Siste publikasjoner

• Weber, Florian; Barrantes Bautista, Alejandro & Tiainen, Hanna (2019). Silicic acid mediated formation of tannic acid nanocoatings. Langmuir.  ISSN 0743-7463. . doi: 10.1021/acs.langmuir.8b04208
• Skjerven, Henrik; Riis, Ulf Harald; Herlofson, Bente Brokstad & Ellingsen, Jan Eirik (2019). In Vivo Accuracy of Implant Placement Using a Full Digital Planning Modality and Stereolithographic Guides. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(1), s 124- 132
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2019). Factors Associated with Oral Implant Failures. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(1), s 17- 21
• Stoustrup, Peter; Resnick, Cory M; Pedersen, T; Abramowicz, Shelly; Michelotti, A; Küseler, Annelise; Verna, Carlalberta; Kellenberger, Christian J.; berit, nordahl; Jankovska, I; Caserta, G; Halbig, Josefine Mareile; Kristensen, Kasper Dahl; Arvidsson, Linda Zamoline; Spiegel, L; Stoll, M L; Lerman, M; Glerup, Mia; Defabianis, P; Frid, Paula Hanna Therese; Alstergren, Per; Cron, Randy Q.; Ringold, Sarah; Nørholt, S.E.; Peltomäki, Timo; Herlin, T; Peacock, Z S & Twilt, Marinka (2019). Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations.. J Rheumatol..  ISSN 1480-3666. . doi: doi.org/10.3899/jrheum.180785
• Ottersen, Margareth Kristensen; Abrahamsson, Anna-Karin; Larheim, Tore & Arvidsson, Linda Zamoline (2019). CBCT characteristics and interpretation challenges of temporomandibular joint osteoarthritis in a hand osteoarthritis cohort.. Dentomaxillofacial Radiology.  ISSN 0250-832X.  48 . doi: 10.1259/dmfr.20180245
• Singh, Preet Bano; Young, Alix; Homayouni, Amin; Hystad Hove, Lene; Petrovski, Beata Eva; Herlofson, Bente Brokstad; Palm, Øyvind; Rykke, Morten & Jensen, Janicke Liaaen (2019). Distorted Taste and Impaired Oral Health May Affect Nutritional Status in Patients with Sicca Complaints. Nutrients.  ISSN 2072-6643.  11(264) . doi: 10.3390/nu11020264
• Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Rossi, Filippo & Perale, Giuseppe (2019). Bone grafts: which is the ideal biomaterial?. Journal of Clinical Periodontology.  ISSN 0303-6979. . doi: 10.1111/jcpe.13058 Vis sammendrag

  Abstract Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio‐maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future Aim Within this narrative review, we discuss possible future biomaterials for bone replacement. Scientific Rationale for Study Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce. Practical Implications In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG. Results We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision‐making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations. Conclusions We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.

• Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein; Rinna, Alessandra; Ellingsen, Jan Eirik & Reseland, Janne Elin (2019). Hydrofluoric acid treatment of titanium surfaces enhance the proliferation of human gingival fibroblasts. Journal of Tissue Engineering.  ISSN 2041-7314. . doi: 10.1177/2041731419828950 Vis sammendrag

  The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts (HGF). HGF cells were exposed to hydrofluoric acid (HF) modified Ti coins (Ti-F) for 1, 3, 7, 14 and 21d, and untreated coins were used as controls. A 5-6 fold increase in the proliferation of HGF on Ti-F compared to Ti surfaces was observed. Enhanced gene expression of IL-6 and OPG was found at 7 d. Increased levels of sclerostin, IL- 6 and OPG in the media from HGF cultured on Ti-F coins were found compared to controls. Our results confirm that HF modified surface may indirectly enhance the firm attachment of implant surface to junction epithelium, soft tissue epithelium, which would give protection for underlying osseous structures making osseointegration of the dental implant possible.

• Klemm, Anne; Gomez-Florit, Manuel; Carvalho, Patricia A.; Wachendörfer, Mattis; Gomes, Manuela E.; Haugen, Håvard Jostein & Tiainen, Hanna (2019). Grain boundary corrosion in TiO2 bone scaffolds doped with group II cations. Journal of the European Ceramic Society.  ISSN 0955-2219.  39, s 1577- 1585 . doi: 10.1016/j.jeurceramsoc.2018.12.055
• Sailer, Irena; Muhlemann, Sven; Kohal, Ralf J.; Spies, Benedikt C.; Pjetursson, Bjarni E.; Lang, Niklaus P.; Gotfredsen, Klaus L.; Ellingsen, Jan Eirik; Francisco, Helena; Özcan, Mutlu; Hassan, Bassam; Pardo, Guillem E.; Bardaji, Javier A.; Kraus, Riccardo D. & Wennerberg, Ann (2018). Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018. Clinical Oral Implants Research.  ISSN 0905-7161.  29(Oct), s 239- 242 . doi: 10.1111/clr.13302
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Short Implants: More Long-Term Data. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(6), s 1237- 1240
• Osswald, Martin; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Stanford, Clark (2018). Use of Oral Implants for Cancer Reconstruction: The Role of the Approach to Vascular Flaps in Implant Outcomes. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(5), s 959- 961
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Radiotherapy and Oral Implants. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(4), s 745- 747
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Osswald, Martin & Stanford, Clark (2018). Understanding Peri-implantitis Through the Lens of the Oral Microbiome. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(3), s 503- 506
• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Crown-to-Implant Ratio: What Is the Latest?. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(2), s 259- 261
• Estafanous, Emad; Chvartszaid, David; Ellingsen, Jan Eirik; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Implant-Retained Removable Partial Dentures: A Reliable Alternative Line of Treatment. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(1), s 17- 20
• Adil, Muhammed Yasin; Xiao, J; Olaffson, J.S.; Chen, Xiangjun; Lagali, Neil; Ræder, Sten; Utheim, Øygunn Aass; Dartt, Darlene A. & Utheim, Tor Paaske (2018). Meibomian Gland Morphology is a Sensitive Early Indicator of Meibomian Gland Dysfunction. American Journal of Ophthalmology.  ISSN 0002-9394.  200, s 16- 25 . doi: 10.1016/j.ajo.2018.12.006 Vis sammendrag

  Purpose To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). Design Cross-sectional study. Subjects Total 538 MGD patients and 21 healthy controls. Methods MG loss on meibography images of upper (UL) and lower lids (LL) was graded on a scale of 0 (lowest degree of MG loss) to 3. MG length, thickness, and interglandular space in the UL were measured. Clinical tests included meibum expression and quality, tear film break-up time, ocular staining, osmolarity, Schirmer I, blink interval timing, and Ocular Surface Disease Index (OSDI) questionnaire. Results Mean UL and LL meibogrades were significantly higher in MGD patients compared to controls (P < .001 for UL and LL). The sensitivity and specificity of the meibograde as a diagnostic parameter for MGD was 96.7% and 85%, respectively. Schirmer I was significantly increased in MGD patients with meibograde 1 compared to patients with meibograde 0, 2, and 3 in the UL (P < .05). MG thickness increased with higher meibograde (P < .001). MG morphology correlated significantly but weakly with several clinical parameters (P < .05). OSDI did not correlate with any MG morphologic parameter. Conclusions Grading of MG loss using meibograde effectively diagnoses MGD. Compensatory mechanisms such as increased aqueous tear production and dilation of MGs make early detection of MGD difficult by standard clinical measures of dry eye, whereas morphologic analysis of MGs reveals an early stage of MGD, and therefore represents a complementary clinical parameter with diagnostic potential.

• Jacobsen, Ioanna Dallari; Crossner, Claes-Göran; Eriksen, Harald; Espelid, Ivar & Ullbro, Arne Christer (2018). Need of non-operative caries treatment in 16-year-olds from Northern Norway. European Archives of Paediatric Dentistry.  ISSN 1818-6300. . doi: 10.1007/s40368-018-0387-z
• Fardal, Øystein; Grytten, Jostein Ivar; Martin, John; Ellingsen, Stig; Fardal, Patrick; Heasman, Peter & Linden, G.J. (2018). Adding smoking to the Fardal model of cost‐effectiveness for the lifetime treatment of periodontal diseases. Journal of Periodontology.  ISSN 0022-3492.  89(11), s 1283- 1289 . doi: 10.1002/JPER.17-0467
• Saltnes, Solfrid Sørgjerd; Geirdal, Amy Østertun; Sæves, Rønnaug Ingun; Jensen, Janicke Liaaen & Nordgarden, Hilde (2018). Experiences of daily life and oral rehabilitation in oligodontia - a qualitative study.. Acta Odontologica Scandinavica.  ISSN 0001-6357. . doi: 10.1080/00016357.2018
• Córdoba, Alba; Manzanaro-Moreno, Nahuel; Colom, Carme; Rønold, Hans Jacob; Lyngstadaas, Ståle Petter; Monjo, Marta & Ramis, Joana M. (2018). Quercitrin Nanocoated Implant Surfaces Reduce Osteoclast Activity In Vitro and In Vivo. International Journal of Molecular Sciences.  ISSN 1422-0067.  19(11) . doi: 10.3390/ijms19113319
• Stakkestad, Øystein; Heyward, Catherine Anne; Lyngstadaas, Ståle Petter; Medin, Tirill; Vondrasek, Jiri; Lian, Aina-Mari; Pezeshki, Gita & Reseland, Janne Elin (2018). An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon.  ISSN 2405-8440.  4(12) . doi: 10.1016/j.heliyon.2018.e01075
• Norton, Inghild; Valør, Liv Oddrun; Koldsland, Odd Carsten; Aass, Anne Merete; Grjibovski, Andrei M. & Preus, Hans Ragnar (2018). Klinisk effekt av et kommersielt munnskyllemiddel på plakk og gingivitt. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(3), s 188- 194
• Øyri, Hauk Furnes; Jonsdottir, Olga Hrønn; Jensen, Janicke Liaaen & Bjørnland, Tore (2018). The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anaesthetics and without the use of systemic antibiotics. Oral surgery, oral medicine, oral pathology and oral radiology.  ISSN 2212-4403. . doi: 10.1016/j.oooo.2018.12.004
• Bossard, Cedric; Granel, Henri; Jallot, Édouard; Vial, Christophe; Tiainen, Hanna; Wittrant, Yohann & Lao, Jonathan (2018). Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration. Biomedical Glasses.  ISSN 2299-3932.  4, s 108- 122 . doi: 10.1515/bglass-2018-0010
• Nermo, Hege; Willumsen, Tiril & Johnsen, Jan-Are Kolset (2018). Changes in dental anxiety among 15‐ to 21‐year‐olds. A 2‐year longitudinal analysis based on the Tromsø study: Fit futures. Community Dentistry and Oral Epidemiology.  ISSN 0301-5661.  s 1- 7 . doi: 10.1111/cdoe.12434
• Høyvik, Ann Catrin; Lie, Birgit & Willumsen, Tiril (2018). Dental anxiety in relation to torture experiences and symptoms of post-traumatic stress disorder. European Journal of Oral Sciences.  ISSN 0909-8836.  s 65- 71 . doi: 10.1111/eos.12592
• Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd; Utheim, Øygunn Aass; Palm, Øyvind; Tashbayev, Behzod; Utheim, Tor Paaske & Galtung, Hilde (2018). Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome. PLoS ONE.  ISSN 1932-6203.  13:e0205762(10), s 1- 14 . doi: 10.1371/journal.pone.0205762
• Hallmer, Fredrik; Anderson, Gunilla; Gotrick, Bengt; Warfvinge, Gunnar; Anderud, Jonas & Bjørnland, Tore (2018). Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw?a 4-year prospective study. Oral surgery, oral medicine, oral pathology and oral radiology.  ISSN 2212-4403.  s 1- 9 . doi: 10.1016/j.oooo.2018.08.015
• Zhang, Xianbin; Gong, He; Fan, Ruoxun & Fang, Juan (2018). Comparative Study between Bone Tissue Engineering Scaffolds with Bull and Rat Cancellous Microarchitectures on Tissue Differentiations of Bone Marrow Stromal Cells: A Numerical Investigation. Journal of Bionic Engineering.  ISSN 1672-6529.  15(5), s 924- 938 . doi: 10.1007/s42235-018-0079-8
• Shabestari, Maziar; Kise, Nina Jullum; Landin, Maria Augusta Dos S Silva; Sessing, Sølve; Hellund, Johan Castberg; Reseland, Janne Elin; Eriksen, Erik Fink & Haugen, Ida Kristin (2018). Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone and Joint Research.  ISSN 2046-3758.  7(6), s 406- 413 . doi: 10.1302/2046-3758.76.BJR-2017-0083.R3
• Anquetil, Florence; Mondanelli, Giada; Gonzalez, Nathaly; Rodriguez Calvo, Teresa; Zapardiel Gonzalo, Jose; Krogvold, Lars; Dahl-Jørgensen, Knut; Van den Eynde, Benoit; Orabona, Ciriana; Grohmann, Ursula & Von Herrath, Matthias G. (2018). Loss of IDO1 expression from human pancreatic β-cells precedes their destruction during the development of Type 1 diabetes. Diabetes.  ISSN 0012-1797.  67(9), s 1858- 1866 . doi: 10.2337/db17-1281
• Khanifam, Pejman; Pullisaar, Helen & Risheim, Helge (2018). Local facial atrophy and permanent anesthesia of right upper lip following subcutaneous extrusion of chlorhexidine digluconate. Oral and Maxillofacial Surgery Cases.  ISSN 2214-5419. . doi: 10.1016/j.omsc.2018.10.009
• Kuric, Enida; Krogvold, Lars; Hanssen, Kristian Folkvord; Dahl-Jørgensen, Knut; Skog, Oskar & Korsgren, Olle (2018). No evidence for presence of mucosal-associated invariant T cells in the insulitic lesions in patients recently diagnosed with Type 1 diabetes. American Journal of Pathology.  ISSN 0002-9440.  188(8), s 1744- 1748 . doi: 10.1016/j.ajpath.2018.04.009
• Diep, My Tien; Sødal, Anne T. Tveit; Skudutyte-Rysstad, Rasa & Hove, Lene Hystad (2018). Rutiner for oral helse på sykehjem: En undersøkelse blant sykehjemsledere. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  118(9), s 694- 699
• Thrane, Per Stanley & Thrane, Alexander Stanley (2018). Nye forskningsmetoder på levende dyr gir uante muligheter :. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(5), s 338- 342
• Hallmer, Fredrik; Korduner, Michael; Møystad, Anne & Bjørnland, Tore (2018). Treatment of diffuse sclerosing osteomyelitis of the jaw with denosumab shows remarkable results – A report of 2 cases. Clinical Case Reports.  ISSN 2050-0904.  6(12), s 2434- 2437 . doi: 10.1002/ccr3.1894
• Tulek, Amela; Saeed, Muhammad; Mulic, Aida; Stenhagen, Kjersti Refsholt; Utheim, Tor Paaske; Galtung, Hilde; Khuu, Cuong; Nirvani, Minou; Kristiansen, Marthe Smedmoen & Sehic, Amer (2018). New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth. Archives of Oral Biology.  ISSN 0003-9969.  96, s 137- 145 . doi: 10.1016/j.archoralbio.2018.08.013
• Dahl, Bjørn Einar; Dahl, Jon Einar & Rønold, Hans Jacob (2018). Digital evaluation of marginal and internal fit of single-crown fixed dental prostheses. European Journal of Oral Sciences.  ISSN 0909-8836.  s 1- 6 . doi: 10.1111/eos.12576
• Alsamaria, Toni Berg; Jalili, Sara & Bjørnland, Tore (2018). Oral implantatbehandling er en vellykket behandling med få komplikasjoner. Overlevelses- og suksessrate for implantater i perioden 2010-2013 ved Avdeling for oral kirurgi og oral medisin, Universitetet i Oslo.. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(9), s 648- 691
• Nermo, Hege; Willumsen, Tiril & Johnsen, Jan-Are Kolset (2018). Prevalence of dental anxiety and associations with oral health, psychological distress, avoidance and anticipated pain in adolescence: a cross-sectional study based on the Tromsø study, Fit Futures. Acta Odontologica Scandinavica.  ISSN 0001-6357.  77(2), s 126- 134 . doi: 10.1080/00016357.2018.1513558
• Colaianni, Graziana; Lippo, Luciana; Sanesi, Lorenzo; Brunetti, Giacomina; Celi, Monica; Cirulli, Nunzio; Passeri, Giovanni; Reseland, Janne Elin; Schipani, Ernestina; Faienza, MF; Tarantino, Umberto; Colucci, Silvia & Grano, Maria (2018). Deletion of the Transcription Factor PGC-1? in Mice Negatively Regulates Bone Mass. Calcified Tissue International.  ISSN 0171-967X. . doi: 10.1007/s00223-018-0459-4
• Grytten, Jostein Ivar & Skau, Irene (2018). Do Patients with More Education Receive More Subsidized Dental Care? Evidence from a Natural Experiment Using the Introduction of a School Reform in Norway as an Instrumental Variable. Medical Care.  ISSN 0025-7079.  56(10), s 877- 882 . doi: 10.1097/MLR.0000000000000976
• Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann & Utheim, Tor Paaske (2018). Tear production levels and dry eye disease severity in a large Norwegian cohort. Current Eye Research.  ISSN 0271-3683.  43(12), s 1465- 1470 . doi: 10.1080/02713683.2018.1514055 Vis sammendrag

  Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. Methods: Patients (n = 1090) with DED of different etiologies received an extensive dry eye work-up: osmolarity (Osm), tear meniscus height (TMH), tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), and meibum quality (MQ). Classification of dry eye severity level (DESL) and diagnosis of meibomian gland dysfunction (MGD) were also included. The cohort was divided into six groups: below and above cut-off values of 5 (groups 1 and 2), 10 (groups 3 and 4), and 15 mm (groups 5 and 6) of ST. Mann-Whitney test and Chi-Square test were used for group comparison of parameters (p ≤ 0.05). Results: The groups 1, 3, and 5 had values indicating more severe DED than the groups 2, 4, 6 with significant difference in DESL, Osm, TFBUT, OPI, OSS, and TMH. Regardless of the choice of cut-off values, there was no statistically significant difference in ME, MQ, and MGD between groups below and above selected cut-off value. When gender difference was considered in each group, significant difference was only observed for DESL (groups 2, 4, and 5), TFBUT (groups 2, 4, and 5), OPI (groups 2 and 6), and ME (group1). Conclusions: Schirmer I is a robust discriminator for DESL, Osm, TFBUT, OPI, OSS, and TMH, but not for ME, MQ, and MGD. Patients with lower tear production levels presented with more severe DED at all three defined cut-off values. Interestingly, the differences in the mean values of DESL were minimal although statistically significant. Thus, the clinical value of different Schirmer levels appears to be limited.

• Wiedmer, David; Cui, Chen; Weber, Florian; Petersen, Fernanda Cristina & Tiainen, Hanna (2018). Antibacterial Surface Coating for Bone Scaffolds Based on the Dark Catalytic Effect of Titanium Dioxide. ACS Applied Materials and Interfaces.  ISSN 1944-8244.  10(42), s 35784- 35793 . doi: 10.1021/acsami.8b12623
• Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin; Tashbayev, Behzod; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C. & Utheim, Tor Paaske (2018). Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. British Journal of Ophthalmology.  ISSN 0007-1161.  (103), s 119- 124 . doi: 10.1136/bjophthalmol-2017-310927 Vis sammendrag

  Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. Methods Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects underwent an extensive dry eye examination, including evaluation of meibomian glands (MGs) by meibography, measurement of tear production and tear film osmolarity and grading of vital staining of the ocular surface. Moreover, slit-lamp biomicroscopy was undertaken, including grading of aniridia-associated keratopathy (AAK). Results Mean tear film osmolarity was significantly higher (314±11 mOsmol/L) in patients with aniridia compared with the healthy control group (303±11 mOsmol/L, p=0.002). Vital staining score was higher in the aniridia group (4.3±3.0) compared with healthy controls (2.4±1.6, p=0.02). The degree of staining correlated positively with the stage of AAK (r=0.44, p=0.008) and negatively with corneal sensitivity (r=−0.45, p=0.012). Number of expressible MGs was lower in aniridia subjects (2.9±1.6) than in controls (4.0±1.3, p=0.007). MG loss, staged from 0 to 3, was higher in the aniridia group than in the control group, both in upper eyelid (0.86±0.89 vs 0.10±0.31, p=0.001) and lower eyelid (0.94±0.73 vs 0.30±0.47, p=0.003). Computerised analyses showed thinning (p=0.004) and lower density (p<0.001) of the MGs compared with the healthy population. Conclusions Patients with congenital aniridia demonstrate increased tear film osmolarity, ocular surface staining, loss of MGs and lower MG expressibility. We conclude that meibomian gland dysfunction and keratopathy are related to development of DED in aniridia.

• Virto, Leire; Cano, Pilar; Jiménez-ortega, Vanesa; Fernández-mateos, Pilar; González, Jerián; Haugen, Håvard Jostein; Esquifino, Ana isabel & Sanz Alonso, Mariano (2018). Melatonin as adjunctive therapy in the treatment of periodontitis associated with obesity. Journal of Clinical Periodontology.  ISSN 0303-6979.  45(11), s 1336- 1346 . doi: 10.1111/jcpe.13013 Vis sammendrag

  Aims To study the effect of adjunctive systemic administration of melatonin to standard mechanical periodontal therapy in obese rats with experimental periodontitis. Materials and methods In 42 Wistar rats with an initial body weight of 180 g., half (n=21) were fed with a high‐fat diet to induce obesity. In both obese and normal‐weight groups, experimental periodontitis was subsequently induced through oral gavages with a combination of Porphyromona gingivalis and Fusobacterium nucleatum. Both groups were randomly allocated to either, no treatment or periodontal treatment consisting on standard mechanical debridement, with either adjunctive chlorhexidine or melatonin. Outcomes were evaluated by the changes in clinical parameters (probing depth modified gingival index, plaque dental index and bleeding on probing), in bone resorption and in the levels of biomarkers in plasma and in gingival tissue (inflammatory cytokines, insulin, leptin, osteocalcin, osteopontin, plasminogen activator inhibitor‐1, intercellular adhesion molecule 1, E‐selectin and lipids). Results In the obese‐periodontitis group, adjunctive melatonin administration resulted in reduced gingival inflammation and bleeding on probing, with significant reductions in probing depth and enhanced bone repair demonstrated by Micro‐CT (15% reduction in alveolar bone destruction) when compared with the same group treated with adjunctive CHX or the normal‐weight rats with either melatonin or CHX. In this melatonin‐treated obese‐periodontitis group, a significant impact on biochemical biomarkers was also demonstrated in both gingival and plasma samples, when compared with the other groups, with significant reductions in pro‐inflammatory cytokines. Conclusions Adjunctive melatonin therapy significantly reduced alveolar bone loss and exerted a protective anti‐inflammatory effect mainly in those experimental animals affected by the co‐morbidity of periodontitis and obesity.

• Brusevold, Ingvild Johnsen; Bie, Thea Martine Granvoll; Baumgartner, Christine Sophie; Das, Runa & Espelid, Ivar (2018). Molar-incisiv misdannelse - beskrivelse og diagnostisk protokoll. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  (7)

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• Arvidsson, Linda Zamoline; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Larheim, Tore (2019). Other Pathologic Conditions of the TMJ. Springer Nature.  ISBN 978331999468-0.  10 s.
• Arvidsson, Linda Zamoline; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Larheim, Tore (2019). High-Grade Inflammatory TMJ Diseases and Traumatic TMJ Conditions. Springer Nature.  ISBN 978-3-319-99468-0.  15 s.
• Larheim, Tore; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Arvidsson, Linda Zamoline (2019). TMJ Disc Disorders and Osteoarthritis. Springer Nature.  ISBN 3319994689.  19 s.

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• Strøm, Kjetil; Willumsen, Tiril & Rønneberg, Anne (2019). Trenger tannleger utdanning i odontologisk psykologi?. Aktuell Nordisk odontologi.  ISSN 1902-3545.  44, s 34- 46 . doi: 10.18261/ISSN.2058-7538-2019-01-04
• Kristensen, Trond Anders; Hovland, Katrine; Birkeland, Kari & Vandevska-Radunovic, Vaska (2018). Third molar eruption after orthodontic treatment wirh and without premolar extraction: A retrospective study.
• Shadnazar, Shervin; Bergman, Axel & Birkeland, Kari (2018). Outcome of orthodontic space-closure and autotransplantation replacing a missing maxillary central incisor..
• Brusevold, Ingvild Johnsen & Espelid, Ivar (2018). Gutt med misdannede tenner. Tidsskrift for Den norske legeforening.  ISSN 0029-2001. . doi: 10.4045
• Klemm, Anne; Haugen, Håvard Jostein & Tiainen, Hanna (2018). Grain boundary corrosion in Sr and Ca doped TiO2 bone scaffold. Vis sammendrag

  Porous TiO2 scaffolds as a bone support structure showed high porosity combined with high compressive strength1. Doping ceramic scaffolds with Ca or Sr leads to even higher compressive strength and formation of impurity rich grain boundaries2. Grain boundary dissolution can occur during bone healing, because of a local pH drop3. To improve the corrosion resistance of cationic doped TiO2 scaffolds, the objective of this study was to investigate the corrosion depending on doping concentration to evaluate corrosion mechanisms.

• Schweikle, Manuel; Bjørnøy, Sindre Hove; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein; Van Helvoort, Antonius; Sikorski, Pawel & Tiainen, Hanna (2018). Self-mineralising synthetic injectable hydrogels for bone repair.
• Blich, Carl Christian (2018). Pengegaloppen. Prioritering av tannhelse i statsbudsjettene.. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(7), s 528- 530
• Grytten, Jostein Ivar (2018). Tannhelseforsikring - en realistisk finansieringsform for tannhelsetjenesten?.
• Grytten, Jostein Ivar (2018). Framtidens tannhelsetjeneste - noen utviklingstrekk.
• Grytten, Jostein Ivar (2018). Tannhelsetjenesten - prioritering og fordeling.
• Grytten, Jostein Ivar (2018). Tannhelsetjenesten - prioritering og fordeling.
• Grytten, Jostein Ivar (2018). Do patients with more education receive more subsidized dental care?.
• de Lange, Thomas; Haugen, Håvard Jostein & Møystad, Anne (2018). Digital Prospects of Formative and Summative Assessment in Dental Education: Technological Opportunities and Challenges. Vis sammendrag

  Abstract: It is a well-known fact that assessment is an important driver for student learning. In the advancement of digital technologies, the question is how digital resources can be used to improve formative and summative assessment in ways that support student learning as well as ensuring knowledge standards for future dental professionals. Two experimental studies on digital assessment have been conducted at the Faculty of Dentistry, University of Oslo. Firstly, digitized formative assessment based on Multiple Choice questionnaires (MCQ) was implemented in testing students’ knowledge from prior parts of their education. Secondly, a pilot-study of a digitized summative assessment in oral radiology was conducted to identify benefits and challenges in applying entirely digital based exams. Results from these experiments are presented and discussed in relation to research on assessment and student learning.

• Trine, Anstorp; Nupen, Åshild Karin & Willumsen, Tiril (2018). Traumesensitiv tannbehandling - hva trengs?, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 15.  s 227 - 248
• Hauge, Mariann Saanum; Storå, Bent Olav & Willumsen, Tiril (2018). Tannlegeadministrert kognitiv atferdsterapi, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 12.  s 179 - 192
• Willumsen, Tiril; Myran, Lena; Hauge, Mariann Saanum & Storå, Bent Olav (2018). Tannbehandlingsangst - tilvenning til tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 11.  s 165 - 178
• Fredriksen, Therese Varvin; Rønneberg, Anne & Johnsen, Ingrid Elevine Berg (2018). Barn på tannklinikken. Normalpsykologisk utvikling og utviklingsstøttende tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 8.  s 121 - 139
• Willumsen, Tiril; Agdal, Maren Gry Lillehaug & Vika, Margrethe Elin (2018). Frykt og angst for tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 6.  s 101 - 113
• Homayouni, Amin; Tashbayev, Behzod; Rusthen, Shermin; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Herlofson, Bente Brokstad; Jensen, Janicke Liaaen & Young, Alix (2018). Can saliva secretion affect oral malodour and oral health-related quality of life?. Vis sammendrag

  The aim of this study was to investigate the relationship between saliva secretion, halitosis and oral health-related quality of life (HRQoL). Informed consent was obtained from 65 participants including 24 patients with primary Sjögren’s Syndrome (pSS, 53±12y), 17 patients with dry eyes and dry mouth not fulfilling the classification for pSS (non-SS-sicca, 53±11y), and 24 healthy controls (49±11y). Unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates were recorded as low (hyposalivation: SWS <0.7 ml/min, UWS <0.1 ml/min) or normal (SWS >0.7 ml/min, UWS >0.1 ml/min). Volatile sulfur compounds (VSC: hydrogen sulphide-H2S, methylmercaptan-CH3SH) in mouth air were measured by gas chromatography. HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Mann-Whitney test was used in data analysis (p<0.05). In general, for UWS, subjects with hyposalivation had significantly higher mean CH3SH-levels than those with normal salivation (27.339.3 vs 9.913.6 ppb). For SWS, subjects with hyposalivation had significantly higher mean H2S-levels (184.5464.8 vs 43.964.1 ppb) and CH3SH-levels (27.237.4 vs 6.58.9 ppb). Within the non-SS patient group, those with hyposalivation had significantly higher H2S-levels than those with normal salivation. In general, there were no significant differences in OHIP-scores based on VSC levels. However, within the non-SS group, those with high H2S-levels (>112 ppb) reported significantly more often that they had “difficulties relaxing due to oral problems”, and that “life has been less satisfactory due to oral problems”, than those with low H2S-levels (<112 ppb). In conclusion, hyposalivation was generally associated with increased levels of oral VSC, indicating oral malodour. Surprisingly, patients with dry eyes and dry mouth who did not fulfill the classification for pSS seemed to be more affected in their daily life than patients who fulfilled the criteria.

• Tiainen, Hanna; Wiedmer, David & Petersen, Fernanda Cristina (2018). Biofilm formation and planktonic growth of S. epidermidis in the presence of phenolic compounds tannic acid and pyrogallol.
• Wiedmer, David; Cui, Chen; Petersen, Fernanda Cristina & Tiainen, Hanna (2018). Antibacterial sol-gel coating for bone scaffolds based on the dark catalytic effect of titanium dioxide.
• Jensen, Janicke Liaaen (2018). Bridging the gap between oral and general health.
• Torgersen, Gerald R.; de Lange, Thomas & Møystad, Anne (2018). Can the use of student created videos enhance learning in oral radiology? Student experiences based on a pilot study.
• Rønneberg, Anne & Willumsen, Tiril (2018). Familievold og omsorgssvikt, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 10.  s 153 - 161
• Herlofson, Bente Brokstad (2018). Medikamentrelatert osteonekrose i kjevene..
• Skaare, Anne B & Willumsen, Tiril (2018). Medication-induced dry mouth in two selected patient groups: A pilot study among general practitioners and dentists based on data collected from electronic patient records. Den norske tannlegeforenings tidende.  ISSN 0029-2303.
• Willumsen, Tiril & Skaare, Anne B (2018). General practitioners and dentists - a pilot project based on data extraction from electronic patient records. Den norske tannlegeforenings tidende.  ISSN 0029-2303.
• Haugen, Håvard Jostein; Reseland, Janne Elin & Gomez-Florit, Manuel (2018). The effect of IDP coated biomaterial.
• Skoglund, Lasse Ansgar (2018). Orofacial smärta. Ett multidisciplinärt omhändertagande (anmeldelse). Den norske tannlegeforenings tidende.  ISSN 0029-2303.  118(10), s 868- 869
• Torper, Jorun; Strøm, Kjetil; Høyvik, Ann Catrin & Willumsen, Tiril (2018). Pasientkommunikasjon, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 3.  s 53 - 71
• Høyvik, Ann Catrin & Woldstad, Marit Irene (2018). Tannbehandling av torturoverlevere, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 16.  s 251 - 260
• Øgaard, Bjørn Andreas (2018, 22. oktober). UiO-forskarar på verdstoppen i siteringar i kjeveortopedi.  Uniforum.
• Nørholt, S.E.; Herlofson, Bente Brokstad; Wexell, Cecilia Larsson; Ehrenstein, V & Schiodt, Morten (2018). The Scandinavisn Osteonecrosis Cohort Stury - Report on 6 years of Research collaboration.
• Tanem, Kristine Eidal; Wilberg, Petter; STENSVOLD, EINAR; Singh, Preet Bano; Skaare, Anne B & Herlofson, Bente Brokstad (2018). Oral late effects and taste function in long-term survivors after treatment of medulloblastoma and supratentorial primitive neuroectodermal tumor during childhood or adolescence - preliminary results.
• Herlofson, Bente Brokstad (2018). Medication-Related Osteonecrosis of the jaw - When to treat non-surgically - Ethics and other dilemmas.
• Herlofson, Bente Brokstad (2018). Update on the Scandinavian MRONJ study.
• Herlofson, Bente Brokstad (2018). Hvilke orale helseutfordringer står munn-og halskreftpasienter overfor etter at kreftbehandlingen er ferdig?.
• Herlofson, Bente Brokstad & Berstad, Johanna Elisabeth Rykke (2018). Munnhulen og kreft.
• Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Saghaug, Elisabeth; Tollisen, Anita; Fjeld, Katrine Gahre; Hove, Lene Hystad; Tallang, Oddveig Utheim; Sundal, Tone & Lerdal, Anners (2018). Rekruttering av pasienter til en klinisk intervensjonsstudie i et Hospice.
• Herlofson, Bente Brokstad (2018). Munnhelse til den palliative pasient.
• Bentele, Horst; Enersen, Morten; Eriksen, Hanne-Merete; Hensten, Arne; Lochner, Vibeke; Lund, Bodil Kristina; Slinde, Ingrid; Teigmo, Bente Olin & Vevelstad, Mildrid Beate (2018). Faglige anbefalinger for smittevern i klinisk odontologisk praksis. [html ]. Vis sammendrag

  Dette dokumentet er en nasjonal anbefaling for smittevern i odontologisk praksis.

• Jensen, Janicke Liaaen (2018). ØNH-nettundervisning: Munntørrhet, implikasjoner for oral helse og livskvalitet.
• Jensen, Janicke Liaaen (2018). Munntørrhetklinikken ved Det odontologiske fakultet Presentasjon for nordiske sjelden-sentre.
• Langeland, Øystein; Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad; Singh, Preet Bano; Rykke, Morten; Aqrawi, Lara Adnan; Chen, Xiangjun; Utheim, Øygunn Aass; Utheim, Tor Paaske; Palm, Øyvind & Jensen, Janicke Liaaen (2018). Comparative Ocular and Oral Findings in Sicca Complex.
• Hynne, Håvard; Tashbayev, Behzod; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad; Rykke, Morten; Aqrawi, Lara Adnan; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Aass, Hans Christian Dalsbotten; Reppe, Sjur; Utheim, Tor Paaske & Jensen, Janicke Liaaen (2018). Evaluation of Dry Eye Disease, Oral Dryness and Inflammatory Cytokines in Primary Sjögren´s Syndrome.
• Jensen, Janicke Liaaen (2018). An interdisciplinary approach, the Norwegain Dry Eye Clinic and The Dry Mouth Clinic.
• Haugen, Håvard Jostein & Ellingsen, Jan Eirik (2018, 30. august). Her skapes fremtidens arbeidsplasser i bioteknologi. [Fagblad].  Apollon. Vis sammendrag

  I det nye laboratoriet Sharelab på Blindern møtes forskere, bedriftsutviklere og investorer. De håper å skape hundrevis av kommersielle arbeidsplasser innen bioteknologi.

• Bjørngaard, Johan Håkon; Nilsen, Sara Marie; Asheim, Andreas; Kaspersen, Silje Lill; Anthun, Kjartan Sarheim; Skarshaug, Lena Janita; Svedahl, Ellen Rabben; Pape, Kristine; Toch-Marquardt, Marlen; Husøy, Sigrid Johanne; Johnsen, Lars Gunnar; Uleberg, Oddvar; Bjørnsen, Lars Petter Bache-Wiig; Dale, Jostein & Næss-Pleym, Lars E. (2018). Sommerseminar om kapasitetspress i helsetjenesten.
• Øgaard, Bjørn Andreas (2018, 08. september). Vil kutte støtte. [Internett].  Dagbladet.

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