Olaf Joseph Franciscus Schreurs

• Schreurs, Olaf Joseph Franciscus; Balta, Maria; Karatsaidis, Andreas & Schenck, Karl (2020). Composition of hemidesmosomes in basal keratinocytes of normal buccal mucosa and oral lichen planus. European Journal of Oral Sciences.  ISSN 0909-8836.  128(5), s 369- 378 . doi: https://doi.org/10.1111/eos.12732 Fulltekst i vitenarkiv. Vis sammendrag

  Oral lichen planus (OLP) is a chronic inflammatory disease displaying ultrastructural disturbances in epithelial hemidesmosomes. The expression of several key hemidesmosomal components in OLP as well as in normal buccal mucosa is, however, unknown. The aim of the study was therefore to examine intracellular and extracellular components involved in hemidesmosomal attachment, in OLP (n = 20) and in normal buccal mucosa (n = 10), by immunofluorescence. In normal buccal mucosa, laminin‐α3γ2, integrin‐α6β4, CD151, collagen α‐1(XVII) chain, and dystonin showed linear expression along the basal membrane, indicating the presence of type I hemidesmosomes. Plectin stained most epithelial cell membranes and remained unphosphorylated at S4642. In OLP, most hemidesmosomal molecules examined showed disturbed expression consisting of discontinuous increases, apicolateral location, and/or intracellular accumulation. Plectin showed S4642‐phosphorylation at the basement membrane, and deposits of laminin‐α3 and laminin‐γ2 were found within the connective tissue. The disturbed expression of hemidesmosomal proteins in OLP indicates deficient attachment of the basal cell layer, which can contribute to detachment and cell death of basal keratinocytes seen in the disease.

• Schreurs, Olaf Joseph Franciscus; Karatsaidis, Andreas; Balta, Maria; Grung, Bjarte; Hals, Else Kristine Breivik & Schenck, Karl (2020). Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus. European Journal of Oral Sciences.  ISSN 0909-8836.  128(1), s 7- 17 . doi: https://doi.org/10.1111/eos.12666 Fulltekst i vitenarkiv. Vis sammendrag

  Keratins form intermediate filaments of the cytoskeleton in keratinocytes and have roles in cell structure, signaling, intracellular transport, and cell death. Oral lichen planus (OLP) is an oral inflammatory disease with derangements in basal keratinocytes and disruption of the basal membrane. Here, we focused on epithelial expression of keratins 8, 18, and 19 because these proteins are known to modulate cell death. Biopsies were taken from buccal oral mucosa of persons with normal oral mucosa (n = 10) or atrophic OLP (n = 10). Cultured normal oral keratinocytes (n = 4) showed expression of mRNA and protein for keratins 8, 18, and 19. Immunohistochemistry showed consistent staining for keratins 8 and 18 in basal keratinocytes of normal oral mucosa. In OLP, staining for keratin (K)8 was mostly negative and staining for K18 was weak. Keratin 19 was expressed irregularly in most biopsies of normal oral mucosa and not at all in OLP. Several mononuclear leukocytes in the cellular infiltrate showed membrane staining for K8 and K18. Positive staining for K16 confirmed partial collapse of the basal cell layer in OLP. The basal cell niche in OLP therefore appeared to be partly populated with keratinocytes demonstrating a higher degree of differentiation (K8− K18− K19− K16+); consequently, such areas may be more susceptible to the action of cell death factors released from the cell infiltrate as a result of lacking the protective, normal keratin present in the basal epithelial cell layer of normal oral mucosa.

• Søland, Tine Merete; Bjerkli, Inger-Heidi; Georgsen, Jeanette B; Schreurs, Olaf Joseph Franciscus; Jebsen, Peter Wilhelm; Laurvik, Helene & Sapkota, Dipak (2020). High-risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue. Clinical and Experimental Dental Research.  ISSN 2057-4347.  7(1), s 70- 77 . doi: 10.1002/cre2.342 Fulltekst i vitenarkiv. Vis sammendrag

  Abstract Objectives: The presence of and the causative role of high-risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high-risk HPV in a homogenous Norwegian cohort of primary and second primary OSCC of the mobile tongue (oral tongue squamous cell carcinoma—OTSCC). Methods: Tissue microarrays containing formalin-fixed and paraffin-embedded cores of 146 OTSCC from the anterior 2/3 of the tongue (n = 128 primary and n = 18 second primary) from a multicentric Norwegian cohort were examined for the presence of high-risk HPV by DNA- and RNA-in situ hybridization (ISH) assays and p16 immunohistochemistry. Results: Transcriptionally active HPV (E6/E7 mRNA) was not identified in any of the OTSCC specimens. In parallel, no tumors were positive for HPV by DNA ISH. Although, 61 (42%) OTSCC demonstrated p16 positivity with varying staining intensity and subcellular localization, only two cases demonstrated strong and uniform p16-staining (both cytoplasmic and nuclear) in >70% of cancer cells. The absence of transcriptionally active high-risk HPV in this cohort of OTSCC indicates that high-risk HPV is an unlikely causative factor in the present material.

• Engen, Stian André; Rørvik, Gro Herredsvela; Schreurs, Olaf Joseph Franciscus; Blix, Inger Johanne S. & Schenck, Karl (2017). The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells. International Journal of Oral Science.  ISSN 1674-2818.  9(3), s 145- 150 . doi: 10.1038/ijos.2017.17 Fulltekst i vitenarkiv. Vis sammendrag

  Streptococcus mitis (S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor (AhR). Activation and functionality of AhR was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for AhR activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an AhR-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by AhR. Elevated levels of prostaglandin E2 (enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of AhR activity. The observed AhR-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce AhR activation is important, also in view of the role that AhR has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages.

• Engen, Stian André; Schreurs, Olaf Joseph Franciscus; Petersen, Fernanda Cristina; Blix, Inger Johanne S.; Bækkevold, Espen Sønderaal & Schenck, Karl (2017). The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes. Scandinavian Journal of Immunology.  ISSN 0300-9475.  87(2), s 80- 87 . doi: 10.1111/sji.12636
• Schenck, Karl; Schreurs, Olaf Joseph Franciscus; Hayashi, Katsuhiko & Helgeland, Kristen (2017). The role of nerve growth factor (NGF) and its precursor forms in oral wound healing. International Journal of Molecular Sciences.  ISSN 1422-0067.  18(2), s 1- 12 . doi: 10.3390/ijms18020386 Fulltekst i vitenarkiv.
• Thorlakson, Hong Huynh; Engen, Stian André; Schreurs, Olaf Joseph Franciscus; Schenck, Karl & Blix, Inger Johanne S. (2017). Lysophophatidic acid induces expression of genes in human oral keratinocytes involved in wournd healing. Archives of Oral Biology.  ISSN 0003-9969.  80, s 153- 159 . doi: 10.1016/j.archoralbio.2017.04.008 Fulltekst i vitenarkiv. Vis sammendrag

  OBJECTIVE: Epithelial cells participate in wound healing by covering wounds, but also as important mediators of wound healing processes. Topical application of the phospholipid growth factor lysophosphatidic acid (LPA) accelerates dermal wound healing and we hypothesized that LPA can play a role in human oral wound healing through its effects on human oral keratinocytes (HOK). DESIGN: HOK were isolated from gingival biopsies and exposed to LPA. The LPA receptor profile, signal transduction pathways, gene expression and secretion of selected cytokines were analyzed. RESULTS: HOK expressed the receptors LPA1, LPA5 and LPA6 and LPA activated the ERK1/2, JNK and p38 intracellular pathways, substantiated by secretion of IL-6 and IL-8. The early (2h) and intermediate (6h) gene expression profiles of HOK after LPA treatment showed a wide array of regulated genes. The majority of the strongest upregulated genes were related to chemotaxis and inflammation, and became downregulated after 6h. At 6h, genes coding for factors involved in extracellular matrix remodeling and re-epithelialization became highly expressed. IL-36γ, not earlier known to be regulated by LPA, was strongly transcribed and translated but not secreted. CONCLUSIONS: After stimulation with LPA, HOK responded by regulating factors and genes that are essential in wound healing processes. As LPA is found in saliva and is released by activated cells after wounding, our results indicate that LPA has a favorable physiological role in oral wound healing. This may further point towards a beneficial role for application of LPA on oral surgical or chronic wounds.

• Schreurs, Olaf Joseph Franciscus; Karatsaidis, Andreas & Schenck, Karl (2016). Phenotypically non-suppressive cells predominate among FoxP3-positive cells in oral lichen planus. Journal of Oral Pathology & Medicine.  ISSN 0904-2512.  45(10), s 766- 773 . doi: 10.1111/jop.12447
• Thorlakson, Hong Huynh; Schreurs, Olaf Joseph Franciscus; Schenck, Karl & Blix, Inger Johanne S. (2016). Lysophosphatidic acid regulates adhesion molecules and enhances migration of human oral keratinocytes.. European Journal of Oral Sciences.  ISSN 0909-8836.  124(2), s 164- 171 . doi: 10.1111/eos.12255
• Bjerkan, Louise; Schreurs, Olav Joseph F; Engen, Stian André; Jahnsen, Frode Lars; Bækkevold, Espen Sønderaal; Blix, Inger Johanne S. & Schenck, Karl (2015). The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal Immunology.  ISSN 1933-0219.  8(1), s 49- 56 . doi: 10.1038/mi.2014.41 Vis sammendrag

  Thymic stromal lymphopoietin (TSLP) has multifaceted immunological functions ranging from maintenance of tolerance to induction of disease. Two human transcript variants of TSLP are described: a long form (variant 1; lfTSLP) consisting of four exons and an alternative, short form (variant 2; sfTSLP) that lacks two exons compared with variant 1. SfTSLP has not been described at the protein level or functionally studied. Here, we demonstrate that the human sfTSLP is the predominant form of TSLP, constitutively expressed at the mRNA and protein level in keratinocytes of oral mucosa and skin and in salivary glands, is released in saliva, and is not regulated in the same manner as the long form. Compared with lfTSLP, sfTSLP exhibits a markedly stronger antibacterial activity. Synthetic sfTSLP did not activate signal transducer and activator of transcription 5 (STAT5) signaling in CD1c+ dendritic cells nor interfered with STAT5 activation by lfTSLP. SfTSLP may, therefore, act as an antimicrobial peptide in the oral cavity and on the skin to create a defense barrier that aids in the control of both commensal and pathogenic microbes. The results show that the two translational products of the TSLP gene have a different expression and different biological properties, and emphasize the importance of analyzing the two TSLP isoforms separately.

• Næsse, Elsebeth Pernille; Schreurs, Olav Joseph F; Messelt, Edvard Berger; Hayashi, Katsuhiko & Schenck, Karl (2013). Distribution of nerve growth factor, pro-nerve growth factor, and their receptors in human salivary glands. European Journal of Oral Sciences.  ISSN 0909-8836.  121(1), s 13- 20 . doi: 10.1111/eos.12008 Vis sammendrag

  Nerve growth factor (NGF) is a pluripotent mediator that is present in a range of human tissues. Nerve growth factor was originally considered important only in neuronal homeostasis and pathophysiology, but later it was also implicated in the pathophysiology of inflammation, epithelial differentiation, and wound healing. In this study, the distribution of nerve growth factor beta (NGF-b) and pro-NGF, and their receptors – tyrosine kinase A (TrkA) and p75NTR – was examined in human parotid, submandibular, sublingual, and labial salivary glands by immunohistochemistry. Intercalated, striated, and collecting-ducts in all gland types showed strong staining for pro-NGF but only weak cytoplasmic or sparse nuclear staining for NGF-b. Tyrosine kinase A was strongly expressed in the ducts of all gland types, whereas p75NTR expression was mainly confined to collecting ducts. In acini, no or only weak cytoplasmic staining was found for all markers, and some nuclei stained positive for NGF-b, pro-NGF, and TrkA. Western blotting of saliva showed secretion of several forms of pro-NGF, while no mature NGF-b was detected. Salivary pro-NGF may play a role in oral wound healing.

• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by CoCl2, a hypoxia mimetic. European Journal of Oral Sciences.  ISSN 0909-8836.  118(2), s 168- 176
• Kolltveit, Kristin Melkevik; Schreurs, Olav Joseph F; Østrem, Janet M; Søland, Tine Merete; Khuu, Cuong; Berge, Tone; Messelt, Edvard Berger; Hayashi, Katsuhiko; Granum, Stine; Spurkland, Anne & Schenck, Karl (2010). Expression of the T-cell-specific adapter protein in oral epithelium. European Journal of Oral Sciences.  ISSN 0909-8836.  118(2), s 159- 167 Vis sammendrag

  The multifunctional T-cell-specific adapter protein (TSAd) was originally described in T cells but is also expressed in epithelial cells from the respiratory tract and in endothelium. In this study, we found expression of TSAd messenger RNA (mRNA) and protein in both human and murine oral mucosal epithelium as well as in human primary oral keratinocyte cell cultures. In TSAd(-/-) mice, the mucosa and skin appeared macroscopically normal, but severe disturbances were observed in the fine structures of the basal membrane and intercellular epithelial spaces upon analysis using transmission electron microscopy. Oral epithelial cells from TSAd(-/-) mice displayed decreased migration compared with cells from wild-type mice, whereas overexpression of TSAd in a human epithelial cell line resulted in impaired proliferation. This study is the first to show that TSAd is expressed in normal oral mucosa, that it is important for the normal ultrastructural morphology of the epithelium and the basal membrane, and that it is involved in the migration and proliferation of oral keratinocytes.

• Larsen, Helga Soppeland; Ruus, Ann-Kristin; Schreurs, Olav Joseph F & Galtung, Hilde Kanli (2010). Aquaporin 11 in the developing mouse submandibular gland. European Journal of Oral Sciences.  ISSN 0909-8836.  118(1), s 9- 13
• Storesund, Trond; Schreurs, Olav Joseph F; Messelt, Edvard Berger; Kolltveit, Kristin Melkevik & Schenck, Karl (2009). Trefoil factor family 3 expression in the oral cavity. European Journal of Oral Sciences.  ISSN 0909-8836.  117(6), s 636- 643 . doi: 10.1111/j.1600-0722.2009.00679.x Vis sammendrag

  This study examined the expression, in oral keratinocytes and in the major and minor salivary glands, of Trefoil factor family 3 (TFF3) peptide. Trefoil factor family 3 messenger RNA (mRNA) and peptide were detected in cultures of normal oral keratinocytes by quantitative real-time polymerase chain reaction (PCR) and western blotting, respectively. Trefoil factor family 3 was found, by immunohistochemical analyses, to be expressed in the basal layers of the oral mucosal epithelium. In salivary glands, immunohistochemical staining showed that TFF3 peptide expression was strongest in the mucous acini of the submandibular and the small salivary glands. Serous cells in the same glands showed weak staining. In the parotid gland, many serous acini showed weak positive staining, while other areas did not. In all glands examined, the intercalated, striated, and collecting ducts were moderately TFF3-positive. Double immunostaining confirmed that mucous (MUC5B positive) cells were moderately or strongly positive for TFF3 and that some serous (MUC7 positive) cells showed restricted TFF3 expression, mostly in a granular pattern. The prevalence of the TFF3 peptide in the salivary secretions of healthy volunteers was detected by western blotting of saliva from minor salivary glands (four of five) and the parotid gland (one of five) and of mixed submandibular/sublingual saliva (five of five). In conclusion, the submandibular and small salivary glands appear to be the major producers of oral TFF3, but duct cells of all glands and keratinocytes of the oral mucosa may also contribute as sources of TFF3 in the oral cavity.

• Hayashi, Katsuhiko; Karatsaidis, Andreas; Schreurs, Olav; Bjørnland, Tore; Sugisaki, Masashi & Schenck, Karl (2008). NGF and its receptors TrkA and p75(NTR) in the epithelium of oral lichen. Journal of Oral Pathology & Medicine.  ISSN 0904-2512.  37(4), s 241- 248 . doi: 10.1111/j.1600-0714.2007.00627.x
• Hayashi, Katsuhiko; Storesund, T; Schreurs, O; Khuu, C; Khuu, Cuong; Husvik, C; Karatsaidis, Andreas; Helgeland, K; Martin-Zanca, D & Schenck, K (2007). Nerve growth factor beta/pro-nerve growth factor and their receptors in normal human oral mucosa. European Journal of Oral Sciences.  ISSN 0909-8836.  115(5), s 344- 354 . doi: 10.1111/j.1600-0722.2007.00480.x
• Karatsaidis, Andreas; Hayashi, Katsuhiko; Schreurs, Olav; Helgeland, Kristen & Schenck, Karl (2007). Survival signalling in keratinocytes of erythematous oral lichen planus. Journal of Oral Pathology & Medicine.  ISSN 0904-2512.  36(4), s 215- 222 . doi: 10.1111/j.1600-0714.2007.00519.x
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Axell, Tonny; Helgeland, K & Schenck, Karl (2004). Identity of TUNEL-positive cells in the oral buccal epithelium of normal mucosa and lichen lesions. Journal of Oral Pathology & Medicine.  ISSN 0904-2512.  33(5), s 264- 268
• Dellacasagrande, Jerome; Schreurs, Olav Joseph F; Hofgaard, Peter Olaf; Omholt, Hilde; Steinsvoll, Svein E B; Schenck, Karl; Bogen, Bjarne & Dembic, Zlatko (2003). Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scandinavian Journal of Immunology.  ISSN 0300-9475.  57(6), s 534- 544
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Axell, Tonny; Helgeland, Kristen & Schenck, Karl (2003). Inhibition of the transforming growth factor-beta/Smad signaling pathway in the epithelium of oral lichen. Journal of Investigative Dermatology.  ISSN 0022-202X.  121(6), s 1283- 1290
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Helgeland, Kristen; Axell, Tonny & Schenck, Karl (2003). Erythematous and reticular forms of oral lichen planus and oral lichenoid reactions differ in pathological features related to disease activity. Journal of Oral Pathology & Medicine.  ISSN 0904-2512.  32(5), s 275- 281
• Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen; Schenck, Karl & Steinsvoll, Svein E B (2003). Matrix metalloproteinases and their inhibitors in gingival mast cells in persons with and without human immunodeficiency virus infection. Journal of Periodontal Research.  ISSN 0022-3484.  38(6), s 575- 582
• Myint, Maung Maung; Odden, Kåre; Schreurs, Olav Joseph F; Halstensen, Trond Sundby & Schenck, Karl (1999). The gingival plasma cell infiltrate in HIV-positive patients with periodontitis is disorganized. Journal of Clinical Periodontology.  ISSN 0303-6979.  26, s 358- 365 Vis sammendrag

  Patients infected with the human immunodeficiency virus (HIV) are highly susceptible to chronic marginal periodontitis (CMP) and the lesion is generally characterized by abundant plasma cell infiltration. HIV-induced reduction of CD4+ T cells may indirectly affect local production of immunoglobulins (Ig). Gingival biopsies taken from 10 HIV+ and 12 HIV- control patients with CMP were washed, fixed in ethanol and embedded in paraffin. Sections were examined after immunohistochemical staining with monoclonal antibodies against IgA, IgA1-2, IgG, IgG1-4, IgM and IgE. Ig-containing cells were counted in 3 separate connective tissue zones (subjacent to pocket epithelium, central zone and subjacent to oral epithelium). HIV+ patients showed a remarkably increased density of all Ig-containing cells in the connective tissue zone subjacent to the oral epithelium (p<0.05) and a lower % of IgG2+ cells in the entire gingival section (p<0.05). In HIV+ patients, the density of IgG-containing cells in the gingiva was strongly correlated with the serum IgG concentration. The altered topical distribution might imply impaired restriction of the inflammatory lesion, additional antigenic challenges by unusual microorganisms in the oral cavity, or be secondary to HIV-induced dysregulation of the B-cell system.

• Yuan, Zuan-Ning; Schreurs, Olav Joseph F; Gjermo, Per E; Helgeland, Kristen & Schenck, Karl (1999). Topical distribution of Fc-gamma, Fc-gammaRII and Fc-gammaRIII in inflamed human gingiva. Journal of Clinical Periodontology.  ISSN 0303-6979.  26, s 441- 447
• Schenck, Karl; Schreurs, Olav Joseph F & Helgeland, Kristen (1997). Apoptose - hvorfor vi ikke blir født med hale. NOFs Tidende.  107, s 2- 8
• Schreurs, Olav Joseph F; Halstensen, Trond Sundby; Dembic, Zlatko; Bogen, Bjarne & Schenck, Karl (1997). TUNEL combined with staining for epithelial cellmarker permits unambiguous localization of apoptic cells in murine thymus. Biochemica.  ISSN 0946-1310.  4, s 19- 21

Se alle arbeider i Cristin

• Schreurs, Olaf Joseph Franciscus; Karatsaidis, Andreas & Schenck, Karl (2019). Deficient expression of keratin 8 and 18 in epithelia of oral lichen planus.
• Stian André, Engen; Schreurs, Olaf Joseph Franciscus; Fernanda, Petersen; Blix, Inger Johanne S.; Espen S., Bækkevold & Schenck, Karl (2018). The regulatory role of the oral commensal Streptococcus mitis on human monocytes.
• Engen, Stian; Schreurs, Olaf Joseph Franciscus; Petersen, Fernanda Cristina; Blix, Inger Johanne S.; Bækkevold, Espen Sønderaal & Schenck, Karl (2017). Regulation of human monocytes by the oral commensal Streptococcus mitis: a role for PGE2?.
• Rørvik, Gro Herredsvela; Schreurs, Olaf Joseph Franciscus; Engen, Stian; Blix, Inger Johanne S.; Petersen, Fernanda Cristina & Schenck, Karl (2017). Antibody reactivity to the oral commensal Streptococcus mitis in serum and saliva.
• Schreurs, Olaf Joseph Franciscus; Karatsaidis, Andreas & Schenck, Karl (2017). Altered change in K8 and K18 epithelial expression in oral lichen planus..
• Hayashi, Katsuhiko; Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Messelt, Edvard Berger; Sugisaki, Masashi & Schenck, Karl (2013). Distribution of NGF and its receptors in human salivary glands.
• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic. European Journal of Cancer.  ISSN 0959-8049.  8(5), s 149- 149
• Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl; Bryne, Magne & Søland, Tine Merete (2010). Induction of invasion in an organotypic oral cancer model by cobalt chloride, a hypoxia mimetic.
• Schreurs, Olav Joseph F; Schenck, Karl & Kolltveit, Kristin Melkevik (2009). FoxP3+ cell densities in oral lichen planus differ according to disease activity.
• Søland, Tine Merete; Brusevold, Ingvild Johnsen; Husvik, Camilla; Schreurs, Olav Joseph F; Schenck, Karl & Bryne, Magne (2008). Manipulation of invasion in a 3D-co-culture organotypic oral cancer model.
• Hayashi, Katsuhiko; Karatsaidis, Andreas; Schreurs, Olav Joseph F; Sugisaki, Masashi & Schenck, Karl (2007). NGF and Its Receptors TrkA and p75NTR in Oral Lichen.
• Hayashi, Katsuhiko; Storesund, Trond; Schreurs, Olav Joseph F; Khuu, Cuong; Husvik, Camilla; Karatsaidis, Andreas; Sugisaki, Masashi & Schenck, Karl (2007). NGF-beta/proNGF and their receptors in normal human oral mucosa. Virchows Archiv.  ISSN 0945-6317.  451, s 545- 546
• Hayashi, Katsuhiko; Storesund, Trond; Schreurs, Olav Joseph F; Khuu, Cuong; Husvik, Camilla; Karatsaidis, Andreas; Sugisaki, Masashi & Schenck, Karl (2007). NGF-ß/proNGF and their receptors in normal human oral mucosa.
• Karatsaidis, Andreas; Hayashi, Katsuhiko; Schreurs, Olav Joseph F; Helgeland, Kristen & Schenck, Karl (2007). Protection against apoptosis in keratinocytes of erythematous oral lichen planus lesions.
• Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Clausen, Ole Petter Fraas; Boysen, Morten Ebbe; Sudbø, Jon & Bryne, Magne (2004). COX-2, APC and beta-catenin in the invasive front of oral squamous cell carcinomas and their relation to prognosis.
• Søland, Tine Merete; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne (2003). Selective COX-2 up-regulation in DNA aneuploid oral precancers; an opportunity for targeted preventive treatment of oral cancer.
• Søland, Tine Merete; Sudbø, Jon; Schreurs, Olav Joseph F; Husvik, Camilla; Koppang, Hanna Strømme & Bryne, Magne (2003). Selective COX-2 up-regulation in DNA aneuploid oral precancers: an opportunity for targeted preventive treatment of oral cancers?.
• Kolltveit, Kristin Melkevik; Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen; Schenck, Karl & Steinsvoll, Svein E B (2002). Mast cells - Mediators of Rapid Matrix Degradation in Periodontitis?.
• Steinsvoll, Svein E B; Kolltveit, Kristin Melkevik; Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen & Schenck, Karl (2002). Mast Cells - Mediators of Rapidly Progressing Periodontitis in HIV+ Patients?.
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Helgeland, Kristen; Axell, Tonny & Schenck, Karl (2001). Transforming growth factor-b (TGF-b1) epithelial expression in oral lichen planus and lichenoid reactions. An immuno-histochemical study.
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Helgeland, Kristen; Axell, Tonny & Schenck, Karl (2001). Transforming growth factor-b (TGF-b1) epithelial expression in oral lichen planus and lichenoid reactions. An immuno-histochemical study.
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Helgeland, Kristen; Axell, Tonny & Schenck, Karl (2001). Transforming growth factor-b (TGF-b1) epithelial expression in oral lichen planus and lichenoid reactions. An immuno-histochemical study.
• Karatsaidis, Andreas; Schreurs, Olav Joseph F; Helgeland, Kristen; Axell, Tonny & Schenck, Karl (2001). Transforming growth factor-b (TGF-b1) epithelial expression in oral lichen planus and lichenoid reactions. An immuno-histochemical study.
• Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen; Schenck, Karl & Steinsvoll, Svein E B (2001). Mast Cells - Mediators of Periodontal Tissue Destruction in HIV+ patients?.
• Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen; Schenck, Karl & Steinsvoll, Svein E B (2001). Mast Cells in Periodontitis Express Strongly Matrixmetalloproteinases.
• Næsse, Elsbeth Pernille; Schreurs, Olav Joseph F; Helgeland, Kristen; Schenck, Karl & Steinsvoll, Svein E B (2000). Mast Cells in Periodontitis Revisited: More than Meets the Eye ?.
• Steinsvoll, Svein E B; Schreurs, Olav Joseph F; Helgeland, Kristen & Schenck, Karl (2000). Mast cell matrix metalloproteinases - potential mediators of periodontal tissue destruction in HIV+ patients.
• Steinsvoll, Svein E B; Schreurs, Olav Joseph F; Helgeland, Kristen & Schenck, Karl (1999). Expression of Matrix Metalloproteinases (MMPs), Inducers and Inhibitors in Chronically Inflamed Gingiva.
• Steinsvoll, Svein E B; Schreurs, Olav Joseph F; Helgeland, Kristen & Schenck, Karl (1999). Tissue inhibitor of matrixmetalloproteinases-1 (TIMP-1) and matrix metalloproteinase (MMP)-1, -2, -9 are increased and co-expressed with transforming growth factor-&#61538;1 (TGF-&#61538;1) in inflamed periodontal tissue.
• Yuan, Zuan-Ning; Schreurs, Olav Joseph F; Gjermo, Per E; Helgeland, Kristen & Schenck, Karl (1998). "Topical distribution of FcgRI, and FcgRII in inflamed human gingiva".
• Schenck, Karl; Schreurs, Olav Joseph F & Helgeland, Kristen (1996). Nitrogenoksyd (NO) - et lite molekyl med et stort virkefelt. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  106, s 132- 135
• Bryne, Magne; Kjærheim, Åsmund & Schreurs, Olav Joseph F (1992). Karbohydrater på celleoverflater er involvert i en rekke biologiske prosesser. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  22(112), s 2859- 2862
• Bryne, Magne; Thrane, Per Stanley; Schreurs, Olav Joseph F & Dabelsteen, E. (1991). Munnhulekreft. Prognostiske aspekter. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  101, s 338- 342

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