Thomas Michel Kuntziger

Professor - Biokjemi
Bilde av Thomas Michel Kuntziger
English version of this page
Telefon +47 22840383
Brukernavn
Besøksadresse Sognsvannsveien 10 Domus Odontologica 0372 Oslo
Postadresse Postboks 1052 Blindern 0316 Oslo

Education

1996-2001         Ph.D. in Cell and Molecular Biology

  • Dr Michel Bornens’ group, Institut Curie / CNRS, Paris, France.
  • Thesis: “On some aspects of microtubule dynamics and centrosome duplication in Xenopus oocytes” obtained summa cum laude (Très honorable avec félicitations).

1992-1996        École Normale Supérieure (ENS) de Cachan, Cachan, France.

1989-1992        Lycée Lakanal, Sceaux, France.

1989                 Baccalauréat, Lycée Henri IV, Paris, France.

 

Work experience

2017-present      Professor

  • Department of Oral Biology, University of Oslo, Norway.
  • Research area: epigenetic mechanisms in cancer progression.
  • 25 referenced publications (h index = 15, Google Scholar).

2015-present      Associate Professor (Førsteamanuensis)

  • Department of Oral Biology, University of Oslo, Norway.

2001-2015          Postdoc and Senior Scientist

  • Professor P. Collas’ group, Institute of Basic Medical Sciences (IMB) and Norwegian Center for Stem Cell Research, University of Oslo, Norway.
  • Research area: nuclear anchoring proteins.
  • In charge of the microscopy resources (three live cell imaging stations).

 

Fellowships and awards

2018                      Anders Jahre Foundation (UNIFOR): MLL histone methyltransferase complexes anchored by AKAP95 in cancer progression: 4,4 k€.

2018                      Nansen Foundation (UNIFOR): MLL histone methyltransferase complexes anchored by AKAP95 in cancer progression: 5,2 k€.

2016                      Faculty of Dentistry (UiO) research grant (Mitotic roles of AKAP95 in chromosomal instability): 11 k€.

2015                      Kreftforeningen Running Costs project (AKAP95 in chromosomal instability and cancer gene bookmarking; 6858142): 20 k€.

2014                      Coordinated and wrote “NuArch: Nuclear Architecture in the regulation of autophagy, DNA repair and gene expression » European Economic Association (EEA) grant project in the frame of the Czech-Norwegian Research Programme (3 years): 1000 k€

2002                      Marie Curie Individual Fellowship MCFI-2001-01266, European Commission, Brussels, Belgium.

2001                      Scientific funding for post-doctoral stay abroad, Fondation pour la Recherche Médicale, Paris, France.

1992                      Selective stipend from the French National Education Ministry to study at ENS de Cachan (4 years).

 

Teaching and supervision experience:

  • Supervisor of:
    • two Ph.D. students (two completed: M. Rogne, 2 first and 1 second authorships; G. Lopez-Soop: 1 first authorship);
    • one postdoc (H.B. Landsverk, 1 first and 1 second authorship);
    • two lab engineers/Master students (A. Rogala: 1 third authorship).
  • Co-supervisor of:
    • two Ph.D. student (two completed: H.B. Landsverk, 2 first and 1 second authorships);
    • one postdoc (E. Delbarre, 3 first and 1 second authorships).
  • General Metabolism lectures, Problem-based learning (PBL) and teacher-led small group courses (LSB) to first-year medical faculty students.
  • Courses in “Gene Regulation and Epigenetics” and “Genome Browsing” to first-year medical faculty students (2014-2015).
  • Representative member of the first-year medical faculty examination commission.
  • “Techniques in Microscopy” lecture to Master in Biomedicine students at Oslo Metropolitan University (OsloMet), Oslo, Norway.
  • Theoretical and practical courses in Cell Biology to bachelor and master students at the Paris VI University, France (1996-2001).

 

Referee experience:

  • PhD evaluation committees: Catholic University of Leuven (Belgium) and University of Oslo.
  • Scientific expert for the Luxembourg National Research Fund (FNR), for the Wallonie National Scientific Research Fund (FNRS) and for the Research Foundation – Flanders (FWO); panel member for the FNR (2012-2015).
  • Referee for Biochemical Journal, Biochemical Society Transactions, Bioinformatics, Cell Biology and Toxicology, Experimental Cell Research, FEBS Journal, European Journal of Cell Biology, PLOS Genetics.

 

Outreach:

  • Life Science Lunch seminar organized by the Science Library and UiO:Life Science (16/11/2016)

 

Courses and training

2017                     Basic Pedagogical Requirements (Pedagogisk Basiskompetanse); Academic Development Unit (FUP), Oslo University, Norway.

2012                     Next-generation sequencing hands-on course; Microarray and Sequencing Core Facility, Oslo University Hospital, Norway.

 2005                     Digital Imaging in Biology, Université Paris VI, France.

2003                     EMBO Course: “Deciphering Chromosomes by Chromatin Immunoprecipitation, Institute of Genetics and Biophysics, Naples. Italy.

 1993                     Internship in the laboratory of Dr D. Louvard, Institut Pasteur, Paris, France.

 

Skills and competences

Mother tongue   French

Other languages Norwegian: Fluent

                              English: Fluent

                              German: Basic/Good

                              Luxembourgish: Basic/Good

Computer skills   Imaging software (Adobe Photoshop, Image J, Olympus microscopes software), proteomic (Scaffold) and genomic browsers (IGV, Galaxy, SignalMap).

 

Organisational / managerial skills

Member of IMB organizing committee for the celebration of UiO’s bicentennial (2011).

Member of IMB seminar arranging committee (2007-2015).

Member of the board for the Skovveien 6A co-ownership.

Publikasjoner

  • Sapkota, Dipak; Wang, Daxin; Schreurs, Olaf Joseph Franciscus; Vallenari, Evan Michael; PandeyDhakal, Sushma & Küntziger, Thomas M. [Vis alle 9 forfattere av denne artikkelen] (2024). Investigation of Roles of SLC38A1 in Proliferation and Differentiation of Mouse Tongue Epithelium and Expression in Human Oral Tongue Squamous Cell Carcinoma. Cancers. ISSN 2072-6694. 16(2). doi: 10.3390/cancers16020405. Fulltekst i vitenarkiv
  • Balta, Maria G.; Schreurs, Olaf Joseph Franciscus; Halder, Rashi; Küntziger, Thomas M.; Sætre, Frank Ove & Blix, Inger Johanne Schytte [Vis alle 9 forfattere av denne artikkelen] (2022). RvD1n-3 DPA Downregulates the Transcription of Pro-Inflammatory Genes in Oral Epithelial Cells and Reverses Nuclear Translocation of Transcription Factor p65 after TNF-α Stimulation. International Journal of Molecular Sciences. ISSN 1661-6596. 23(23), s. 1–11. doi: 10.3390/ijms232314878. Fulltekst i vitenarkiv
  • Balta, Maria; Schreurs, Olaf Joseph Franciscus; Hansen, Trond Vidar; Tungen, Jørn Eivind; Vik, Anders & Glaab, Enrico [Vis alle 10 forfattere av denne artikkelen] (2022). Expression and function of resolvin RvD1n-3 DPA receptors in oral epithelial cells. European Journal of Oral Sciences. ISSN 0909-8836. 130:e12883(4), s. 1–10. doi: 10.1111/eos.12883. Fulltekst i vitenarkiv
  • Rørvik, Gro Herredsvela; Liskiewicz, Krystyna Anna; Kryuchkov, Fedor; Naemi, Ali-Oddin; aasheim, Hans-Christian & Petersen, Fernanda Cristina [Vis alle 8 forfattere av denne artikkelen] (2020). Cyclic di-adenosine monophosphate regulates metabolism and growth in the oral commensal streptococcus mitis. Microorganisms. ISSN 2076-2607. 8:1269(9), s. 1–21. doi: 10.3390/microorganisms8091269. Fulltekst i vitenarkiv
  • Rogne, Marie; Chu, Dinh Toi; Küntziger, Thomas M.; Mylonakou, Maria-Niki; Collas, Philippe & Tasken, Kjetil (2018). OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. Molecular Biology of the Cell. ISSN 1059-1524. 29(12), s. 1487–1501. doi: 10.1091/mbc.E17-09-0538. Fulltekst i vitenarkiv
  • Lopez Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil & Thiede, Bernd [Vis alle 8 forfattere av denne artikkelen] (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle. ISSN 1538-4101. 16(10), s. 947–956. doi: 10.1080/15384101.2017.1310350. Fulltekst i vitenarkiv
  • Delbarre, Erwan; Ivanauskiene, Kristina; Spirkoski, Jane; Shah, Akshay; Vekterud, Kristin & Moskaug, Jan Øivind [Vis alle 10 forfattere av denne artikkelen] (2017). PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX. Genome Research. ISSN 1088-9051. 27(6), s. 913–921. doi: 10.1101/gr.215830.116. Fulltekst i vitenarkiv
  • Legartová, Soña; Sehnalová, Petra; Malyšková, Barbora; Küntziger, Thomas M.; Collas, Philippe & Cmarko, Dušan [Vis alle 10 forfattere av denne artikkelen] (2016). Localized Movement and Levels of 53BP1 Protein Are Changed by g-irradiation in PML Deficient Cells. Journal of Cellular Biochemistry. ISSN 0730-2312. 117(11), s. 2583–2596. doi: 10.1002/jcb.25551.
  • Suchánková, Jana; Kozubek, Stanislav; Legartová, Soña; Sehnalová, Petra; Küntziger, Thomas Michel & Bártová, Eva (2015). Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci. Biology of the Cell. ISSN 0248-4900. 107(12), s. 440–454. doi: 10.1111/boc.201500050.
  • Ivanauskiene, Kristina; Delbarre, Erwan; McGhie, James; Küntziger, Thomas Michel; Wong, Lee-Jun C. & Collas, Philippe (2014). The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Research. ISSN 1088-9051. 24(10), s. 1584–1594. doi: 10.1101/gr.173831.114.
  • Delbarre, Erwan; Ivanauskiene, Kristina; Küntziger, Thomas Michel & Collas, Philippe (2013). DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin. Genome Research. ISSN 1088-9051. 23(3), s. 440–451. doi: 10.1101/gr.142703.112.
  • Ørpetveit, Irene; Küntziger, Thomas Michel; Sindre, Hilde; Rimstad, Espen & Dannevig, Birgit Helene (2012). Infectious pancreatic necrosis virus (IPNV) from salmonid fish enters, but does not replicate in, mammalian cells. Virology Journal. ISSN 1743-422X. 9. doi: 10.1186/1743-422X-9-228.
  • Pidoux, Guillaume; Witczak, Oliwia; Jarnæss, Elisabeth; Myrvold, Linda; Urlaub, Henning & Stokka, Anne Jorunn [Vis alle 8 forfattere av denne artikkelen] (2011). Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO Journal. ISSN 0261-4189. 30(21), s. 4371–4386. doi: 10.1038/emboj.2011.365. Fulltekst i vitenarkiv
  • Kuntziger, Thomas Michel; Landsverk, Helga Bjarnason; Collas, Philippe & Syljuåsen, Randi (2011). Protein phosphatase 1 regulators in DNA damage signaling. Cell Cycle. ISSN 1538-4101. 10(9), s. 1356–1362. doi: 10.4161/cc.10.9.15442.
  • Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Reiner, Andrew Henry; Sørensen, Anita Løvstad; Kuntziger, Thomas Michel & Collas, Philippe (2010). Chromatin Environment of Histone Variant H3.3 Revealed by Quantitative Imaging and Genome-scale Chromatin and DNA Immunoprecipitation. Molecular Biology of the Cell. ISSN 1059-1524. 21(11), s. 1872–1884. doi: 10.1091/mbc.E09-09-0839.
  • Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Vis alle 10 forfattere av denne artikkelen] (2010). The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Reports. ISSN 1469-221X. 11(11), s. 868–875. doi: 10.1038/embor.2010.134.
  • Rogne, Marie; Stokka, Anne Jorunn; Tasken, Kjetil; Collas, Philippe & Kuntziger, Thomas Michel (2009). Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Human Molecular Genetics. ISSN 0964-6906. 18(5), s. 978–987. doi: 10.1093/hmg/ddn425.
  • Kuntziger, Thomas Michel; Rogne, Marie; Folstad, Rikke Lise & Collas, Philippe (2006). Association of PP1 with its regulatory subunit AKAP149 is regulated by serine phosphorylation flanking the RVXF motif of AKAP149. Biochemistry. ISSN 0006-2960. 45(18), s. 5868–5877.
  • Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Gaustad, Kristine Gjul; Marstad, Anne & Collas, Philippe (2006). In vitro reprogramming of nuclei and cells. Methods in molecular biology. ISSN 1064-3745. s. 259–268.
  • Rogne, Marie; Landsverk, Bjarnason Helga; Eynde, A.V.; Beullens, Monique; Bollen, M. & Collas, Philippe [Vis alle 7 forfattere av denne artikkelen] (2006). The KH-Tudor domain of A-Kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry. ISSN 0006-2960. 45(50), s. 14980–14989.
  • Landsverk, Bjarnason Helga; Rogne, Marie; Bollen, M.; Kuntziger, Thomas Michel & Collas, Philippe (2005). PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochemical Journal. ISSN 0264-6021. 15, s. 709–17.
  • Håkelien, Anne-Mari; Gaustad, Kristine Gjul; Taranger, Christel Kjær; Skålhegg, Bjørn Steen; Kuntziger, Thomas Michel & Collas, Philippe (2005). Long-term in vitro, cell-type-specific genome-wide reprogramming of gene expression. Experimental Cell Research. ISSN 0014-4827. 10, s. 32–47.
  • Kuntziger, Thomas Michel & Collas, Philippe (2004). Transdifferentiation. I Lanza, Robert (Red.), Adult and Fetal Stem Cells. Academic Press. ISSN 0124366414. s. 147–151.
  • Collas, Philippe; Kuntziger, Thomas Michel & Landsverk, Helga Bjarnason (2004). Anchoring of protein kinase and phosphatase signaling units. Topics in Current Genetics. ISSN 1610-2096. 5, s. 145–165.
  • Landsverk, Helga B.; Håkelien, Anne-Mari; Kuntziger, Thomas Michel; Robl, J.M.; Skålhegg, Bjørn Steen & Collas, Philippe (2002). Reprogrammed gene expression in a somatic cell-free extract. EMBO Reports. ISSN 1469-221X. 3(4), s. 384–389.

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  • Rogala, Agnieszka; Kristoffersen, Anne Karin; Enersen, Morten; Sapkota, Dipak & Küntziger, Thomas M. (2021). Defining the role of Porphyromonas gingivalis’ peptidyl arginine deiminase (PPAD) in oral carcinoma.
  • Rogala, Agnieszka; Follin-Arbelet, Benoit; Kristoffersen, Anne Karin; Enersen, Morten; Sapkota, Dipak & Küntziger, Thomas M. (2019). Defining the role of Porphyromonas gingivalis peptidyl arginine deiminase (PPAD) in oral carcinoma.
  • López-Soop, Graciela; Rønningen, Torunn; Rogala, Agnieszka; Richartz, Nina; Blomhoff, Heidi Kiil & Thiede, Bernd [Vis alle 8 forfattere av denne artikkelen] (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle. ISSN 1538-4101. 16(10), s. 947–956. doi: 10.1080/15384101.2017.1310350..
  • Küntziger, Thomas M. (2017). AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint.
  • Küntziger, Thomas Michel (2016). A-Kinase Anchoring Protein AKAP95 interacts with Nuclear Pore Complex Protein Tpr and prevents chromosome lagging during cell division.
  • Lopez Soop, Graciela; Reiner, Andrew Henry; Thiede, Bernd; Collas, Philippe & Küntziger, Thomas Michel (2015). Regulation of Normal Mitotic Progression by A-kinase Anchoring Protein 95 (AKAP95).
  • Küntziger, Thomas Michel (2014). Respective roles of histone chaperone DEK and A-Kinase anchoring protein AKAP95 in chromatin deposition of histone H3.3 and in genome architecture.
  • Küntziger, Thomas Michel; Lund, Eivind Gard & Collas, Philippe (2013). Signal molecules anchoring at proliferation and differentiation genes by A-Kinase Anchoring Protein (AKAP) 95.
  • Ivanauskiene, Kristina; Delbarre, Erwan; Küntziger, Thomas Michel & Collas, Philippe (2012). DAXX-dependent recruitment of histone variant H3.3 to PML bodies before deposition into chromatin. The FEBS Journal. ISSN 1742-464X. 279, s. 505–505.
  • Küntziger, Thomas Michel; Lund, Eivind Gard & Collas, Philippe (2012). Signal molecules anchoring at proliferation and differentiation genes by A-Kinase Anchoring Protein (AKAP) 95.
  • Collas, Philippe; Delbarre, Erwan; Küntziger, Thomas Michel; Lund, Eivind Gard; Ruppelt, Anja & Reiner, Andrew Henry [Vis alle 7 forfattere av denne artikkelen] (2012). Epigenetic programming of stromal cell fate. International Journal of Molecular Medicine. ISSN 1107-3756. 30, s. S57–S57.
  • Küntziger, Thomas Michel (2011). Mikroskopiske teknikker.
  • Kuntziger, Thomas Michel (2010). Mikrotubuli og celledeling.
  • Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Vis alle 10 forfattere av denne artikkelen] (2010). The protein phosphatase 1 regulator PNUTS is a novel component of the DNA damage response.
  • Kuntziger, Thomas Michel (2009). Mikrotubuli og celledeling.
  • Kuntziger, Thomas Michel (2009). Mutually exclusive binding of PP1 and RNA to A-kinase-anchoring protein AKAP149 affects the mitochondrial network.
  • Landsverk, Helga Bjarnason; Mora-Bermudez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Vis alle 10 forfattere av denne artikkelen] (2009). PP1 nuclear targeting subunit (PNUTS/p99/R111/CAT53) is an integral part of the G2 DNA damage checkpoint.
  • Delbarre, Erwan; Jacobsen, Bente Marie Berntsen; Kuntziger, Thomas Michel & Collas, Philippe (2009). Epigenetic environment of the histone variant H3.3 revealed by integration of imaging and genome-scale ChIP information.
  • Kuntziger, Thomas Michel (2008). Mikrotubuli og celledeling.
  • Kuntziger, Thomas Michel (2007). Sur quelques aspects de l’organisation et de la dynamique de la chromatine dans le noyau des cellules animales.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Delbarre, Erwan; Håkelien, Anne-Mari; Kuntziger, Thomas Michel & Collas, Philippe (2007). Chromatin organization in human adipose stem cells and murine myoblasts expressing lamin A mutations.
  • Kuntziger, Thomas Michel (2003). Study of chromatin-associated proteins anchoring signaling complexes.
  • Landsverk, Helga Bjarnason; Beullens, Monique; Kuntziger, Thomas Michel; Bollen, Mathieu & Collas, Philippe (2003). AKAP149 is a novel PP1 specifier required to maintain nuclear intergrity in G1 phase.
  • Folstad, Rikke Lise Steen; Kuntziger, Thomas Michel; Beullens, Monique; Landsverk, Helga Bjarnason; Bollen, Mathieu & Collas, Philippe (2003). Nuclear envelope anchoring of PP1 by A-kinase anchoring protein AKAP149.
  • Kuntziger, Thomas Michel (2002). Chromatin remodeling in in vitro reprogrammed nuclei.

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Publisert 1. okt. 2015 10:34 - Sist endret 17. sep. 2018 11:55

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