, followed by C. glabrata 9%, C. parapsilosis 5%, C. tropicalis 4%, C. krusei 2%, C. guilliermondii 2% and C. dubliniesis 2%. Nine patients had 2-3 different species. C. albicans strains were susceptible to fluconazole in 97.5%. One C. parapsilosis and one C. tropicalis strain were resistant to anidulafungin. One C. glabrata was resistant to fluconazole and another was just below the threshold for resistance. The sequencing confirmed the biochemical identification.
Conclusion: C. albicans was the most prevalent species. Variation in susceptibility was observed in patients with mixed colonies. Combinations of Candida species and the lack of identification and susceptibility testing may lead to inadequate treatment.
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Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad
[Show all 10 contributors for this article]
(2022).
Identification and susceptibility testing of oral candidiasis in advanced cancer patients – an important diagnostic tool.
Show summary
Background: Candida albicans is the most common fungal species detected in the oral cavity. Studies of oral fungal samples have shown an increased prevalence of non-C. albicans species in mixed infection with C. albicans. Non-C. albicans and C. albicans are associated with varying degrees of resistance to azole. This may have implications for treatment, due to acquired antifungal resistance.
Aims: To assess the diversity and susceptibility of detected Candida species in the oral cavity in patients with advanced cancer.
Methods: Clinical fungal isolates sampled in 2014-2016 from 45 patients in a hospice unit were analyzed. A total of 56 isolates were grown on chromID Candida plates. After phenotypic identification by colour of the colonies, one single colony of each species was re-cultivated and prepared for identification on a VITEK2® system. Susceptibility testing with E-test was performed on RPMI agar, and the antifungal agents fluconazole, amphotericin B, anidulafungin and nystatin were tested.
Results: A total of 56 Candida isolates were identified. The diversity of Candida species was dominated by C. albicans at 89%, followed by C. glabrata 11%, C. parapsilosis 7%, C. tropicalis 4%, C. krusei 2%, C. guilliermondii 2% and C. dubliniesis 2%. Thirty-six patients had monoculture, and nine patients had 2-3 different species detected. Almost all C. albicans strains (97.5%) were susceptible to fluconazole. One C. parapsilosis and one C. tropicalis strain were resistant to anidulafungin. One C. glabrata was resistant to fluconazole and another was just below the threshold for resistance.
Conclusion: C. albicans was the most prevalent Candida species in our sample. Variation in susceptibility was observed in patients with both C. albicans and C. glabrata. Combinations of Candida species and the lack of identification and susceptibility testing may lead to inadequate treatment and accelerate the development of resistance.
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Hynne, Håvard; Aqrawi, Lara A.; Chen, Xiangjun; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten
[Show all 14 contributors for this article]
(2021).
Cytokine profiling, clinical oral and ocular manifestations post radiotherapy
.
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Herlofson, Bente Brokstad
(2021).
Munnhulekreft - Orale potensielt maligne tilstander, orale alarmsymptomer
Pasienter på benmodulerende behandling.
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Herlofson, Bente Brokstad
(2021).
Pasienter på antiresorptiv behandling og kjeveosteonekrose.
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Bjørkeng, Astrid Skiftesvik; Herlofson, Bente Brokstad & Myhre, Sigrun
(2021).
Podkast: Hvordan virker kreftbehandling på kroppen?
[Internet].
Universitetet i Oslo, Universitetsplassen podkast.
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Herlofson, Bente Brokstad
(2021).
Hvordan forholde seg til pasienter på benmodulerende behandling - Når kan tenner ekstraheres?
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Herlofson, Bente Brokstad
(2021).
Munnhelse ved kreft og kreftbehandling.
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Herlofson, Bente Brokstad; Lund, Bodil Kristina; Pinholt, Else Marie & Seppänen-Kaijansinkko, Riitta
(2021).
The Nordic Success Story - Four women in Oral and maxillofacial Surgery from four Nordic countries.
Face to Face, Magazine, IAOMS.
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Herlofson, Bente Brokstad; Schiødt, Morten & Wexell, Cecilia Larsson
(2021).
Acute and chronic inflammation, osteomyelitis, medication-related ostoenecrosis of the jaw and osteoradionecrosis.
In Bjørnland, Tore (Eds.),
Nordic Textbook of Oral and Maxillofacial Surgery.
Munksgaard Forlag.
ISSN 978-87-628-2012-8.
p. 151–182.
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Herlofson, Bente Brokstad
(2020).
Pasienter på benmodulerende behandling og osteonekrose - med fokus på myelomatose.
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Herlofson, Bente Brokstad
(2020).
Jaw osteomyelitis/osteonecrosis - clinical presentation, diagnosis, therapy.
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Steffensen, Inger-Lise; Alexander, Jan; Binderud, Mona-Lise; Bruzell, Ellen Merete; Dahl, Knut Helkås & Granum, Berit
[Show all 13 contributors for this article]
(2020).
Risk assessments of aspartame, acesulfame K, sucralose and benzoic acid from soft drinks, "saft", nectar and flavoured water.
European Journal of Nutrition and Food Safety.
ISSN 2347-5641.
12(8),
p. 66–68.
doi:
10.9734/EJNFS72020/v12i830265.
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Herlofson, Bente Brokstad
(2020).
Kreftpasienter på antiresorptiv behandling med risiko for utvikling av osteonekrose i kjevene.
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Herlofson, Bente Brokstad
(2020).
Pasienter på benmodulerende behandling og osteonekrose.
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Herlofson, Bente Brokstad
(2019).
Pasienter som skal ha eller som står på på benmodulerende behandling - samarbeid mellom lege og tannlege.
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Herlofson, Bente Brokstad
(2019).
The Scandinavian ONJ Cohort Study - 8 year research collaboration on ONJ in Norway, Sweden and Denmark.
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Lossius, Sara Ekern & Herlofson, Bente Brokstad
(2019).
Sunn munn, god helse.
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Herlofson, Bente Brokstad
(2019).
Oral cancer awareness week.
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Herlofson, Bente Brokstad
(2019).
Jaw bone pathology - a challenge for the wave of new medical treatments in cancer and osteoporosis.
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Herlofson, Bente Brokstad
(2019).
Oral health issues in the society, with a focus on cancer and cancer treatment. A research project.
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Herlofson, Bente Brokstad
(2019).
Pasienter på benmodulerende behandling.
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Herlofson, Bente Brokstad
(2019).
Oral medisin.
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Herlofson, Bente Brokstad
(2019).
Oppdatering vedrørende pasienter på benmodulerende behandling.
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Herlofson, Bente Brokstad
(2019).
Rettigheter og oppfølging av oral helse ved kreftsykdom.
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Herlofson, Bente Brokstad & Ingstad, Hanne Kleven
(2019).
Oral cancer og oral medisin. .
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Jensen, Janicke Liaaen; Chen, Xiangjun; Hynne, Håvard; Westgaard, Kristine Løken; Hove, Lene Hystad & Young, Alix
[Show all 14 contributors for this article]
(2019).
Sjögren’s versus irradiated head-neck cancer patients: oral and ocular investigations.
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Hynne, Håvard; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Amdal, Cecilie Delphin; Hove, Lene Hystad & Young, Alix
[Show all 10 contributors for this article]
(2019).
Oral and Ocular Findings in Radiated Head-and Neck Cancer Patients.
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Young, Alix; Singh, Preet Bano; Hynne, Håvard; Løken Westergaard, Kristine; Hove, Lene Hystad & Rykke, Morten
[Show all 10 contributors for this article]
(2019).
Oral Investigations in Head and Neck Cancer Patients after Radiotherapy.
Show summary
Objectives: To investigate oral complaints and findings in head and neck cancer (HNC) patients who had received radiotherapy and compare them with controls.
Methods: As part of a larger study, 30 HNC patients (14 female, age 64.2±9.6y) and 26 age- and sex-matched controls (13 female, 62.9±12.9y, p=0.850) were examined at the Dry Mouth Clinic, Faculty of Dentistry, Oslo. Oral health-related quality of life (OHRQoL) was assessed using the short form Oral Health Impact Profile (OHIP-14: high score-low OHRQoL). Self-reported dysgeusia (yes/no) and sense of taste (10-point VAS: high score-good smell sense) were recorded. Taste scores were recorded using taste strips (high score-good taste function). Oral candida counts were determined from cheek and tongue swabs (0=no growth, 1=minimal, 2=moderate, 3=severe). Volatile sulphur compounds (VSC) in mouth air samples were determined by gas chromatography and related to perceptive threshold-levels (H2S≤112ppb, CH3SH≤26ppb). Between-group comparisons were performed using Mann-Whitney U test and Chi-square test.
Results: The HNC patients reported significantly poorer OHRQoL than controls (OHIP sum-score: 18.4±12.4 vs 1.2±2.0, p<0.001). They reported significantly poorer sense of taste compared to controls (6.4±2.4 vs 7.8±1.9, p=0.018), and more often dysgeusia (26.7% vs 7.7%, p=0.087). The measured gustatory scores (20.4±6.4 vs 22.3±4.6, p=0.315) were similar for both groups. Candida scores were significantly higher in the patient group (1.6±1.3 vs 0.7±0.9, p=0.024). The percentage of HNC patients who had oral H2S above the threshold level was significantly lower than for the controls (0% vs 27%, p<0.05). This was not the case for CH3SH (5.5% vs 27%, p=0.105).
Conclusion: After radiotherapy, these HNC patients experienced negative oral consequences of the treatment. They reported poorer OHRQoL, and had reduced taste sensation and higher oral candida counts. However, the underlying reason for less problems with halitosis in HNC patients than in controls is worth further exploration.
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Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Dahl, Marianne; Saghaug, Elisabeth & Slaaen, Joran
[Show all 7 contributors for this article]
(2019).
Dry mouth - a missing symptom in multiple assessment tools?
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Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad & Saghaug, Elisabeth
[Show all 10 contributors for this article]
(2019).
A comparison of normal saline mouth rinse and mouth rinse based on Salvia officinalis in palliative care: A randomized controlled trial.
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Homayouni, Amin; Tashbayev, Behzod; Rusthen, Shermin; Hove, Lene Hystad; Rykke, Morten & Singh, Preet Bano
[Show all 9 contributors for this article]
(2018).
Can saliva secretion affect oral malodour and oral health-related quality of life?
Show summary
The aim of this study was to investigate the relationship between saliva secretion, halitosis and oral health-related quality of life (HRQoL). Informed consent was obtained from 65 participants including 24 patients with primary Sjögren’s Syndrome (pSS, 53±12y), 17 patients with dry eyes and dry mouth not fulfilling the classification for pSS (non-SS-sicca, 53±11y), and 24 healthy controls (49±11y). Unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates were recorded as low (hyposalivation: SWS <0.7 ml/min, UWS <0.1 ml/min) or normal (SWS >0.7 ml/min, UWS >0.1 ml/min). Volatile sulfur compounds (VSC: hydrogen sulphide-H2S, methylmercaptan-CH3SH) in mouth air were measured by gas chromatography. HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Mann-Whitney test was used in data analysis (p<0.05). In general, for UWS, subjects with hyposalivation had significantly higher mean CH3SH-levels than those with normal salivation (27.339.3 vs 9.913.6 ppb). For SWS, subjects with hyposalivation had significantly higher mean H2S-levels (184.5464.8 vs 43.964.1 ppb) and CH3SH-levels (27.237.4 vs 6.58.9 ppb). Within the non-SS patient group, those with hyposalivation had significantly higher H2S-levels than those with normal salivation. In general, there were no significant differences in OHIP-scores based on VSC levels. However, within the non-SS group, those with high H2S-levels (>112 ppb) reported significantly more often that they had “difficulties relaxing due to oral problems”, and that “life has been less satisfactory due to oral problems”, than those with low H2S-levels (<112 ppb). In conclusion, hyposalivation was generally associated with increased levels of oral VSC, indicating oral malodour. Surprisingly, patients with dry eyes and dry mouth who did not fulfill the classification for pSS seemed to be more affected in their daily life than patients who fulfilled the criteria.
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Herlofson, Bente Brokstad
(2018).
Medikamentrelatert osteonekrose i kjevene. .
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Nørholt, S.E.; Herlofson, Bente Brokstad; Wexell, Cecilia Larsson; Ehrenstein, V & Schiodt, Morten
(2018).
The Scandinavisn Osteonecrosis Cohort Stury - Report on 6 years of Research collaboration.
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Tanem, Kristine Eidal; Wilberg, Petter; STENSVOLD, EINAR; Singh, Preet Bano; Skaare, Anne B & Herlofson, Bente Brokstad
(2018).
Oral late effects and taste function in long-term survivors after treatment of medulloblastoma and supratentorial primitive neuroectodermal tumor during childhood or adolescence - preliminary results.
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Herlofson, Bente Brokstad
(2018).
Medication-Related Osteonecrosis of the jaw - When to treat non-surgically - Ethics and other dilemmas.
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Herlofson, Bente Brokstad
(2018).
Update on the Scandinavian MRONJ study.
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Herlofson, Bente Brokstad
(2018).
Hvilke orale helseutfordringer står munn-og halskreftpasienter overfor etter at kreftbehandlingen er ferdig?
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Herlofson, Bente Brokstad & Berstad, Johanna Elisabeth Rykke
(2018).
Munnhulen og kreft.
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Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Saghaug, Elisabeth; Tollisen, Anita & Fjeld, Katrine Gahre
[Show all 10 contributors for this article]
(2018).
Rekruttering av pasienter til en klinisk intervensjonsstudie i et Hospice.
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Herlofson, Bente Brokstad
(2018).
Munnhelse til den palliative pasient.
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Langeland, Øystein; Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad & Hove, Lene Hystad
[Show all 14 contributors for this article]
(2018).
Comparative Ocular and Oral Findings in Sicca Complex.
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Hynne, Håvard; Tashbayev, Behzod; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad & Rykke, Morten
[Show all 14 contributors for this article]
(2018).
Evaluation of Dry Eye Disease, Oral Dryness and Inflammatory Cytokines in Primary Sjögren´s Syndrome.
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Herlofson, Bente Brokstad; Kjølle, Gry Karina; Westgaard, Kristine Løken; Løndalen, Ayca & Bruland, Øyvind
(2018).
Osteonecrosis of the jaw in a patient with bone metastatic prostate cancer after long-term bisphosphonate treatment with severe deterioration following radium-223.
Clinical Genitourinary Cancer.
ISSN 1558-7673.
p. 1–4.
doi:
10.1016/j.clgc.2018.05.003.
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Tashbayev, Behzod; Chen, Xiangjun; Utheim, Øa; Rusthen, Shermin; Young, Alix & Herlofson, Bente Brokstad
[Show all 14 contributors for this article]
(2018).
Primary Sjögren´s Syndrome and Non-Sjögren´s Sicca Syndrome Patients; unexpected differences in symptoms and findings of dry eye disease, dry mouth, and oral health related quality of life
.
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Tanem, Kristine Eidal; Wilberg, Petter; Diep, Phoi Pohi; Ruud, Ellen; Brinch, Lorentz & Skaare, Anne B
[Show all 7 contributors for this article]
(2017).
Mucosal and dental late effects in long-term survivors after allogeneic stem cell transplantation with Norwegian condition regimen performed during childhood, adolescence or young adulthood
.
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Skaare, Anne B; Szyszko, Ewa Alicja & Herlofson, Bente Brokstad
(2017).
Orofacial Granulomatosis in Children - Knowledge Among Norwegian Dental Clinicians.
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Jensen, Janicke Liaaen; Herlofson, Bente Brokstad; Young, Alix; Hove, Lene Hystad & Galtung, Hilde
(2017).
Verdien av spytt.
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Jensen, Janicke Liaaen; Herlofson, Bente Brokstad & Hove, Lene Hystad
(2017).
Spyttet vårt er livsviktig.
Aftenposten (morgenutg. : trykt utg.).
ISSN 0804-3116.
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Herlofson, Bente Brokstad; Preus, Hans Ragnar; Rønold, Hans Jacob; Ørstavik, Dag & Reppen, Kjetil
(2017).
Hvorfor gikk det galt?
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Herlofson, Bente Brokstad; Jensen, Janicke Liaaen & Singh, Preet Bano
(2017).
Lite spytt, blottlagt bein og vond smak, hva kan det være?
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Solem, Anne Guri & Herlofson, Bente Brokstad
(2017).
Oral helse - en viktig del av total helse.
[Business/trade/industry journal].
Munn og Mæle, Munn - og halskreftforeningens foreningsblad.
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Herlofson, Bente Brokstad
(2017).
Controversies in the management of jaw necrosis; ORN and MRONJ.
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Herlofson, Bente Brokstad
(2017).
Oral helse og kreftpasienter.
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Herlofson, Bente Brokstad; Wexell, Cecilia Larsson; Nørholt, Sven Erik; Igland, Eivind; Cardemil, Carina & Ehrenstein, Vera
[Show all 7 contributors for this article]
(2017).
The Scandinavian osteonecrosis cohort study - What have we learned during the first 5 years of reserach collaboration.
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Herlofson, Bente Brokstad; Johnsen, Petter J; Kløv, Marte; Skøyen, Christoffer; Tingberg, Marianne & Bjørnland, Tore
(2017).
Autotransplantation of immature premolars using the Oslo-protocol. Outcome of 100 consecutive transplantations during a 3 years period.
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Herlofson, Bente Brokstad
(2017).
Munnhelse og kreft.
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Herlofson, Bente Brokstad
(2017).
Arktis seminaret 2017; Alarmsymptomer ved munnhulekreft.
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Herlofson, Bente Brokstad
(2017).
Orale seneffekter og livskvalitet etter kreftbehandling.
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Rusthen, Shermin; Young, Alix; Preet, Bano; Tashbayev, Behzod; Garen, Torhild Oddveig & Aqrawi, Lara A.
[Show all 11 contributors for this article]
(2017).
Is Health-related Quality of Life Correlated to Oral Status in Primary Sjögren’s Syndrome Patients?