Anders Verket

• Eckhoff, Tonje Moen; Mauland, Erik Klepsland; Verket, Anders & Melbye, Elisabeth Lind (2026). Reliability and Construct Validity of a Questionnaire for Assessment of Patient-Reported Outcomes in Implant Dentistry. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.70110. Fulltekst i vitenarkiv Vis sammendrag

  Objectives The study aimed to evaluate the reliability and construct validity of a questionnaire assessing patient-reported outcomes following dental implant rehabilitation. Material and Methods A questionnaire was mailed to patients 8 years posttreatment to assess experiences with dental implant therapy, including satisfaction, oral function, perceived pretreatment information and complications. Patients completed the questionnaire again during a clinical examination. Internal consistency was evaluated using Cronbach's alpha and corrected item-total correlations (CITC), while test–retest reliability was assessed with intraclass correlation coefficients (ICC). Construct-related validity was examined through associations between questionnaire domains and oral health related quality of life (OHRQoL) measured by OHIP-14. Results A total of 206 patients completed the questionnaire twice. For individual items, ICCs ranged from 0.39 to 0.75 and CITCs from 0.39 to 0.66. The full questionnaire had an alpha of 0.78 and an ICC of 0.78. Construct-related validity was supported through associations between the questionnaire domains patient satisfaction, pretreatment information and the OHIP-14 sum scores. Conclusions The questionnaire demonstrated acceptable internal consistency reliability, good test–retest performance, and reasonable construct validity.

• Shanbhag, Siddharth; Stødle, Ida Haukåen; Lie, Stein Atle; Alonso, Mariano Sanz & Verket, Anders (2025). Histological Outcomes of Root Coverage Procedures: A Systematic Review With Meta‐Analysis. Journal of Periodontal Research. ISSN 0022-3484. 61(1), s. 9–29. doi: 10.1111/jre.70043. Fulltekst i vitenarkiv Vis sammendrag

  Objective: To answer the focused PEOS question: In animals or humans with gingival recession defects (P) what are the histological outcomes (O) of different root coverage procedures (RCPs) (E) in preclinical or clinical studies (S)? Methods: Electronic databases (MEDLINE, EMBASE, CENTRAL) were searched for eligible studies reporting histological outcomes of RCPs in large‐animal models or humans. Histomorphometric data from animal studies were summarized as pooled means (PM) for each RCP and compared between different RCPs using effect sizes (ES) based on random‐effects meta‐analyses. Results: Overall, 41 preclinical (32 canine‐, 5 porcine‐, 4 primate‐models) and 43 clinical studies, mostly case reports/series, were included. The most frequently reported RCPs were coronally advanced flaps with or without connective tissue grafts or soft‐tissue substitutes. Biologicals, such as enamel matrix derivatives (EMD) or membranes, were sometimes used as adjuncts in RCPs. In human biopsies, healing following RCPs mostly occurred via the formation of long junctional epithelium (JE) and connective tissue (CT) adhesion. Some degree of periodontal regeneration was reported in half of the studies. In canine studies with experimentally created defects and limited observation times, PM of new bone, cementum, and CT attachment ranged from 0.17 to 0.50, 0.97 to 2.39, and 1.31 to 2.47, respectively. Meta‐analyses revealed significantly greater new cementum with inserting fibers when using biologicals, particularly EMD (ES 0.86–0.92), or membranes (ES 0.87) as adjuncts in RCPs. Conclusion: Healing following RCPs is generally characterized by “repair” (long JE and CT adhesion). Based on animal studies, the adjunctive use of biologicals or membranes in RCPs may enhance periodontal regeneration at least in the short term.

• Herrera, David; Tonetti, Maurizio S.; Chapple, Iain; Kebschull, Moritz; Papapanou, Panos N. & Sculean, Anton [Vis alle 68 forfattere av denne artikkelen] (2025). Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis. Journal of Clinical Periodontology. ISSN 0303-6979. 52(S29), s. 33–33. doi: 10.1111/jcpe.14152. Fulltekst i vitenarkiv Vis sammendrag

  ABSTRACT Background This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid development of new technologies, the implementation of the 2018 classification and the declarations of the World Health Organisation on diagnosis and oral health. Aim To update and evaluate the evidence on diagnostic methods, considering recent advances in knowledge and the implementation of the 2018 classification. Methods The European Workshop Committee of the European Federation of Periodontology guided the development of a consensus report after commissioning eight systematic reviews within three working groups. The reviews were discussed during the in‐person consensus meeting involving 70 participants from 21 different countries. Results Working Group 1 discussed innovations in traditional diagnostic approaches, justified manual probing as the reference standard and assessed the value of image‐based methods. Working Group 2 analysed diagnostic tests based on microbial and host biomarkers and genetic diagnostic tests. Working Group 3 covered emerging technologies to be used within dental and non‐dental clinical settings, focusing principally on the impact of questionnaire‐based assessments and artificial intelligence systems (AIS) in interpreting different data modalities. Conclusion Although manual periodontal probing is firmly established as the reference standard, additional approaches based on imaging, biomarkers, host genetics, questionnaires and the development of emerging applied data science methods (e.g., AIS) are increasingly integrated in periodontal diagnostics.

• Maal, Mehrnaz Beheshti; Bueno, Jaime; Koldsland, Odd Carsten; Alonso, Mariano Sanz & Verket, Anders (2025). Oral Hygiene Reinforcement With or Without Repeated Instrumentation in the Treatment of Peri‐Implant Mucositis—A Randomised Controlled Trial. Journal of Clinical Periodontology. ISSN 0303-6979. doi: 10.1111/jcpe.70012. Fulltekst i vitenarkiv Vis sammendrag

  ABSTRACT Aim To assess the efficacy of repeated submarginal mechanical instrumentation, as an adjunct to oral hygiene instruction, in the treatment of peri‐implant mucositis. Material and Methods Patients with peri‐implant mucositis were allocated to a control group receiving oral hygiene instructions only, or a test group with adjunctive repeated ultrasonic instrumentation with a polyetheretherketone tip. Bleeding on probing reduction was the primary outcome. A blinded examiner recorded clinical variables, and intraoral scans were obtained at baseline, 12 weeks and 24 weeks. Results In total, 58 patients were recruited, and 50 completed the study. Clinical parameters improved from baseline in both groups. There were no significant differences in the reduction of the extent nor the severity of bleeding on probing between the control and the test group at the 12‐ and 24‐week follow‐ups, but a significantly higher reduction in the peri‐implant mucosa volume was observed in the test group from 12 to 24 weeks. Conclusions Ultrasonic instrumentation with a polyetheretherketone tip adjunctive to oral hygiene instructions did not render a higher reduction in bleeding on probing or lead to improved clinical outcomes. Still, it resulted in a higher reduction of the peri‐implant mucosa volume as compared to oral hygiene instructions alone.

• Mauland, Erik Klepsland; Maal, Mehrnaz Beheshti; Melbye, Elisabeth Lind; Aarbu, Naomi Østergren; Sørensen, Karoline & Ellingsen, Stig Aanerød [Vis alle 9 forfattere av denne artikkelen] (2025). The impact of peri-implant diseases and complications on oral health-related quality of life following dental implant therapy in Norway: A cross-sectional study. Clinical Oral Implants Research. ISSN 0905-7161. 36(10), s. 1219–1233. doi: 10.1111/clr.14467. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: To report oral health-related quality of life (OHRQoL) in a sample rehabilitated with dental implants and assess the influence of self-reported implant complications and clinical peri-implant status. A secondary aim was to investigate associations between OHIP-14 scores and patient-related variables. Materials and Methods: The Norwegian National Insurance Scheme registry for implant rehabilitation in 2014 was searched, and patients (n = 3083) were mailed a survey including OHIP-14, questions about peri-implant status, and patient-related variables. A subsample was examined clinically (n = 242). Associations of self-reported implant complications and clinical peri-implant status with OHIP-14 scores were evaluated by the Kruskal–Wallis test and logistic regression models. Results: The OHIP-14 mean sum score reported by the 1299 survey respondents was 4.1 (± 6.4). Self-report of complications was associated with higher OHIP-14 scores in a dose-dependent manner. Lower education (OR 1.54, 95% CI 1.05–2.22), female sex (OR 1.75, 95% CI 1.23–2.56), technical complication(s) (OR 1.58, 95% CI: 1.07–2.34), biological complication(s) (OR 2.41, 95% CI 1.67–3.49) and poor cleansability (OR 2.94, 95% CI 1.64–5.37) were associated (p < 0.05) with higher OHIP-14 mean sum scores in the adjusted regression model. For the 242 patients examined clinically, the OHIP-14 mean sum score was 3.8 (± 6.5). Peri-implant soft tissue dehiscence (OR 2.53, 95% CI 1.17–5.49) was associated with higher OHIP-14 mean sum scores in the adjusted regression model. Conclusions: OHIP-14 scores were low in this study, indicating good OHRQoL following implant rehabilitation in Norway. Complications lowered OHRQoL in a dose–response manner, confirmed by self-reports of complications and by the presence of peri-implant soft tissue dehiscence.

• Stødle, Ida Haukåen; Imber, Jean-Claude; Shanbhag, Siddharth; Salvi, Giovanni E.; Verket, Anders & Stähli, Alexandra (2025). Methods for Clinical Assessment in Periodontal Diagnostics: A Systematic Review. Journal of Clinical Periodontology. ISSN 0303-6979. 52(29), s. 58–73. doi: 10.1111/jcpe.14145. Fulltekst i vitenarkiv
• Stødle, Ida Haukåen; Koldsland, Odd Carsten; Lukina, Polina; Andersen, Ina Lervåg; Mjønes, Patricia Gjertrud & Rønne, Elin [Vis alle 9 forfattere av denne artikkelen] (2024). Undiagnosed Celiac Disease and Periodontal Bone Loss: A Cross-Sectional Radiological Assessment from the HUNT Study. International Journal of Dentistry. ISSN 1687-8728. 2024(1). doi: 10.1155/2024/1952244. Fulltekst i vitenarkiv Vis sammendrag

  Objective. The objective was to assess radiographic periodontal bone loss in a population with previously undiagnosed celiac disease, and to compare it to a reference group without celiac disease. Background. Periodontitis and celiac disease are chronic inflammatory diseases with possible similar features related to immune reactions and microbial dysbiosis. The relationship between these two diseases is not clear. Methods. Clinical variables, blood samples, and answers to questionnaires were collected from participants in the fourth Trøndelag Health Study (HUNT4). Celiac disease was determined based on transglutaminase 2 (TG2), immunoglobulin A (IgA), and G (IgG) in serum samples. Seropositive individuals were invited to endoscopic examination and tissue sampling. Radiographically assessed bone loss caused by periodontitis in two different levels of severity was applied as outcome, that is, ≥15% and >33% of root length. Bone loss was determined in panoramic images in participants that had attended radiographic examination in the HUNT4 Oral Health Study or in the HUNT4 Coeliac Disease Study. The association between previously undiagnosed celiac disease and radiographic bone loss was estimated by adjusted Poisson regression models. Results. Radiographic assessment was completed in 485 individuals with celiac disease determined by positive serology and in 4,727 individuals with negative serology (without celiac disease). Compared to nonceliacs, seropositive participants were less likely to present with ≥15% radiographic bone loss (prevalence ratio (PR) 0.89 (95% CI 0.84–0.96). A similar association was also observed after histopathological confirmation of celiac disease (PR 0.89 (95% CI 0.82–0.98). No association between undiagnosed celiac disease and periodontal bone loss was observed when analyses were limited to individuals with severe bone loss (>33%). Conclusion. In this study of previously undiagnosed celiac disease and periodontal bone loss, newly diagnosed celiac disease was associated with less likelihood of presenting with ≥15% radiographic bone loss compared to a nonceliac reference group.

• Mauland, Erik Klepsland; Sørensen, Karoline; Aarbu, Naomi Østergren; Verket, Anders; Ellingsen, Stig Aanerød & Bull, Vibeke Hervik [Vis alle 9 forfattere av denne artikkelen] (2024). A Cross-Sectional Study of Peri-Implant Diseases in a Random Norwegian Population: Prevalence, Risk Indicators, and Clinical Validation of Patient-Reported Outcomes. Clinical Oral Implants Research. ISSN 0905-7161. 36(2), s. 153–165. doi: 10.1111/clr.14371. Fulltekst i vitenarkiv Vis sammendrag

  Objectives The primary aim of this study was to investigate the prevalence of peri-implant diseases in a randomly selected Norwegian population. The secondary aims were to explore risk indicators for peri-implant diseases and to validate self-reported outcome measures from a survey with clinical parameters. Material and Methods Patients (n = 3083) rehabilitated with dental implants in 2014 were mailed a questionnaire and invited to a clinical examination. A randomly selected subset of responders underwent a clinical examination (n = 242). Full mouth clinical and radiographic examinations were conducted. Multiple logistic regression was used to assess patient-related risk indicators for peri-implantitis. Self-reported data were compared with data from the clinical examination using Spearman correlation and binary logistic regression. Results The prevalence of peri-implantitis was 17.0% at patient level and 8.6% at implant level, according to the 2018 classification. Risk indicators for peri-implantitis included smoking and periodontitis in the adjusted model. The correlation was strong (r = 0.91, p < 0.001) between number of self-reported implants and clinical counts, whereas self-reported peri-implant inflammation was associated with peri-implantitis (OR 6.4 [95% CI 3.0, 13.7]). Conclusions Smoking and periodontitis were identified as key risk indicators for peri-implantitis. Questionnaire data rendered clinically valid estimates of implant number, and self-reported peri-implant inflammation was associated with clinical peri-implantitis.

• Stødle, Ida Haukåen; Sen, Abhijit; Høvik, Hedda; Verket, Anders & Koldsland, Odd Carsten (2023). Association between periodontitis stages and self-reported diseases in a Norwegian population: the HUNT study. BMC Oral Health. 23(1), s. 1–10. doi: 10.1186/s12903-023-03743-z. Fulltekst i vitenarkiv Vis sammendrag

  Background The relationships between periodontitis and non-communicable diseases (NCDs) have been investigated through several different case-definitions. The differences in methodology may have hindered the basis of comparison between these studies. The classification from the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions offers a unison platform that may facilitate future comparison of such research. The present study aimed to reproduce associations between periodontitis and other NCDs using the 2017 Classification, in the Trøndelag Health Study (HUNT). Material and methods The fourth HUNT-survey was carried out between 2017 and 2019. Clinical variables, blood samples and answers to questionnaires were collected from 4933 participants. Periodontal status was assessed based on the latest staging system, and its associations with NCDs were estimated by logistic regression models adjusted for potential confounders. Results Compared to no or Stage I periodontitis, participants with Stage III/IV periodontitis (radiographic bone loss exceeding 33%) were associated with cardiovascular disease, hyperglycemia in participants with diabetes and chronic obstructive pulmonary disease (COPD)/emphysema. Associations with hyperglycemia in participants with diabetes and COPD/emphysema were also observed in participants with Stage II periodontitis. The only observed association when considering never-smokers alone, was with COPD/emphysema. Conclusion Periodontitis Stage II and III/IV were associated with major NCDs. Effect sizes increased with increasing periodontitis stages, which implies greater occurrence of coincident comorbidities in patients with severe periodontitis.

• Haugbo, Helena Oladottir; Klepp, Pasquale Catherine & Verket, Anders (2023). Ulcerative colitis and periodontitis–a cross-sectional pilot study from a Norwegian cohort. Acta Odontologica Scandinavica. ISSN 0001-6357. doi: 10.1080/00016357.2023.2210660. Fulltekst i vitenarkiv Vis sammendrag

  Background Inflammatory bowel disease, which includes ulcerative colitis (UC), is an inflammatory disorder with potential impact on periodontal disease, but evidence to date for this association is limited. The primary aim of this study was to investigate the prevalence of periodontitis according to the 2017-classification in a cohort of subjects with UC. The secondary aim was to assess a potential correlation of periodontal status with previous UC disease parameters and to assess oral health-related quality-of-life. Method A cohort from a community hospital in Norway with confirmed extensive UC was comprehensively examined. Periodontal parameters, OHIP-14 and demographic variables were collected. Previous UC data including colon activity index (CAI), Mayo score and years of UC diagnosis was used to explore a potential correlation with periodontal status. Results A total of 50 out of 63 invited patients participated. According to the 2017-classification, 74% of the patients presented periodontitis. No correlation was found between periodontitis (stage, grade, bleeding on probing or probing pocket depth ≥6mm) and CAI, Mayo score, or years with UC diagnosis. Conclusions Within the limitations of this study, the prevalence of periodontitis among patients with mild UC for more than 12 years was in line with that reported from a Norwegian general population. No correlation between periodontitis and UC disease indices or years with UC diagnosis was observed. The study suggests that the susceptibility to periodontitis may be limited in patients with well treated or mild UD who regularly attend the dental office, despite a considerable UC disease duration.

• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Vis alle 9 forfattere av denne artikkelen] (2023). Non-surgical treatment of mild to moderate peri-implantitis with an oscillating chitosan brush or a titanium curette—12-month follow-up of a multicenter randomized clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14078. Fulltekst i vitenarkiv
• Verket, Anders; Koldsland, Odd Carsten; Bunæs, Dagmar Fosså; Lie, Stein Atle & Romandini, Mario (2023). Non-surgical therapy of peri-implant mucositis—Mechanical/physical approaches: A systematic review. Journal of Clinical Periodontology. ISSN 0303-6979. doi: 10.1111/jcpe.13789. Fulltekst i vitenarkiv Vis sammendrag

  Aim To study in humans with peri-implant mucositis the efficacy of (Q1) mechanical/physical instrumentation over oral hygiene instructions alone; (Q2) any single mode of mechanical/physical instrumentation over others; (Q3) combinations of mechanical/physical instrumentation over single modes; and (Q4) repetitions of mechanical/physical instrumentation over single administration. Materials and Methods Randomized clinical trials (RCTs) fulfilling specific inclusion criteria established to answer the four PICOS questions were included. A single search strategy encompassing the four questions was applied to four electronic databases. Two review authors independently screened the titles and abstracts, carried out full-text analysis, extracted the data from the published reports and performed the risk of bias assessment through the RoB2 tool of the Cochrane Collaboration. In case of disagreement, a third review author took the final decision. Treatment success (i.e., absence of bleeding on probing [BoP]), BoP extent and BoP severity were considered as the implant-level outcomes of critical importance for the present review. Results A total of five papers reporting on five RCTs, involving 364 participants and 383 implants, were included. Overall, treatment success rates after mechanical/physical instrumentation ranged from 30.9% to 34.5% at 3 months and from 8.3% to 16.7% at 6 months. Reduction in BoP extent was 19.4%–28.6% at 3 months, 27.2%–30.5% at 6 months and 31.8%–35.1% at 12 months. Reduction in BoP severity was 0.3–0.5 at 3 months and 0.6–0.8 at 6 months. Q2 was addressed in two RCTs, which reported no differences between glycine powder air-polishing and ultrasonic cleaning, as well as between chitosan rotating brush and titanium curettes. Q3 was addressed by three RCTs, which showed no added effect of glycine powder air-polishing over the use of ultrasonic and of diode laser over ultrasonic/curettes. No RCTs were identified that answered Q1 and Q4. Conclusions Several mechanical/physical instrumentation procedures including curettes, ultrasonics, lasers, rotating brushes and air-polishing are documented; however, a beneficial effect over oral hygiene instructions alone or superiority over other procedures could not be demonstrated. Moreover, it remains unclear whether combinations of different procedures or their repetition over time may provide additional benefits.

• Mauland, Erik Klepsland; Bull, Vibeke Hervik; Melbye, Elisabeth Lind & Verket, Anders (2023). Patient-reported outcomes following dental implant rehabilitation according to reason for missing teeth: A survey from a Norwegian population 8 years following treatment. Journal of Clinical Periodontology. ISSN 0303-6979. doi: 10.1111/jcpe.13895. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Aim The aim of this study was to assess patient‐reported outcomes (PROs) 8 years after dental implant rehabilitation in a sample with tooth loss due to periodontitis (TLP) and a sample with missing teeth for other reasons (MTOR). Materials and Methods The Norwegian National Insurance Scheme registry of subsidized dental implant therapy was searched, and patients ( n  = 3083) rehabilitated with dental implants in 2014 were mailed a questionnaire. PROs were described by relative frequencies, and the TLP and MTOR subsamples were compared using chi‐square test. Multiple linear regression analyses were used to investigate variables potentially predicting PROs. Results Of the respondents ( n  = 1299), more than 90% were partly or fully satisfied with the treatment outcome. Complications were reported by 44.2%. Patients who lost teeth due to periodontitis ( n  = 784) reported greater oral function improvement and better pre‐treatment information, and were more likely to experience complications when compared with patients who lost teeth for other reasons ( n  = 515). Age, level of education, self‐funded cost, pre‐treatment information, history of complications and the reason for missing teeth were found to predict PROs. Conclusions In a Norwegian population rehabilitated with dental implants in 2014, satisfaction with the treatment outcome and the aesthetic outcome was high, irrespective of the reason for missing teeth. Self‐report of complications and lack of pre‐treatment information were the strongest predictors of inferior patient satisfaction and also predicted inferior oral function.

• Thieu, Minh Khai Le; Mauland, Erik Klepsland & Verket, Anders (2022). Satisfaction and preferences among patients with both implant-supported single crown and tooth-supported fixed dental prosthesis: a pilot study. Acta Odontologica Scandinavica. ISSN 0001-6357. doi: 10.1080/00016357.2022.2155239. Fulltekst i vitenarkiv Vis sammendrag

  Objective The objective of the study was to assess patient-reported preferences and outcomes in patients rehabilitated with both an implant-supported single crown (ISC) and a tooth-supported fixed dental prosthesis (FDP). Materials and methods The electronic journal system at the Faculty of Dentistry, University of Oslo, was searched to find patients presenting both an ISC and an FDP replacing no more than two teeth between abutments. Identified patients that agreed answered a questionnaire followed by a clinical examination. Descriptive statistics was calculated. Results Thirty patients were included. The mean function time was 11.8 years for FDPs and 6.6 years for ISCs. All but three patients were satisfied with both rehabilitation modalities. No patients were unsatisfied with aesthetics or function of either rehabilitation. All patients reported satisfactory function of their restorations and reported chewing without problems. The self-reported post-operative complications were few, but less than observed in the clinical examinations. Conclusions More patients reported food impaction with their FDP as compared to their ISC. Function and aesthetics of FDPs and ISCs were rated similarly, but more patients found the ISC treatment more uncomfortable. Despite this finding, most patients would prefer to undergo ISC treatment if they were to replace another missing tooth.

• Thieu, Minh Khai Le; Stoetzel, Sabine; Rahmati, Maryam; Khassawna, Thaqif El; Verket, Anders & Sanz-Esporrin, Javier [Vis alle 9 forfattere av denne artikkelen] (2022). Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO<inf>2</inf> block or a xenogeneic graft in chronic alveolar defects. Clinical Implant Dentistry and Related Research. ISSN 1523-0899. doi: 10.1111/cid.13143. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic non-contained bone defects using a non-resorbable TiO2 block. Material and methods Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomisation: TiO2 block: TiO2-scaffold and a collagen membrane, DBBM particulates: Deproteinised bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha smooth muscle actin (α-SMA), osteopontin, osteocalcin, tartrate-resistant acid phosphatase and collagen type I. Histomorphometry was performed on Movat Pentachrome and Von Kossa/Van Gieson stained sections. Stereolithographic models were used to compare alveolar profile changes. Results The percentage of α-SMA and osteopontin increased in TiO2 group after 12 weeks of healing at the bone-scaffold interface, while collagen type I increased in the empty control group. In the defect area, α-SMA decreased in the empty control group, while collagen type I increased in the DBBM group. All groups maintained alveolar profile from 4 to 12 weeks, but TiO2 group demonstrated the widest soft tissue contour profile. Conclusions The present findings suggested contact osteogenesis when GBR is performed with a TiO2 block or DBBM particulates. The increase in osteopontin indicated a potential for bone formation beyond 12 weeks. The alveolar profile data indicated a sustained lateral increase in lateral bone augmentation using a TiO2 block and a collagen membrane, as compared to DBBM and a collagen membrane or a collagen membrane alone.

• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Vis alle 9 forfattere av denne artikkelen] (2022). Non-surgical treatment of mild to moderate peri-implantitis using an oscillating chitosan brush or a titanium curette—A randomized multicentre controlled clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14007. Fulltekst i vitenarkiv Vis sammendrag

  Objectives This prospective, parallel-group, examiner-blinded, multicentre, randomized, controlled clinical trial aimed to assess the efficacy of an oscillating chitosan brush (OCB) versus titanium curettes (TC) on clinical parameters in the non-surgical treatment of peri-implantitis. Material and Methods In five dental specialist clinics, 39 patients with one implant with mild to moderate peri-implantitis, defined as 2–4 mm radiographic reduced bone level, bleeding index (BI) ≥ 2, and probing pocket depth (PPD) ≥ 4 mm were randomly allocated to test and control groups, receiving OCB or TC debridement, respectively. Treatment was performed at baseline and three months. PPD, BI, and Plaque index (PI) were measured at six sites per implant and recorded by five blinded examiners at baseline, one, three, and six month(s). Pus was recorded as present/not present. Changes in PPD and BI were compared between groups and analysed using multilevel partial ordinal and linear regression. Results Thirty-eight patients completed the study. Both groups showed significant reductions in PPD and BI at six months compared with baseline (p < .05). There was no statistically significant difference in PPD and BI changes between the groups. Eradication of peri-implant disease as defined was observed in 9.5% of cases in the OCB group and 5.9% in the TC group. Conclusions Within the limitations of this six-month multicentre clinical trial, non-surgical treatment of peri-implantitis with OCB and TC showed no difference between the interventions. Eradication of disease was not predictable for any of the groups.

• Könönen, Eija; Klausen, Bjarne; Verket, Anders & Derks, Jan (2022). Non-surgical periodontal therapy: Recommendations by the European Federation of Periodontology and guidelines in Nordic countries. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 132(1), s. 22–31. doi: 10.56373/2022-1-5. Fulltekst i vitenarkiv
• Verket, Anders; Klausen, Bjarne; Könönen, Eija & Derks, Jan (2022). Kirurgisk parodontalbehandling: Anbefalinger fra European Federation of Periodontology og retningslinjer i de nordiske lande. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 132(1), s. 34–41. doi: 10.56373/2022-1-6. Fulltekst i vitenarkiv
• Rosing, Kasper; Björnsson, Magnús; Pöllänen, Marja; Klinge, Björn & Verket, Anders (2022). Organisering af parodontal diagnostik og behandling i de nordiske lande. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 132(2), s. 148–157. doi: 10.56373/2022-2-7. Fulltekst i vitenarkiv
• Sørdahl, Anne Judith & Verket, Anders (2022). Patient and professional use of the root coverage esthetic score (RES) and how it relates to patient satisfaction following periodontal plastic surgery. BMC Oral Health. 22(1). doi: 10.1186/s12903-022-02326-8. Fulltekst i vitenarkiv Vis sammendrag

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• Stødle, Ida Haukåen; Verket, Anders; Høvik, Hedda; Sen, Abhijit & Koldsland, Odd Carsten (2021). Prevalence of periodontitis based on the 2017 classification in a Norwegian population. The HUNT Study. Journal of Clinical Periodontology. ISSN 0303-6979. doi: 10.1111/jcpe.13507. Fulltekst i vitenarkiv Vis sammendrag

  Aim This cross-sectional study assesses the prevalence of periodontitis in a large Norwegian population, based on the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions. The prevalence of periodontitis was determined by bone loss recorded on radiographs (orthopantomogram [OPG] and bitewing [BW]) and by clinical examination. Materials and methods As part of a large population health study (The HUNT Study), 7347 participants aged 19 years and older were invited to the HUNT4 Oral Health Study. Radiographic bone loss (RBL) and periodontal stage and grade were assessed in 4863 participants. Results Periodontal examination was performed in 4863 participants. RBL and clinical registrations corresponding to periodontitis as defined were observed in 72.4%. The prevalence of periodontitis increased after 40 years of age, with severe forms occurring primarily after 60 years of age. Stage I was observed in 13.8%, Stage II in 41.1%, Stage III in 15.3%, and Stage IV in 2.3% of the population. Grade A, B, and C was observed in 5.7%, 60.2%, and 6.2%, respectively. Conclusion Periodontitis was frequently observed in the investigated population. The prevalence of periodontitis Stage III and Stage IV combined was observed in 17.6% of the study population.

• Thieu, Minh Khai Le; Haugen, Håvard Jostein; Esporrin, Javier Sanz; Sanz, Mariano; Lyngstadaas, Ståle Petter & Verket, Anders (2021). Guided bone regeneration of chronic non-contained bone defects using a volume stable porous block TiO2 scaffold: An experimental in vivo study. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.13708. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To evaluate new lateral bone formation and lateral volume augmentation by guided bone regeneration (GBR) in chronic non‐contained bone defects with the use of a non‐resorbable TiO2‐block. Materials and methods Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for eight weeks before treatment by GBR. Each hemimandible was randomly allocated to 4 or 12‐week healing time after GBR and three intervention groups were assigned by block randomization: TiO2 block: TiO2‐scaffold and a collagen membrane, DBBM particles: Deproteinized bovine bone mineral (DBBM) and a collagen membrane, Empty control: Collagen membrane only. Microcomputed tomography (microCT) was used to measure the lateral bone formation and width augmentation. Histological outcomes included descriptive analysis and histomorphometric measurements. Results MicroCT analysis demonstrated increasing new bone formation from four to twelve weeks of healing. The greatest width of mineralized bone was seen in the empty controls, and the largest lateral volume augmentation was observed in the TiO2 block sites. The DBBM particles demonstrated more mineralized bone in the grafted area than the TiO2 blocks, but small amounts and less than the empty control sites. Conclusion The TiO2 blocks rendered the largest lateral volume augmentation but also less new bone formation compared to the DBBM particles. The most new lateral bone formation outward from the bone defect margins was observed in the empty controls, indicating that the presence of either graft material leads to slow appositional bone growth.

• Hussain, Badra; Haugen, Håvard Jostein; Aass, Anne Merete; Alonso, Mariano Sanz; Antonoglou, Georgios & Bouchard, Philippe [Vis alle 23 forfattere av denne artikkelen] (2021). Peri-Implant Health and the Knowing-Doing Gap—A Digital Survey on Procedures and Therapies. Frontiers in Dental Medicine. 2(726607). doi: 10.3389/fdmed.2021.726607. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: Peri-implant tissue maintenance and treatment is becoming a serious challenge in implantology. With increasing numbers of implants being placed, more cases of peri-implant mucositis and peri-implantitis is seen. A digital survey on peri-implant disease management was issued to experts in periodontology and implantology to identify the tools and procedures most commonly used today to treat peri-implant diseases and successfully manage peri-implant health. The primary aim was to assess whether there is consensus in the choice of treatment to manage peri-implant diseases and to prevent their recurrence once treated. The secondary aim was to obtain insight into future protocols and /or devices, and the research and development needed. Materials and Methods: Participants in this digital survey were professionals specialising in periodontology, oral surgery, and implant dentistry. The questionnaire included both a series of closed- and open-ended questions. A total of 16 countries participated. The survey was sent by e-mail to 70 individuals, 66 received the survey and 37 of receivers responded, two of the participants were excluded due to insufficient filling of the survey. In the end 35 respondents completed the survey. Results: Respondents agree that the efficacy of mechanical and chemical decontamination of implant surfaces needs to be improved and better documented. It is a common opinion that the current remedies, mostly adapted from periodontal practises, do not provide effective and reliable clinical outcomes when treating peri-implant ailments. There is a general agreement amongst experts that regularly scheduled (3–6-month intervals) maintenance treatments are essential for maintaining peri-implant health in patients experiencing implant complications. Respondents are also concerned about unnecessary use of systemic antibiotics for managing peri-implant health. Conclusion: Regardless of agreements in parts, there was no observed consensus on the most effective treatment options for treating peri-implantitis. The experts all agree it is an urgent need for well-designed, long-term follow-up randomised and controlled clinical trials comparing interventions to provide an evidence-based strategy for peri-implant health management.

• Thieu, Minh Khai Le; Homayouni, Amin; Hæren, Lena Ringsby; Tiainen, Hanna; Verket, Anders & Ellingsen, Jan Eirik [Vis alle 13 forfattere av denne artikkelen] (2021). Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomaterials Research. ISSN 1226-4601. 25(43). doi: 10.1186/s40824-021-00245-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthetic TiO2 block scaffold was placed in circumferential peri-implant defects with buccal fenestrations. Methods The mandibular premolars were extracted and the alveolar bone left to heal for 4 weeks prior to implant placement in six minipigs. Two cylindrical defects were created in each hemi-mandible and were subsequent to implant placement allocated to treatment with either TiO2 scaffold or sham in a split mouth design. After 12 weeks of healing time, the samples were harvested. Microcomputed tomography (MicroCT) was used to investigate defect fill and integrity of the block scaffold. Distances from implant to bone in vertical and horizontal directions, percentage of bone to implant contact and defect fill were analysed by histology. Results MicroCT analysis demonstrated no differences between the groups for defect fill. Three of twelve scaffolds were partly fractured. At the buccal sites, histomorphometric analysis demonstrated higher bone fraction, higher percentage bone to implant contact and shorter distance from implant top to bone 0.5 mm lateral to implant surface in sham group as compared to the TiO2 group. Conclusions This study demonstrated less bone formation with the use of TiO2 scaffold block in combination with implant placement in cylindrical defects with buccal bone fenestrations, as compared to sham sites.

• Maal, Mehrnaz Beheshti & Verket, Anders (2021). Implantoplasty- provoking or reducing inflammation? – a systematic scoping review. Acta Odontologica Scandinavica. ISSN 0001-6357. doi: 10.1080/00016357.2021.1945142. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To evaluate clinical parameters associated with inflammation after adjunctive implantoplasty in conjunction with surgical treatment of peri-implantitis. Materials and methods A systematic literature search was performed in 2 databases until 29. December 2020 to find publications that report on clinical parameters after surgical peri-implantitis treatment which included adjunctive implantoplasty. Clinical studies on implantoplasty reporting on BoP as outcome were included, but other clinical or radiographic outcomes were also considered. Results The search resulted in 18 articles that fulfilled the inclusion criteria. The results indicated improvements of BoP and clinical parameters following surgical peri-implantitis treatment with adjunctive implantoplasty. Conclusions Within its limits, the findings of the present scoping review indicated that BoP is reduced following surgical peri-implantitis treatment with adjunctive implantoplasty, and that this improvement is in line with surgical peri-implantitis treatment without adjunctive implantoplasty.

• Skallevold, Hans Erling & Verket, Anders (2020). Myasthenia gravis og orale utfordringer. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 130(8), s. 614–617. Fulltekst i vitenarkiv
• Bunæs, Dagmar Fosså; Verket, Anders; Aass, Anne Merete & Bolstad, Anne Isine (2020). Kopplingen mellan diabetes typ2 och parodontal sjukdom. Tandläkartidningen. ISSN 0039-6982. 112(1), s. 48–53. Fulltekst i vitenarkiv
• Maal, Mehrnaz Beheshti; Ellingsen, Stig Aanerød; Reseland, Janne Elin & Verket, Anders (2020). Experimental implantoplasty outcomes correlate with fibroblast growth in vitro. BMC Oral Health. 20, s. 25–25. doi: 10.1186/s12903-020-1012-1. Fulltekst i vitenarkiv Vis sammendrag

  Background Implantoplasty is an option in peri-implantitis treatment, but little is known about the effect on the soft tissue. The aim of the study was to characterize surface roughness following experimental implantoplasty and to examine its effect on human fibroblast growth and secretion of selected proteins. Methods Titanium grade IV coins were mechanically treated with six different rotating bur sequences; diamond burs or carbide burs alone, or followed by either Arkansas stone bur or silicone burs. Machined and rough-surface sandblasted, acid-etched (SLA) coins were used as control. The surface topography was characterized by scanning electron microscope and profilometer. Human gingival fibroblasts from two donors were cultured on the coins to quantify the effect on cell morphology, growth, and protein secretion by confocal microscopy and multiplex immunoassay. Results All surface roughness parameters were lower for the surfaces treated with experimental implantoplasty than for the SLA surface, and the sequence of carbide burs followed by silicone burs rendered the least rough surface of the test groups. The implantoplasty procedures changed the elemental composition of the titanium surface. High surface roughness showed a weak to moderate negative correlation to fibroblast growth, but induced a higher secretion of VEGF, IL-6 and MCP-3 to the cell medium compared to the least rough surfaces of the test groups. At day 30 fibronectin levels were higher in the SLA group. Conclusions The surface roughness following implantoplasty demonstrated a weak to moderate negative correlation with the growth of fibroblasts. The addition of Arkansas stone and silicon burs to the experimental implantoplasty bur protocol rendered an initial increase in fibroblast growth. Implantoplasty altered the elemental composition of the titanium surface, and had an effect on the fibroblast cytokine secretion and fibronectin levels.

• Bunæs, Dagmar; Verket, Anders; Aass, Anne Merete & Bolstad, Anne Isine (2020). Tyypin 2 diabeteksen ja parodontaalisairauksien välinen yhteys. Suomen hammaslaakarilehti. ISSN 0355-4090. 3, s. 24–29. Fulltekst i vitenarkiv
• Bunæs, Dagmar Fosså; Verket, Anders; Aass, Anne Merete & Bolstad, Anne Isine (2020). A cross-link between diabetes mellitus type 2 and periodontal disease. Tandlægebladet. ISSN 0039-9353. 124, s. 24–29. Fulltekst i vitenarkiv
• Bunæs, Dagmar Fosså; Verket, Anders; Aass, Anne Merete & Bolstad, Anne Isine (2020). Sammenheng mellom diabetes mellitus Type 2 og periodontal sykdom. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 130(1), s. 10–16. Fulltekst i vitenarkiv Vis sammendrag

  Tidsskriftet mangler DOI, la til nettsidelenke i kommentarfelt i stedet. /CVN 01.02.21 https://www.tannlegetidende.no/i/2020/1/m-122

• Verket, Anders; Lyngstadaas, Ståle Petter; Tiainen, Hanna; Rønold, Hans Jacob & Wohlfahrt, Johan Caspar (2018). Impact of particulate deproteinized bovine bone mineral and porous titanium granules on early stability and osseointegration of dental implants in narrow marginal circumferential bone defects. International Journal of Oral & Maxillofacial Surgery. ISSN 0901-5027. 47(8), s. 1086–1094. doi: 10.1016/j.ijom.2018.02.007. Fulltekst i vitenarkiv Vis sammendrag

  The use of two particulate bone graft substitute materials in experimental narrow marginal peri-implant bone defects was investigated with respect to early bone healing and implant stability. Porous titanium granules, oxidized white porous titanium granules (WPTG), and demineralized bovine bone mineral (DBBM) were characterized in vitro, after which the two latter materials were tested in experimental peri-implant bone defects in six minipigs, with empty defects as control. After mandibular premolar extraction, the top 5 mm of the alveoli were widened to 6 mm in diameter, followed by the placement of six implants, three on each side, in each pig. Six weeks of healing was allowed. The WPTG showed better mechanical properties. No significant differences in resonance frequency analysis were found directly after compacting or healing, and similar quantities of defect bone formation were observed on micro-computed tomography for all groups. Histomorphometric analysis demonstrated a more coronal bone-to-implant contact in the DBBM group, which also displayed more defect bone fill as compared to the WPTG group. The better mechanical properties observed for WPTG appear of negligible relevance for the early stability and osseointegration of implants.

• Verket, Anders; Müller, Benjamin; Wohlfahrt, Johan Caspar; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein [Vis alle 7 forfattere av denne artikkelen] (2016). TiO2 scaffolds in peri-implant dehiscence defects: an experimental pilot study. Clinical Oral Implants Research. ISSN 0905-7161. 27(10), s. 1200–1206. doi: 10.1111/clr.12725. Fulltekst i vitenarkiv
• Pullisaar, Helen; Verket, Anders; Szoke, Krisztina; Tiainen, Hanna; Haugen, Håvard Jostein & Brinchmann, Jan E. [Vis alle 8 forfattere av denne artikkelen] (2015). Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds. Journal of Tissue Engineering. 6. doi: 10.1177/2041731415575870. Fulltekst i vitenarkiv Vis sammendrag

  The purpose of bone tissue engineering is to employ scaffolds, cells, and growth factors to facilitate healing of bone defects. The aim of this study was to assess the viability and osteogenic differentiation of primary human osteoblasts and adipose tissue–derived mesenchymal stem cells from various donors on titanium dioxide (TiO2) scaffolds coated with an alginate hydrogel enriched with enamel matrix derivative. Cells were harvested for quantitative reverse transcription polymerase chain reaction on days 14 and 21, and medium was collected on days 2, 14, and 21 for protein analyses. Neither coating with alginate hydrogel nor alginate hydrogel enriched with enamel matrix derivative induced a cytotoxic response. Enamel matrix derivative–enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue–derived mesenchymal stem cells seemed unaffected by enamel matrix derivative. The alginate hydrogel coating procedure may have potential for local delivery of enamel matrix derivative and other stimulatory factors for use in bone tissue engineering.

• Lyngstadaas, Ståle Petter; Verket, Anders; Pinholt, Else Marie; Mertens, Christian; Haanæs, Hans R & Wall, Gert [Vis alle 8 forfattere av denne artikkelen] (2015). Titanium granules for augmentation of the maxillary sinus- a multicenter study. Clinical Implant Dentistry and Related Research. ISSN 1523-0899. 17, s. e594–e600. doi: 10.1111/cid.12291. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Rønold, Hans Jacob & Wohlfahrt, Johan Caspar (2014). Osseointegration of dental implants in extraction sockets preserved with porous titanium granules - an experimental study. Clinical Oral Implants Research. ISSN 0905-7161. 25(2), s. E100–E108. doi: 10.1111/clr.12070. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Rasmusson, Lars; Haanæs, Hans R; Wallstrøm, M. & Wall, Gert [Vis alle 7 forfattere av denne artikkelen] (2013). Maxillary Sinus Augmentation with Porous Titanium Granules: A Microcomputed Tomography and Histologic Evaluation of Human Biopsy Specimens. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 28(3), s. 721–728. doi: 10.11607/jomi.2853. Fulltekst i vitenarkiv Vis sammendrag

  PURPOSE: The aim of this study was to assess bone ingrowth into porous titanium granules used for maxillary sinus augmentation. MATERIALS AND METHODS: Eighteen biopsy specimens from 17 patients participating in a clinical trial on sinus augmentation using porous titanium granules (PTG) were received in the laboratory. The specimens (trephine cores of 4.5 mm) were obtained 6 months after PTG placement. After being embedded in methacrylate, the samples were scanned in a microcomputed tomography (micro-CT) scanner. Specimens were then cut along the long axis and central slices were ground to 70 μm before staining with hematoxylin and eosin. RESULTS: The micro-CT analysis demonstrated an average bone fill of 19% (standard deviation [SD] 5.8%), whereas the graft material occupied 22.7% (SD 4.7%). The volume of newly formed bone decreased with the distance from the residual bone of the sinus floor. Two-dimensional histomorphometric analysis demonstrated a mean area of new bone of 16.1% (SD 9.4%). The PTG alone occupied 25.9% of the total mean area (SD 6.1%). The newly formed bone consisted mainly of woven bone growing in close contact with the granules and bridging the intergranular space. The remaining area was occupied predominantly by nonmineralized connective tissue. There were no signs of inflammation in any of the biopsy specimens. CONCLUSIONS: After 6 months, new bone had formed at a similar rate and quality as has been reported for other well-recognized bone graft substitutes. The new bone formed in close contact with the PTG, suggesting that the material is osteoconductive.

• Haugen, Håvard Jostein; Cabrer, Marta Monjo; Rubert, Marina; Verket, Anders; Lyngstadaas, Ståle Petter & Ellingsen, Jan Eirik [Vis alle 8 forfattere av denne artikkelen] (2013). Porous Ceramic Titanium Dioxide Scaffolds Promote Bone Formation in Rabbit Peri-Implant Cortical Defect Model. Acta Biomaterialia. ISSN 1742-7061. 9(2), s. 5390–5399. doi: 10.1016/j.actbio.2012.09.009. Fulltekst i vitenarkiv Vis sammendrag

  Titanium oxide (TiO2) scaffolds have previously been reported to exhibit very low mechanical strength. However, we have been able to produce a scaffold that features a high interconnectivity, a porosity of 91% and a compressive strength above 1.2 MPa. This study analysed the in vivo performance of the porous TiO2 scaffolds in a peri-implant cortical defect model in the rabbit. After 8 weeks of healing, morphological microCT analyses of the defects treated with the TiO2 scaffolds had significantly higher bone volume, bone surface and bone surface to volume ratio when compared to sham, both in the cortical and bone marrow compartment. No adverse effects, i.e. tissue necrosis or inflammation as measured by LDH activity and real-time RT-PCR analysis were observed. Moreover, the scaffold did not hinder bone growth onto the adjacent cortical titanium implant. Histology clearly demonstrated new bone formation in the cortical sections of the defects and presence of newly formed bone in close proximity to the scaffold surface and the surface of the adjacent Ti implant. Bone to material contact between the newly formed bone and the scaffold was observed in the histological sections. Islets of new bone were also present in the marrow compartment albeit in scarce amounts. In conclusion, the present investigation demonstrates that TiO2 scaffolds osseointegrate well and is a suitable scaffold for peri-implant bone healing and growth. --------------------------------------------------------------------------------

• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2012). Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs. Acta Biomaterialia. ISSN 1742-7061. 8(6), s. 2384–2391. doi: 10.1016/j.actbio.2012.02.020. Fulltekst i vitenarkiv Vis sammendrag

  The osteoconductive capacity of TiO2 scaffolds was investigated by analysing the bone ingrowth into the scaffold structure following their placement into surgically modified extraction sockets in Gottingen minipigs. Non-critical size defects were used in order to ensure sufficient bone regeneration for the evaluation of bone ingrowth to the porous scaffold structure, and sham sites were used as positive control. Micro-CT analysis revealed 73.6 ± 11.1 % of the available scaffold pore space to be occupied by newly formed bone tissue, and the volumetric bone mineral density of the regenerated bone was comparable to that of the native cortical bone. Furthermore, histological evidence for vascularisation and presence of bone lamellae surrounding some of the blood vessels was observed also within the inner regions of the scaffold, indicating that the highly interconnected pore structure of the TiO2 scaffolds supports unobstructed formation of viable bone tissue within the entire scaffold structure. In addition, bone tissue was found in direct contact with 50.0 ± 21.5 % of the TiO2 struts demonstrating the good biocompatibility and osteoconductivity of the scaffold material. Keywords Bone scaffold; Titanium dioxide; Pore structure; Bone ingrowth; Implant integration Corresponding author. Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

• Tiainen, Hanna; Verket, Anders; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter & Wohlfahrt, Johan Caspar (2012). Dimensional ridge preservation with a novel highly porous TiO2 scaffold: an experimental study in minipigs. International Journal of Biomaterials. ISSN 1687-8787. doi: 10.1155/2012/851264. Fulltekst i vitenarkiv
• Verket, Anders; Tiainen, Hanna; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Nilsen, Ola & Reseland, Janne Elin (2012). Enhanced Osteoblast Differentiation on Scaffolds Coated with TiO2 Compared to SiO2 and CaP Coatings. Biointerphases. ISSN 1934-8630. 7(36). doi: 10.1007/s13758-012-0036-8. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Rønold, Hans Jacob & Wohlfahrt, Johan Caspar (2012). Microcomputed Tomography and Histological Analysis of a Maxillary Implant Retrieved 19 Months After Placement and Indirect Sinus Augmentation With Biphasic Calcium Phosphate: A Case Report. Clinical Advances in Periodontics. ISSN 2573-8046. 4(1), s. 38–42. doi: 10.1902/cap.2012.120075. Fulltekst i vitenarkiv

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• Stødle, Ida Haukåen; Koldsland, Odd Carsten; Lukina, Polina; Andersen, Ina Lervåg; Mjønes, Patricia Gjertrud & Rønne, Elin [Vis alle 9 forfattere av denne artikkelen] (2024). Undiagnosed coeliac disease and periodontal bone loss: A cross-sectional radiological assessment from the HUNT Study. Fulltekst i vitenarkiv
• Stødle, Ida Haukåen; Koldsland, Odd Carsten; Lukina, Polina; Andersen, Ina Lervåg; Mjønes, Patricia Gjertrud & Rønne, Elin [Vis alle 9 forfattere av denne artikkelen] (2024). Periodontitt hos personer med tidligere ukjent cøliaki. Fulltekst i vitenarkiv
• Haugen, Håvard Jostein; Thieu, Minh Khai Le; Sanz-Esporrin, Javier; Alonso, Mariano Sanz & Verket, Anders (2021). GUIDED BONE REGENERATION OF CHRONIC NON-CONTAINED BONE DEFECTS USING A VOLUME STABLE POROUS TIO2 SCAFFOLD: AN EXPERIMENTAL IN VIVO STUDY. Fulltekst i vitenarkiv
• Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases. Fulltekst i vitenarkiv
• Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases. Fulltekst i vitenarkiv
• Maal, Mehrnaz Beheshti; Stig, Aanerød Ellingsen; Reseland, Janne Elin & Verket, Anders (2018). Impact of implantoplasty on surface roughness and human fibroblast growth in vitro. Fulltekst i vitenarkiv
• Gordeladze, Jan Oxholm; Reseland, Janne Elin; Haugen, Håvard Jostein; Haugen, Sigrid; Stakkestad, Øystein & Johnsen, Gaute Floer [Vis alle 9 forfattere av denne artikkelen] (2014). Epigenetic factors involved in the "mineralizing/demineralizing" capability of cell phenotypes: Histone deacetylaces (HDACs/Sirts), transcription factors (TFs), microRNAs, and vitamin K2 (MK-7). Fulltekst i vitenarkiv
• Pullisaar, Helen; Verket, Anders; Szoke, Krisztina; Tiainen, Hanna; Haugen, Håvard Jostein & Brinchmann, Jan E. [Vis alle 8 forfattere av denne artikkelen] (2014). Extracellular matrix coated ceramic scaffold enhance osteoblast differentiation. Fulltekst i vitenarkiv
• Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter & Verket, Anders (2013). Tannleger uten framtidsskrekk. Forskning.no. ISSN 1891-635X. Fulltekst i vitenarkiv
• Andriukaitiene, Laura; Bolstad, Napat Limchaichana; Verket, Anders & Kerosuo, Eero N (2013). Effect of smear layer on the adaptation of two sealers to root canal dentine: a micro-CT evaluation. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2012). Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs. Bone. ISSN 8756-3282. 50, s. S115–S115. doi: 10.1016/j.bone.2012.02.354. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2012). Highly porous TiO2 scaffolds for bone repair. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Rasmusson, Lars & Wohlfahrt, Johan Caspar (2012). Sinus Augmentation with Porous Titanium Granules- MicroCT and Histological Analysis. Fulltekst i vitenarkiv
• Verket, Anders; Tiainen, Hanna; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2012). Enhanced Osteoblast Differentiation on Scaffolds Coated with TiO2 Compared to SiO2 and CaP Coatings. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2012). Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2012). Highly porous TiO2 scaffolds show excellent bone ingrowth in vivo. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter & Wohlfahrt, Johan Caspar (2011). Augmentation of the Maxillary Sinus Floor Using Porous Titanium Granules. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2011). Assessment of bone ingrowth into porous TiO2 bone scaffold. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Rønold, Hans Jacob & Wohlfahrt, Johan Caspar (2011). Implants inserted in Extraction Sockets Grafted with Porous Titanium Granules. Fulltekst i vitenarkiv
• Tiainen, Hanna; Wohlfahrt, Johan Caspar; Verket, Anders; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2011). Ultra-porous titanium dioxide scaffolds for bone repair. Fulltekst i vitenarkiv
• Petzold, Christiane; Verket, Anders; Yousefi, Shahbaz; Jonski, Grazyna & Reseland, Janne Elin (2010). Tannforskning og dårlig ånde. Fulltekst i vitenarkiv

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