Qianli Ma

Forsker - Biomaterialer

English version of this page

E-post qianlima@odont.uio.no

Brukernavn

Besøksadresse Geitmyrsveien 71 0455 Oslo

Postadresse Postboks 1109 Blindern 0317 Oslo

Last ned visittkort

Academic Interests

Qianli is currently involve in various research project on bone graft material, dental implant surface modification and materials-related host immune response.

Higher education and employment history

Qianli received a Master degree of Clinical Dentistry (implantable materials) 2011 and doctoral degree of Clinical Dentistry (Biomaterials and host response) 2014 in School of Dentistry, Fourth Military Medical University, China. His PhD thesis was "Improved implant osseointegration via mediation of macrophage polarization". Qianli has been working with monocytic inflammatory response to biomaterials at Fourth Military Medical University (Postdoc, 20015-2018) and Osteogenic/osteolytic microenvironment in NTNU (Postdoc, 2019-2022).

Besides a biomaterials researcher, he was also an dental specialist in Prosthodontics and Dental implantology and very experienced at surgical operation and the application of various kinds of dental materials.

Publikasjoner

Vitenskapelige artikler og bokkapitler

Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca Mare & Roseth, Ingrid Aass [Vis alle 19 forfattere av denne artikkelen] (2021). Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience. ISSN 2589-0042. 25(1). doi: 10.1016/j.isci.2021.103605. Fulltekst i vitenarkiv Vis sammendrag
Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia. We here demonstrate that endogenously expressed, intracellular IL-32 interacts with components of the mitochondrial respiratory chain and promotes oxidative phosphorylation. Knocking out IL-32 in three myeloma cell lines reduced cell survival and proliferation in vitro and in vivo. High-throughput transcriptomic and MS-metabolomic profiling of IL-32 KO cells revealed that cells depleted of IL-32 had perturbations in metabolic pathways, with accumulation of lipids, pyruvate precursors, and citrate. IL-32 was expressed in a subgroup of myeloma patients with inferior survival, and primary myeloma cells expressing IL-32 had a gene signature associated with immaturity, proliferation, and oxidative phosphorylation. In conclusion, we demonstrate a previously unrecognized role of IL-32 in the regulation of plasma cell metabolism.
Ødegaard, Kristin Sirnes; Ouyang, Lingzi; Ma, Qianli; Buene, Glenn; Wan, Di & Elverum, Christer Westum [Vis alle 9 forfattere av denne artikkelen] (2021). Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells. Journal of materials science. Materials in medicine. ISSN 0957-4530. 32(97). doi: 10.1007/s10856-021-06572-0. Fulltekst i vitenarkiv
Ma, Qianli; Jiang, Nan; Shuang, Liang; Fulin, Chen; Liang, Fang & Xian, Wang [Vis alle 8 forfattere av denne artikkelen] (2020). Functionalization of a clustered TiO2 nanotubular surface with platelet derived growth factor-BB covalent modification enhances osteogenic differentiation of bone marrow mesenchymal stem cells. Biomaterials. ISSN 0142-9612. 230, s. 119650–119650. doi: 10.1016/j.biomaterials.2019.119650.
Ma, Qianli; Jiang, Nan; Liang, Shuang; Chen, Fulin; Fang, Liang & Wang, Xian [Vis alle 8 forfattere av denne artikkelen] (2019). Functionalization of a clustered TiO2 nanotubular surface with platelet derived growth factor-BB covalent modification enhances osteogenic differentiation of bone marrow mesenchymal stem cells. Biomaterials. ISSN 0142-9612. 230(119650). doi: 10.1016/j.biomaterials.2019.119650.

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Publisert 25. apr. 2022 13:13 - Sist endret 26. apr. 2022 14:47