Siste publikasjoner

• Bunæs, Dagmar Fosså; Verket, Anders; Aass, Anne Merete & Bolstad, Anne Isine (2020). Sammenheng mellom diabetes mellitus Type 2 og periodontal sykdom. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  130(1), s 10- 16
• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2020). Lokal blødtvævsatrofi i kinden og sensibilitetstab i højre side af overlæben efter subkutan ekstrusion af klorhexidindiglukonat i forbindelse med endodontisk behandling. Tandlægebladet.  ISSN 0039-9353.
• Brunetti, Giacomina; Belisario, DC; Bortolotti, Sara; Storlino, Giuseppina; Colaianni, Graziana; Faienza, Maria F; Sanesi, Lorenzo; Alliod, Valentina; Buffoni, Lucio; Centini, Elisa; Voena, Claudia; Pulito, Roberta; Novello, Silvia; Ingravallo, Giuseppe; Rizzi, Rita; Mori, Giorgio; Reseland, Janne Elin; Ware, Carl F; Colucci, Silvia; Ferracini, Riccardo; Grano, Maria & Roato, Ilaria (2020). LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients. Journal of Bone and Mineral Research.  ISSN 0884-0431. . doi: 10.1002/jbmr.3942
• Haugen, Hilde Kjærnet; Myhrer, Trude & Willumsen, Tiril (2019). Nedsatt livskvalitet og oral funksjon etter hjerneslag. En kvalitativ studie. Sykepleien Forskning.  ISSN 1890-2936. . doi: https://doi.org/10.4220/Sykepleienf.2019.79355
• Grytten, Jostein Ivar; Bukholm, Ida Rashida Khan; Blich, Carl Christian; Rongen, Gunnar & Skau, Irene (2019). Norsk pasientskadeerstatning - diagnostikk og behandlingssvikt. En oversikt.. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129, s 1088- 1095
• Listl, Stefan; Grytten, Jostein Ivar & Birch, Stephen (2019). What is health Economics?. Community Dental Health.  ISSN 0265-539X.  36, s 1- 13 . doi: doi:10.1922/CDH_4581Listl13
• Kranstad, Vibeke; Søftestad, Siri; Fredriksen, Therese Varvin & Willumsen, Tiril (2019). Being considerate every step of the way: a qualitative study analysing trauma‐sensitive dental treatment for childhood sexual abuse survivors. European Journal of Oral Sciences.  ISSN 0909-8836.  127(6), s 539- 546 . doi: 10.1111/eos.12661
• Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil Satish; Dartt, Darlene Ann & Utheim, Tor Paaske (2019). Diagnostic Test Efficacy of Meibomian Gland Morphology and Function. Scientific Reports.  ISSN 2045-2322.  9(1) . doi: 10.1038/s41598-019-54013-4
• Jackson, Catherine; Ernø, Ina Myklebust; Ringstad, Håkon; Tønseth, Kim Alexander; Dartt, Darlene Ann & Utheim, Tor Paaske (2019). Simple limbal epithelial transplantation: Current status and future perspectives: Concise review. Stem Cells Translational Medicine.  ISSN 2157-6564.  s 2- 13 . doi: 10.1002/sctm.19-0203
• Deeb, Asma; Elbarbary, Nancy S.; Smart, Carmel E; Beshyah, Salem A; Habeb, Abdelhadi; Kalra, Sanjay; Al Alwan, Ibrahim; Babiker, Amir; Al Amoudi, Reem; Pulungan, Aman Bhakti; Humayun, Khadija; Issa, Umer; Jalaludin, Mohamed Yazid; Sanhay, Rakesh; Akanov, Zhanay; Krogvold, Lars & de Beaufort, Carine (2019). ISPAD Clinical Practice Consensus Guidelines: Fasting during Ramadan by young people with diabetes. Pediatric Diabetes.  ISSN 1399-543X. . doi: 10.1111/pedi.12920
• Tanzi, Maria Cristina; gantz, daniel; Bertoldi, Serena; negrini, Nicola Contessi & Haugen, Håvard Jostein (2019). Polymers and Scaffolds with Improved Blood Compatibility and Enhanced Cellular Response with Focus on Polyurethane Foams Functionalized with Amino-Amide Groups. Journal of Advanced Biotechnology and Bioengineering.  ISSN 2311-1755.  7, s 18- 29 . doi: 10.12970/2311-1755.2019.07.03 Vis sammendrag

  Biofunctionalization of biomaterial substrates has gained increasing interest in Tissue Engineering (TE) to create functional scaffolds with improved performances and capable of directing cellular behaviour. This work takes into account the functionalization of polyurethane (PU) foams with an active molecule, the diamino-diamide diol PIME, purposely designed to be inserted in the structure of linear PUs and previously found to be able to improve hemo-, cytocompatibility and bacterial resistance of these biomaterials. Here, for the first time, the gas foaming process previously set up for biocompatible PU foams was modified, and different methods were tested to obtain structurally stable foams containing PIME. The obtained foams and respective controls showed appropriate porosity (Ø = 407 ÷ 589 ± 30 m; > 90% open porosity), similar density ( 0.14 g/cm3) and hydrophilicity (water uptake  300%) and adequate compressive properties (E = 0.058 ÷ 0.170 Mpa; Hysteresis Area = 2.07 ÷ 5.59 x 10-3 J/cm3, < 5% residual deformation). PU foams containing PIME exhibited a more spherical pore geometry; the foam obtained by applying a higher stirring speed during synthesis (PU-3kP) exhibited a lower mean pore size and an elastic modulus higher than that of the other foams. FT-IR spectroscopy indicated the presence of new absorption bands and structural changes attributable to the presence of PIME. Cytotoxicity tests performed with the cell line L929 verified the absence of cytotoxic effects. All foams were able to support L929 fibroblasts proliferation and vitality for seven days; PIME-containing foams showed higher values of cell proliferation (p<0.05) that the respective controls. Keywords: Polyurethane foams, scaffold, functionalization, bioactive molecule, PIME, open porosity, compressive properties, cell interactions, L929, fibroblasts.

• Pullisaar, Helen; Colaianni, Graziana; Lian, Aina-Mari; Vandevska-Radunovic, Vaska; Grano, Maria & Reseland, Janne Elin (2019). Irisin promotes growth, migration and matrix formation in human periodontal ligament cells. Archives of Oral Biology.  ISSN 0003-9969. . doi: 10.1016/j.archoralbio.2019.104635
• Giannobile, WV; Berglundh, Tord; Al-Nawas, Bilal; Araujo, M.; Bartold, PM; Bouchard, P; Chapple, Iain L.C.; Gruber, Reinhart; Lundberg, Pernilla; Sculean, Anton; Lang, NP; Lyngstadaas, Ståle Petter; Kebschull, M; Galindo-Moreno, P; Schwartz, Z; Shapira, L; Stavropoulos, Andreas & Reseland, Janne Elin (2019). Biological factors involved in alveolar bone regeneration: Consensus report of Working Group 1 of the 15th European Workshop on Periodontology on Bone Regeneration.. Journal of Clinical Periodontology.  ISSN 0303-6979.  s 6- 11 . doi: 10.1111/jcpe.13130
• Gamage, Thilini H; Lengle, Emma; Gunnes, Gjermund; Pullisaar, Helen; Holmgren, Asbjørn; Reseland, Janne Elin; Merckoll, Else; Corti, Stefania; Mizobuchi, Masahiro; Morales, RaulJ; Tsiokas, Leonidas; Tjønnfjord, GeirE; Lacruz, Rodrigo S; Lyngstadaas, Ståle Petter; Misceo, Doriana & Frengen, Eirik (2019). STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone. Cell Calcium.  ISSN 0143-4160.  85 . doi: 10.1016/j.ceca.2019.102110
• Skarstein, Kathrine; Jensen, Janicke Liaaen; Galtung, Hilde; Jonsson, Roland; Brokstad, Karl Albert & Aqrawi, Lara A. (2019). Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren’s syndrome. Autoimmunity.  ISSN 0891-6934.  52(7-8), s 242- 250 . doi: 10.1080/08916934.2019.1684475
• Nogueira, Liebert Parreiras; Rhayara, Dias & Danielle, Bonfim (2019). The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil. Stem Cells International.  ISSN 1687-966X. Vis sammendrag

  In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. Although a wide variety of methods have been used to expand BMSCs on a large scale by using good manufacturing practice (GMP), little attention has been paid to whether the expansion procedures indeed allow the maintenance of critical cell characteristics and potency, which are crucial for therapeutic effectiveness. Here, we described standard procedures adopted in our facility for the manufacture of clinical-grade BMSC products with a preserved capacity to generate bone in vivo in compliance with the Brazilian regulatory guidelines for cells intended for use in humans. Bone marrow samples were obtained from trabecular bone. After cell isolation in standard monolayer flasks, BMSC expansion was subsequently performed in two cycles, in 2- and 10-layer cell factories, respectively. The average cell yield per cell factory at passage 1 was of 21.93±12.81×106 cells, while at passage 2, it was of 83.05±114.72×106 cells. All final cellular products were free from contamination with aerobic/anaerobic pathogens, mycoplasma, and bacterial endotoxins. The expanded BMSCs expressed CD73, CD90, CD105, and CD146 and were able to differentiate into osteogenic, chondrogenic, and adipogenic lineages in vitro. Most importantly, nine out of 10 of the cell products formed bone when transplanted in vivo. These validated procedures will serve as the basis for in-house BMSC manufacturing for use in clinical applications in our center.

• Knudsen, Dyveke; Ottersen, Margareth Kristensen; Ørstavik, Dag & Sunde, Pia Titterud (2019). Multiple idiopatiske cervikale rotresorpsjoner - forekomst og kasuistikker :. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129(4), s 342- 351
• Grytten, Jostein Ivar; Skau, Irene & Sørensen, Rune Jørgen (2019). Who dies early? Education, mortality and causes of death in Norway. Social Science and Medicine.  ISSN 0277-9536. . doi: 10.1016/j.socscimed.2019.112601 Vis sammendrag

  We estimated the effects of education on mortality and causes of death in Norway. We identified causal effects by exploiting the staggered implementation of a school reform that increased the length of compulsory education from seven to nine years. The municipality-level education data were combined with complete records of all deaths from 1960 to 2015 from the Norwegian Cause of Death Registry. These data covered the entire life span of persons aged 16–64. One additional year of education caused a reduction in mortality of about 10% for men. The effect was negligible for women. For men, a large part of the effect was due to fewer accidental deaths. We suggest two explanations for this finding. First, there are differences in risk-taking behaviour between people with a high level of education and those with a low level. Second, more education leads to upward occupational mobility. This mobility is mainly from occupations for which the risk of accidents is high to occupations for which the risk is low. Our results supported the fundamental cause theory. This is because education had a stronger effect on mortality for causes of death that are preventable than for causes of death that are not preventable. More education had no effect on the probability of dying of diseases that were amenable to medical intervention only. This gives some support to our results that patients are treated equally, independent of their level of education. This may be due to the large public involvement in financing and provision of health services.

• Schlueter, Nadine; Amaechi, Bennett T.; Bartlett, David; Buzalaf, Marília A.; Carvalho, Thiago Saads; Ganss, Carolina; Hara, Anderson T.; Huysmans, Marie-Charlotte D.N.J.M.; Lussi, Adrian; Moazzez, Rebecca; Vieira, Alexandre Rezende; West, Nicola X.; Wiegand, Annette; Young, Alix & Lippert, Frank (2019). Terminology of erosive tooth wear: Consensus report of a workshop organized by the ORCA and the cariology research Group of the IADR. Caries Research.  ISSN 0008-6568.  s 1- 5 . doi: 10.1159/000503308 Vis sammendrag

  Our understanding of erosive tooth wear and its contributing factors has evolved considerably over the last decades. New terms have been continuously introduced, which frequently describe the same aspects of this condition, whereas other terms are being used inappropriately. This has led to unnecessary confusion and miscommunication between patients, professionals, and researchers. A group of 15 experts, selected by the European Organization for Caries Research (ORCA) and the Cariology Research Group of the International Association for Dental Research (IADR), participated in a 2-day workshop to define the most commonly used terms in erosive tooth wear. A modified Delphi method was utilized to reach consensus. At least 80% agreement was achieved for all terms discussed and their definitions related to clinical conditions and processes, basic concepts, diagnosis, risk, and prevention and management of erosive tooth wear. Use of the terms agreed on will provide a better understanding of erosive tooth wear and intends to enable improved communication on this topic.

• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2019). Lokal bløtvevsatrofi i kinn og tap av følelse i høyre overleppe etter subkutan ekstrusjon av klorheksidindiglukonat i forbindelse med endodontisk behandling. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129, s 706- 710
• Norum, Thomas Åge; Aass, Anne Merete & Koldsland, Odd Carsten (2019). Pain and morbidity after non-surgical and surgical treatment of peri-implantitis. Acta Odontologica Scandinavica.  ISSN 0001-6357. . doi: 10.1080/00016357.2019.1632474
• Ohrvik, Hanne Gran & Hjortsjö, Carl (2019). Retrospective study of patients with amelogenesis imperfecta treated with different bonded restoration techniques. Clinical and Experimental Dental Research.  ISSN 2057-4347. . doi: 10.1002/cre2.243
• Schiodt, Morten; Otto, Sven; Fedele, Stefano; Bedogni, Alberto; Nicolatou-Galitis, Ourania; Guggenberger, Robert; Herlofson, Bente Brokstad; Ristow, Oliver & Kofod, Thomas (2019). Workshop of European task force on medication‐related osteonecrosis of the jaw—Current challenges. Oral Diseases.  ISSN 1354-523X.  s 1- 7 . doi: 10.1111/odi.13160
• Rønneberg, Anne; Nordgarden, Hilde; Skaare, Anne B & Willumsen, Tiril (2019). Barriers and factors influencing communication between dental professionals and Child Welfare Services in their everyday work. International Journal of Paediatric Dentistry.  ISSN 0960-7439.  29(6), s 684- 691 . doi: 10.1111/ipd.12507
• Zigante, Martina; Pavlic, Andrej; Vandevska-Radunovic, Vaska; Mathewson, Alana; Kotarac Knezevic, Ana & Špalj, Stjepan (2019). Changes of mandibular dental arch shape during adolescence and its influence on late mandibular incisor crowding. HOMO: Journal of Comparative Human Biology.  ISSN 0018-442X.  70(3), s 185- 192 . doi: 10.1127/homo/2019/1070
• Stenhagen, Kjersti Refsholt; Holme, Børge; Tveit, Anne Bjørg; Lussi, Adrian & Carvalho, Thiago Saads (2019). Analytical strategies for clinical studies on dental erosive wear. BMC Oral Health.  ISSN 1472-6831.  19(1), s 1- 9 . doi: 10.1186/s12903-019-0834-1 Vis sammendrag

  Background There is a need for analytical techniques for measuring Erosive Tooth Wear (ETW) on natural surfaces in clinical studies. The purpose was to investigate the use of two instruments aimed to assess initial to more advanced stages of ETW. Methods Human premolar enamel samples (2x3mm) (n = 24), were polished flat and mounted in resin cylinders (4 cylinders, 6 samples in each). Part 1: Baseline analyses by White Light Interferometer (WLI), Surface Reflection Intensity (SRI: TableTop and OptiPen) and Surface Hardness (SH). Erosion (1% citric acid (pH 3.6) for 1, 2, 4, 6, 8, 10 min. SRI and SH analyses after every erosion episode and by WLI after 10 min. New indentations were made and enamel loss; was measured by change in indentation depths from toothbrush abrasion (200 g, 60 strokes, 30 s). Another series of 2 × 5 min erosion (totally15 min and 20 min) was analysed with SH and SRI after each erosion, and by WLI (on samples and impressions of samples) after 20 min. Part 2 investigated WLI performance in the interface where initial erosion increases in severity and substance loss occurs. The samples were repolished. Baseline analyses by WLI, SRI (TableTop and OptiPen) and SH. Four cylinders were etched for 1, 2, 4, 8 min respectively and analysed by SRI, SH on samples, and WLI on samples and impressions). Results Part1: SRI decreased from baseline to ~ 6 min etch and increased slightly after abrasion, the two devices correlated well (ICC 0.98 p < 0.001, Spearmans rs 0.91 p < 0.001). SH decreased nearly linearly to 10 min etch, but increased distinctly after abrasion. Mean enamel loss from abrasion alone was 0.2 μm (change in indentation depths). After 10 min etch, it was 0.27 μm (WLI) and after 20 min etch, it was 2.2 μm measured on samples vs 2.4 μm on impressions of samples (7% higher). Part 2: From baseline to 8 min etch; SRI and SH decreased whereas WLI presented increasing etch depths. Conclusions With some adjustments, the use of SRI and WLI in combination seems to be a promising strategy for monitoring ETW in clinical studies.

• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences.  ISSN 0909-8836. . doi: 10.1111/eos.12654
• Strøm, Kjetil; Skaare, Anne B & Willumsen, Tiril (2019). Dental anxiety in 18-year-old Norwegians in 1996 and 2016. Acta Odontologica Scandinavica.  ISSN 0001-6357. . doi: 10.1080/00016357.2019.1637933
• Ellingsen, Jan Eirik; Stanford, Clark; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin (2019). Ceramic Implant-Supported Single Crowns and Fixed Dental Prostheses: A Real Alternative to Metal-Ceramic?. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(4), s 804- 808
• Aqrawi, Lara Adnan; Galtung, Hilde; Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Skarstein, Kathrine & Jensen, Janicke Liaaen (2019). Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers. Arthritis Research & Therapy.  ISSN 1478-6354.  21, s 1- 14 . doi: 10.1186/s13075-019-1961-4
• Zandi, Homan; Petronijevic, Nikola; Mdala, Ibrahimu; Kristoffersen, Anne Karin; Enersen, Morten; Rocas, Isabela N.; Siqueira, José F. Jr. & Ørstavik, Dag (2019). Outcome of endodontic retreatment Using 2 root canal irrigants and influence of infection on healing as determined by a molecular method: A Randomized Clinical Trial. Journal of Endodontics.  ISSN 0099-2399.
• Russell, Mark A.; Redick, Sambra; Blodgett, David M.; Richardson, Sarah J.; Leete, Pia; Krogvold, Lars; Dahl-Jørgensen, Knut; Bottino, Rita; Brissova, Marcela; Spaeth, Jason M.; Babon, Jenny Aurielle B.; Haliyur, Rachana; Powers, Alvin C.; Yang, Chaoxing; Kent, Sally C.; Derr, Alan G.; Kucukural, Alper; Garber, Manuel G.; Morgan, Noel G. & Harlan, David M. (2019). HLA class II antigen processing and presentation pathway components demonstrated by transcriptome and protein analyses of islet ?-cells from donors with type 1 diabetes. Diabetes.  ISSN 0012-1797.  68(5), s 988- 1001 . doi: 10.2337/db18-0686
• Eliassen, Morten; Hjortsjö, Carl; Olsen-Bergem, Heming & Bjørnland, Tore (2019). Self-exercise programmes and occlusal splints in the treatment of TMD-related myalgia – Evidence-based medicine?. Journal of Oral Rehabilitation.  ISSN 0305-182X.  s 1- 7 . doi: 10.1111/joor.12856
• Sagen, Mina Aker; Kvam, Ketil; Ruyter, Ivar Eystein & Rønold, Hans Jacob (2019). Debonding mechanism of zirconia and lithium disilicate resin cemented to dentin. Acta Biomaterialia Odontologica Scandinavica.  ISSN 2333-7931.  5(1), s 22- 29 . doi: 10.1080/23337931.2018.1561188
• Rusthen, Shermin; Kristoffersen, Anne Karin; Young, Alix; Galtung, Hilde; Petrovski, Beata; Palm, Øyvind; Enersen, Morten & Jensen, Janicke Liaaen (2019). Dysbiotic salivary microbiota in dry mouth and primary Sjögren’s syndrome patients. PLOS ONE.  ISSN 1932-6203.  14(6), s 1- 15 . doi: 10.1371/journal.pone.0218319
• Vandevska-Radunovic, Vaska; Maneva, Marija & Zuzelova, Marija (2019). Prevalence of Dental Anomalies in Deciduous Teeth and their Correlation with the Permanent Dentition: Double Teeth, Hypodontia and Hyperdontia. International Journal of Dentistry and Oral Health.  ISSN 2378-7090.  5(3), s 1- 4 . doi: doi.org/10.16966/2378-7090.292
• Mohammed, Hisham; Cirgic, Emina; Rizk, Mumen Z & Vandevska-Radunovic, Vaska (2019). Effectiveness of prefabricated myofunctional appliances in the treatment of Class II division 1 malocclusion: a systematic review. European Journal of Orthodontics.  ISSN 0141-5387.  s 1- 10 . doi: doi:10.1093/ejo/cjz025
• Ketharanathan, Vimalan; Torgersen, Gerald R.; Petrovski, Beata & Preus, Hans Ragnar (2019). Radiographic alveolar bone level and levels of serum 25-OH-Vitamin D3 in ethnic Norwegian and Tamil periodontitis patients and their periodontally healthy controls.. BMC Oral Health.  ISSN 1472-6831.  19(1) . doi: 10.1186/s12903-019-0769-6 Vis sammendrag

  Background Studies suggest association between low serum 25-OH-Vitamin D3 (VitD) and chronic destructive periodontal diseases. The main sources of VitD is sun exposure and fat fish. Subjects with dark skin will therefore generate less VitD as response to sun exposure. The aim of the study was to assess the radiographic bone level and levels of serum VitD in ethnic Norwegian and Tamil periodontitis patients and their respective healthy controls. Methods Twenty-seven Tamil periodontitis patients living in Norway were compared to 21 Tamil controls as well as to 21 Norwegian periodontitis patients and 23 Norwegian controls. Marginal bone level was diagnosed on radiographs. VitD levels were diagnosed in blood samples by high-performance liquid chromatography-mass spectrometry. Results VitD levels were lower in Norwegian periodontitis patients than in controls, while no significant differences were observed between Tamil periodontitis patients and controls despite the significant difference between RBL between the periodontitis patients and controls in both groups. When calculating the odds ratio for having periodontal disease in both populations together, it appeared that one unit increased serum VitD (i.e. 1 nmol/L) decreased the odds of having radiographic bone loss by 4%. Conclusion According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined.

• Myint, Maung; Støvne, Sven Asbjørn; Sæves, Rønnaug Ingun; Bjørnland, Tore & Jensen, Janicke Liaaen (2019). Dental implants in individuals with osteogenesis imperfecta: a 6-year follow-up study. Oral Surgery.  ISSN 1752-2471.  s 1- 6 . doi: 10.1111/ors.12416
• Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Hua, Yanjun; Eidet, Jon Roger; Stojanovic, Aleksandar; Dartt, Darlene A. & Utheim, Tor Paaske (2019). Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients. Current Eye Research.  ISSN 0271-3683.  44(9), s 941- 947 . doi: 10.1080/02713683.2019.1604972 Vis sammendrag

  Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), meibum quality (MQ), and diagnosis of meibomian gland dysfunction (MGD). Receiver-operating characteristic curve (ROC) analysis considering optimum balanced sensitivity and specificity (close to 50%) was used for assessment. Results: The present study on more than 1,000 patients indicates that the OSDI in the ROC curve analysis is a poor discriminator of pathological scores for TFBUT ≤ 5 (AUC = 0.553; p = .012) and ≤10 s (AUC = 0.608; p = .002), OSS ≥ 3 (AUC = 0.54; p = .043), ST ≤ 5 (AUC = 0.550; p = .032) and ≤10 mm/5 min (AUC = 0.544; p = .016), and ME ≥ 1 (AUC = 0.594; p = <0.001). Pathological scores for osmolarity >308 and >316 mOsm/L, OPI, OSS > 1, MQ, and MGD could not be discriminated by OSDI (p > .05). Conclusion: Cut-off values for the OSDI can be defined to discriminate pathological TFBUT (≤5 and ≤10), OSS (≥3), ST (≤5 and ≤10) and ME, however, the discriminability was low. Our comprehensive study emphasises the importance of taking both symptoms and signs into account in DED management.

• Sanz, Mariano; Dahlin, Christer; Apatzidou, Danae; Artzi, Zvi; Bozic, Darco; Calciolari, Elena; De Bruyn, Hugo; Dommisch, Henrik; Donos, Nicos; Eickholz, Peter; Ellingsen, Jan Eirik; Haugen, Håvard Jostein; Herrera, David; Lambert, France; Layrolle, Pierre; Montero, Eduardo; Mustafa, Kamal Babikeir Eln; Omar, Omar & Schliephake, Henning (2019). Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology.  ISSN 0303-6979.  46(21), s 82- 91 . doi: 10.1111/jcpe.13123
• Skjerven, Henrik; Olsen-Bergem, Heming; Rønold, Hans Jacob; Riis, Ulf Harald & Ellingsen, Jan Eirik (2019). Comparison of postoperative intraoral scan versus cone beam computerised tomography to measure accuracy of guided implant placement—A prospective clinical study. Clinical Oral Implants Research.  ISSN 0905-7161.  30(6), s 531- 541 . doi: 10.1111/clr.13438
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Osswald, Martin & Stanford, Clark (2019). Understanding the Role of Titanium Particles and Corrosion in Peri-implantitis. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(3), s 561- 564
• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas; Osswald, Martin & Stanford, Clark (2019). Oral Implants Made of Zirconia: An Update for 2019. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(2), s 307- 310
• Uhlen, Marte-Mari Nordsetmoen; Valen, Håkon; Karlsen, Line Christin Schrøder; Skaare, Anne B; Bletsa, Athanasia; Ansteinsson, Vibeke & Mulic, Aida (2019). Treatment decisions regarding caries and dental developmental defects in children - A questionnaire-based study among Norwegian dentists. BMC Oral Health.  ISSN 1472-6831.  19(1) . doi: 10.1186/s12903-019-0744-2
• Preus, Hans Ragnar; Maharajasingam, Nisha; Rosic, Jovana & Baelum, Vibeke (2019). Oral hygiene phase revisited: How different study designs have affected results in intervention studies. Journal of Clinical Periodontology.  ISSN 0303-6979.  46(5), s 548- 551 . doi: 10.1111/jcpe.13109
• Gustafsson, Miriam K.; Romundstad, Pål Richard; Stafne, Signe Nilssen; Helvik, Anne-Sofie; Stunes, Astrid Kamilla; Mørkved, Siv; Salvesen, Kjell Å; Thorsby, Per Medbøe; Mosti, Mats Peder & Syversen, Unni (2019). The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial. BMC Pregnancy and Childbirth.  ISSN 1471-2393.  19:76, s 1- 10 . doi: 10.1186/s12884-019-2220-z Fulltekst i vitenarkiv.
• Chen, Xiangjun; Aqrawi, Lara Adnan; Utheim, Tor Paaske; Tashbayev, Behzod; Utheim, Øygunn Aass; Reppe, Sjur; Hove, Lene Hystad; Herlofson, Bente Brokstad; Singh, Preet Bano; Palm, Øyvind; Galtung, Hilde & Jensen, Janicke Liaaen (2019). Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations.. Scientific Reports.  ISSN 2045-2322.  9(1) . doi: 10.1038/s41598-019-43714-5
• Weber, Florian; Liao, Wei-Chih; Barrantes Bautista, Alejandro; Edèn, Mattias & Tiainen, Hanna (2019). Silicate‐Phenolic Networks: Coordination Mediated Deposition of Bioinspired Tannic Acid Coatings. Chemistry - A European Journal.  ISSN 0947-6539.  25(42), s 9870- 9874 . doi: 10.1002/chem.201902358
• Geissler, Sebastian; Gomez-Florit, Manuel; Wiedmer, David; Barrantes Bautista, Alejandro; Petersen, Fernanda Cristina & Tiainen, Hanna (2019). In vitro performance of bioinspired phenolic nanocoatings for endosseous implant applications. ACS biomaterials science & engineering.  ISSN 2373-9878. . doi: 10.1021/acsbiomaterials.9b00566
• Hardersen, Line Rørslett; Enersen, Morten; Kristoffersen, Anne Karin; Ørstavik, Dag & Sunde, Pia Titterud (2019). Maintenance of the aseptic working field during endodontic treatment. Acta Odontologica Scandinavica.  ISSN 0001-6357.  s 1- 6 . doi: 10.1080/00016357.2019.1606935 Vis sammendrag

  ABSTRACT Objective: The aim of this clinical quality study was to determine whether the aseptic working field is maintained during the endodontic procedure. Materials and methods: Bacterial samples were collected from the rubber dam of 27 patients during endodontic treatment performed by postgraduate students at the Department of Endodontics, University of Oslo. A bacterial sample was first obtained immediately after disinfection of the working field (A), and the second sample was collected just before obturation or dressing with calcium hydroxide cement (B). Aerobic cultivation technique and PCR were used for detection of bacterial growth and species. Results: All samples were negative on culturing except in one case, which showed positive results with cultivation in both sample A and B. Specie detected with cultivation technique were Streptococcus mitis. With PCR technique, 6 samples in 5 patients (11%), showed positive results. Species detected with PCR technique were Bacteroidales spp. Propionibacterium spp., Bacteroidetes spp., Prevotella nigrescens, Haemophilus parainfluenzae, Neisseria elongata, Alloprevotella tannerae, Capnocytophaga granulosa, Cardiobacterium hominis, Fusobacterium nucleatum and Streptococcus mitis. Conclusion: The present study showed that an aseptic working field was maintained throughout the endodontic procedure in 81% (22/27) of the cases after disinfection of the rubber dam.

• Rahmati, Maryam; Zahra, Alipanahi & Mozafari, Masoud (2019). Emerging Biomedical Applications of Algal Polysaccharides. Current pharmaceutical design.  ISSN 1381-6128.  25(11), s 1335- 1344 . doi: 10.2174/1381612825666190423160357 Vis sammendrag

  Abstract: Background: Over the past two decades, there have been substantial progress and a growing body of research on using natural polymeric biomaterials in emerging biomedical applications. Among different natural biopolymers, polysaccharides have gained considerable attraction among biomedical scientists and surgeons due to their biocompatibility, biodegradability, anti-inflammatory, and antimicrobial properties. In recent years, algalbased polysaccharides including agar, alginate, and carrageenan, have been broadly suggested for different biomedical applications. Methods: The aim of this paper is discussing various possible applications of algal-based polysaccharides in biomedical engineering particularly in controlled drug delivery systems. The main properties of each algal polysaccharide will be discussed, and particular drug delivery applications will be presented. Results: Algal polysaccharides can be detected in a group of photosynthetic unite as their key biomass constituents. They provide a range of variety in their size, shape, liquefaction, chemical stability, and crosslinking ability. In addition, algal polysaccharides have shown exceptional gelling properties including stimuli-responsive behavior, softness, and swelling properties. Conclusion: All the mentioned properties of alga polysaccharides lead to their successful usage in biomedical applications specially targeted and controlled drug delivery systems such as particles, capsules, and gels.

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• Rahmati, Maryam; Blaker, Jonathan James; Lyngstadaas, Ståle Petter; Mano, Joao F. & Haugen, Håvard Jostein (2020). Designing multigradient biomaterials for skin regeneration. Materials Today.  ISSN 1369-7021.  5 . doi: 10.1016/j.mtadv.2019.100051 Vis sammendrag

  Skin defects are amongst the main causes of morbidity and mortality worldwide, which account for significantly high socioeconomic costs. Today, much attention is being paid to tissue engineering and biomaterials strategies for skin regeneration, and among them, there is increasing interest in using multigradient biomaterials. Gradient-based approaches are an emerging trend in tissue engineering for the homogeneous delivery of therapeutic agents by using biomaterials. Several studies have acknowledged that wound repair mechanisms could be enhanced through biomimicking physicochemical properties of different skin layers. In addition, in different layers of skin tissue, cells experience various physicochemical gradients, which potentially regulate their behaviors. Therefore, interface tissue engineering and biomaterials approaches are gaining increasing attention for skin regeneration through the incorporation of physicochemical gradients within the engineered constructs. This review first presents a necessary overview of the biological properties of skin tissue and its changes during repair in different tissue injuries. Fundamental issues and necessities of using different types of gradient scaffolds and interface tissue engineering strategies for skin regeneration are addressed. The focus of this review is on describing current progress in designing gradient scaffolds for controlling and directing cellular and molecular responses in skin tissue. The main used fabrication approaches, including both traditional and advanced methods for designing multigradient scaffolds, are also discussed.

• Grytten, Jostein Ivar & Skau, Irene (2019). Causal effect of education on receiving subsidized fixed prosthodontic treatment.
• Kinge, Jonas Minet & Grytten, Jostein Ivar (2019). Allmenndekningen og perinatal helse.
• Grytten, Jostein Ivar (2019). Nasjonale registre i tannhelsetjenesten - hva har vi og hva trenger vi?.
• Børsting, Torunn; Schuller, Annemarie; van Dommelen, Paula; Stafne, Signe Nilssen; Skeie, Marit Slåttelid; Skaare, Anne B; Gustafsson, Miriam K.; Syversen, Unni; Stunes, Astrid Kamilla; Mosti, Mats Peder; Mørkved, Siv; Salvesen, Kjell Å & Natland Fagerhaug, Tone (2019). Associations between maternal vitamin D status in second and third trimester of pregnancy and offspring enamel hypomineralisation at 7-9 years: a longitudinal study. Norsk Epidemiologi, Supplement.  ISSN 0803-4206.  28
• Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases..
• Liskiewicz, Krystyna Anna; Sunde, Pia Titterud; Verket, Anders; Økstad, Ole Andreas & Simm, Roger (2019). C-di-GMP signaling in Treponema denticola and its role in pathogenesis of periodontal diseases..
• Stunes, Astrid Kamilla; Mosti, Mats Peder; Seim, Klara Evjen; Trydal, Elise Constance; Stafne, Signe Nilssen; Gustafsson, Miriam K. & Syversen, Unni (2019). Maternal vitamin D status in 2nd and 3rd trimester and offspring bone mass at age 8–9 years: an observational study.
• Jensen, Janicke Liaaen (2019). My research: saliva and oral health - from the lab to the patient to the society - what did I learn?.
• Jensen, Janicke Liaaen (2019). Utvikling av nytt produkt mot tørr munn, innledninggsforedrag.
• Herlofson, Bente Brokstad (2019). The Scandinavian ONJ Cohort Study - 8 year research collaboration on ONJ in Norway, Sweden and Denmark..
• Lossius, Sara Ekern & Herlofson, Bente Brokstad (2019, 21. oktober). Sunn munn, god helse.. [Internett].
• Herlofson, Bente Brokstad (2019). Oral cancer awareness week.
• Herlofson, Bente Brokstad (2019). Jaw bone pathology - a challenge for the wave of new medical treatments in cancer and osteoporosis..
• Herlofson, Bente Brokstad (2019). Oral health issues in the society, with a focus on cancer and cancer treatment. A research project..
• Herlofson, Bente Brokstad (2019). Pasienter på benmodulerende behandling..
• Herlofson, Bente Brokstad (2019). Oral medisin.
• Herlofson, Bente Brokstad (2019). Oppdatering vedrørende pasienter på benmodulerende behandling..
• Herlofson, Bente Brokstad (2019). Rettigheter og oppfølging av oral helse ved kreftsykdom.
• Herlofson, Bente Brokstad & Ingstad, Hanne Kleven (2019). Oral cancer og oral medisin..
• Wilberg, Petter (2019). Kreftpasienten - Har vi som tannhelsepersonell noe å tilby? Svaret er ja, men kan DU nok om det?.
• Pawlik, A; Sulka, G.D. & Haugen, Håvard Jostein (2019). Fabrication and characterization of doxycycline-coated nanoporous TiO2 layers.
• Blix, Ellen; Eskild, Anne; Skau, Irene & Grytten, Jostein Ivar (2019). Har innføringen av STAN-teknologien i Norge ført til færre dødfødsler, dødsfall hos nyfødte eller at færre barn blir født med lav apgar-skår? En populasjonstudie.
• Blich, Carl Christian (2019). Tannhelseforsikring - til gode for hvem? :. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129(4), s 366- 367
• Høyvik, Ann Catrin; Weie, Ingrid Volden; Tveter, Karianne & Willumsen, Tiril (2019). Are dentists familiar with the rights of torture survivors?.
• Haugen, Håvard Jostein (2019). Novel nano-computed tomography techniques applied to dental research.
• Haugen, Håvard Jostein (2019). Experimental Peri-implantitis around Titanium Implants with a Modified Titanium Surface with a Phosphonic Acid Monolayer. NanoCT Results of an Experimental In-vivo Investigation.
• Haugen, Håvard Jostein (2019). Micro-porosities Revealed in Hybrid Dental Composites by Nano X-ray Tomography.
• Haugen, Håvard Jostein (2019). Micro and nano-CT applied to dental research.
• Haugen, Håvard Jostein (2019). Structural and Bio-inspired Bioceramic Materials and Implants.
• Jensen, Janicke Liaaen; Chen, Xiangjun; Hynne, Håvard; Westgaard, Kristine Løken; Hove, Lene Hystad; Young, Alix; Rykke, Morten; Singh, Preet Bano; Tashbayev, Behzod; Utheim, Øygunn Aass; Utheim, Tor Paaske; Palm, Øyvind; Amdal, Cecilie Delphin & Herlofson, Bente Brokstad (2019). Sjögren’s versus irradiated head-neck cancer patients: oral and ocular investigations.
• Hynne, Håvard; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Amdal, Cecilie Delphin; Hove, Lene Hystad; Young, Alix; Rykke, Morten; Chen, Xiangjun; Utheim, Tor Paaske & Jensen, Janicke Liaaen (2019). Oral and Ocular Findings in Radiated Head-and Neck Cancer Patients.
• Jensen, Janicke Liaaen (2019). Bærekraftig alderdom - en sunn sjel med en sunn munnhule i et sunt legeme.
• Jensen, Janicke Liaaen (2019). Munnhygiene - et oversett område.
• Young, Alix; Singh, Preet Bano; Hynne, Håvard; Løken Westergaard, Kristine; Hove, Lene Hystad; Rykke, Morten; Xiangjun, Chen; Herlofson, Bente Brokstad; Amdahl, Cecilie Delphin & Jensen, Janicke Liaaen (2019). Oral Investigations in Head and Neck Cancer Patients after Radiotherapy. Vis sammendrag

  Objectives: To investigate oral complaints and findings in head and neck cancer (HNC) patients who had received radiotherapy and compare them with controls. Methods: As part of a larger study, 30 HNC patients (14 female, age 64.2±9.6y) and 26 age- and sex-matched controls (13 female, 62.9±12.9y, p=0.850) were examined at the Dry Mouth Clinic, Faculty of Dentistry, Oslo. Oral health-related quality of life (OHRQoL) was assessed using the short form Oral Health Impact Profile (OHIP-14: high score-low OHRQoL). Self-reported dysgeusia (yes/no) and sense of taste (10-point VAS: high score-good smell sense) were recorded. Taste scores were recorded using taste strips (high score-good taste function). Oral candida counts were determined from cheek and tongue swabs (0=no growth, 1=minimal, 2=moderate, 3=severe). Volatile sulphur compounds (VSC) in mouth air samples were determined by gas chromatography and related to perceptive threshold-levels (H2S≤112ppb, CH3SH≤26ppb). Between-group comparisons were performed using Mann-Whitney U test and Chi-square test. Results: The HNC patients reported significantly poorer OHRQoL than controls (OHIP sum-score: 18.4±12.4 vs 1.2±2.0, p<0.001). They reported significantly poorer sense of taste compared to controls (6.4±2.4 vs 7.8±1.9, p=0.018), and more often dysgeusia (26.7% vs 7.7%, p=0.087). The measured gustatory scores (20.4±6.4 vs 22.3±4.6, p=0.315) were similar for both groups. Candida scores were significantly higher in the patient group (1.6±1.3 vs 0.7±0.9, p=0.024). The percentage of HNC patients who had oral H2S above the threshold level was significantly lower than for the controls (0% vs 27%, p<0.05). This was not the case for CH3SH (5.5% vs 27%, p=0.105). Conclusion: After radiotherapy, these HNC patients experienced negative oral consequences of the treatment. They reported poorer OHRQoL, and had reduced taste sensation and higher oral candida counts. However, the underlying reason for less problems with halitosis in HNC patients than in controls is worth further exploration.

• Khan, Sadia Nazir; Koldsland, Odd Carsten & Hjortsjö, Carl (2019). Bacteriostatic effect of filling materials used in implant-abutment-screw-channel: A pilot study.
• Brusevold, Ingvild Johnsen (2019). Vipeholmstudiene. Store Norske Leksikon (Nettutgaven).
• Jensen, Janicke Liaaen & Hove, Lene Hystad (2019). Eldres munnhelse: La oss fortelle historien om Berit.
• Jensen, Janicke Liaaen (2019). Munn- og øyetørrhet, implikasjoner for generell helse og livskvalitet.
• Weber, Florian; Barrantes Bautista, Alejandro & Tiainen, Hanna (2019). Plant polyphenolic inspired anti-inflammatory and anti-bacterial surface modifications for dental implants.
• Ivanchenko, M.; Aqrawi, Lara Adnan; Björk, Albin; Wahren-Herlenius, M. & Chemin, K. (2019). FoxP3+CXCR5+CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome. Clinical and Experimental Immunology.  ISSN 0009-9104.  195(3), s 305- 309 . doi: 10.1111/cei.13244
• Weber, Florian; Liao, Wei-Chih; Barrantes Bautista, Alejandro; Edèn, Mattias & Tiainen, Hanna (2019). Silicic acid mediated formation of tannic acid coatings.
• Gustafsson, Miriam K.; Thorsby, Per Medbøe; Syversen, Unni & Mosti, Mats Peder (2019). The response of vitamin D metabolites to a single bout of resistance and endurance exercise in healthy young adults.
• Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Dahl, Marianne; Saghaug, Elisabeth; Slaaen, Joran & Lerdal, Anners (2019). Dry mouth - a missing symptom in multiple assessment tools?.
• Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad; Saghaug, Elisabeth; Slaaen, Joran; Sundal, Tone; Tollisen, Anita & Lerdal, Anners (2019). A comparison of normal saline mouth rinse and mouth rinse based on Salvia officinalis in palliative care: A randomized controlled trial.
• Bremnes, Alexander (2019). Air-gap or grids, for shunt radiography?.
• Skoglund, Lasse Ansgar & Barkvoll, Pål (2019). Blåreseptordningen og tannlegen:Hvorfor holdes pasienter med odontologiske tilstander utenfor?. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129(5), s 472- 473
• Jokstad, Asbjørn; Bjørnland, Tore; Dahl, Bjørn L.; Hansen, Torbjørn Leif; Hjortsjö, Carl; Heggem Julsvoll, Elisabeth; Mo, Arild; Olsen-Bergem, Heming; Robinson, Hilde Stendal & Skeie, Marit Slåttelid (red.) (2019). Diagnostiske kriterier for temporomandibulære forstyrrelser (TMD): Vurderingsverktøy: Norwegian. Version 28Apr2019.

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