Fernanda Cristina Petersen

• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, T.; Morrison, D.A. & Petersen, Fernanda Cristina (2018). High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes. BMC Genomics.  ISSN 1471-2164.  19(1) . doi: 10.1186/s12864-018-4802-y
• Shekhar, Sudhanshu; Schenck, Karl & Petersen, Fernanda Cristina (2018). Exploring Host–Commensal Interactions in the Respiratory Tract. Frontiers in Immunology.  ISSN 1664-3224.  8, s 1- 7 . doi: doi: 10.3389/fimmu.2017.01971 Full text in Research Archive. Show summary

  Commensal microbes are currently in the limelight in biomedical research because they play an important role in health and disease. Humans harbor an enormous diversity of commensals in various parts of the body, including the gastrointestinal and respiratory tracts. Advancement in metagenomic and other omic approaches, and development of suitable animal models have provided an unprecedented appreciation into the diversity of commensals, and the intricacies of their intimate communication with the host immune system. Most studies have focused on the host–commensal interaction in the gut, while less is known on this relationship in other sites of the body, such as the respiratory tract. In this article, we review emerging data from human and animal studies on the host responses to respiratory commensals, immune cross-reactivity between commensals and pathogens, and use of commensals as a vaccine delivery system. A better understanding of the delicate interplay between commensals and host may aid in efforts to develop effective vaccines and therapeutics.

• Engen, Stian André; Schreurs, Olaf Joseph Franciscus; Petersen, Fernanda Cristina; Blix, Inger Johanne S.; Bækkevold, Espen Sønderaal & Schenck, Karl (2017). The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes. Scandinavian Journal of Immunology.  ISSN 0300-9475.  87(2), s 80- 87 . doi: 10.1111/sji.12636
• Junges, Roger; Khan, Rabia; Tovpeko, Yanina; Åmdal, Heidi Aarø; Petersen, Fernanda Cristina & Morrison, Donald (2017). Markerless genome editing in competent streptococci. Methods in molecular biology.  ISSN 1064-3745.  1537, s 233- 247 . doi: 10.1007/978-1-4939-6685-1_14 Full text in Research Archive.
• Junges, Roger; Salvadori, Gabriela; Shekhar, Sudhanshu; Åmdal, Heidi Aarø; Periselneris, Jimstan; Chen, Tsute; Brown, Jeremy S. & Petersen, Fernanda Cristina (2017). A quorum-sensing system that regulates Streptococcus pneumoniae biofilm formation and surface polysaccharide production. mSphere.  ISSN 2379-5042.  2(5), s 1- 18 . doi: 10.1128/mSphere.00324-17
• Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute; Morrison, Donald A & Petersen, Fernanda Cristina (2017). A positive feedback loop mediated by Sigma X enhances expression of the streptococcal regulator ComR. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-04768-5
• Rukke, Håkon Valen; Scheie, Anne Aamdal & Petersen, Fernanda Cristina (2017). Oral mikroflora - et reservoar av antibiotikaresistensgener. Aktuell Nordisk odontologi.  ISSN 1902-3545.  s 43- 59 . doi: 10.18261 Show summary

  Et av de store fremskrittene innen medisinen i det forrige århundre var oppdagelsen av antibiotika. Kort tid etter introduksjonen av ulike antibiotika oppdaget man at bakteriene kunne bli resistente. Resistens mot antibiotika er en global trussel og utfordring. Bare innen Den europeiske union, Island og Norge var det estimert at infeksjoner med antibiotikaresistente bakterier kostet 25.000 mennesker livet i 2007. Bakterier kan bli resistente enten ved spontane mutasjoner eller ved opptak av DNA fra miljøet, en prosess kjent som horisontal genoverføring. Gener som gir opphav til resistens, finnes i miljøet rundt oss og i den humane normalflora, inkludert den orale mikrobiota. Normalfloraen utgjør et reservoar av resistensgener, som kan overføres til mer patogene bakterier. Bruk av antibiotika selekterer for resistente bakterier og kan stimulere til horisontal genoverføring. Økningen av resistente bakterier krever en bevisst holdning til forskrivelse og bruk av antibiotika. Bruk bør forbeholdes og være basert på evidensbasert kunnskap, der det er til nytte for pasienten.

• Salvadori, Gabriela; Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2017). Natural transformation of oral streptococci by use of synthetic pheromones. Methods in molecular biology.  ISSN 1064-3745.  s 219- 232 . doi: 10.1007/978-1-4939-6685-1_13 Full text in Research Archive.
• Wiedmer, David; Petersen, Fernanda Cristina; Lönn-Stensrud, Jessica & Tiainen, Hanna (2017). Antibacterial effect of hydrogen peroxide - titanium dioxide suspensions in the decontamination of rough titanium surfaces. Biofouling (Print).  ISSN 0892-7014.  33(6), s 451- 459 . doi: 10.1080/08927014.2017.1322585
• Wilson, Robert; Cohen, Jonathan M.; Reglinski, Mark; Jose, Ricardo J.; Chan, Win Yan; Marshall, Helina-Elaine; de Vogel, Corné; Gordon, Stephen V.; Goldblatt, David; Petersen, Fernanda Cristina; Baxendale, Helen & Brown, Jeremy S. (2017). Naturally acquired human immunity to pneumococcus is dependent on antibody to protein antigens. PLoS Pathogens.  ISSN 1553-7366.  13:e1006137(1) . doi: 10.1371/journal.ppat.1006137
• Khan, Rabia; Rukke, Håkon Valen; Høvik, Hedda; Åmdal, Heidi Aarø; Chen, T.; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Comprehensive Transcriptome Profiles of Streptococcus mutans UA159 Map Core Streptococcal Competence Genes. mSystems.  ISSN 2379-5077.  1(2) . doi: 10.1128/mSystems.00038-15 Full text in Research Archive. Show summary

  In Streptococcus mutans, an oral colonizer associated with dental caries, development of competence for natural genetic transformation is triggered by either of two types of peptide pheromones, competence-stimulating peptides (CSPs) (18 amino acids [aa]) or SigX-inducing peptides (XIPs) (7 aa). Competence induced by CSP is a late response to the pheromone that requires the response regulator ComE and the XIP-encoding gene comS. XIP binds to ComR to allow expression of the alternative sigma factor SigX and the effector genes it controls. While these regulatory links are established, the precise set of effectors controlled by each regulator is poorly defined. To improve the definition of all three regulons, we used a high-resolution tiling array to map global changes in gene expression in the early and late phases of the CSP response. The early phase of the CSP response was limited to increased gene expression at four loci associated with bacteriocin production and immunity. In the late phase, upregulated regions expanded to a total of 29 loci, including comS and genes required for DNA uptake and recombination. The results indicate that the entire late response to CSP depends on the expression of comS and that the immediate transcriptional response to CSP, mediated by ComE, is restricted to just four bacteriocin-related loci. Comparison of the new data with published transcriptome data permitted the identification of all of the operons in each regulon: 4 for ComE, 2 for ComR, and 21 for SigX. Finally, a core set of 27 panstreptococcal competence genes was identified within the SigX regulon by comparison of transcriptome data from diverse streptococcal species.

• Rukke, Håkon Valen; Engen, Stian André; Schenck, Karl & Petersen, Fernanda Cristina (2016). Capsule expression in Streptococcus mitis modulates interaction with oral keratinocytes and alters susceptibility to human antimicrobial peptides. Molecular Oral Microbiology.  ISSN 2041-1006.  31(4), s 302- 313 . doi: 10.1111/omi.12123 Show summary

  Streptococcus mitis is a colonizer of the oral cavity and the nasopharynx, and is closely related to Streptococcus pneumoniae. Both species occur in encapsulated and unencapsulated forms, but in S. mitis the role of the capsule in host interactions is mostly unknown. Therefore, the aim of this study was to examine how capsule expression in S. mitis can modulate interactions with the host with relevance for colonization. The S. mitis type strain, as well as two mutants of the type strain, an isogenic capsule deletion mutant, and a capsule switch mutant expressing the serotype 4 capsule of S. pneumoniae TIGR4, were used. Wild-type and capsule deletion strains of S. pneumoniae TIGR4 were included for comparison. We found that capsule production in S. mitis reduced adhesion to oral and lung epithelial cells. Further, exposure of oral epithelial cells to encapsulated S. mitis resulted in higher interleukin-6 and CXCL-8 transcription levels relative to the unencapsulated mutant. Capsule expression in S. mitis increased the sensitivity to human neutrophil peptide 1-3 but reduced the sensitivity to human β-defensin-3 and cathelicidin. This was in contrast with S. pneumoniae in which capsule expression has been generally associated with increased sensitivity to human antimicrobial peptides (AMPs). Collectively, these findings indicate that capsule expression in S. mitis is important in modulating interactions with epithelial cells, and is associated with increased or reduced susceptibility to AMPs depending on the nature of the AMP.

• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Overcoming the barrier of low efficiency during Genetic transformation of Streptococcus mitis. Frontiers in Microbiology.  ISSN 1664-302X.  7 . doi: 10.3389/fmicb.2016.01009 Full text in Research Archive.
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Overcoming the barrier of low efficiency during natural transformation of Streptococcus mitis. Frontiers in Microbiology.  ISSN 1664-302X.
• Morrison, D.A.; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø & Petersen, Fernanda Cristina (2015). Genome editing by natural genetic transformation in Streptococcus mutans. Journal of Microbiological Methods.  ISSN 0167-7012.  119, s 134- 141 . doi: 10.1016/j.mimet.2015.09.023
• Engen, Stian André; Rukke, Håkon Valen; Becattini, Simone; Jarrossay, David; Blix, Inger Johanne S.; Petersen, Fernanda Cristina; Sallusto, Federica & Schenck, Karl (2014). The Oral Commensal Streptococcus mitis Shows a Mixed Memory Th Cell Signature That Is Similar to and Cross-Reactive with Streptococcus pneumoniae. PLoS ONE.  ISSN 1932-6203.  9(8) . doi: 10.1371/journal.pone.0104306 Full text in Research Archive.
• Rukke, Håkon Valen; Kalluru, Raja Sab; Repnik, Urska; Gerlini, Alice; Jose, Ricardo J.; Periselneris, Jimstan; Marshall, Helina-Elaine; Griffiths, Gareth; Oggioni, Marco Rinaldo; Brown, Jeremy & Petersen, Fernanda Cristina (2014). Protective role of the capsule and impact of serotype 4 switching on Streptococcus mitis. Infection and Immunity.  ISSN 0019-9567.  82(9), s 3790- 3801 . doi: 10.1128/IAI.01840-14
• Henderson, Elisabet; Schneider, Sigurd; Petersen, Fernanda Cristina; Haugen, Håvard Jostein; Wohlfahrt, Johan Caspar; Ekstrand, Karl & Ekfeldt, Anders (2013). Chemical debridement of contaminated titanium surfaces: An in vitro study. Acta Odontologica Scandinavica.  ISSN 0001-6357.  71(3-4), s 957- 964 . doi: 10.3109/00016357.2012.734423 Show summary

  Abstract Objective. To compare the efficacy of different chemical solutions when used for chemical debridement of biofilm contaminated titanium surfaces in an in-vitro experimental study. Materials and methods. Commercially pure titanium discs with a diameter of 6.2 mm and height of 2 mm, mirror-polished with a measured surface amplitude value S(A) = 0.037 μm ± 0.009 were used as test-surfaces. A biofilm was simulated with multi-layers of Staphylococcus epidermidis ATCC359844 covering the entire titanium surface. The chemical agents tested were: 3% H(2)O(2), 0.2% Chlorhexidine, 24% EDTA-gel, 3% H(2)O(2) mixed with 1.6 g/L TiO(2) and sterile saline solution. The decontamination effect was evaluated by optical density analysis using spectrophotometry and with scanning electron microscopy (SEM) images of the remaining biofilm. Results. The suspensions of 3% H(2)O(2) and 1.6 g/L TiO(2) or 3% H(2)O(2) alone were the most effective in removing S. epidermidis biofilms (p < 0.05), whereas 0.2% chlorhexidine or 24% EDTA gel had no significant effects. SEM images of the remaining biofilms supported the quantitative results indicating the higher efficacy of 3% H(2)O(2) and 1.6 g/L TiO(2) or 3% H(2)O(2) alone. It also revealed that EDTA, despite a non-significant effect on reducing the amount of established biofilms, was able to alter the biofilm architecture, as demonstrated by increased interspaced regions. Conclusions. In this in vitro study the decontamination potential of a suspension of 3% H(2)O(2) and 1.6 g/L TiO(2) or 3% H(2)O(2) alone were encouraging. Whether such procedures would have a similar effect in vivo remains to be determined.

• Khan, R; Rukke, HV; Ricomini, AP; Fimland, G; Arntzen, Magnus; Thiede, Bernd & Petersen, Fernanda Cristina (2012). Extracellular Identification of a Processed Type II ComR/ComS Pheromone of Streptococcus mutans. Journal of Bacteriology.  ISSN 0021-9193.  194(15), s 3781- 3788 . doi: 10.1128/JB.00624-12
• Lönn-Stensrud, Jessica; Naemi, Ali-Oddin; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2012). Thiophenones inhibit Staphylococcus epidermidis biofilm formation at nontoxic concentrations. FEMS Immunology and Medical Microbiology.  ISSN 0928-8244.  65(2), s 326- 334 . doi: 10.1111/j.1574-695X.2012.00964.x
• Rukke, Håkon Valen; Hegna, Ida Kristin & Petersen, Fernanda Cristina (2012). Identification of a functional capsule locus in Streptococcus mitis. Molecular Oral Microbiology.  ISSN 2041-1006.  27(2), s 95- 108 . doi: 10.1111/j.2041-1014.2011.00635.x
• Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2011). Competence stimulating peptides in oral bacterial signaling: Possible implications in a community life, In P. Kolenbrander (ed.),  Oral Microbial Communities: Genomic Inquiry and Interspecies Communication.  ASM International.  ISBN 978-1-55581-503-5.  kapittel 16.  s 235 - 246
• Rukke, Håkon Valen; Hegna, Ida Kristin & Petersen, Fernanda Cristina (2011). Identification of a functional capsule locus in Streptococcus mitis. Molecular Oral Microbiology.  ISSN 2041-1006. . doi: 10.1111/j.2041-1014.2011.00635.x
• Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2010). Natural transformation of oral streptococci. Methods in molecular biology.  ISSN 1064-3745.  666, s 167- 180
• Ahmed, Nibras Abdul; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). AI-2/LuxS Is Involved in Increased Biofilm Formation by Streptococcus intermedius in the Presence of Antibiotics. Antimicrobial Agents and Chemotherapy.  ISSN 0066-4804.  53(10), s 4258- 4263 . doi: 10.1128/AAC.00546-09
• Lönn-Stensrud, Jessica; Landin, Maria Augusta Dos S Silva; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  63(2), s 309- 316 . doi: 10.1093/jac/dkn501
• Ahmed, Nibras Ayad; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2008). Biofilm formation and autoinducer-2 signaling in Streptococcus intermedius: role of thermal and pH factors. Oral Microbiology and Immunology.  ISSN 0902-0055.  23(6), s 492- 497
• da Silva, Daniele Pecharki Marques; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2008). LuxS and expression of virulence factors in Streptococcus intermedius. Oral Microbiology and Immunology.  ISSN 0902-0055.  23, s 79- 83
• da Silva, Daniele Pecharki Marques; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2008). Role of hyaluronidase in Streptococcus intermedius biofilm. Microbiology.  ISSN 1350-0872.  154 . doi: 10.1099/mic.0.2007/012393-0
• Scheie, Anne Aamdal & Petersen, Fernanda Cristina (2008). Antimicrobials in caries control, In Ole Fejerskov & Edwina Kidd (ed.),  Dental Caries. The disease and its clinical management.  Blackwell Munksgaard.  ISBN 9781405138895.  Kapittel 16.  s 265 - 279
• Ahmed, Nibras Ayad; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus. Journal of Antimicrobial Chemotherapy.  ISSN 0305-7453.  60, s 49- 53 . doi: 10.1093/jac/dkm124
• Busscher, Henk J.; van de Belt-Gitter, Betsy; Dijsktra, Rene J.; Norde, Willem; Petersen, Fernanda Cristina; Scheie, Anne Aamdal & van der Mei, Henny C. (2007). Intermolecular forces and enthalpies in the adhesion of Streptococcus mutans and an antigen I/II-deficient mutant to laminin films. Journal of Bacteriology.  ISSN 0021-9193.  189(8), s 2988- 2995 . doi: 10.1128/JB.01731-06
• Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2007). Synthetic bromated furanone inhibits autoinducer-2-mediated communication and biofilm formation in oral streptococci. Oral Microbiology and Immunology.  ISSN 0902-0055.  22, s 340- 346

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• Fejerskov, Ole; Nyvad, Bente; Kidd, Edwina; Scheie, Anne Aamdal; Rukke, Håkon Valen & Petersen, Fernanda Cristina (2015). Are antimicrobials necessary in caries prophylaxis?. Wiley Blackwell.  ISBN 9781118935828.  12 s.
• Scheie, Anne Aamdal & Petersen, Fernanda Cristina (2007). Bakteriene snakker seg inn i en biofilm livsstil. Munksgaard Forlag.  ISBN 978-87-628-0633-7.  14 s.

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• Cowley, Lauren A.; Petersen, Fernanda Cristina; Junges, Roger; Hanage, William P & Morrison, Donald A. (2017). Co-culture of S. pneumoniae strains fosters large recombination events.
• Cowley, Lauren A.; Petersen, Fernanda Cristina; Junges, Roger; Hanage, William P & Morrison, Donald A. (2017). Large recombination events readily occurring in biofilm cultures of Streptococcus pneumoniae.
• Engen, Stian; Schreurs, Olaf Joseph Franciscus; Petersen, Fernanda Cristina; Blix, Inger Johanne S.; Bækkevold, Espen Sønderaal & Schenck, Karl (2017). Regulation of human monocytes by the oral commensal Streptococcus mitis: a role for PGE2?.
• Gomez-Florit, Manuel; Geissler, Sebastian; Wiedmer, David; Petersen, Fernanda Cristina & Tiainen, Hanna (2017). Multifunctional polyphenol nanocoatings for improved tissue integration of dental implants.
• Junges, Roger; Salvadori, Gabriela; Chen, Tsute; Åmdal, Heidi A.; Jimstan N., Periselneris; Jeremy S., Brown & Petersen, Fernanda Cristina (2017). A bacterial pheromone system regulates biofilm formation and colonization..
• Junges, Roger; Salvadori, Gabriela; Sudhanshu, Shekhar; Åmdal, Heidi A.; Jimstan N., Periselneris; Chen, Tsute; Jeremy S., Brown & Petersen, Fernanda Cristina (2017). An Rgg/SHP quorum sensing system reduces virulence and fitness in Streptococcus pneumoniae.
• Rørvik, Gro Herredsvela; Schreurs, Olaf Joseph Franciscus; Engen, Stian; Blix, Inger Johanne S.; Petersen, Fernanda Cristina & Schenck, Karl (2017). Antibody reactivity to the oral commensal Streptococcus mitis in serum and saliva.
• Salvadori, Gabriela; Junges, Roger & Petersen, Fernanda Cristina (2017). A Competence-Induced Bacteriocin Reduces Growth of Oral Pathogenic Bacteria.
• Salvadori, Gabriela; Junges, Roger; Chen, Tsute & Petersen, Fernanda Cristina (2017). A Competence-Induced Bacteriocin Reduces Growth of Oral Pathogenic Bacteria..
• Salvadori, Gabriela; Junges, Roger; Morrison, Donald A. & Petersen, Fernanda Cristina (2017). High efficiency genetic transformation in encapsulated pneumococcus.
• Shekhar, Sudhanshu; Khan, Rabia; Ferreira, Daniela; Schenck, Karl; Kwon, Keehwan & Petersen, Fernanda Cristina (2017). Streptococcus mitis-specific antibodies show cross-reactivity with a range of virulent Streptococcus pneumoniae serotypes.
• Shekhar, Sudhanshu; Khan, Rabia; Ferreira, Daniela; Schenck, Karl; Kwon, Keehwan & Petersen, Fernanda Cristina (2017). Streptococcus mitis-specific antibodies show cross-reactivity with a range of virulent Streptococcus pneumoniae serotypes.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi A.; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). Markerless Genome Editing in Oral Streptococci.
• Junges, Roger; Salvadori, Gabriela; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). High efficiency genetic transformation in Streptococcus Mitis.
• Junges, Roger; Salvadori, Gabriela; Åmdal, Heidi A.; Morrison, Donald A.; Chen, Tsute & Petersen, Fernanda Cristina (2016). Global response of Streptococcus mitis to the competence-stimulating peptide.
• Khan, Rabia; Shekhar, Sudhanshu & Petersen, Fernanda Cristina (2016). Identification of common surface exposed proteins between S. mitis and S. pneumoniae by cell surface shaving proteomics.
• Salvadori, Gabriela; Junges, Roger; Chen, Tsute; Morrison, Donald A. & Petersen, Fernanda Cristina (2016). High-resolution profiles of the CSP signaling pathway in Streptococcus mitis SK321 and NCTC12261T..
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi A.; Chen, Tsute & Petersen, Fernanda Cristina (2016). Transcriptome response of Streptococcus mitis to the competence pheromone (Hatton Award representation).
• Wiedmer, David; Tiainen, Hanna; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina & Haugen, Håvard Jostein (2016). TiO2-H2O2 as decontamination agent - an in vitro study.
• Wiedmer, David; Tiainen, Hanna; Petersen, Fernanda Cristina & Haugen, Håvard Jostein (2016). H2O2-TiO2 as potential treatment for peri-implantitis – an in vitro study.
• Engen, Stian André; Rukke, Håkon Valen; Becattini, Simone; Jarrossay, David; Blix, Inger Johanne S.; Petersen, Fernanda Cristina; Sallusto, Federica & Schenck, Karl (2015). The oral commensal Streptococcus mitis shows a mixed memory Th cell signature that is similar to and cross-reactive with Streptococcus pneumoniae..
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). A new link between two Streptococcus mutans pheromones.
• Junges, Roger; Khan, Rabia; Åmdal, Heidi Aarø; Morrison, Donald A. & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptoccocus mutans to the sigX-inducing peptide (XIP).
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). A New Pheromone in Streptococcus mitis Enhances Biofilm Formation.
• Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Characterization of an Rgg/SHP system in Streptococcus mitis that allows communication with Streptococcus pneumoniae.
• Marshall, Helina-Elaine; Petersen, Fernanda Cristina & Brown, Jeremy (2015). Differential complement sensitivity of Streptococcus pneumoniae and Streptococcus mitis.
• Petersen, Fernanda Cristina; Khan, Rabia; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Morrison, Donald A. (2015). A new link between the Streptococcus mutans XIP and CSP pheromone pathways revealed by directional RNA-sequencing.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Identification of Streptococcus mitis competence pheromone responsive genes by transcriptome analysis.
• Salvadori, Gabriela; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome response of Streptococcus mitis to the competence pheromone.
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Streptococcus mitis response to the competence pheromone.
• Silva, Gabriela Salvadori; Junges, Roger; Åmdal, Heidi Aarø; Chen, Tsute & Petersen, Fernanda Cristina (2015). Transcriptome analysis of Streptococcus mitis response to the competence pheromone.
• Junges, Roger; Rukke, HV; Åmdal, HA; Chen, Tsute & Petersen, Fernanda Cristina (2014). Streptococcus mitis transcriptome changes in response to a novel pheromone.
• Dahle, Ulf R & Petersen, Fernanda Cristina (2013). ANTIMICROBIAL RESISTANCE Incentives for developing new antibiotics or antimicrobial strategies. BMJ (British Medical Journal).  ISSN 0959-8146.  346 . doi: 10.1136/bmj.f2136
• Landin, Maria Augusta Dos S Silva; Lonn-Stensrud, Jessica; Petersen, Fernanda Cristina; Benneche, Tore & Scheie, Anne Aamdal (2013). Effekter av ikke toksiske furanoner på biofilm dannelse. Show summary

  Staphylococcus epidermidis (S. epidermis) er ofte påvist i biofilm som foråsaker infeksjoner forbundet med medisinske inplantater. Noen furanoner minsker biofilm dannelse tilsynelatende uten å forårsake irritasjon eller genotoksiske effekter, og uten å påvirke S. epidermidis vekst. Furanoner hindrer kommunikasjon mellom bakterier og har stor potensial for å hemme biofilm dannelse. Mål: Å studere biofilmhemmende og genotoksisk effekt av ulike furanoner Materialer og metoder: 11 furanoner ble undersøkt vha bioluminisens og biofilm assayer. MIC (minste inhiberende konsentrasjon) for disse furanonene ble bestemt for å undersøke om dannelse av biofilm eller bakterievekst ble påvirket. Effekter av furanoner på bakterie kommunikasjon ble også undersøkt ved bioluminisensmålinger. Preliminære genotoksiske effekter hos CD-1 muselever og nyrer ble undersøkt vha mikromatriser og membran matriser. Resultater: Fire furanoner ble valgt ut for videre biofilm analyser etter bioluminisens test. Hver furanon ble testet med konsentrasjoner som ikke påvirket bakterie proliferasjon, men biofilm dannelse ble signifikant redusert ved bruk av disse furanoner. For de to mest effektive furanoner (F202 og F202) som også ble testet in vivo, ble det ikke påvist akutt toksisitet eller genotoksisitet.

• Khan, Rabia; Rukke, Håkon Valen; Filho, Antonio Pedro Ricomini; Fimland, Gunnar; Arntzen, Magnus; Thiede, Bernd & Petersen, Fernanda Cristina (2012). Extracellular Identification of a Processed Type II ComR/ComS Pheromone of Streptococcus mutans. Journal of Bacteriology.  ISSN 0021-9193.  194(15), s 3781- 3788 . doi: 10.1128/​JB.00624-12 Full text in Research Archive.
• Petersen, Fernanda Cristina (2012). Communication among the inhabitants of the oral cavity.
• Rukke, Håkon Valen & Petersen, Fernanda Cristina (2012). Regulation of chain length during competence delevopment in Streptococcus mitis.
• Petersen, Fernanda Cristina (2011). Commensal and pathogenic streptococci: deciphering their language.
• Petersen, Fernanda Cristina (2011). THE FASCINATING PNEUMOCOCCAL “SUGAR-COAT”.
• Rukke, Håkon Valen; Hegna, Ida Kristin & Petersen, Fernanda Cristina (2011). Capsule expression in Streptococcus mitis.
• Rukke, Håkon Valen; Hegna, Ida Kristin & Petersen, Fernanda Cristina (2011). Functional characterization of the Streptococcus mitis capsule locus.
• Rukke, Håkon Valen & Petersen, Fernanda Cristina (2011). Capsule locus transfer between Streptococcus mitis and Streptococcus pneumoniae.
• Rukke, Håkon Valen & Petersen, Fernanda Cristina (2011). Kapselbytte blant ulike streptokokker.
• Schneider, Sigurd; Henderson, Elisabet; Wohlfahrt, Johan Caspar; Taxt-Lamolle, Sebastien Francis Michel; Gustumhaugen, Eva; Petersen, Fernanda Cristina; Ekstrand, Karl; Ekfeldt, Anders & Haugen, Håvard Jostein (2011). A nano chemical debridement solution shows high efficiency on contaminated titanium surface. European Cells and Materials.  ISSN 1473-2262.  21, s 19
• Petersen, Fernanda Cristina (2010). Streptococci: deciphering their language.
• Petersen, Fernanda Cristina (2010). Streptococcus mutans communication: the undefinable something.
• Giertsen, Elin; Olsen, Ingar; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2009). Oral biofilm. Jubileumshefte for Det odontologiske fakultet.  s 17- 19.
• Petersen, Fernanda Cristina (2009). Kan vi delta i bakteriell kommunikasjon for å behandle infeksjoner?.
• Petersen, Fernanda Cristina (2009). The human microbiota: rather unknown inhabitants.
• Nesse, Live; Vestby, Lene K.; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond; Langsrud, Solveig; Benneche, Tore & Scheie, Anne Aamdal (2008). The effect of a synthetic bromated furanone on the production of biofilm by different Salmonella wild type strains.
• Petersen, Fernanda Cristina (2008). Oral colonizers: a reservoir of antibiotic resistance genes.
• Scheie, Anne Aamdal; Petersen, Fernanda Cristina & Abdul-Majeed Ahmed, Nibras Ayad (2008). AI-2 signaling in the Streptococcus anginosus group.
• Scheie, Anne Aamdal; Petersen, Fernanda Cristina & da Silva, Daniele Pecharki Marques (2008). Streptococcus intermedius-Molecular mechanisms of biofilm formation and virulence expression.
• Vestby, Lene Karine; Nesse, Live Lingaas; Lönn-Stensrud, Jessica; Petersen, Fernanda Cristina; Møretrø, Trond; Langsrud, Solveig; Benneche, Tore & Scheie, Anne Aamdal (2008). AI-2 production by different wild-type Salmonella strains and the effect of biofilm formation by introducing AHL, GMP and a synthetic bromated furanones.
• da Silva, Daniele Pecharki Marques; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Role of hyaluronidase in biofilm formation and adhesion to keratinocytes by Streptococcus intermedius.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). AI-2 Mediated Biofilm Formation in Oral Streptococci is Inhibited by Bromated Furanone.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakterier snakker, vi lider. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Bakteriesnakk gir tanntrøbbel. Forskning.no : nettavis med nyheter fra norsk og internasjonal forskning.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is Inhibited by Synthetic Brominated Furanones. Show summary

  The coagulase-negative staphylococci (CNS) are commensals of human skin and mucous membranes. Staphylococcus epidermidis is the most frequently isolated CNS species, and also one of the major nosocomial pathogens associated with infections on medical implants. The cause of infections is primarily related to biofilm formation on the implant. S. epidermidis infections represent a major burden to the public health system, and are often responsible for prolonged hospitalisation and occasional deaths. Microorganisms in nature prefer a biofilm life style. Biofilm infections are often difficult to treat due to increased resistance both to antibiotics and to the immune system. The algae Delisea pulchra produces bromated furanones that prevent bacterial biofilm formation on its surface. Similar furanones may interfere with both autoinducer-2 and autoinducer-1 signalling in Gram-positive and Gram-negative microorganisms without affecting bacterial growth.

• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Biofilm formation in Staphylococcus epidermidis is inhibited by synthetic bromated furanones.
• Lönn-Stensrud, Jessica; Benneche, Tore; Petersen, Fernanda Cristina & Scheie, Anne Aamdal (2007). Furanones Inhibit AI-2 Mediated Communication in Bacteria at Non-Irritant Concentrations.
• Petersen, Fernanda Cristina (2007). Communication and biofilm formation in streptococci.
• Petersen, Fernanda Cristina (2007). Extracellular DNA and biofilm formation.
• Petersen, Fernanda Cristina (2007). Talking streptococci into forming biofilms.

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