Maria Landin

Researcher
Image of Maria Landin
Norwegian version of this page
Mobile phone +47 45 50 26 87
Available hours 08:00 -15:00
Username
Visiting address KLINLAB
Postal address Postbox 1109 Blindern 0317 Oslo

Professional interests

  • miRNAs, ncRNAs and lncRNAs as regulators of the transcriptome
  • Transcriptome
  • Bioinformatics
  • Tooth and craniofacial development
  • Biomaterials
  • Toxicogenomics/ General toxicology
  • Embryology, Genetics, Immunology
  • Brominated flamme retardants

Education

PhD-Dr Scientist  University of  Oslo         2011

Cand. Scientist     University of  Oslo         2005

Cand. Mag.           University of  Oslo        2002

Academic Activity

-During her PhD, she investigated and mapped the global gene

expressionin murine toothbuds using molecular biological Methods.

This resulted in the creation of a transcriptome database

(68 microarrays) entailing 16 time points of murine tooth

Development from the embryonic day 11th up to 8 days

post-partum (E11.5- P7).This novel method gave a better picture

of the Genetic events occuring during murine tooth Development.

 

-Identified new genes that have not been previously described

in tooth Development.

 

-She was the first to detect enamel genes (Ambn, Amelx and Enam)

and their translated proteins  in  tooth buds prior to mineralisation.

These were sensational results in 2006 because these genes

and respective translated proteins were expressed

much earlier than previously assumed.

 

-Established In Situ hibridisation (Ribo-and oligoprobes) at the institute

from january 2000-2011.

 

-She also developed a new method for isolation/extraction

of RNA from cells grown on scaffolds  at the Oral Research

laboratorium from september 2011-2013

 

-Currently researching on the rolle microRNAs (miRNAs)

play in the regulationof the murine transcriptome using

loss-of-function studies. 

 

-Main supervisor for PhD candidate Natalie Skalleberg

in the Project : MicroRNAs during murine tooth development

 

-Editorial Board member/peer reviewer of

American Journal of Bioscience and

Bioengineering, SciencePG

 

-Colaborates with  Linda Bergersen/Cecile Morland Group at IOB

 

-She also colaborates with the Oral Research laboratorium (ORL/IKO) ,

mlapping the transcriptome in biopsies or cells cultivated under various conditions.

 

-Participant of the faculty funded Project '' Why do biomaterials fail and how can failure be minimized''. Professor Janne Elin Reseland is the Project leder.

Working atm at the Clinical Research Lab started in Mai 2019-2020

Osmundsen and his Group also built two additional databases (2005-2015):

-A microRNA database comprising around 200 miRNA microarrays covering various developmental stages of murine tooth Development.

 

-A transcriptome datatbase  of around 50 microarrays covering different stages of murine sublingual salivary glands development.

 

http://loop.frontiersin.org/people/48668/overview

http://www.researchgate.net/profile/Maria_Landin

http://uio.academia.edu/MariaLandin

Citations

http://scholar.google.no/citations?user=NznxQ9UAAAAJ&hl=no

Media contributions

http://www.tannlegetidende.no/i/2012/9/Tidende09-449

http://www.odont.uio.no/iob/om/aktuelt/aktuelle-saker/2015/gener_analysert.html

http://www.forskningstorget.net/

http://www.odont.uio.no/om/aktuelt/aktuelle-saker/2015/full-aktivitet-pa-forskningstorget.html

Favorite URL's

http://www.bio.no/

http://www.miljostatus.no/tema/kjemikalier/prioritetslisten/bromerte-flammehemmere/

Tags: MicroRNA, microarray, qPCR, In Situ Hybridisation (ISH), RNA, DNA, transcriptomics, genomics, tooth development, bioinformatics

Publications

  • Yang, Yang; Pullisaar, Helen; Landin, Maria Augusta Dos S Silva; Heyward, Catherine Anne; Schröder, Maria & Geng, Tianxiang [Show all 8 contributors for this article] (2021). FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2021.105061. Full text in Research Archive
  • Shabestari, Maziar; Ghadakchi Shabestari, Yashar; Landin, Maria Augusta Dos S Silva; Pepaj, Milaim; Cleland, Timothy & Reseland, Janne Elin [Show all 7 contributors for this article] (2020). Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays. International Journal of Rheumatic Diseases. ISSN 1756-1841. 23(6), p. 788–799. doi: 10.1111/1756-185X.13843. Full text in Research Archive
  • Shabestari, Maziar; Kise, Nina Jullum; Landin, Maria Augusta Dos S Silva; Sessing, Sølve; Hellund, Johan Castberg & Reseland, Janne Elin [Show all 8 contributors for this article] (2018). Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone and Joint Research. ISSN 2046-3758. 7(6), p. 406–413. doi: 10.1302/2046-3758.76.BJR-2017-0083.R3. Full text in Research Archive
  • Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Landin, Maria Augusta Dos S Silva & Reseland, Janne Elin (2016). Alendronate alters osteoblast activities. Acta Odontologica Scandinavica. ISSN 0001-6357. 74(7), p. 550–557. doi: 10.1080/00016357.2016.1217041.
  • Sidaly, Rivan; Landin, Maria Augusta Dos S Silva; Suo, Zhenhe; Snead, Malcom; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2015). Hypoxia increases the expression of enamel genes and cytokines in an ameloblast-derived cell line. European Journal of Oral Sciences. ISSN 0909-8836. 123(5), p. 335–340. doi: 10.1111/eos.12201.
  • Landin, Maria Augusta Dos S Silva; Nygård, Ståle; Shabestari, Maziar; Babaie, Eshrat; Reseland, Janne Elin & Osmundsen, Harald (2015). Mapping the global mRNA transcritome during development of the murine first molar. Frontiers in Genetics. ISSN 1664-8021. 6(47). doi: 10.3389/fgene.2015.00047. Full text in Research Archive
  • Riksen, Elisabeth Aurstad; Landin, Maria Augusta Dos S Silva; Reppe, Sjur; Nakamura, Yoikio; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2014). Enamel Matrix Derivative Promote Primary Human Pulp Cell Differentiation and Mineralization. International Journal of Molecular Sciences. ISSN 1422-0067. 15(5), p. 7731–7749. doi: 10.3390/ijms15057731. Full text in Research Archive
  • Pham, Thi Ngoc Maria Huong; Landin, Maria Augusta Dos S Silva; Tiainen, Hanna; Reseland, Janne Elin; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2014). The effect of hydrofluoric acid treatment of titanium and titanium dioxide surface on primary human osteoblasts. Clinical Oral Implants Research. ISSN 0905-7161. 25(3), p. 385–394. doi: 10.1111/clr.12150.
  • Pullisaar, Helen; Tiainen, Hanna; Landin, Maria Augusta Dos S Silva; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein & Reseland, Janne Elin [Show all 7 contributors for this article] (2013). Enhanced in vitro osteoblast differentiation on TiO2 scaffold coated with alginate hydrogel containing simvastatin. Journal of Tissue Engineering. ISSN 2041-7314. 4, p. 1–13. doi: 10.1177/2041731413515670. Full text in Research Archive
  • Kristoffersen, Anne Karin; Enersen, Morten; Kverndokk, Ellen Kristine; Sunde, Pia Titterud; Landin, Maria Augusta Dos S Silva & Solheim, Tore [Show all 8 contributors for this article] (2012). Human papillomavirus subtypes in oral lesions compared to healthy oral mucosa. Journal of Clinical Virology. ISSN 1386-6532. 53(4), p. 364–366. doi: 10.1016/j.jcv.2011.12.023.
  • Qalb-E-Saleem, Khan Ahmed; Sehic, Amer; Skalleberg, Natalie Sharim; Landin, Maria Augusta Dos S Silva; Khuu, Cuong & Risnes, Steinar [Show all 7 contributors for this article] (2012). Expression of delta-like 1 homologue and insulin-like growth factor 2 through epigenetic regulation of the genes during development of mouse molar. European Journal of Oral Sciences. ISSN 0909-8836. 120(4), p. 292–302. doi: 10.1111/j.1600-0722.2012.00976.x.
  • Landin, Maria Augusta Dos S Silva; Shabestari, Maziar Ghadakchi; Babaie, Eshrat; Reseland, Janne Elin & Osmundsen, Harald (2012). Gene expression profiling during murine tooth development. Frontiers in Genetics. ISSN 1664-8021. 3. doi: 10.3389/fgene.2012.00139.
  • Qalb-E-Saleem, Khan Ahmed; Press, Charles McLean; Sehic, Amer; Landin, Maria Augusta Dos S Silva; Risnes, Steinar & Osmundsen, Harald (2010). Expression of prion gene and presence of prion protein during development of mouse molar tooth germ. European Journal of Oral Sciences. ISSN 0909-8836. 118(6), p. 559–565. doi: 10.1111/j.1600-0722.2010.00783.x.
  • Lönn-Stensrud, Jessica; Landin, Maria Augusta Dos S Silva; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections? Journal of Antimicrobial Chemotherapy. ISSN 0305-7453. 63(2), p. 309–316. doi: 10.1093/jac/dkn501.
  • Etokebe, Godfrey; Kuchler, Axel Matthias; Haraldsen, Guttorm; Landin, Maria Augusta Dos S Silva; Osmundsen, Harald & Dembic, Zlatko (2009). Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds. Archives of Oral Biology. ISSN 0003-9969. 54(11), p. 1002–1007. doi: 10.1016/j.archoralbio.2009.08.005.
  • Nilsen, Anja; Landin, Maria A.; Haug, Kristin Huse; Fonnum, Frode; Berger, Urs & Osmundsen, Harald (2008). Comparative hepatic gene expression profiling of rats treated with 1H, 1H, 2H, 2H-heptadecafluorodecan-1-o1 or with pentadecafluorooctanoic acid. Physiological Genomics. ISSN 1094-8341. 34(3), p. 285–303. doi: 10.1152/physiolgenomics.00225.2007.
  • Osmundsen, Harald; Landin, Maria Augusta Dos S Silva; From, Sigurd Hjalmar; Kolltveit, Kristin Melkevik & Risnes, Steinar (2007). Changes in gene-expression during development of the murine molar tooth germ. Archives of Oral Biology. ISSN 0003-9969. 52, p. 803–813. doi: 10.1016/j.archoralbio.2007.02.008. Full text in Research Archive

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  • Gordeladze, Jan Oxholm; Landin, Maria Augusta Dos S Silva; Johnsen, Gaute Floer; Haugen, Håvard Jostein & Osmundsen, Harald (2017). Vitamin K2 and its Impact on Tooth Epigenetics. IntechOpen. ISBN 978-953-51-3020-8. 27 p.
  • Osmundsen, Harald; Jevnaker, Anne-Marthe & Landin, Maria Augusta Dos S Silva (2012). kap 10 Deoxyoligonucleotide Microarrays for Gene Expression Profiling in Murine Tooth Germs. Springer. ISBN 978-1-61779-860-3. 189 p.

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  • Landin, Maria Augusta Dos S Silva; Yashar Ghadakchi , Shabestari; Sehic, Amer; Reseland, Janne Elin & Osmundsen, Harald (2014). MK-7 enhances expression of genes related to bone, enamel and dentin, and reduces the expression of genes related to apoptosis in developing murine molars.
  • Landin, Maria Augusta Dos S Silva; Lonn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2013). Effekter av ikke toksiske furanoner på biofilm dannelse.
  • Pullisaar, Helen; Tiainen, Hanna; Landin, Maria Augusta Dos S Silva; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein & Reseland, Janne Elin [Show all 7 contributors for this article] (2013). Enhanced in vitro bone differentiation on TiO₂ scaffold coated with simvastatin.
  • Pullisaar, Helen; Tiainen, Hanna; Landin, Maria Augusta Dos S Silva; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein & Reseland, Janne Elin [Show all 7 contributors for this article] (2013). Local delivery of simvastatin enhances bone differentiation on porous titanium dioxide scaffold.
  • Pullisaar, Helen; Tiainen, Hanna; Landin, Maria Augusta Dos S Silva; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein & Reseland, Janne Elin [Show all 7 contributors for this article] (2013). Local delivery of simvastatin on titanium dioxide scaffolds; a tissue engineering model.
  • Pullisaar, Helen; Tiainen, Hanna; Landin, Maria Augusta Dos S Silva; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein & Reseland, Janne Elin [Show all 7 contributors for this article] (2013). Coating titanium dioxide scaffold with simvastatin in alginate promote osteoblast differentiation in vitro.
  • Pham, Thi Ngoc Maria Huong; Landin, Maria Augusta Dos S Silva; Tiainen, Hanna; Reseland, Janne Elin; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2013). The Effect Of Hydrofluoric Acid Treatment Of Titanium And Titanium Dioxide Surface on Primary Human Osteoblasts .
  • Landin, Maria Augusta Dos S Silva; Stunes, Astrid Kamilla; Syversen, Unni & Reseland, Janne Elin (2012). Adipokines expressed in cells participating in cranial development. Bone. ISSN 8756-3282. 50, p. S79–S79. doi: 10.1016/j.bone.2012.02.230.
  • Landin, Maria Augusta Dos S Silva; Stunes, Kamilla; Osmundsen, Harald; Syversen, Unni & Reseland, Janne Elin (2012). Expression of adipokines during murine craniofacial and tooth development.
  • Landin, Maria Augusta Dos S Silva (2007). Molecular biology methods in craniofacial development research.
  • Landin, Maria Augusta Dos S Silva (2007). Mapping gene expression during tooth development an overview.
  • Landin, Maria Augusta Dos S Silva; Geronimo, Benedicto Abrigos; Woldene, Toril & Osmundsen, Harald (2007). Mapping gene expression during tooth development I.
  • Landin, Maria Dos S Silva (2006). Geneekspresjonsanalyser etter eksponering for HBCDD.
  • Landin, Maria Dos S Silva (2006). Differences in gene expression at various developmental stages of the murine molar tooth germ.
  • Landin, Maria Dos S Silva (2006). Effekts of treatment of mice with hexabromocyclododecane (HBCD) on gene-expression in liver.
  • Landin, Maria Dos S Silva (2005). Changes in gene-expression during development of the murine molar tooth-bud2.
  • Landin, Maria Dos S Silva (2005). Changes in gene-expression during development of the murine molar tooth-bud.
  • Landin, Maria Dos S Silva (2005). Effekter av bromerte flammehemmere på genekspresjon i muselever-en toksikogenomisk tilnærming. Toksikologen. ISSN 1504-5773. 15(4), p. 46–47.
  • Landin, Maria Dos S Silva (2004). Effects of treatment of PPAR-a knock-out mice with hexabromocyclododecane (HBCD).
  • Landin, Maria Augusta Dos S Silva & Osmundsen, Harald (2011). Mapping of gene expression during murine tooth development. Unipub forlag. ISSN 978-82-91757-65-0.
  • Landin, Maria Augusta Dos S Silva (2010). Mapping of gene expression during murine tooth development : expression profiling of mRNAs in the developing murine first molar tooth germ. Faculty of Dentistry, University of Oslo. ISSN 978-82-91757-65-0.
  • Landin, Maria Dos S Silva (2004). Effekter av Bromerte Flammehemere på Geneksprejon i Muselever. En toksikogenomisk tilnærming. BYBSYS Duo.
  • Landin, Maria Augusta Dos S Silva (2004). Effekter av bromerte flammehemmere på genekspresjon i muselever : en toksikogenomisk tilnærming. DUO Digitale utgivelser ved UiO.

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Published May 11, 2020 1:54 PM - Last modified Feb. 17, 2021 6:51 PM