Institutt for klinisk odontologi, UiO

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Odontologi (tannlege)

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Forskning

Tester gel og titanbørste for rengjøring av tannimplantater
Angela De Lauretis har undersøkt hvordan geler og en titanbørste påvirker proteinbelegg på titanoverflater og cellenes evne til å feste seg etter rengjøring. Doktorgradsarbeidet gir kunnskap som kan brukes i videre utvikling av metoder for rengjøring av tannimplantater. Forsøkene er gjort i laboratoriet, og effekten hos pasienter må undersøkes videre.
Slik kan røntgen avsløre skjulte strukturer i bløtvev
Bløtvev er notorisk vanskelig å studere i tre dimensjoner. Strukturer som blodårer, celler og bindevev slipper røntgenstråler nesten rett gjennom, og blir derfor svake eller helt usynlige på vanlige røntgenbilder. Nå viser ny forskning at dette problemet kan løses ved å kombinere røntgenavbildning med målrettet bruk av kontrastmidler.
De fleste er fornøyde med implantatbehandlingen i Norge
En fersk studie viser at så mange som 90 % er fornøyde med implantatbehandlingen de har fått hos norske tannleger. Behandlingsformen har stor betydning for at mange pasienter opplever god livskvalitet relatert til oral helse.
Tanninsyre og probiotika kan gi bedre vilkår for titanimplantater
Overflatebehandling av titanimplantater med tanninsyre og probiotikabakterier fremmer både integrering i kjevebeinet og forhindrer bakterieangrep i munnen. Det kan bedre vilkårene for et vellykket resultat ved innsetting av titanimplantat.

Gå til forskning

Ved Det odontologiske fakultet har vi et bredt og avansert behandlingstilbud. Vi tilbyr tannbehandling hos studenter og spesialistkandidater i tillegg til at leger og tannleger henviser til instituttet ved behov for avansert diagnostisk utredning og behandling i munnhule og kjeve.

Informasjon om tilbudet

Wang, Qiang; Jamous, Reem; Ma, Qianli; Linke, Dirk; Lyngstadaas, Ståle Petter & Saiz, Augustine Mark [Vis alle 12 forfattere av denne artikkelen] (2026). Early porcine wound responses to two application regimens of a hydrogen peroxide-poloxamer gel. Smart Materials in Medicine. 7, s. 536–551. doi: 10.1016/j.smaim.2026.10.004. Fulltekst i vitenarkiv Vis sammendrag
Hydrogen peroxide (H2O2) is widely used to reduce biofilm burden during implant-surface decontamination, but its reactivity creates a clinical trade-off between antimicrobial action and host-tissue injury. We compared early tissue responses to brief application followed by irrigation and removal versus application without planned removal of the same H2O2–Poloxamer formulation. In a porcine full-thickness wound model, wounds were largely closed at day 7. Brief application followed by irrigation and removal (Brief-removal) was associated with lower wound closure and higher TNF-α staining than Sham, but neither outcome differed significantly from application without planned removal (Retained-gel). Rete-ridge density was lower with Brief-removal than with both Sham and Retained-gel. Both regimens reduced local IL-10 expression. Exploratory proteomics screening suggested candidate host-response differences, but none of the 6981 protein groups met the false discovery rate threshold in the pig-adjusted analysis. Measurements suggested a decline in peroxide in recovered gel over the first 4 h in an ex vivo assay, whereas the gel matrix persisted for days in a separate vial system. These findings characterize early tissue responses to two application protocols but do not establish the underlying tissue H2O2 exposure profiles. Further studies linking tissue exposure, antimicrobial activity, and healing are needed before an application protocol can be recommended.
Saghir, Saloua; Hlinkova, Jana; Samara, Athina & Schiavone, Giuseppe (2026). Multimodal in vitro biocompatibility assessment of functionalized PEDOT neural interfaces. iScience. 29(11). doi: 10.1016/j.isci.2026.118078. Fulltekst i vitenarkiv Vis sammendrag
Conductive polymers such as poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have emerged as promising neural interface materials due to their favorable electrochemical and mechanical properties. However, biological assessment of new bioelectrode coatings remains dependent on conventional cytotoxicity assays and animal studies, providing limited insight into cell-material interactions. Here, we present a multimodal in vitro framework for evaluating the biocompatibility of functionalized PEDOT coatings as neural interfaces. Standard PEDOT:PSS, functionalized PEDOT:polydopamine (PDA), and PEDOT:dopamine-grafted hyaluronic acid (DAHA) coatings were characterized electrochemically and assessed using SH-SY5Y cells through viability measurements, profilometry, 3D reconstruction, immunofluorescence imaging, and targeted gene expression analysis. While all coatings support cell viability, substrate-dependent differences were observed in cellular organization, multicellular aggregation, extracellular-matrix- and focal-adhesion-associated architecture, and the expression of genes related to cell-matrix interactions and intercellular communication. Our findings demonstrate mechanistic insights surpassing conventional tests, a valuable intermediate step to guide material development prior to in vivo experiments.

Se alle arbeider i NVA

Klepaker, Ingrid Volden; Stangvaltaite-Mouhat, Lina; Sødal, Anne Thea Tveit; Korzeniewska, Lubomiła; Kopperud, Simen E. & Uhlen-Strand, Marte-Mari (2026). Co-creating a Digital Intervention to Improve Oral Health Literacy among Young Adults. Fulltekst i vitenarkiv Vis sammendrag
Aim: This study aimed to use a co-creation approach to develop a digital intervention to improve oral health literacy among young adults in Norway. Methods: A convenience sample of young adults (experience experts, n=10) and stakeholders from the Public Dental Service (professional experts, n=5) participated in an iterative three-step co-creation process conducted through three workshops. According to the Regional Committee for Medical and Health Research Ethics (REC South-East), the current study fell outside the Norwegian Health Research Act and did not require approval from a regional ethics committee. The study was approved by Norwegian Agency for Shared Services in Education and Research (Sikt, ref. nr: 869907) and was conducted in Eastern Norway between March and June 2026. Written informed consent was obtained from all participants. All workshops were facilitated by a team of four researchers. Step 1 (Exploration): Barriers, needs, and potential solutions related to oral health literacy were explored in a World Café workshop, informing a semi-structured interview guide. Step 2 (Development): Focus group interviews with professional experts and experience experts generated deeper insights into the identified barriers and needs and guided the development of a prototype digital intervention. Step 3 (Test and Evaluation): The prototype was presented to all participants. Professional experts participated in focus group discussions, while experience experts completed usability tasks and the System Usability Scale (SUS), to test and evaluate the prototype’s functionality and user experience. Results: Key barriers, needs, and user-driven solutions for improving oral health literacy among young adults were identified. These informed the content and design of the prototype intervention, including prioritised topics and features. Usability testing indicated that experience experts generally found the prototype useful for accessing relevant information and easy to navigate, with SUS scores suggesting above-average usability. Professional experts highlighted its potential value in supporting communication and preventive care. Conclusion: Co-creation facilitated the identification of barriers early in the process and contributed to the development of a prototype that was relevant, usable and closely aligned with users’ needs and preferences.