Institutt for klinisk odontologi, UiO

• Santervas, Leonor Roa; Skovlund, Eva; Ringstad, Ingrid Beate; Kristoffersen, Espen Saxhaug; Fjeld, Katrine Gahre & Hove, Lene Hystad [Vis alle 9 forfattere av denne artikkelen] (2026). Frailty in relation to general and oral health-related quality of life among older adults in municipal acute care. Journal of Frailty & Aging (JFA). ISSN 2260-1341. 15(5). doi: 10.1016/j.tjfa.2026.100207. Fulltekst i vitenarkiv Vis sammendrag

  Frailty is associated with poorer health-related quality of life (HRQoL) in older adults, but studies rarely assess general and oral HRQoL concurrently in acute care populations. Objectives: To examine the associations between frailty and general as well as oral HRQoL among older adults admitted to a municipal in-patient acute care (MipAC) unit. Design: Cross-sectional study. Setting: Oslo MipAC unit, Norway. Participants: A total of 382 patients aged 70 years or older admitted to the MipAC unit between January and September 2023. Measurements: Frailty was assessed using the Clinical Frailty Scale (CFS). General HRQoL was measured with the 15D instrument and a single-item global life satisfaction question. Oral HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP 14). Associations between frailty and HRQoL were analyzed using linear, ordinal logistic, and binary logistic regression. Exploratory analyses of 15D and OHIP-14 dimensions were performed using non-parametric trend tests. Results: Increasing frailty was significantly associated with lower 15D scores (adjusted B -0.053, 95% CI -0.061 to -0.045), higher odds of lower life satisfaction (adjusted OR 1.19, 95% CI 1.02 to 1.39), and higher odds of reporting oral health impacts on the OHIP-14 (adjusted OR 1.25, 95% CI 1.05 to 1.48). Most 15D dimensions declined with increasing frailty, except distress. For OHIP-14, significant associations were observed for functional limitation, physical pain, and psychological disability. Conclusions: Frailty assessed with the CFS was consistently associated with reduced general and oral HRQoL in older adults admitted to a MipAC unit. These findings support the clinical relevance of simple frailty assessment during acute admission and suggest that it may help identify patients at risk of poorer quality of life.

• Canciani, Elena; Pavarini, Matteo; Darijani, Mohammadamin; Elyasi, Zohreh; Moscatelli, Monica & Scalia, Alessandro [Vis alle 11 forfattere av denne artikkelen] (2026). Cu/Zn-doped PEO titanium with waveform-tunable bioactivity for dental implants. Surfaces and Interfaces. s. 111016–111016. doi: 10.1016/j.surfin.2026.111016. Fulltekst i vitenarkiv

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• Haugli, Ketil Hegerstrøm (2026). Properties and Biological Effects of Alloys and Acrylic Polymers in Dental Materials. OsloMet - storbyuniversitetet. ISSN 9788283648386. Fulltekst i vitenarkiv Vis sammendrag

  Prosthodontic devices made from metals and acrylics release substances during use. The substances include ions from alloys, primarily residual monomers and additives from acrylics, and wear particles. The type of alloy, variations in resin chemistry, and manufacturing techniques, including associated processing treatments, can influence material properties and the release of substances, raising concerns about their biocompatibility. European regulatory authorities have classified certain substances as SVHCs (Substances of Very High Concern). Elemental cobalt used in dental alloys and a specific initiator system commonly used in 3D-printed acrylics are among these substances. Based on laboratory studies, the two main research objectives in this doctoral thesis were to 1) investigate the ion release and cytotoxicity associated with the corrosion of Co-Cr and Pd-Ag dental alloys, and 2) to assess how manufacturing techniques and processing treatments of acrylic-based occlusal device materials influence the material properties, including biological properties. To enhance clinical relevance, the alloys were subjected to dynamic corrosion testing. Compared to the standard static test (ISO 22674), cyclic loading to simulate mastication was introduced. In vitro assays were used to assess cell viability and protein expression after exposing human cell lines to material-based extracts. Workflows for the acrylic-based materials were established based on manufacturing techniques and processing treatments. Between-group comparisons were performed to assess properties associated with release/degradation, biofilm formation, and cellular effects. Based on the key findings, the alloys showed low ion release, meeting the requirements in the standard. No significant increase in ion release was observed in the dynamic experimental corrosion test compared to the standardized test. Only zinc and cobalt ions exhibited cytotoxic effects at higher concentrations (above 250 μM), and exposure in combination with other elements from the respective alloys did not alter the toxic effect. The workflows for the acrylic-based materials showed several differences across the evaluated parameters. Very low water solubility values were observed for both the milling and the autopolymerization material, while the stereolithography (SLA)-printed material exhibited the highest water solubility and sorption. The print materials showed significantly lower Vickers hardness values than the milling and autopolymerization materials. All workflows achieved low surface roughness, indicating good polishability and the ability to attain a smooth surface, which can reduce biofilm retention. The milling material exhibited significantly higher Streptococcus mutans biofilm formation in the culture plate approach (72 h) compared to the autopolymerization material. An upregulation of cytoprotective proteins was demonstrated in oral epithelial cells exposed to material-based extracts in a concentration-dependent manner for all workflows except for the milling material and the autopolymerization material stored for 12 h in dH2O. Similarly, reduced cell viability was observed for all workflows, except for the autopolymerization material stored in dH2O for 12 h. No clear differences in material properties, except for cellular effects, were observed within the same print material when subjected to different post-curing protocols. However, inter-material comparisons between the print materials revealed variations in specific properties. Within the limitations of this research, the alloys demonstrated high corrosion resistance, characterized by low ion release, under both static and dynamic corrosion testing conditions. Water storage for 12 h of the autopolymerization material reduced cellular effects, indicating promising biocompatibility. Future research should explore whether this simple treatment also applies to other materials, such as those used in printing and milling. Low hardness values of the print materials suggest a higher susceptibility to wear and degradation, which should be evaluated in clinical contexts. Future studies should also investigate biofilm formation on 3D-printed acrylic-based materials, with attention to material chemistry, printing technology, object orientation, and surface characteristics.

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