Disputas: Matthias Johannes Frank

Matthias Johannes Frank vil forsvare sin avhandling for graden Ph.d.: Bioactive coating for titanium based bone anchored implants

Tid og sted for prøveforelesning

Torsdag 5. september klokken 09.15;  Geitmyrsveien 69 - Auditorium 1

Bedømmelseskomité

  • Dr. Cornelia Wolf- Brandstetter
  • Leitender Oberassistent, dr. med. MD Marcus Eblenkamp
  • Postdoktor, Ph.d. Carl Hjortsjö - komiteleder

Disputasleder

Studiedekan Anne Merete Aass

Sammendrag:

The use of an electrochemical process for coating biomolecules onto titanium based bone anchored dental implant materials was investigated. The results showed that the surface hydrogen content of a sand-blasted and acid-etched (SBAE) surface may be altered by electrochemical polarization in acidic solution. It was suggested that a hydrogen-rich, SBAE surface provides an appropriate substrate for attaching charged biomolecules to titanium based materials such a process whilst decreasing the process time in comparison to an unmodified surface.

The created hydride layer was used as an intermediate layer for linker-free attachment of biomolecules to the surface while maintaining the original surface topography in a range that is commonly regarded as desired for endosseous dental implants. The results showed that enamel matrix derivate and strontium were successfully attached to the surfaces. Both coatings were bio-available, intact, and had maintained their bioactivity. The results of an in vitro study suggested that the surface coatings had improved bioactive properties over non-coated surfaces whilst the effect of the coating could neither be supported nor rejected in an in vivo study.

Publisert 18. juni 2013 10:49 - Sist endret 22. aug. 2013 10:00