Siste publikasjoner

• Singer, Susanne; Amdal, Cecilie Delphin; Hammerlid, Eva; Tomaszewska, Iwona M; Silva, Joaquim Castro; Mehanna, Hisham; Dos Santos, Marcos Antonio; Inhestern, Johanna; Brannan, Christine; Yarom, Noam; Fullerton, Amy; Pinto, Monica; Arraras, Juan I; Kiyota, Naomi; Bonomo, Pierluigi; Sherman, Allen C; Baumann, Ingo; Galalae, Razvan; González, Loreto Fernández; Nicolatou-Galitis, Ourania; Abdel-Hafeez, Zeinab; Raber-Durlacher, Judith; Schmalz, Claudia; Zotti, Paola; Boehm, Andreas; Hofmeister, Dirk; Trivic, Sanja Krejovic; Loo, Suat; Chie, Wei-Chu; Bjordal, Kristin; Herlofson, Bente Brokstad; Gregoire, Vincent & Licitra, Lisa (2019). International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV. Head and Neck.  ISSN 1043-3074. . doi: https://doi.org/10.1002/hed.25609
• Rahmati, Maryam & Mozafari, Masoud (2019). Selective Contribution of Bioactive Glasses to Molecular and Cellular Pathways. ACS biomaterials science & engineering.  ISSN 2373-9878. . doi: 10.1021/acsbiomaterials.8b01078 Vis sammendrag

  Over the past few decades, biomedical scientists and surgeons have given substantial attention to bioactive glasses as promising, long-lasting biomaterials that can make chemical connections with the neighboring hard and soft tissues. Several studies have examined the cellular and molecular responses to bioactive glasses to determine if they are suitable biomaterials for tissue engineering and regenerative medicine. In this regard, different ions and additives have been used recently to induce specific characteristics for selective cellular and molecular responses. This Review briefly describes foreign-body response mechanisms and the role of adsorbed proteins as the key players in starting interactions between cells and biomaterials. It then explains the physicochemical properties of the most common bioactive glasses, which have a significant impact on their cellular and molecular responses. It is expected that, with the development of novel strategies, the physiochemical properties of bioactive glasses can be engineered to precisely control proteins’ adsorption and cellular functions after implantation.

• Marbach, Felix; Rustad, Cecilie; Riess, Angelika; Dukic, Dejan; Hsieh, Tzung-Chien; Jobani, Itanar; Prescott, Trine; Bevot, Andrea; Erger, Florian; Houge, Gunnar; Redfors, Maria; Altmueller, Janine; Stokowy, Tomasz; Gilissen, Christian; Kubisch, Christian; Scarano, Emanuela; Mazzanti, Laura; Fiskerstrand, Torunn v/dødsbo; Krawitz, Peter M.; Lessel, Davor & Netzer, Christian (2019). The discovery of a LEMD2-associated nuclear envelopathy with early progeroid appearance suggests advanced applications for ai-driven facial phenotyping. American Journal of Human Genetics.  ISSN 0002-9297.  104(4), s 749- 757 . doi: 10.1016/j.ajhg.2019.02.021
• Jorde, Rolf; Stunes, Kamilla; Kubiak, Julia Magdalena; Joakimsen, Ragnar Martin; Grimnes, Guri; Thorsby, Per Medbøe & Syversen, Unni (2019). Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency. Bone.  ISSN 8756-3282. . doi: 10.1016/j.bone.2019.04.002
• Rahmati, Maryam & Mozafari, Masoud (2019). Biocompatibility of alumina‐based biomaterials–A review. Journal of Cellular Physiology.  ISSN 0021-9541. . doi: 10.1002/jcp.27292 Vis sammendrag

  In today's medicine world, alumina‐based biomaterials owing to their excellent biomechanical, and biocompatibility properties play a key role in biomedical engineering. However, the literature still suffers from not having a valid database regarding the protein adsorption and subsequently cell responses to these surfaces. Proteins by adsorption on biomaterials surfaces start interpreting the construction and also arranging the biomaterials surfaces into a biological language. Hence, the main concentration of this review is on the protein adsorption and subsequently cell responses to alumina’s surface, which has a wide range biomedical applications, especially in dentistry and orthopedic applications. In the presented review article, the general principles of foreign body response mechanisms, and also the role of adsorbed proteins as key players in starting interactions between cells and alumina‐based biomaterials will be discussed in detail. In addition, the essential physicochemical, and mechanical properties of alumina surfaces which significantly impact on proteins and cells responses as well as the recent studies that have focused on the biocompatibility of alumina will be given. An in depth understanding of how the immune system interacts with the surface of alumina could prove the pivotal importance of the biocompatibility of alumina on its success in tissue engineering after implantation in body.

• Rahmati, Maryam & Mozafari, Masoud (2019). Nano-Immunoengineering: Opportunities and Challenges. Current Opinion in Biomedical Engineering.  ISSN 2468-4511. . doi: 10.1016/j.cobme.2019.02.001 Vis sammendrag

  Over the past few years, with the rapid progress in the field of nano-biotechnology and also increasing concerns regarding nanosafety, suggesting new strategies for modulating the toxicity of nanomaterials has attracted much attentions among biomedical engineering scientists. Recently, designing nanomaterials with high biocompatibility is a great challenge in the biomedicine world. It is crucial to investigate operative approaches for modulating the effects of nanomaterials’ surfaces on the cellular and molecular responses. Unlike many toxicological investigations and chemistry synthesis, the biocompatibility of nanomaterials still remains in its infancy. This short review addresses the current research concerning using nanomaterials in biomedical engineering applications. A general overview of the immunological responses to nanomaterials will be concisely discussed.

• Rahmati, Maryam & Mozafari, Masoud (2019). Biological Response to Carbon-Family Nanomaterials: Interactions at the Nano-Bio Interface. Frontiers in Bioengineering and Biotechnology.  ISSN 2296-4185. . doi: 10.3389/fbioe.2019.00004 Vis sammendrag

  During the last few decades, several studies have suggested that carbon-based nanomaterials, owing to their unique properties, could act as promising candidates in biomedical engineering application. Wide-ranging research efforts have investigated the cellular and molecular responses to carbon-based nanomaterials at the nano-bio interfaces. In addition, a number of surface functionalization strategies have been introduced to improve their safety profile in the biological environment. The present review discusses the general principles of immunological responses to nanomaterials. Then, it explains essential physico-chemical properties of carbon-familynanomaterials, including carbon nanotubes (CNTs), graphene, fullerene, carbon quantum dots (CDs), diamond-like carbon (DLC), and mesoporous carbon biomaterials (MCNs), which significantly affect the immunological cellular and molecular responses at the nano-bio interface. The discussions also briefly highlight the recent studies that critically investigated the cellular and molecular responses to various carbon-based nanomaterials. It is expected that the most recent perspective strategies for improving the biological responses to carbon-based nanomaterials can revolutionize their functions in emerging biological applications.

• Mandal, Emeline; Andersson, Maud Els-Marie; Filip, Charles & Øgaard, Bjørn Andreas (2019). Eighteen-Year Follow-Up of 160 Consecutive Individuals Born With Unilateral Cleft Lip or Cleft Lip and Alveolus Treated by the Oslo Cleft Lip and Palate Team. The Cleft Palate-Craniofacial Journal.  ISSN 1055-6656. . doi: https://doi.org/10.1177%2F1055665618820753
• Zhu, Hao; Xiongfa, Ji; Hanfeng, Guan; Liming, Zhao; Libo, Zhao; Changyu, Liu; Cong, Cai; Weijing, Li; Tenghui, Tao; Reseland, Janne Elin; Haugen, Håvard Jostein & Xiao, Jun (2019). Tantalum Nanoparticles Reinforced Polyetheretherketone Shows Enhanced Bone Formation. Materials Science and Engineering C: Materials for Biological Applications.  ISSN 0928-4931. . doi: 10.1016/j.msec.2019.03.091 Vis sammendrag

  Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the property of PEEK. By adding nanoparticles, fibers, elastic modulus and strength of PEEK can be changed to meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced to modify the properties of PEEK, in which PEEK was reinforced with different contents of tantalum nanoparticles (from 1%wt to 9%wt). Mechanical properties and biological functions (both in vitro and in vivo) were then investigated. The highest elastic modulus and compressive strength were observed in 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization and osteogenesis related gene expression showed preferable results in 3%Ta-PEEK and 5%Ta-PEEK. Improved bone integration was shown in 3%Ta-PEEK and 5%Ta-PEEK in vivo. Above all, enhanced mechanical properties and promoted bone formation were proved for 3%Ta-PEEK and 5%Ta-PEEK compared to others groups both in vivo and in vitro, suggesting that the addition of tantalum nanoparticles modified the osseointegration ability of PEEK. This composite of tantalum and PEEK could have a clinical potential for orthopedic implants.

• Schweikle, Manuel; Bjørnøy, Sindre Hove; Van Helvoort, Antonius; Haugen, Håvard Jostein; Sikorski, Pawel & Tiainen, Hanna (2019). Stabilisation of amorphous calcium phosphate in polyethylene glycol hydrogels. Acta Biomaterialia.  ISSN 1742-7061. . doi: https://doi.org/10.1016/j.actbio.2019.03.044 Vis sammendrag

  Acellular polymer-calcium phosphate composites are promising bone graft materials. Hydrogels are suitable for providing a temporary matrix, while calcium phosphate minerals serve as ion depots for calcium and phosphate required for de novo bone formation. Crystalline calcium phosphates are stable under biological conditions and are commonly used in such scaffolds. However, the low solubility of these phases reduces the availability of free ions and potentially obstructs the remodelling necessary for the formation of mineralised tissue. Here, we investigate two different strategies to stabilise amorphous calcium phosphates in a synthetic polyethylene glycol-based hydrogel matrix. In vitro experiments mimicking an injectable application showed that amorphous calcium phosphate (ACP) of variable stability was formed in the hydrogel matrices. In additive-free composites, ACP transformed into brushite within minutes. Citrate or zinc additives were found to stabilise the formed ACP phase to different degrees. In the presence of citrate, ACP was stable for at least 2 h before it transformed into hydroxyapatite within 3–20 days. Partial calcium substitution with zinc (Zn/Ca = 10%) produced zinc-doped ACP of high stability that did not show signs of crystallisation for at least 20 days. The presented methods and findings open new possibilities for the design of novel injectable synthetic bone graft materials. The possibility to produce ACP with tailorable stability promises great potential for creating temporary scaffolds with good osteogenic properties. Statement of significance Synthetic hydrogel-calcium phosphate (CaP) composites are promising biomaterials to replace human- and animal-derived bone scaffolds. Most reported hydrogel-CaP composite materials employ crystalline CaP phases that lack the osteoinductive properties of autograft. Stabilising amorphous calcium phosphates (ACP) could overcome this limitation, readily delivering calcium and phosphate ions and facilitating remodelling into new bone tissue. The design of synthetic hydrogel-ACP scaffolds, however, requires more understanding of the mineralisation processes in such matrices. This study presents a model system to characterise the complex mineral formation and transformation processes within a hydrogel matrix. We demonstrate a facile route to produce self-mineralising injectable synthetic hydrogels and prove two different strategies to stabilise ACP for different periods within the formed composites.

• Henriksson, Ingrid Christina Heuck; Andersson, Els-Marie & Møystad, Anne (2019). Hypodontia and retention of third molars in Norwegian medieval skeletons: dental radiography in osteoarchaeology. Acta Odontologica Scandinavica.  ISSN 0001-6357.  s 1- 5 . doi: 10.1080/00016357.2018.1549749
• Mann, Vivek; Grimm, Daniela; Corydon, Thomas J.; Krüger, Marcus; Wehland, Markus; Riwaldt, Stefan; Sahana, Jayashree; Kopp, Sascha; Bauer, Johan; Reseland, Janne Elin; Infanger, Manfred; Lian, Aina Mari; Okoro, Elvis & Sundaresan, Alamelu (2019). Influence of Simulated Microgravity on Growth of Human Fetal Osteoblasts and Characterization of the Derived Three Dimensional Bone Construct.. International Journal of Molecular Sciences.  ISSN 1422-0067.  30(6) . doi: 10.3390/ijms20061357
• Bergstrand, Sara; Ingstad, Hanne Kleven; Møystad, Anne & Bjørnland, Tore (2019). Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint osteoarthritis. Journal of Oral Science.  ISSN 1343-4934.  61(1), s 82- 88 . doi: 10.2334/josnusd.17-0423
• Weber, Florian; Barrantes Bautista, Alejandro & Tiainen, Hanna (2019). Silicic acid mediated formation of tannic acid nanocoatings. Langmuir.  ISSN 0743-7463.  35, s 3327- 3336 . doi: 10.1021/acs.langmuir.8b04208
• Skjerven, Henrik; Riis, Ulf Harald; Herlofson, Bente Brokstad & Ellingsen, Jan Eirik (2019). In Vivo Accuracy of Implant Placement Using a Full Digital Planning Modality and Stereolithographic Guides. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(1), s 124- 132
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2019). Factors Associated with Oral Implant Failures. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  34(1), s 17- 21
• Stoustrup, Peter; Resnick, Cory M; Pedersen, T; Abramowicz, Shelly; Michelotti, A; Küseler, Annelise; Verna, Carlalberta; Kellenberger, Christian J.; berit, nordahl; Jankovska, I; Caserta, G; Halbig, Josefine Mareile; Kristensen, Kasper Dahl; Arvidsson, Linda Zamoline; Spiegel, L; Stoll, M L; Lerman, M; Glerup, Mia; Defabianis, P; Frid, Paula Hanna Therese; Alstergren, Per; Cron, Randy Q.; Ringold, Sarah; Nørholt, S.E.; Peltomäki, Timo; Herlin, T; Peacock, Z S & Twilt, Marinka (2019). Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations.. J Rheumatol..  ISSN 1480-3666. . doi: doi.org/10.3899/jrheum.180785
• Ottersen, Margareth Kristensen; Abrahamsson, Anna-Karin; Larheim, Tore & Arvidsson, Linda Zamoline (2019). CBCT characteristics and interpretation challenges of temporomandibular joint osteoarthritis in a hand osteoarthritis cohort.. Dentomaxillofacial Radiology.  ISSN 0250-832X.  48 . doi: 10.1259/dmfr.20180245
• Singh, Preet Bano; Young, Alix; Homayouni, Amin; Hystad Hove, Lene; Petrovski, Beata Eva; Herlofson, Bente Brokstad; Palm, Øyvind; Rykke, Morten & Jensen, Janicke Liaaen (2019). Distorted Taste and Impaired Oral Health May Affect Nutritional Status in Patients with Sicca Complaints. Nutrients.  ISSN 2072-6643.  11(264) . doi: 10.3390/nu11020264
• Saltnes, Solfrid Sørgjerd; Geirdal, Amy Østertun; Sæves, Rønnaug Ingun; Jensen, Janicke Liaaen & Nordgarden, Hilde (2019). Experiences of daily life and oral rehabilitation in oligodontia - a qualitative study.. Acta Odontologica Scandinavica.  ISSN 0001-6357. . doi: 10.1080/00016357.2018.1535137
• Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Rossi, Filippo & Perale, Giuseppe (2019). Bone grafts: which is the ideal biomaterial?. Journal of Clinical Periodontology.  ISSN 0303-6979. . doi: 10.1111/jcpe.13058 Vis sammendrag

  Abstract Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio‐maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future Aim Within this narrative review, we discuss possible future biomaterials for bone replacement. Scientific Rationale for Study Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Laboratory studies tend to focus on advanced production methods and novel biomaterial features, which can be costly to produce. Practical Implications In this review, we ask why such a limited number of BGs are clinically available when compared to extensive laboratory studies. We also discuss what features are needed for an ideal BG. Results We have identified the key properties of current bone substitutes and have provided important information to guide clinical decision‐making and generate new perspectives on bone substitutes. Our results indicated that different mechanical and biological properties are needed despite each having a broad spectrum of variations. Conclusions We foresee bone replacement composite materials with higher levels of bioactivity, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.

• Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein; Rinna, Alessandra; Ellingsen, Jan Eirik & Reseland, Janne Elin (2019). Hydrofluoric acid treatment of titanium surfaces enhance the proliferation of human gingival fibroblasts. Journal of Tissue Engineering.  ISSN 2041-7314. . doi: 10.1177/2041731419828950 Vis sammendrag

  The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts (HGF). HGF cells were exposed to hydrofluoric acid (HF) modified Ti coins (Ti-F) for 1, 3, 7, 14 and 21d, and untreated coins were used as controls. A 5-6 fold increase in the proliferation of HGF on Ti-F compared to Ti surfaces was observed. Enhanced gene expression of IL-6 and OPG was found at 7 d. Increased levels of sclerostin, IL- 6 and OPG in the media from HGF cultured on Ti-F coins were found compared to controls. Our results confirm that HF modified surface may indirectly enhance the firm attachment of implant surface to junction epithelium, soft tissue epithelium, which would give protection for underlying osseous structures making osseointegration of the dental implant possible.

• Klemm, Anne; Gomez-Florit, Manuel; Carvalho, Patricia A.; Wachendörfer, Mattis; Gomes, Manuela E.; Haugen, Håvard Jostein & Tiainen, Hanna (2019). Grain boundary corrosion in TiO2 bone scaffolds doped with group II cations. Journal of the European Ceramic Society.  ISSN 0955-2219.  39, s 1577- 1585 . doi: 10.1016/j.jeurceramsoc.2018.12.055
• Wigen, Tove Irene; Winsnes, Karianne Ervik; Varatharajan, Rahavy & Wang, Nina Johanne (2019). Kariesforebyggende arbeid på helsestasjon. Den norske tannlegeforenings tidende.  ISSN 0029-2303.
• Løken, Sonja Yr; Wigen, Tove Irene & Wang, Nina Johanne (2019). Recall intervals in children are individualized and extended. Acta Odontologica Scandinavica.  ISSN 0001-6357.
• Skalleberg, Natalie Sharim; Xianbin, Yang; Babaie, Eshrat; Crystal, John Michael; Geronimo, Benedicto Abrigos; Reseland, Janne Elin; Osmundsen, Harald & Landin, Maria Augusta Dos S Silva (2019). Effects of miR-214 knockout on 214/199 cluster expression levels during mineralization of the first murine molar. PLoS biology.  ISSN 1544-9173. Vis sammendrag

  The objectives of this study were to investigate the effects induced on the 214/199 cluster and consequently murine miRNome while miR-214 was temporarily knocked out on the first murine molar. Endogenous expression of individual microRNAs (miRNAs) of 214/199 cluster during mineralization stages was also mapped. Nucleotide alignment of miR-214 mature sequence and comparative genomics was used to find target genes for this miR during mineralization of the first murine molar. The effects of temporary knockdown of miR-214 were induced by in vivo transfection with antagomir-214 in situ at the first murine molar. The expression levels of microRNAs (miRs) were measured by real-time reverse transcription polymerase chain reaction (real-time RT-PCR) from the day of birth (P0) up to post-natal day 14 (P14). The effects of in vivo transfection with the antagomir on the mouse miRNome was assayed using oligonucleotide miRNA arrays. The levels of mRNA expression of target genes regulated, directly or indirectly, by the 214/199 cluster were measured using deoxyoligonucleotide microarrays. RT-PCR results after In vivo transfection with antagomir-214 suggest that temporarily knockout of miR-214 induces opposite responses on the levels of expression of miR-199-5p and miR-199-3p. Resulting endogenous expression levels of individual microRNAs of the cluster 214/199 suggest that miR-199-3p follows the same expression pattern as miR-214 throughout: the late bell stages (P0-P2), tooth mineralization (P3-P9) and up to tooth eruption (P14). The Bioinformatics analysis results, of murine miRNome affected by in vivo transfection with antagomir-214, suggested that downregulated miRNAs were significantly associated with cell cycle and cell proliferation. Reciprocally, upregulated miRs were significantly associated with organ development, cell death and /or cell survival. Results from nucleotide alignment of miR-214 mature sequence and comparative genomics suggested; glutamate metabotrophic reseptor 5 (Grm5), laminin beta 3(Lamb3), bromodomain containing 2 (Brd2), suppressor of cytokine signaling 7 (Socs7), methyl transferase homolog 1(Hen1), Re1- silencing transcription factor.

• Rahmati, Maryam; Pennisi, Cristian pablo; Mobasheri, Ali & Mozafari, Masoud (2018). Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine, In Kursad Turksen (ed.),  Cell Biology and Translational Medicine, Volume 3.  Springer Nature.  ISBN 978-3-030-04185-4.  5. Vis sammendrag

  Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

• Rahmati, Maryam; Pennisi, Cristian pablo; Mobasheri, Ali & Mozafari, Masoud (2018). Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends, In Kursad Turksen (ed.),  Cell Biology and Translational Medicine, Volume 4.  Springer Nature.  ISBN 978-3-030-10486-3.  1. Vis sammendrag

  Biomaterials are key components in tissue engineering and regenerative medicine applications, with the intended purpose of reducing the burden of disease and enhancing the quality of life of a large number of patients. The success of many regenerative medicine strategies, such as cell-based therapies, artificial organs, and engineered living tissues, is highly dependent on the ability to design or produce suitable biomaterials that can support and guide cells during tissue healing and remodelling processes. This chapter presents an overview about basic research concerning the use of different biomaterials for tissue engineering and regenerative medicine applications. Starting from a historical perspective, the chapter introduces the basic principles of designing biomaterials for tissue regeneration approaches. The main focus is set on describing the main classes of biomaterials that have been applied in regenerative medicine, including natural and synthetic polymers, bioactive ceramics, and composites. For each class of biomaterials, some of the most important physicochemical and biological properties are presented. Finally, some challenges and concerns that remain in this field are presented and discussed.

• Sefat, Farshid; Raja, Tehmeena israr; Zafar, Muhammad sohail; Khurshid, Zohaib; Najeeb, Shariq; Zohaib, Sana; Ahmadi, Ehsaneh daghigh; Rahmati, Maryam & Mozafari, Masoud (2018). Nanoengineered biomaterials for cartilage repair, In Masoud Mozafari; Jayakumar Rajadas & David l Kaplan (ed.),  Nanoengineered Biomaterials for Regenerative Medicine.  Elsevier.  ISBN 9780128133569.  3. Vis sammendrag

  Cartilage disorders are among the primary causes of severe joint pain, physical disability, and quality of life impairments in the world's aging population. Although many approaches have been suggested for treating cartilage diseases, these approaches generally have acted only as painkillers and have failed to completely cure the disorders. Consequently, tissue engineering and biomaterial approaches aimed at cartilage regeneration have gained a great deal of attention among scientists. Several studies have reported positive results when using different kinds of 3D scaffolds for cartilage regeneration, such as polymeric-based scaffolds. In addition, recent nanotechnological developments have offered potential opportunities to greatly improve the properties of tissue-engineered scaffolds. Nanoscience approaches are focused on suggesting some novel substitutes that could more precisely mimic the ECM conditions of natural cartilage. This chapter serves as an introduction to the key factors related to cartilage tissue, including its anatomy, histology, and physiology, that biomaterials scientists need to take into account to successfully mimic the ECM of cartilage tissue. In addition, the progress of biomaterials and tissue engineering in this tissue will be discussed. The discussion will then emphasize the nanotechnological strategies, advancements, and drawbacks involved in cartilage regeneration.

• Rahmati, Maryam & Mozafari, Masoud (2018). Protein adsorption on polymers. Materials Today Communications.  ISSN 2352-4928. . doi: 10.1016/j.mtcomm.2018.10.024 Vis sammendrag

  Although a promising progress has been recently accomplished in polymer science, cell biology, immunology and biotechnology, the biocompatibility of biomaterials still remains a critical issue to address. At present, some polymeric biomaterials are still encountering with the difficulty of foreign body responses (FBRs) including blood–material interactions, inflammation, and immune system responses. It has been widely reported that controlling the physiochemical properties of biomaterials could potentially lead to having a precise control over the kind, quantity, conformation, and duration of adsorbed proteins onto the polymer’s surface. It has been well accepted that the interactions between biomaterials and immune cells could be to a great extent controlled through regulating the protein adsorption mechanism. In this review, the role of adsorbed proteins, as important players in the initiation of interactions between cells and polymers, will be discussed in detail. Furthermore, the critical physicochemical properties of the polymer’s surface which significantly impact on the functions of proteins and cells will be given. The discussion will then address the recent contradicting reports, for which a range of engineering solutions have been suggested. There are promising ways for controlling the proteins adsorption and subsequent cellular responses to polymeric biomaterials.

• Rahmati, Maryam & Mozafari, Masoud (2018). A critical review on the cellular and molecular interactions at the interface of zirconia-based biomaterials. Ceramics International.  ISSN 0272-8842. . doi: 10.1016/j.ceramint.2018.06.196 Vis sammendrag

  In the past few years, zirconia has gained a great attention among biomedical scientists due to its extraordinary strength and fracture toughness, negligible thermal conductivity, good biocompatibility and chemical inertness. In this regard, there is still room for the manipulation of zirconia-based biomaterials regarding the protein adsorption and subsequently cell responses to the surface. Protein adsorption on biomaterials surfaces start interpreting the construction and also arranging the surface characteristics into a biological language. In this review, the role of adsorbed proteins as key players in starting interactions between cells and zirconia-based biomaterials will be discussed in detail. The discussion will then highlight discussions on the implementation of innovative strategies to engineer the physiochemical properties of this class of biomaterials. It is expected that these promising solutions can better control proteins adsorption and cellular functions after implantation in the body.

• Vecchio, Federica; Lo Buono, Nicola; Stabilini, Angela; Nigi, Laura; Dufort, Matthew J.; Geyer, Susan; Rancoita, Paola Maria; Cugnata, Federica; Mandelli, Alessandra; Valle, Andrea; Leete, Pia; Mancarella, Francesca; Linsley, Peter S.; Krogvold, Lars; Herold, Kevan C.; Larsson, Helena Elding; Richardson, Sarah J.; Morgan, Noel G.; Dahl-Jørgensen, Knut; Sebastiani, Guido; Dotta, Francesco; Bosi, Emanuele & Battaglia, Manuela (2018). Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes. JCI Insight.  ISSN 2379-3708.  3(18), s 1- 17 . doi: 10.1172/jci.insight.122146
• Bardakci, Ayse Gul; Haydari, Maliha; Koldsland, Odd Carsten; Aass, Anne Merete; Sandvik, Leiv & Preus, Hans Ragnar (2018). Sammenligning av effekten av 0,06%, 0,12% og 0,2% klorheksidin på plakk, blødning og bivirkninger i en eksperimentell gingivittmodell : en dobbeltblind, randomisert klinisk studie. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(8), s 584- 590
• Marroquin, Talia Yolanda; Karkhanis, Shalmira; Kvaal, Sigrid Ingeborg; Kruger, Estie & Tennant, Marc (2018). Overcoming population differences for dental age estimation in adults through pulp/tooth volume calculations: a pilot study. Australian Journal of Forensic Sciences.  ISSN 0045-0618. . doi: 10.1080/00450618.2018.1554089
• Møller, Elise Lindland; Lien, Oda Bergjordet & Dahl, Jon Einar (2018). Peroksidfrie tannblekemidler. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(10), s 772- 777 Vis sammendrag

  Stadig oftere møter vi som tannleger pasienter med spørsmål vedrørende ekstern tannbleking. Pasientene ønsker anbefalinger for hva slags blekemiddel de bør velge, og mener med dette hvilken type som gir lysest og mest holdbart resultat. Blekemidler basert på hydrogenperoksid eller karbamidperoksid skal utelukkende selges via tannlege. De peroksidfrie blekemidlene kan imidlertid selges fritt. Med denne studien ønsket vi å se på forskjellen i effekt mellom de to typene tannbleking, peroksidholdig vs. peroksidfri tannbleking, slik at vi blir bedre rustet til å gi råd til våre pasienter. Vi utførte en laboratoriestudie, hvor det ble foretatt bleking av ekstraherte tenner, for å finne forskjell i lysning mellom peroksidholdige og peroksidfrie blekemidler. Det ble foretatt målinger før bleking, rett etter bleking og åtte måneder etter. Fargen til tennene ble avlest i en lysboks, ved hjelp av en Vita Lumin-Vacuum fargeskala. De to operatørene leste av resultatene uavhengig av hverandre, og sammenliknet til slutt resultatene. Vi fant at peroksidfrie produkter kan gi en umiddelbar lysning av tannen på grunn av endret lysbrytning ved at produktene inneholder syrer som etser tannoverflaten. Effekten var imidlertid ikke langvarig i motsetning til peroksidholdige blekemidler.

• Peanchitlertkajorn, Supakit; Mercado, Ana; Daskalogiannakis, John; Hathaway, Ronald; Russell, Kathleen; Semb, Gunvor; Shaw, William; Lamichane, Manish; Cohen, Marilyn & Long, Ross E. (2018). An Intercenter Comparison of Nasolabial Appearance Including a Center Using Nasoalveolar Molding. The Cleft Palate-Craniofacial Journal.  ISSN 1055-6656.  55(5), s 655- 663 . doi: 10.1177/1055665618754947
• Peanchitlertkajorn, Supakit; Mercado, Ana; Daskalogiannakis, John; Hathaway, Ronald; Russell, Kathleen; Semb, Gunvor; Shaw, William; Lamichane, Manish; Fessler, Jennifer & Long, Ross E. (2018). An Intercenter Comparison of Dental Arch Relationships and Craniofacial Form Including a Center Using Nasoalveolar Molding. The Cleft Palate-Craniofacial Journal.  ISSN 1055-6656.  55(6), s 821- 829 . doi: 10.1597/16-018
• Sailer, Irena; Muhlemann, Sven; Kohal, Ralf J.; Spies, Benedikt C.; Pjetursson, Bjarni E.; Lang, Niklaus P.; Gotfredsen, Klaus L.; Ellingsen, Jan Eirik; Francisco, Helena; Özcan, Mutlu; Hassan, Bassam; Pardo, Guillem E.; Bardaji, Javier A.; Kraus, Riccardo D. & Wennerberg, Ann (2018). Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018. Clinical Oral Implants Research.  ISSN 0905-7161.  29(Oct), s 239- 242 . doi: 10.1111/clr.13302
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Complications With Zygomatic Implant Treatment. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(6), s 1193- 1197
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy; Ellingsen, Jan Eirik & Chvartszaid, David (2018). Use of Oral Implants for Cancer Reconstruction: The Role of the Approach to Vascular Flaps in Implant Outcomes. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(5), s 959- 961
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Dental Implant Treatment of Atrophic Arches With or Without Augmentation. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(4), s 735- 739
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Osswald, Martin & Stanford, Clark (2018). The Implant-Abutment-Soft Tissue Interface: Change is Hard!. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(3), s 497- 500
• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas; Osswald, Martin & Stanford, Clark (2018). Considerations for Implant-Supported Cemented Restorations. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(2), s 253- 256
• Stanford, Clark; Chvartszaid, David; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Oates, Thomas; Estafanous, Emad & Osswald, Martin (2018). Implant-Retained Removable Partial Dentures: A Reliable Alternative Line of Treatment. International Journal of Oral & Maxillofacial Implants.  ISSN 0882-2786.  33(1), s 17- 20
• Adil, Muhammed Yasin; Xiao, Jiaxin; Olafsson, Jonatan; Chen, Xiangjun; Lagali, Neil; Ræder, Sten; Utheim, Øygunn Aass; Dartt, Darlene A. & Utheim, Tor Paaske (2018). Meibomian Gland Morphology is a Sensitive Early Indicator of Meibomian Gland Dysfunction. American Journal of Ophthalmology.  ISSN 0002-9394.  200, s 16- 25 . doi: 10.1016/j.ajo.2018.12.006 Vis sammendrag

  Purpose To investigate the relationship between meibomian gland (MG) morphology and clinical dry eye tests in patients with meibomian gland dysfunction (MGD). Design Cross-sectional study. Subjects Total 538 MGD patients and 21 healthy controls. Methods MG loss on meibography images of upper (UL) and lower lids (LL) was graded on a scale of 0 (lowest degree of MG loss) to 3. MG length, thickness, and interglandular space in the UL were measured. Clinical tests included meibum expression and quality, tear film break-up time, ocular staining, osmolarity, Schirmer I, blink interval timing, and Ocular Surface Disease Index (OSDI) questionnaire. Results Mean UL and LL meibogrades were significantly higher in MGD patients compared to controls (P < .001 for UL and LL). The sensitivity and specificity of the meibograde as a diagnostic parameter for MGD was 96.7% and 85%, respectively. Schirmer I was significantly increased in MGD patients with meibograde 1 compared to patients with meibograde 0, 2, and 3 in the UL (P < .05). MG thickness increased with higher meibograde (P < .001). MG morphology correlated significantly but weakly with several clinical parameters (P < .05). OSDI did not correlate with any MG morphologic parameter. Conclusions Grading of MG loss using meibograde effectively diagnoses MGD. Compensatory mechanisms such as increased aqueous tear production and dilation of MGs make early detection of MGD difficult by standard clinical measures of dry eye, whereas morphologic analysis of MGs reveals an early stage of MGD, and therefore represents a complementary clinical parameter with diagnostic potential.

• Jacobsen, Ioanna Dallari; Crossner, Claes-Göran; Eriksen, Harald; Espelid, Ivar & Ullbro, Arne Christer (2018). Need of non-operative caries treatment in 16-year-olds from Northern Norway. European Archives of Paediatric Dentistry.  ISSN 1818-6300. . doi: 10.1007/s40368-018-0387-z Fulltekst i vitenarkiv.
• Fardal, Øystein; Grytten, Jostein Ivar; Martin, John; Ellingsen, Stig; Fardal, Patrick; Heasman, Peter & Linden, G.J. (2018). Adding smoking to the Fardal model of cost‐effectiveness for the lifetime treatment of periodontal diseases. Journal of Periodontology.  ISSN 0022-3492.  89(11), s 1283- 1289 . doi: 10.1002/JPER.17-0467
• Córdoba, Alba; Manzanaro-Moreno, Nahuel; Colom, Carme; Rønold, Hans Jacob; Lyngstadaas, Ståle Petter; Monjo, Marta & Ramis, Joana M. (2018). Quercitrin Nanocoated Implant Surfaces Reduce Osteoclast Activity In Vitro and In Vivo. International Journal of Molecular Sciences.  ISSN 1422-0067.  19(11) . doi: 10.3390/ijms19113319 Fulltekst i vitenarkiv.
• Stakkestad, Øystein; Heyward, Catherine Anne; Lyngstadaas, Ståle Petter; Medin, Tirill; Vondrasek, Jiri; Lian, Aina-Mari; Pezeshki, Gita & Reseland, Janne Elin (2018). An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon.  ISSN 2405-8440.  4(12) . doi: 10.1016/j.heliyon.2018.e01075
• Øyri, Hauk Furnes; Jonsdottir, Olga Hrønn; Jensen, Janicke Liaaen & Bjørnland, Tore (2018). The use of a tetracycline drain reduces alveolar osteitis: a randomized prospective trial of third molar surgery under local anaesthetics and without the use of systemic antibiotics. Oral surgery, oral medicine, oral pathology and oral radiology.  ISSN 2212-4403. . doi: 10.1016/j.oooo.2018.12.004
• Bossard, Cedric; Granel, Henri; Jallot, Édouard; Vial, Christophe; Tiainen, Hanna; Wittrant, Yohann & Lao, Jonathan (2018). Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration. Biomedical Glasses.  ISSN 2299-3932.  4, s 108- 122 . doi: 10.1515/bglass-2018-0010
• Nermo, Hege; Willumsen, Tiril & Johnsen, Jan-Are Kolset (2018). Changes in dental anxiety among 15‐ to 21‐year‐olds. A 2‐year longitudinal analysis based on the Tromsø study: Fit futures. Community Dentistry and Oral Epidemiology.  ISSN 0301-5661.  s 1- 7 . doi: 10.1111/cdoe.12434 Fulltekst i vitenarkiv.
• Høyvik, Ann Catrin; Lie, Birgit & Willumsen, Tiril (2018). Dental anxiety in relation to torture experiences and symptoms of post-traumatic stress disorder. European Journal of Oral Sciences.  ISSN 0909-8836.  s 65- 71 . doi: 10.1111/eos.12592
• Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd; Utheim, Øygunn Aass; Palm, Øyvind; Tashbayev, Behzod; Utheim, Tor Paaske & Galtung, Hilde (2018). Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome. PLoS ONE.  ISSN 1932-6203.  13:e0205762(10), s 1- 14 . doi: 10.1371/journal.pone.0205762
• Hallmer, Fredrik; Anderson, Gunilla; Gotrick, Bengt; Warfvinge, Gunnar; Anderud, Jonas & Bjørnland, Tore (2018). Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw?a 4-year prospective study. Oral surgery, oral medicine, oral pathology and oral radiology.  ISSN 2212-4403.  s 1- 9 . doi: 10.1016/j.oooo.2018.08.015
• Zhang, Xianbin; Gong, He; Fan, Ruoxun & Fang, Juan (2018). Comparative Study between Bone Tissue Engineering Scaffolds with Bull and Rat Cancellous Microarchitectures on Tissue Differentiations of Bone Marrow Stromal Cells: A Numerical Investigation. Journal of Bionic Engineering.  ISSN 1672-6529.  15(5), s 924- 938 . doi: 10.1007/s42235-018-0079-8

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• Arvidsson, Linda Zamoline; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Larheim, Tore (2019). Other Pathologic Conditions of the TMJ. Springer Nature.  ISBN 978331999468-0.  10 s.
• Arvidsson, Linda Zamoline; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Larheim, Tore (2019). High-Grade Inflammatory TMJ Diseases and Traumatic TMJ Conditions. Springer Nature.  ISBN 978-3-319-99468-0.  15 s.
• Larheim, Tore; Knutsen, Bjørn Mork; Hol, Caroline; Abrahamsson, Anna-Karin; Ottersen, Margareth Kristensen & Arvidsson, Linda Zamoline (2019). TMJ Disc Disorders and Osteoarthritis. Springer Nature.  ISBN 3319994689.  19 s.

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• Tanzi, Maria Cristina; gantz, daniel; Bertoldi, Serena; negrini, Nicola Contessi & Haugen, Håvard Jostein (2019). FUNCTIONALIZED POLYURETHANE FOAMS AS TISSUE SCAFFOLDS WITH ENHANCED CELLULAR RESPONSE. Vis sammendrag

  Recentadvancementsintissueengineeringrequirethedevelopmentoftailoredscaffoldswithphysicochemicalcuesabletopromotespecificandpositiveresponsesoncellsofthetargettissue • Biomedicalpolyurethanes(PU)exhibitgoodresilienceandfatiguestrength,goodcytoandhemocompatibilityandlowbacteriaadhesion;PUfoamscanbedesignedassuitablescaffoldsintissueengineering[1-3] • The diamino-diamide diolPIME (figure)canform stable complexes with heparin, due to the protonation of its tertiary amino groups at a physiological pH, has excellent cytocompatibility and can promote cells adhesion and proliferation on linear PUs containing

• Skoglund, Lasse Ansgar & Vigen, Ellen Christine (2019). Medisinske gassprodukter, slik som oksygen og lystgass i odontologisk praksis. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  129(4), s 354- 356
• Fjeld, Katrine Gahre; Hove, Lene Hystad; Bargbidi, Mitra; Abrahamsen, Siren & Heggestad, Anne Kari Tolo (2019). Eldre som ikke koopererer-etiske aspekter. Aktuell Nordisk odontologi.  ISSN 1902-3545.
• Bremnes, Alexander & Ween, Borgny (2019). Optimisation of shunt radiography.
• Strøm, Kjetil; Willumsen, Tiril & Rønneberg, Anne (2019). Trenger tannleger utdanning i odontologisk psykologi?. Aktuell Nordisk odontologi.  ISSN 1902-3545.  44, s 34- 46 . doi: 10.18261/ISSN.2058-7538-2019-01-04
• Pihlstrom, Bruce L; Hodges, James S; Michalowicz, Bryan S.; Wohlfahrt, Johan Caspar & Garcia, Raul I (2018). Authors' response. The Journal of the American Dental Association (1939).  ISSN 0002-8177.  149(9), s 751- 752 . doi: 10.1016/j.adaj.2018.07.010
• Rosvold, Elin Olaug; Svensberg, Karin; Kalleberg, Birgitte; Mathiesen, Liv; Hellesø, Ragnhild & Hove, Lene Hystad (2018). SamPraks Research Project at UiO.
• Kristensen, Trond Anders; Hovland, Katrine; Birkeland, Kari & Vandevska-Radunovic, Vaska (2018). Third molar eruption after orthodontic treatment wirh and without premolar extraction: A retrospective study.
• Shadnazar, Shervin; Bergman, Axel & Birkeland, Kari (2018). Outcome of orthodontic space-closure and autotransplantation replacing a missing maxillary central incisor..
• Brusevold, Ingvild Johnsen & Espelid, Ivar (2018). Gutt med misdannede tenner. Tidsskrift for Den norske legeforening.  ISSN 0029-2001. . doi: 10.4045
• Klemm, Anne; Haugen, Håvard Jostein & Tiainen, Hanna (2018). Grain boundary corrosion in Sr and Ca doped TiO2 bone scaffold. Vis sammendrag

  Porous TiO2 scaffolds as a bone support structure showed high porosity combined with high compressive strength1. Doping ceramic scaffolds with Ca or Sr leads to even higher compressive strength and formation of impurity rich grain boundaries2. Grain boundary dissolution can occur during bone healing, because of a local pH drop3. To improve the corrosion resistance of cationic doped TiO2 scaffolds, the objective of this study was to investigate the corrosion depending on doping concentration to evaluate corrosion mechanisms.

• Schweikle, Manuel; Bjørnøy, Sindre Hove; Lyngstadaas, Ståle Petter; Haugen, Håvard Jostein; Van Helvoort, Antonius; Sikorski, Pawel & Tiainen, Hanna (2018). Self-mineralising synthetic injectable hydrogels for bone repair.
• Blich, Carl Christian (2018). Pengegaloppen. Prioritering av tannhelse i statsbudsjettene.. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(7), s 528- 530
• Grytten, Jostein Ivar (2018). Tannhelseforsikring - en realistisk finansieringsform for tannhelsetjenesten?.
• Grytten, Jostein Ivar (2018). Framtidens tannhelsetjeneste - noen utviklingstrekk.
• Grytten, Jostein Ivar (2018). Tannhelsetjenesten - prioritering og fordeling.
• Grytten, Jostein Ivar (2018). Tannhelsetjenesten - prioritering og fordeling.
• Grytten, Jostein Ivar (2018). Do patients with more education receive more subsidized dental care?.
• de Lange, Thomas; Haugen, Håvard Jostein & Møystad, Anne (2018). Digital Prospects of Formative and Summative Assessment in Dental Education: Technological Opportunities and Challenges. Vis sammendrag

  Abstract: It is a well-known fact that assessment is an important driver for student learning. In the advancement of digital technologies, the question is how digital resources can be used to improve formative and summative assessment in ways that support student learning as well as ensuring knowledge standards for future dental professionals. Two experimental studies on digital assessment have been conducted at the Faculty of Dentistry, University of Oslo. Firstly, digitized formative assessment based on Multiple Choice questionnaires (MCQ) was implemented in testing students’ knowledge from prior parts of their education. Secondly, a pilot-study of a digitized summative assessment in oral radiology was conducted to identify benefits and challenges in applying entirely digital based exams. Results from these experiments are presented and discussed in relation to research on assessment and student learning.

• Trine, Anstorp; Nupen, Åshild Karin & Willumsen, Tiril (2018). Traumesensitiv tannbehandling - hva trengs?, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 15.  s 227 - 248
• Hauge, Mariann Saanum; Storå, Bent Olav & Willumsen, Tiril (2018). Tannlegeadministrert kognitiv atferdsterapi, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 12.  s 179 - 192
• Willumsen, Tiril; Myran, Lena; Hauge, Mariann Saanum & Storå, Bent Olav (2018). Tannbehandlingsangst - tilvenning til tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 11.  s 165 - 178
• Fredriksen, Therese Varvin; Rønneberg, Anne & Johnsen, Ingrid Elevine Berg (2018). Barn på tannklinikken. Normalpsykologisk utvikling og utviklingsstøttende tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 8.  s 121 - 139
• Willumsen, Tiril; Agdal, Maren Gry Lillehaug & Vika, Margrethe Elin (2018). Frykt og angst for tannbehandling, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 6.  s 101 - 113
• Norton, Inghild; Valør, Liv Oddrun; Koldsland, Odd Carsten; Aass, Anne Merete; Grjibovski, Andrei M. & Preus, Hans Ragnar (2018). Klinisk effekt av et kommersielt munnskyllemiddel på plakk og gingivitt. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  128(3), s 188- 194
• Homayouni, Amin; Tashbayev, Behzod; Rusthen, Shermin; Hove, Lene Hystad; Rykke, Morten; Singh, Preet Bano; Herlofson, Bente Brokstad; Jensen, Janicke Liaaen & Young, Alix (2018). Can saliva secretion affect oral malodour and oral health-related quality of life?. Vis sammendrag

  The aim of this study was to investigate the relationship between saliva secretion, halitosis and oral health-related quality of life (HRQoL). Informed consent was obtained from 65 participants including 24 patients with primary Sjögren’s Syndrome (pSS, 53±12y), 17 patients with dry eyes and dry mouth not fulfilling the classification for pSS (non-SS-sicca, 53±11y), and 24 healthy controls (49±11y). Unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates were recorded as low (hyposalivation: SWS <0.7 ml/min, UWS <0.1 ml/min) or normal (SWS >0.7 ml/min, UWS >0.1 ml/min). Volatile sulfur compounds (VSC: hydrogen sulphide-H2S, methylmercaptan-CH3SH) in mouth air were measured by gas chromatography. HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Mann-Whitney test was used in data analysis (p<0.05). In general, for UWS, subjects with hyposalivation had significantly higher mean CH3SH-levels than those with normal salivation (27.339.3 vs 9.913.6 ppb). For SWS, subjects with hyposalivation had significantly higher mean H2S-levels (184.5464.8 vs 43.964.1 ppb) and CH3SH-levels (27.237.4 vs 6.58.9 ppb). Within the non-SS patient group, those with hyposalivation had significantly higher H2S-levels than those with normal salivation. In general, there were no significant differences in OHIP-scores based on VSC levels. However, within the non-SS group, those with high H2S-levels (>112 ppb) reported significantly more often that they had “difficulties relaxing due to oral problems”, and that “life has been less satisfactory due to oral problems”, than those with low H2S-levels (<112 ppb). In conclusion, hyposalivation was generally associated with increased levels of oral VSC, indicating oral malodour. Surprisingly, patients with dry eyes and dry mouth who did not fulfill the classification for pSS seemed to be more affected in their daily life than patients who fulfilled the criteria.

• Tiainen, Hanna; Wiedmer, David & Petersen, Fernanda Cristina (2018). Biofilm formation and planktonic growth of S. epidermidis in the presence of phenolic compounds tannic acid and pyrogallol.
• Wiedmer, David; Cui, Chen; Petersen, Fernanda Cristina & Tiainen, Hanna (2018). Antibacterial sol-gel coating for bone scaffolds based on the dark catalytic effect of titanium dioxide.
• Jensen, Janicke Liaaen (2018). Bridging the gap between oral and general health.
• Torgersen, Gerald R.; de Lange, Thomas & Møystad, Anne (2018). Can the use of student created videos enhance learning in oral radiology? Student experiences based on a pilot study.
• Rønneberg, Anne & Willumsen, Tiril (2018). Familievold og omsorgssvikt, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 10.  s 153 - 161
• Herlofson, Bente Brokstad (2018). Medikamentrelatert osteonekrose i kjevene..
• Skaare, Anne B & Willumsen, Tiril (2018). Medication-induced dry mouth in two selected patient groups: A pilot study among general practitioners and dentists based on data collected from electronic patient records. Den norske tannlegeforenings tidende.  ISSN 0029-2303.
• Willumsen, Tiril & Skaare, Anne B (2018). General practitioners and dentists - a pilot project based on data extraction from electronic patient records. Den norske tannlegeforenings tidende.  ISSN 0029-2303.
• Haugen, Håvard Jostein; Reseland, Janne Elin & Gomez-Florit, Manuel (2018). The effect of IDP coated biomaterial.
• Skoglund, Lasse Ansgar (2018). Orofacial smärta. Ett multidisciplinärt omhändertagande (anmeldelse). Den norske tannlegeforenings tidende.  ISSN 0029-2303.  118(10), s 868- 869
• Torper, Jorun; Strøm, Kjetil; Høyvik, Ann Catrin & Willumsen, Tiril (2018). Pasientkommunikasjon, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 3.  s 53 - 71
• Høyvik, Ann Catrin & Woldstad, Marit Irene (2018). Tannbehandling av torturoverlevere, I: Tiril Willumsen; Lena Myran & Jostein Paul Årøen Lein (red.),  Odontologisk psykologi.  Gyldendal Akademisk.  ISBN 9788205510791.  Kap. 16.  s 251 - 260
• Øgaard, Bjørn Andreas (2018, 22. oktober). UiO-forskarar på verdstoppen i siteringar i kjeveortopedi.  Uniforum.
• Nørholt, S.E.; Herlofson, Bente Brokstad; Wexell, Cecilia Larsson; Ehrenstein, V & Schiodt, Morten (2018). The Scandinavisn Osteonecrosis Cohort Stury - Report on 6 years of Research collaboration.
• Tanem, Kristine Eidal; Wilberg, Petter; STENSVOLD, EINAR; Singh, Preet Bano; Skaare, Anne B & Herlofson, Bente Brokstad (2018). Oral late effects and taste function in long-term survivors after treatment of medulloblastoma and supratentorial primitive neuroectodermal tumor during childhood or adolescence - preliminary results.

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