Disputas: Matthias Johannes Frank
Matthias Johannes Frank vil forsvare sin avhandling for graden Ph.d.: Bioactive coating for titanium based bone anchored implants
Tid og sted for prøveforelesning
Torsdag 5. september klokken 09.15; Geitmyrsveien 69 - Auditorium 1
- Dr. Cornelia Wolf- Brandstetter
- Leitender Oberassistent, dr. med. MD Marcus Eblenkamp
- Postdoktor, Ph.d. Carl Hjortsjö - komiteleder
Studiedekan Anne Merete Aass
The use of an electrochemical process for coating biomolecules onto titanium based bone anchored dental implant materials was investigated. The results showed that the surface hydrogen content of a sand-blasted and acid-etched (SBAE) surface may be altered by electrochemical polarization in acidic solution. It was suggested that a hydrogen-rich, SBAE surface provides an appropriate substrate for attaching charged biomolecules to titanium based materials such a process whilst decreasing the process time in comparison to an unmodified surface.
The created hydride layer was used as an intermediate layer for linker-free attachment of biomolecules to the surface while maintaining the original surface topography in a range that is commonly regarded as desired for endosseous dental implants. The results showed that enamel matrix derivate and strontium were successfully attached to the surfaces. Both coatings were bio-available, intact, and had maintained their bioactivity. The results of an in vitro study suggested that the surface coatings had improved bioactive properties over non-coated surfaces whilst the effect of the coating could neither be supported nor rejected in an in vivo study.