Siste publikasjoner

• Jamous, Reem; Nysæther, Ingvild; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter; Fredriksson, Malin Vestin & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2026). Multi-Scale Assessment of Scaffold-Guided Regeneration in Human Extraction Sockets Using an Ultra-Porous TiO₂ Biomaterial. Acta Biomaterialia. ISSN 1742-7061. doi: 10.1016/j.actbio.2026.08.041. Fulltekst i vitenarkiv Vis sammendrag

  Ultra-porous TiO₂ scaffolds are architected non-degradable ceramic graft substitutes, but human evidence relating their structural integration to local tissue maturation remains limited. This exploratory study assessed scaffold-associated healing in a prospective clinical cohort registered at ClinicalTrials.gov (NCT06269497; 10 patients, 11 treated sites). Cone-beam computed tomography (CBCT)-based segmentation at baseline and follow-up was used to quantify changes in bone volume, radiographic low-density/non-mineralized volume, and radiographically detectable scaffold volume. Eleven scaffold-associated specimens were examined using non-decalcified histology, histomorphometry, and immunohistochemistry; nine were retrieved at approximately 6 months, one at 4 months, and one at 9 months. CBCT showed within-site increases in bone and total tissue volume and a reduction in radiographically detectable scaffold volume. Histology showed extensive pore colonization by osteoid-rich tissue, localized mineralization, and limited residual cartilage, consistent with ongoing but incomplete matrix maturation. Normalized RunX2 showed a positive exploratory association with absolute bone volume change, whereas associations with osteocalcin were uncertain and endpoint-dependent. CD206/CD68 and the vessel-to-osteoid ratio were more closely associated with low-density/non-mineralized volume outcomes than with bone-volume change. Osteoclast-associated variables were evaluable in only four sites and were interpreted descriptively. These findings are exploratory and do not establish causality or comparative efficacy, but they characterize tissue-scaffold interactions during human extraction-socket healing.

• Demir, Ali Aslan; Combriat, Thomas Michel Daniel; Heyward, Catherine Anne; Tiainen, Hanna; Carlier, Aurélie & Dysthe, Dag Kristian (2026). A cellular automaton model of osteogenic differentiation reveals identifiability limits of endpoint assays. Frontiers in Systems Biology. 6. doi: 10.3389/fsysb.2026.1872774. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Standard differentiation assays sample cell states only at discrete time points, while the underlying progression unfolds continuously and heterogeneously across cells. As a result, different combinations of proliferation, commitment, and maturation dynamics can converge to similar endpoint measurements. This many-to-one mapping between latent trajectories and observable readouts constitutes a partially observed inverse problem that limits mechanistic interpretation. Although this ambiguity is inherent to many experimental systems, it is rarely examined using models that connect cell-state dynamics to assay-level quantities. Methods We present OsteoMin, a coarse-grained cellular automaton that links stochastic transitions between pre-osteoblast and osteoblast states to experimentally measurable readouts of alkaline phosphatase activity, collagen deposition, and mineralization. Model parameters were constrained using literature-reported kinetics and evaluated against dexamethasone and menaquinone-4 perturbations. The framework enables systematic analysis of how cell-state progression, matrix maturation, and external perturbations shape differentiation outcomes. Results OsteoMin reproduces qualitative assay trends and quantifies the identifiability limits of endpoint assays. Distinct perturbation families often produce similar endpoint responses (macro-F1 ≈ 0.42$), indicating limited discriminative power. Incorporating temporal trajectories improves separability (macro-F1 ≈ 0.78$), demonstrating that most identifiable information resides in marker dynamics rather than terminal measurements. Sobol analysis shows that early markers depend on proliferation timing, whereas late mineralization is governed by nonlinear matrix maturation and parameter interactions. Discussion These results show that endpoint assays constrain overall progression but do not uniquely identify underlying mechanisms. OsteoMin provides a framework linking differentiation dynamics to assay observables and a basis for assessing identifiability in endpoint-driven systems.

• Lauretis, Angela De; Santacroce, Marco; Wang, Qiang; Ramirez, Manuel; Ma, Qianli & Lyngstadaas, Ståle Petter [Vis alle 9 forfattere av denne artikkelen] (2026). Combined Chemical and Mechanical Debridement Enhances Salivary Protein Removal from Titanium while Maintaining Biological Properties. ACS Biomaterials Science and Engineering. doi: 10.1021/acsbiomaterials.5c01973. Fulltekst i vitenarkiv Vis sammendrag

  Effective decontamination of dental implants is essential for managing peri-implant diseases, yet its impact on the salivary pellicle and cell response remains unclear. As the pellicle mediates bacterial and host cell interactions, investigating how decontamination alters its composition is key to understanding the effects on biological outcomes. Accordingly, we examined how a Poloxamer 407 (P407) hydrogel, a P407 + hydrogen peroxide (H2O2) hydrogel, a titanium brush, and their combinations influence the adsorbed salivary proteins and cell adhesion on OsseoSpeed-like titanium surfaces. Surfaces with salivary proteins were treated with different decontamination methods and re-exposed to saliva. Protein quantity was measured using the BCA assay, while the proteomic composition and molecular functions of the adsorbed proteins were determined by liquid chromatography-mass spectrometry and gene ontology analysis. Human bone marrow mesenchymal stem cell (hBMMSC) adhesion was assessed on the surfaces, and cytotoxicity was evaluated using an LDH assay. Protein-coated and protein-free surfaces served as controls. Although protein levels were consistent across groups after either decontamination or recontamination, each treatment produced a different proteomic profile. Mechanical decontamination, alone or combined with chemicals, enhanced protein removal efficiency. Combined treatments yielded reduced protein diversity following recontamination and enriched adhesion-related proteins. None of the treatments compromised hBMMSC adhesion nor made the surface cytotoxic. Decontamination methods selectively modify the proteomic profile. Combined chemical and mechanical decontamination promotes the removal of salivary proteins and limits their readsorption while preserving cytocompatibility, supporting their relevance to peri-implant health.

• Lauretis, Angela De; Wang, Qiang; Santacroce, Marco; Thiede, Bernd; Ma, Qianli & Lyngstadaas, Ståle Petter [Vis alle 9 forfattere av denne artikkelen] (2025). A Comparative Study of the Impact of Chemical Debridement Products on the Proteomic Profile of the Salivary Pellicle and Cell Adhesion on OsseoSpeed Titanium Dental Implant Surfaces. ACS Applied Materials & Interfaces. ISSN 1944-8244. 17(39), s. 54592–54592. doi: 10.1021/acsami.5c14570. Fulltekst i vitenarkiv
• Nysæther, Ingvild; Haugen, Håvard Jostein; Khassawna, Thaqif El; Jamous, Reem; Afnan, Shoresh & Santacroce, Marco [Vis alle 10 forfattere av denne artikkelen] (2025). Clinical Performance of Ultra‐Porous TiO2 Scaffold as Bone Graft Substitute in Human Alveolar Ridge Preservation—A Feasibility Study. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.70074. Fulltekst i vitenarkiv Vis sammendrag

  Objectives This study evaluates the safety and osteoconductive potential of a ceramic TiO2 scaffold in human alveolar bone, hypothesising that placement in human extraction sockets is safe, supports bone ingrowth and preserves ridge dimensions. Material and Methods Nine subjects requiring the extraction of ≥ 1 premolar or molar tooth were enrolled. Full-thickness mucoperiosteal flaps were elevated. Following tooth extraction, porous ceramic TiO2 scaffolds were adjusted chair-side, placed into the extraction socket and covered by a resorbable collagen membrane. After 6 months of healing, before dental implant placement, a biopsy was performed at the site where the scaffold had been placed. Histomorphometric and micro-CT analyses were made. CBCT images were made at baseline and at 6 months to assess alveolar ridge dimensional changes. Implants placed in regenerated bone were followed for 21 months. Results Scaffold customisation with chairside adjustment was straightforward. No serious adverse events were observed during the 6 months following scaffold implantation. One scaffold was removed due to an early exposure, while the remaining 9 scaffolds successfully integrated. Two sites presented with minor soft tissue dehiscences at 1–2 weeks, which healed spontaneously. Micro-CT and histology confirmed new bone formation. Soft tissue healing was favourable, with no adverse reactions. Dimensional analysis revealed minimal changes in alveolar ridge width and height, indicating effective preservation of volume. Conclusions This clinical study confirms that TiO2 scaffolds are a safe and effective option for promoting bone regrowth and preserving volume in human alveolar bone, thereby facilitating bone formation and maintaining ridge dimensions post-extraction.

• Lauretis, Angela de; Wang, Qiang; Santacroce, Marco; Thiede, Bernd; Ma, Qianli & Lyngstadaas, Ståle Petter [Vis alle 9 forfattere av denne artikkelen] (2025). A Comparative Study of the Impact of Chemical Debridement Products on the Proteomic Profile of the Salivary Pellicle and Cell Adhesion on OsseoSpeed Titanium Dental Implant Surfaces. ACS Applied Materials & Interfaces. ISSN 1944-8244. 17, s. 54579–54592. doi: 10.1021/acsami.5c14570. Fulltekst i vitenarkiv Vis sammendrag

  Background and objectives: Dental implants are commonly used for tooth replacement, with excellent success rates over 10 years. However, exposure to oral cavity bacteria makes them susceptible to biofilm accumulation, which can lead to peri-implant diseases. The salivary pellicle, a protein-rich layer formed on implant surfaces, mediates bacterial adhesion and cell attachment. Effective decontamination is essential for managing bacterial infections, yet no consensus exists on the best chemical agent. Understanding how chemical agents affect the pellicle proteomic profile may guide the selection of optimal treatments. Methods: We investigate the impact of chemical decontamination agents on the salivary pellicle on OsseoSpeed-like titanium dental implant surfaces using a BCA assay and proteomics, and on cell adhesion using human gingival fibroblasts (HGF) and human bone marrow mesenchymal stem cells (hBMSC). We compare the effects of hydrogen peroxide (H2O2), Poloxamer 407 (P407), P407 + H2O2 and sodium hypochlorite + amino acids (NaOCl + AA) using the salivary pellicle and a clean titanium surface as controls. By quantifying and identifying proteins on titanium surfaces after decontamination, this study reveals how chemical agents affect the salivary pellicle. Results: All products reduced the total protein on the surfaces, with the P407 + H2O2 hydrogel demonstrating lower protein variety and superior effectiveness in preventing surface recontamination. Not all proteins were removed during decontamination procedures, and unique proteins were detected in each experimental condition, suggesting protein readsorption depends on surface chemistry. P407 + H2O2 shows the highest enrichment in integrin- and cadherin-binding proteins upon recontamination. P407 and P407 + H2O2 promoted HGFs and hBMSCs attachment. Conversely, NaOCl + AA and H2O2 showed lower HGFs and hBMSCs counts. Conclusion: The P407 + H2O2 hydrogel had the strongest decontamination effect and limited surface recontamination. Each chemical agent produced a distinct proteomic profile. P407 and P407 + H2O2 promoted initial cell adhesion.

• Lauretis, Angela de; Agger, Anne Eriksson; Pal, Antara; Pedersen, Jan Skov; Szostak, Szymon Mikolaj & Lund, Reidar [Vis alle 10 forfattere av denne artikkelen] (2025). Balancing sterilization and functional properties in Poloxamer 407 hydrogels: comparing heat and radiation techniques. Regenerative Biomaterials. 12. doi: 10.1093/rb/rbaf005. Fulltekst i vitenarkiv Vis sammendrag

  Poloxamer 407, also known as Pluronic® F127, is gaining interest in the cosmetic, biomedical, and pharmaceutical fields for its biocompatibility, safety, and thermosensitive properties. Ensuring sterility is critical in clinical applications, and sterilization is often preferred over aseptic processing. However, sterilization can impact the hydrogel's functional properties. In this study, we investigate the effects of steam heat (121°C, 20 min), dry heat (160°C, 1 h), gamma irradiation (25 kGy), and electron beam (e-beam) irradiation (15 kGy and 25 kGy) on a 30%w/v Poloxamer 407 hydrogel formulation. Our analysis encompasses gelling properties, pH, Fourier-transform infrared (FTIR) spectroscopy, Gel Permeation Chromatography (GPC), Small-angle X-ray scattering (SAXS), rheology, swelling, degradation by-products, and lactate dehydrogenase (LDH) release of the sterilised hydrogels, comparing them to a non-sterile counterpart. We demonstrated that heat sterilisation alters the hydrogel’s gelling and structural properties due to water evaporation and oxidation under harsh temperature conditions, especially when applying the dry heat method. Gamma irradiation proved unsuitable, resulting in an acidic and cytotoxic hydrogel due to oxidative degradation. In contrast, e-beam irradiation preserves the hydrogel's elasticity, gelling, and structural properties while enhancing mechanical resilience and moderating swelling. Therefore, e-beam irradiation within the 15 – 25 kGy range appears to be the most suitable method for sterilizing a 30%w/v Poloxamer 407 hydrogel.

• Lauretis, Angela de; Santacroce, Marco; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter; Linke, Dirk & Haugen, Håvard Jostein (2025). Surface-specific outcomes of mechanical debridement with titanium, chitosan and nitinol brushes on titanium dental implant surfaces. Journal of Dentistry. ISSN 0300-5712. doi: 10.1016/j.jdent.2025.106010. Fulltekst i vitenarkiv Vis sammendrag

  Objectives Dental implants are susceptible to peri‑implant inflammation caused by bacterial biofilms, with surface properties playing a key role in bacterial adhesion and osseointegration. While mechanical debridement is essential for biofilm removal, consensus on the optimal tool remains limited. In this study, we evaluate the impact of a titanium, a chitosan and a nitinol brush on the surface properties of four titanium dental implant surfaces: OsseoSpeed®-like, SLActive®-like, machined, and polished. Methods Profilometry, contact angle measurements, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) were used to assess the surface properties and chemistry. Results SEM and profilometry revealed that the titanium and nitinol brushes altered the morphology and topography of the rough OsseoSpeed®-like and SLActive®-like surfaces, while these effects were less pronounced on machined surfaces. Conversely, the chitosan brush caused minimal changes, but its bristles wore down quickly by physical abrasion, increasing surface carbon as detected by EDX and identified by XPS as organic material. Conversely, XPS confirmed that carbon contamination in samples treated with metal brushes was primarily environmental. The increased hydrophobicity observed across all groups was linked to carbon contamination. Polished surfaces remained unaffected by mechanical debridement. Conclusions The chitosan brush showed minimal surface alterations, but the rapid bristle wear left organic residues that increased hydrophobicity. The titanium and nitinol brushes caused more pronounced surface changes, while contributing to increased hydrophobicity through environmental carbon contamination during debridement. Clinical significance Dental implant surface properties, including topography, morphology, wettability, and surface chemistry, play a critical role in bacterial adhesion and osseointegration. Selecting an optimal mechanical debridement instrument requires balancing the effective removal of biofilm with the impact on the implant surface properties.

• Stanford, Clark M.; Chvartszaid, David; Saito, Hanae; Estafanous, Emad; Ellingsen, Jan Eirik & Osswald, Martin (2024). How Long Does It Take for Implant Success to Be Truly Successful? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(3), s. 337–341. Fulltekst i vitenarkiv
• Khan, Sadia Nazir; Koldsland, Odd Carsten; Tiainen, Hanna & Hjortsjö, Carl (2024). Anatomical three-dimensional model with peri-implant defect for in vitro assessment of dental implant decontamination. Clinical and Experimental Dental Research. 10(1). doi: 10.1002/cre2.841. Fulltekst i vitenarkiv Vis sammendrag

  Abstract Objectives Access to the implant surface plays a significant role in effective mechanical biofilm removal in peri‐implantitis treatment. Mechanical decontamination may also alter the surface topography of the implant, potentially increasing susceptibility to bacterial recolonization. This in vitro study aimed to evaluate a newly developed, anatomically realistic, and adaptable three‐dimensional (3D)printed model with a peri‐implant bone defect to evaluate the accessibility and changes of dental implant surfaces after mechanical decontamination treatment. Material and Methods A split model of an advanced peri‐implant bone defect was prepared using 3D printing. The function of the model was tested by mechanical decontamination of the exposed surface of dental implants (Standard Implant Straumann AG) coated with a thin layer of colored occlusion spray. Two different instruments for mechanical decontamination were used. Following decontamination, the implants were removed from the split model and photographed. Image analysis and fluorescence spectroscopy were used to quantify the remaining occlusion spray both in terms of area and total amount, while scanning electron microscopy and optical profilometry were used to analyze alteration in the implant surface morphology. Results The 3D model allowed easy placement and removal of the dental implants without disturbing the implant surfaces. Qualitative and quantitative assessment of removal of the occlusion spray revealed differences in the mechanism of action and access to the implant surface between tested instruments. The model permitted surface topography analysis following the decontamination procedure. Conclusion The developed 3D model allowed a realistic simulation of decontamination of implant surfaces with colored occlusion spray in an advanced peri‐implant defect. 3D printing allows easy adaptation of the model in terms of the shape and location of the defect. The model presents a valuable tool for in vitro investigation of the accessibility and changes of the implant surface after mechanical and chemical decontamination.

• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Osswald, Martin; Saito, Hanae & Stanford, Clark (2024). Implant Fracture: An Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(6), s. 809–814. Fulltekst i vitenarkiv
• Khan, Sadia Nazir; Ribeiro-Vidal, Honorato; Virto, Leire; Bravo, Enrique; Nuevo, Paula & Koldsland, Odd Carsten [Vis alle 8 forfattere av denne artikkelen] (2024). The Decontamination Effect of an Oscillating Chitosan Brush Compared With an Ultrasonic PEEK-Tip: An In Vitro Study Using a Dynamic Biofilm Model. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14360. Fulltekst i vitenarkiv
• Estafanous, Emad; Stanford, Clark; Chvartszaid, David; Oates, Thomas & Ellingsen, Jan Eirik (2024). Clinical performance of dental implants. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(2), s. 201–205. Fulltekst i vitenarkiv
• Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Oates, Thomas & Osswald, Martin (2024). Prosthetic complications in implant restorations. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(1), s. 14–17. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Stanford, Clark M.; Chvartszaid, David; Saito, Hanae; Estafanous, Emad & Osswald, Martin (2024). All-Ceramic Implant-Supported Single Crowns (SCs) and Fixed Dental Prostheses (FDPs): How Good Are They? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 39(4), s. 501–505. Fulltekst i vitenarkiv
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Ellingsen, Jan Eirik & Tiainen, Hanna (2023). Backscatter from therapeutic doses of ionizing irradiation does not impair cell migration on titanium implants in vitro. Clinical Oral Investigations. ISSN 1432-6981. doi: 10.1007/s00784-023-05128-6. Fulltekst i vitenarkiv Vis sammendrag

  Objective The influence of radiation backscatter from titanium on DNA damage and migration capacity of human osteoblasts (OBs) and mesenchymal stem cells (MSCs) may be critical for the osseointegration of dental implants placed prior to radiotherapy. In order to evaluate effects of radiation backscatter, the immediate DNA damage and migration capacity of OBs and MSCs cultured on titanium or plastic were compared after exposure to ionizing irradiation. Materials and methods Human OBs and MSCs were seeded on machined titanium, moderately rough fluoride-modified titanium, or tissue culture polystyrene, and irradiated with nominal doses of 2, 6, 10, or 14 Gy. Comet assay was performed immediately after irradiation, while a scratch wound healing assay was initiated 24 h post-irradiation. Fluorescent live cell imaging documented the migration. Results DNA damage increased with higher dose and with backscatter from titanium, and MSCs were significantly more affected than OBs. All doses of radiation accelerated the cell migration on plastic, while only the highest dose of 10 Gy inhibited the migration of both cell types on titanium. Conclusions High doses (10 Gy) of radiation inhibited the migration capacity of both cell types on titanium, whereas lower doses (2 and 6 Gy) did not affect the migration of either OBs or MSCs. Clinical relevance Fractionated doses of 2 Gy/day, as distributed in conventional radiotherapy, appear not to cause severe DNA damage or disturb the migration of OBs or MSCs during osseointegration of dental implants.

• Hussain, Badra; Khan, Sadia Nazir; Agger, Anne Eriksson; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Bueno, Jaime [Vis alle 7 forfattere av denne artikkelen] (2023). A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces. Journal of Functional Biomaterials. 14(8). doi: 10.3390/jfb14080394. Fulltekst i vitenarkiv Vis sammendrag

  Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBone®Clean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilised for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel®. Among the tested chemical decontamination candidates, NuBone®Clean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBone®Clean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomised clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in implant dentistry

• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2023). The Reoccurring Issue of Peri-implantitis: What Have We Learned So Far? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(1), s. 15–17. Fulltekst i vitenarkiv
• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Vis alle 9 forfattere av denne artikkelen] (2023). Non-surgical treatment of mild to moderate peri-implantitis with an oscillating chitosan brush or a titanium curette—12-month follow-up of a multicenter randomized clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14078. Fulltekst i vitenarkiv
• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2023). Implant Placement in Bony Defects of Variable Sizes. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(2), s. 215–217. Fulltekst i vitenarkiv
• Chvartszaid, David; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). Implant care in frail, dependent, and institutionalized elders. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(4), s. 640–642. Fulltekst i vitenarkiv
• Oates, Thomas; Ellingsen, Jan Eirik; Estafanous, Emad; Osswald, Martin; Chvartszaid, David & Stanford, Clark (2023). What guidance do we need? A look at the accuracy of guided surgical approaches to implant placement. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(3), s. 410–414. doi: 10.11607/jomi.2023.3.tar. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Chvartszaid, David; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). The use of short dental implants: Where are we today? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(5), s. 842–846. Fulltekst i vitenarkiv
• Chvartszaid, David; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin; Estafanous, Emad & Stanford, Clark (2023). Socket shield technique: A new way to deal with an old problem. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 38(6), s. 1078–1082. Fulltekst i vitenarkiv
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Tiainen, Hanna & Ellingsen, Jan Eirik (2023). The dose-dependent impact of γ-radiation reinforced with backscatter from titanium on primary human osteoblasts. Biomaterial Investigations in Dentistry. 10(1). doi: 10.1080/26415275.2023.2209116. Fulltekst i vitenarkiv Vis sammendrag

  In head and neck cancer patients receiving dental implants prior to radiotherapy, backscatter from titanium increases the radiation dose close to the surface, and may affect the osseointegration. The dose-dependent effects of ionizing radiation on human osteoblasts (hOBs) were investigated. The hOBs were seeded on machined titanium, moderately rough fluoride-modified titanium, and tissue culture polystyrene, and cultured in growth- or osteoblastic differentiation medium (DM). The hOBs were exposed to ionizing γ-irradiation in single doses of 2, 6 or 10 Gy. Twenty-one days post-irradiation, cell nuclei and collagen production were quantified. Cytotoxicity and indicators of differentiation were measured and compared to unirradiated controls. Radiation with backscatter from titanium significantly reduced the number of hOBs but increased the alkaline phosphatase activity in both types of medium when adjusted to the relative cell number on day 21. Irradiated hOBs on the TiF-surface produced similar amounts of collagen as unirradiated controls when cultured in DM. The majority of osteogenic biomarkers significantly increased on day 21 when the hOBs had been exposed to 10 Gy, while the opposite or no effect was observed after lower doses. High doses reinforced with backscatter from titanium resulted in smaller but seemingly more differentiated subpopulations of osteoblasts.

• Thieu, Minh Khai Le; Stoetzel, Sabine; Rahmati, Maryam; Khassawna, Thaqif El; Verket, Anders & Sanz-Esporrin, Javier [Vis alle 9 forfattere av denne artikkelen] (2022). Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO<inf>2</inf> block or a xenogeneic graft in chronic alveolar defects. Clinical Implant Dentistry and Related Research. ISSN 1523-0899. doi: 10.1111/cid.13143. Fulltekst i vitenarkiv Vis sammendrag

  Objectives To evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic non-contained bone defects using a non-resorbable TiO2 block. Material and methods Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomisation: TiO2 block: TiO2-scaffold and a collagen membrane, DBBM particulates: Deproteinised bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha smooth muscle actin (α-SMA), osteopontin, osteocalcin, tartrate-resistant acid phosphatase and collagen type I. Histomorphometry was performed on Movat Pentachrome and Von Kossa/Van Gieson stained sections. Stereolithographic models were used to compare alveolar profile changes. Results The percentage of α-SMA and osteopontin increased in TiO2 group after 12 weeks of healing at the bone-scaffold interface, while collagen type I increased in the empty control group. In the defect area, α-SMA decreased in the empty control group, while collagen type I increased in the DBBM group. All groups maintained alveolar profile from 4 to 12 weeks, but TiO2 group demonstrated the widest soft tissue contour profile. Conclusions The present findings suggested contact osteogenesis when GBR is performed with a TiO2 block or DBBM particulates. The increase in osteopontin indicated a potential for bone formation beyond 12 weeks. The alveolar profile data indicated a sustained lateral increase in lateral bone augmentation using a TiO2 block and a collagen membrane, as compared to DBBM and a collagen membrane or a collagen membrane alone.

• Khan, Sadia Nazir; Koldsland, Odd Carsten; Roos-Jansåker, Ann-Marie; Wohlfahrt, Johan Caspar; Verket, Anders & Mdala, Ibrahimu [Vis alle 9 forfattere av denne artikkelen] (2022). Non-surgical treatment of mild to moderate peri-implantitis using an oscillating chitosan brush or a titanium curette—A randomized multicentre controlled clinical trial. Clinical Oral Implants Research. ISSN 0905-7161. doi: 10.1111/clr.14007. Fulltekst i vitenarkiv Vis sammendrag

  Objectives This prospective, parallel-group, examiner-blinded, multicentre, randomized, controlled clinical trial aimed to assess the efficacy of an oscillating chitosan brush (OCB) versus titanium curettes (TC) on clinical parameters in the non-surgical treatment of peri-implantitis. Material and Methods In five dental specialist clinics, 39 patients with one implant with mild to moderate peri-implantitis, defined as 2–4 mm radiographic reduced bone level, bleeding index (BI) ≥ 2, and probing pocket depth (PPD) ≥ 4 mm were randomly allocated to test and control groups, receiving OCB or TC debridement, respectively. Treatment was performed at baseline and three months. PPD, BI, and Plaque index (PI) were measured at six sites per implant and recorded by five blinded examiners at baseline, one, three, and six month(s). Pus was recorded as present/not present. Changes in PPD and BI were compared between groups and analysed using multilevel partial ordinal and linear regression. Results Thirty-eight patients completed the study. Both groups showed significant reductions in PPD and BI at six months compared with baseline (p < .05). There was no statistically significant difference in PPD and BI changes between the groups. Eradication of peri-implant disease as defined was observed in 9.5% of cases in the OCB group and 5.9% in the TC group. Conclusions Within the limitations of this six-month multicentre clinical trial, non-surgical treatment of peri-implantitis with OCB and TC showed no difference between the interventions. Eradication of disease was not predictable for any of the groups.

• Sagen, Mina Aker & Dahl, Bjørn Einar (2022). Resin-baserte sementer – egenskaper som påvirker klinisk suksess av indirekte restaureringer. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 132(9), s. 716–722. doi: 10.56373/2022-9-4. Fulltekst i vitenarkiv
• Mo, Arild; Hjortsjö, Carl & Jokstad, Asbjørn (2022). Maxillary overdenture on three implants retained by low-profile stud attachments – A prospective cohort study. Journal of Oral Rehabilitation. ISSN 0305-182X. 49(11), s. 1069–1079. doi: 10.1111/joor.13364. Fulltekst i vitenarkiv Vis sammendrag

  Background: Clinical data are needed on long-term outcomes of removable implantsupported prostheses in the fully edentulous maxilla as a function of the number of implants, effects of the attachment system and other clinical variables.<p> <p>Objective: To restore individuals with an edentate maxilla with a metal-reinforced removable prosthesis without palatal coverage retained by low-profile stud attachments on three implants. <p>Methods: The regional ethics committee approved a prospective cohort study that included all consecutive patients treated in a private speciality clinic. Primary outcomes were patients reported, that is denture satisfaction scale and oral health-related quality of life – OHIP-20. Secondary outcomes were implant- (bone loss, implant complications and peri-implant conditions) and prosthesis-related (prosthesis complications, maintenance needs and mucosa condition). <p>Results: Thirty-two study participants were recruited between March 2007 and October 2016 and followed for a minimum of five years. According to Kruskal–Wallis tests, the OHIP-20 and Denture Satisfaction Scale questionnaire pre-treatment scores differed significantly. After an average of 6.7 years, peri-implant bone loss of more than 2 mm was observed on 17% of all implants, while no or minor bone loss was seen on 38%. The estimated success of implants was 0.95 at 168 months. The estimated success of the prosthesis, that is no adverse events or need for any repairs, was 0.55 at 156 months. <p>Conclusion: The positive findings in the current clinical study strengthen the notion that for many individuals with an edentulous maxilla, a removable prosthesis retained by three implants fitted with low-profile stud-attachment is a reliable technical solution.

• Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W.; Chvartszaid, David & Stanford, Clark M. (2022). Dental Implant Success: Systematic Reviews and Clinical Outcomes. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(2), s. 231–234. Fulltekst i vitenarkiv
• Hæreid, Marika Koutsouri; Stangvaltaite-Mouhat, Lina; Ansteinsson, Vibeke Elise; Mdala, Ibrahimu & Ørstavik, Dag Solmund (2022). Periapical status transitions in teeth with posts versus without posts: a retrospective longitudinal radiographic study. Acta Odontologica Scandinavica. ISSN 0001-6357. doi: 10.1080/00016357.2022.2049865. Fulltekst i vitenarkiv Vis sammendrag

  Objectives The aim of this study was to compare periapical status transitions in teeth after post placement compared with other post-endodontic treatments in root-filled teeth. Material and methods This retrospective longitudinal radiographic study included radiographs of 284 patients with root filled and restored teeth with composite fillings (Endo-fill group, n = 100), crown or fixed prosthesis (Endo-crown group, n = 82) or post and core restorations (Endo-post group, n = 102). All post and core restorations were made of gold alloy. The radiographs taken at the end of endodontic treatment, at the end of post-endodontic treatment and at least 8 months after post-endodontic treatment were evaluated. Post-operative periapical status was assessed according to the periapical index (PAI) and all teeth included in the study had no apical periodontitis preoperatively. Multi-state Markov analysis was used to assess periapical status transitions among the treatment groups. Results Of 284 root-filled teeth without apical periodontitis at baseline, 7.7% developed clear apical pathology within a minimum of 8 months observational period. In the Endo-post group 11 (10.78%) teeth transited from Healthy (PAI 1) to Disease (PAI 2-4) state compared with eight (9.75%) in the Endo-crown group and four (4%) in the Endo-fill group. The transition probabilities from Healthy (PAI 1) to Mild diseased (PAI 2) were 17.5% in the Endo-post group, 13.1% in the Endo-crown group and 5.3% in the Endo-fill group. Multivariate analysis showed that teeth in the Endo-fill group had 60% lower hazard to transit from Healthy (PAI 1) to Mild diseased (PAI 2) state [HR 0.40; 95% CI 0.12, 0.94]. A period exceeding 8 months between the end of the endodontic treatment and prosthetic treatment significantly increased the hazard of disease progression by three times compared with a period of ≤8 months [HR 3.16; 95% CI 1.06, 9.42]. Conclusions Teeth without radiographic lesions at baseline and restored with posts had higher hazard to transit from healthy to diseased periapical status compared with teeth restored with composite restorations. Controlled clinical trials with longer follow-up periods are needed to validate these findings.

• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2022). Strategies for the Treatment of Peri-implantitis—Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(4), s. 634–637. Fulltekst i vitenarkiv
• Sagen, Mina Aker; Vos, Linda; Dahl, Jon Einar & Rønold, Hans Jacob (2022). Shear bond strength of resin bonded zirconia and lithium disilicate - effect of surface treatment of ceramics and dentin. Biomaterial Investigations in Dentistry. 9(1), s. 10–19. doi: 10.1080/26415275.2022.2038177. Fulltekst i vitenarkiv Vis sammendrag

  Introduction Materials and methods Results Discussion Acknowledgements Disclosure statement Additional information References Full Article Figures & data References Citations Metrics Licensing Reprints & Permissions View PDFView EPUB Abstract Objectives:The purpose of the study was to investigate the effect of ceramic surface pretreatment, effect of resin cement and dentin surface roughness on shear bond strength. Methodology: Zirconia rods (n = 140) were randomly assigned to air born particle abrasion with aluminum oxide (Al2O3) or hot etching with potassium hydrogen difluoride (KHF2). Lithium disilicate rods (LDS; n = 50) etched with hydrofluoric acid served as reference material. In Part 1 of the study, ceramic rods were cemented to bovine dentin using 5 dual-polymerizing resin cements (Variolink Esthetic, Multilink Automix (Ivoclar Vivadent), Duo-Link (BISCO Dental), Panavia F2.0 (Kuraray Dental), RelyX Unicem (3 M)). Shear bond strength was tested and fracture morphology determined. In Part 2 of the study, test groups with the highest frequency of adhesive fractures between cement and dentin were selected for further bond strength testing with different surface roughness of dentin; ground with P1200 or P80 silicon carbide paper. Dentin samples were fractured vertically to the cemented surface and the adherence between cement and dentin was studied. Results: The results of Part 1 showed that hot etching of zirconia significantly improved bond strength to Duo-Link cement. In Part 2, RelyX Unicem showed significantly higher bond strength to P1200 compared to P80 ground dentin. For Variolink Esthetic, bond strengths to P1200 and P80 ground dentin were similar. Adhesive fracture between cement and dentin dominated. Conclusions: A smooth dentin surface (P1200) improved bond strength to RelyX Unicem. Surface roughness was not important for Variolink Esthetic.

• Stanford, Clark M.; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad W.; Oates, Thomas W. & Osswald, Martin (2022). Zirconia Implants—A 2022 Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(1), s. 16–18. Fulltekst i vitenarkiv
• Stanford, Clark M.; Estafanous, Emad; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Chvartszaid, David (2022). What’s Happening in the Nanoverse? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 37(5), s. 855–857. Fulltekst i vitenarkiv
• Osswald, Martin; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2021). Digital Planning and Surgical Guidance: Planning Perfection, Achieving Excellence. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 366(5), s. 847–849. Fulltekst i vitenarkiv
• Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2021). Use of zygoma-anchored implants for oral rehabilitation. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(2), s. 213–217. Fulltekst i vitenarkiv
• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2021). Single Implants in the Anterior Maxilla. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(6), s. 1058–1063. Fulltekst i vitenarkiv
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2021). It’s a Brave New World: How Should We Use Antibiotics? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(3), s. 417–421. Fulltekst i vitenarkiv
• Estafanous, Emad; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2021). The implant-supported dental fixed prosthesis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(1), s. 15–19. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2021). Short Implants: Documentation for Clinical Use in Rehabilitation of Edentulous Posterior Arches. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 36(4), s. 625–630. Fulltekst i vitenarkiv
• Øilo, Marit; Haugli, Ketil; Rønold, Hans Jacob; Ulsund, Amanda H.; Ruud, Amund & Kvam, Ketil (2021). Pre-cementation procedures’ effect on dental zirconias with different yttria content. Dental Materials. ISSN 0109-5641. 37(9), s. 1425–1436. doi: 10.1016/j.dental.2021.07.001. Fulltekst i vitenarkiv Vis sammendrag

  Objectve Several pre-cementation procedures have been advocated to enhance adhesion between zirconia and resin-based cement. There is, however, limited documentation on how these pre-treatments affect the strength of zirconia crowns as most tests are performed on discs or bars. The aim was to assess the effect of pre-cementation procedures on fracture mode, fracture strength and cement retention on zirconia. Methods Two dental zirconia materials with different yttria content were assessed (<4 and>5 mol%). Both discs (n = 45) and crown-shaped specimens (n = 30) of the two materials were pretreated with either air-abrasion or hot-etching with KHF2 and compared with untreated controls with regards to surface roughness, crystallography, wettability, cement adhesion and fracture strength. Results and Significance Air-abrasion improves adhesion and strength of zirconia with moderate yttria content (<4 mol%). Acid etching with heated KHF2 showed the best effect on strength and cement retention on zirconia with higher yttria content (>5 mol%). Application of KHF2 was, however, complicated on crown-shaped specimens. Pre-treatment and cementation protocols should be optimized for different dental zirconias to improve both strength and retention. Keywords Dental ceramics Luting agents Surface modification Fractography Zirconuim dioxide

• Young, Alix; Hove, Lene Hystad; Stevning, Karen; Løvik, Sara-Emilie & Hjortsjö, Carl (2021). Kan tannpasta gjøre tennene mer sårbare? En in vitro pilotstudie om endring i fukting av emalje uttrykt ved kontaktvinkelmålinger. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 131(9), s. 796–801. Fulltekst i vitenarkiv
• Sagen, Mina Aker; Dahl, Jon Einar; Matinlinna, Jukka Pekka; Tibballs, John Earl & Rønold, Hans Jacob (2021). The influence of the resin-based cement layer on ceramic-dentin bond strength. European Journal of Oral Sciences. ISSN 0909-8836. s. 1–9. doi: 10.1111/eos.12791. Fulltekst i vitenarkiv Vis sammendrag

  The purpose of the study was to measure the cement thickness obtained when ceramic rods were luted to dentin and to analyze the relation between cement thickness and the previously published tensile bond strength of similar test specimens. In addition, the ISO standard 4049:2019 method was used to determine the film thickness of the used cements. Zirconia (n = 100) and lithium disilicate (n = 50) rods were cemented to bovine dentin using one of five different resin-based cements. The ceramic-dentin test specimens were cut into two slices and the cement thickness was measured using a scanning electron microscope and compared to the bond strength values of similar specimens already published. The mean cement thickness recorded for ceramic rods cemented to dentin was in the range 20–40 µm, which was larger than the cement film thickness found by the ISO method. The cement film thickness determined according to ISO standard methods did not concur with the results obtained when cementing ceramic rods to dentin. For cementing ceramic restorations, a cement thickness in the range 25–35 µm seems to be favorable for the bond strength.

• Thieu, Minh Khai Le; Homayouni, Amin; Hæren, Lena Ringsby; Tiainen, Hanna; Verket, Anders & Ellingsen, Jan Eirik [Vis alle 13 forfattere av denne artikkelen] (2021). Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model. Biomaterials Research. ISSN 1226-4601. 25(43). doi: 10.1186/s40824-021-00245-3. Fulltekst i vitenarkiv Vis sammendrag

  Background Insufficient bone volume around an implant is a common obstacle when dental implant treatment is considered. Limited vertical or horizontal bone dimensions may lead to exposed implant threads following placement or a gap between the bone and implant. This is often addressed by bone augmentation procedures prior to or at the time of implant placement. This study evaluated bone healing when a synthetic TiO2 block scaffold was placed in circumferential peri-implant defects with buccal fenestrations. Methods The mandibular premolars were extracted and the alveolar bone left to heal for 4 weeks prior to implant placement in six minipigs. Two cylindrical defects were created in each hemi-mandible and were subsequent to implant placement allocated to treatment with either TiO2 scaffold or sham in a split mouth design. After 12 weeks of healing time, the samples were harvested. Microcomputed tomography (MicroCT) was used to investigate defect fill and integrity of the block scaffold. Distances from implant to bone in vertical and horizontal directions, percentage of bone to implant contact and defect fill were analysed by histology. Results MicroCT analysis demonstrated no differences between the groups for defect fill. Three of twelve scaffolds were partly fractured. At the buccal sites, histomorphometric analysis demonstrated higher bone fraction, higher percentage bone to implant contact and shorter distance from implant top to bone 0.5 mm lateral to implant surface in sham group as compared to the TiO2 group. Conclusions This study demonstrated less bone formation with the use of TiO2 scaffold block in combination with implant placement in cylindrical defects with buccal bone fenestrations, as compared to sham sites.

• Osswald, Martin; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2020). "The lucky fibula 2.0". International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(5), s. 875–877. Fulltekst i vitenarkiv
• Brennhovd, Anders; Petrovski, Beata & Hjortsjö, Carl (2020). Benoppbygging før implantatinnsetting – overlevelse og suksess. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 130(10), s. 796–805. Fulltekst i vitenarkiv
• Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2020). Dental student implant education. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(6), s. 1072–1075. Fulltekst i vitenarkiv
• Seitz, Elke; Hjortsjö, Carl; Dahl, Jon Einar & Saxegaard, Erik (2020). Dentin to dentin adhesion using combinations of resin cements and adhesives from different manufacturers - a novel approach. Biomaterial Investigations in Dentistry. 7(1), s. 96–104. doi: 10.1080/26415275.2020.1793677. Fulltekst i vitenarkiv Vis sammendrag

  Aims The aims of this study were to present a novel method to analyse dentin bond strength and to evaluate the bond strength of combining adhesive systems and resin cement from different manufacturers. Methods Human wisdom teeth were ground flat to the dentin on parallel surfaces and axially cut into two parts. Dentin cylinders (Ø 3 mm) were drilled from one half of each tooth. The other half from each tooth was embedded in epoxy resin with the dentin surface exposed. The specimens were ground with silicone carbide paper and the dentin cylinders were cemented onto the dentin surface of the other half of the same tooth. Materials: Resin cement and adhesive systems from three different manufacturers were used in various combinations (n = 8 per group). Cement and adhesive from the same manufacturer served as control. Shear bond strength (SBS) was measured and fracture modes were registered. Results and conclusions: The highest median SBS value was found in a bonding combination between cement and a non-corresponding adhesive (33.1 MPa) and one of the lowest values was found in one of the controls (15.3 MPa). Cohesive fractures were most frequent. The results indicated that combining adhesive and cement from different manufacturers did not compromise the dentin bonding. The novel test method is recommended for evaluating dentin bonding.

• Haugen, Håvard Jostein; Soltvedt, Brandon Michael; Nguyen, Peter Haitrieu; Rønold, Hans Jacob & Johnsen, Gaute Floer (2020). Discrepancy in alloy composition of imported and non-imported porcelain-fused-to-metal (PFM) crowns produced by Norwegian dental laboratories. Biomaterial Investigations in Dentistry. doi: 10.1080/26415275.2020.1724512. Fulltekst i vitenarkiv Vis sammendrag

  Even though the use of full ceramic crowns have become a well-established practice in dental clinics compare to the last decade, the use of imported casted porcelain-fused-to-metal (PFMs) crowns is still prevalent. The use of imported PFMs is often economically driven; however, when dentists order PFMs, they do not have capabilities to examine its true alloy content. Therefore, we raise the questions whether cheaper imported PFMs have more discrepancies in alloy content compared to domestically produced PFMs? This study included 62 porcelain-fused-to-metal crowns: 41 produced in Norway and 21 imported. Their alloy-composition was determined non-destructively by EDX and SEM. Imported PFMs demonstrated larger deviations compared with non-imported PFMs. Significant deviation was found in key metallic elements in the different alloys (W, In, Pd, Ag). The detected deviations in key element such as Wolfram and Indium could influence the PFMs service time. These finding may be of international concern.

• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Huynh-Ba, Guy; Estafanous, Emad & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2020). Enhancing Implant Stability with Osseodensification: Remember That Biology Happens! International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(3), s. 457–460. Fulltekst i vitenarkiv
• Huynh-Ba, Guy; Estafanous, Emad; Ellingsen, Jan Eirik; Oates, Thomas; Osswald, Martin & Chvartszaid, David [Vis alle 7 forfattere av denne artikkelen] (2020). Antibiotics and Implant Therapy Revisited. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(2), s. 244–247. Fulltekst i vitenarkiv
• Estafanous, Emad; Chvartszaid, David; Ellingsen, Jan Eirik; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2020). Effect of Medications/Chemotherapy on Osseointegration. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(1), s. 15–21. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2020). Impact of Tobacco Smoking on Peri-implantitis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 35(4), s. 671–673. Fulltekst i vitenarkiv
• Skjerven, Henrik; Olsen-Bergem, Heming; Rønold, Hans Jacob; Riis, Ulf Harald & Ellingsen, Jan Eirik (2019). Comparison of postoperative intraoral scan versus cone beam computerised tomography to measure accuracy of guided implant placement—A prospective clinical study. Clinical Oral Implants Research. ISSN 0905-7161. 30(6), s. 531–541. doi: 10.1111/clr.13438. Fulltekst i vitenarkiv
• Oates, Thomas; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2019). Understanding the Role of Titanium Particles and Corrosion in Peri-implantitis. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(3), s. 561–564. Fulltekst i vitenarkiv
• Huynh-Ba, Guy; Chvartszaid, David; Ellingsen, Jan Eirik; Estafanous, Emad; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2019). Oral Implants Made of Zirconia: An Update for 2019. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(2), s. 307–310. Fulltekst i vitenarkiv
• Sanz, Mariano; Dahlin, Christer; Apatzidou, Danae; Artzi, Zvi; Bozic, Darco & Calciolari, Elena [Vis alle 19 forfattere av denne artikkelen] (2019). Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology. ISSN 0303-6979. 46(21), s. 82–91. doi: 10.1111/jcpe.13123. Fulltekst i vitenarkiv Vis sammendrag

  Background and Aims To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies. Material and Methods Four background review publications served to elaborate this consensus report. Results and Conclusions Biomaterials used as bone grafts must meet specific requirements: biocompatibility, porosity, osteoconductivity, osteoinductivity, surface properties, biodegradability, mechanical properties, angiogenicity, handling and manufacturing processes. Currently used biomaterials have demonstrated advantages and limitations based on the fulfilment of these requirements. Similarly, membranes for guided bone regeneration (GBR ) must fulfil specific properties and potential biological mechanisms to improve their clinical applicability. Pre‐clinical and clinical studies have evaluated the added effect of bone morphogenetic proteins (mainly BMP ‐2) and autologous platelet concentrates (APC s) when used as bioactive agents to enhance bone regeneration. Three main approaches using cell therapies to enhance bone regeneration have been evaluated: (a) “minimally manipulated” whole tissue fractions; (b) ex vivo expanded “uncommitted” stem/progenitor cells; and (c) ex vivo expanded “committed” bone‐/periosteum‐derived cells. Based on the evidence from clinical trials, transplantation of cells, most commonly whole bone marrow aspirates (BMA ) or bone marrow aspirate concentrations (BMAC ), in combination with biomaterial scaffolds has demonstrated an additional effect in sinus augmentation and horizontal ridge augmentation, and comparable bone regeneration to autogenous bone in alveolar cleft repair.

• Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein; Rinna, Alessandra; Ellingsen, Jan Eirik & Reseland, Janne Elin (2019). Hydrofluoric acid treatment of titanium surfaces enhance the proliferation of human gingival fibroblasts. Journal of Tissue Engineering. 10. doi: 10.1177/2041731419828950. Fulltekst i vitenarkiv Vis sammendrag

  The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts (HGF). HGF cells were exposed to hydrofluoric acid (HF) modified Ti coins (Ti-F) for 1, 3, 7, 14 and 21d, and untreated coins were used as controls. A 5-6 fold increase in the proliferation of HGF on Ti-F compared to Ti surfaces was observed. Enhanced gene expression of IL-6 and OPG was found at 7 d. Increased levels of sclerostin, IL- 6 and OPG in the media from HGF cultured on Ti-F coins were found compared to controls. Our results confirm that HF modified surface may indirectly enhance the firm attachment of implant surface to junction epithelium, soft tissue epithelium, which would give protection for underlying osseous structures making osseointegration of the dental implant possible.

• Skjerven, Henrik; Riis, Ulf Harald; Herlofson, Bente Brokstad & Ellingsen, Jan Eirik (2019). In Vivo Accuracy of Implant Placement Using a Full Digital Planning Modality and Stereolithographic Guides. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(1), s. 124–132. doi: 10.11607/JOMI.6939. Fulltekst i vitenarkiv
• Sagen, Mina Aker; Kvam, Ketil; Ruyter, Ivar Eystein & Rønold, Hans Jacob (2019). Debonding mechanism of zirconia and lithium disilicate resin cemented to dentin. Biomaterial Investigations in Dentistry. 5(1), s. 22–29. doi: 10.1080/23337931.2018.1561188. Fulltekst i vitenarkiv Vis sammendrag

  To evaluate debonding mechanism of zirconia and lithium disilicate cemented to dentin mimicking what could occur in a clinical setting. A null hypothesis of no difference in tensile bond strength between groups of zirconia and lithium disilicate cemented with resin cements was also tested. Zirconia rods (n = 100) were randomly assigned to two different surface treatment groups; air borne particle abrasion and hot etching by potassium hydrogen difluoride (KHF2). Lithium disilicate rods (n = 50) were surface etched by hydrofluoric acid (HF). Five different dual cure resin cements were used for cementing rods to bovine dentin. Ten rods of each test group were cemented with each cement. Test specimens were thermocycled before tensile bond strength testing. Fracture morphology was visualized by light microscope. Mean surface roughness (Sa value) was calculated for randomly selected rods. Cohesive fracture in cement was the most frequent observed fracture morphology. Combination of adhesive and cohesive fractures were second most common. Fracture characterized as an adhesive between rod and cement was not observed for KHF2 etched zirconia. Highest mean tensile bond strength was observed when cementing air borne particle abraded zirconia with Variolink Esthetic (Ivoclar Vivadent). All surface treatments resulted in Sa values that were significant different from each other. The number of cohesive cement fractures observed suggested that the cement was the weakest link in bonding of zirconia and lithium disilicate.

• Nilsson, Andree; Johansson, Lars-Åke; Stenport, Victoria; Wennerberg, Ann & Ekfeldt, Anders (2019). Infraposition of anterior maxillary implant-supported single-tooth restorations in adolescent and adult patients-A prospective follow-up study up to 6 years. Clinical Implant Dentistry and Related Research. ISSN 1523-0899. doi: 10.1111/cid.12818. Fulltekst i vitenarkiv
• Stanford, Clark M.; Estafanous, Emad W.; Osswald, Martin; Ellingsen, Jan Eirik; Oates, Thomas W. & Huynh-Ba, Guy [Vis alle 7 forfattere av denne artikkelen] (2019). THEMATIC. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 34(1), s. 17–21. Fulltekst i vitenarkiv
• Ohrvik, Hanne Gran & Hjortsjö, Carl (2019). Retrospective study of patients with amelogenesis imperfecta treated with different bonded restoration techniques. Clinical and Experimental Dental Research. doi: 10.1002/cre2.243. Fulltekst i vitenarkiv Vis sammendrag

  Objective The aim of this retrospective study was to evaluate clinical success and satisfaction of patients with amelogenesis imperfecta treated with three different types of bonded restorations at a university clinic. Materials and Methods One hundred fifty‐four restorations in 15 subjects with mean age of 17.3 years (SD 8.2) were evaluated after treatment with three different types of bonded restorations: all ceramic enamel‐dentin bonded restorations, prefabricated composite veneers, and direct composite resin restorations. A modified version of the Californian Dental Association system for quality evaluation of dental care and a questionnaire assessing patient satisfaction were used for classification. The restorations were evaluated with respect to patient satisfaction, esthetics, technical, and biological complications. Results Mean observation period for the restorations was 42.5 months (SD 35.6). All restorations were in place at the time of the examination. Surface and color calibration showed a success of 95% for the ceramic enamel‐dentin bonded restorations, 44% for the direct composite resin restorations, and 0% for the prefabricated composite veneers. The same pattern was evident for anatomy and marginal integrity. The subjects reported a high degree of satisfaction with both the esthetics and function of their restorations. Conclusion The results indicated that all ceramic restorations demonstrated the best results for patients with amelogenesis imperfecta.

• Eliassen, Morten; Hjortsjö, Carl; Olsen-Bergem, Heming & Bjørnland, Tore (2019). Self-exercise programmes and occlusal splints in the treatment of TMD-related myalgia – Evidence-based medicine? Journal of Oral Rehabilitation. ISSN 0305-182X. s. 1–7. doi: 10.1111/joor.12856. Fulltekst i vitenarkiv Vis sammendrag

  Background The low‐cost and reversible treatments concerning disorders of the masticatory muscles represent a vast array of regimens. Common treatments include information, stretching exercises, manual therapy, acrylic splints and cognitive behavioural therapy. Objective The aim of this study was to evaluate the evidence behind the use of self‐exercising programmes and occlusal splints in the treatment of myofascial pain. Methods We conducted a thorough search of five databases, using four cardinal search terms in combination with twelve supporting terms. We also assessed the evidence quality, using GRADEpro software. Results The search resulted in 4967 individual studies. 18 studies met the inclusion criteria and were re‐evaluated. Conclusion The selected studies were in favour of a self‐care or an occlusal splint treatment of myalgia. However, a GRADE assessment showed that 14 of the 18 selected studies had low or very low evidence quality. Studies also showed weaknesses with regard to nomenclature and reproducibility. Hence, it is our professional opinion that the evidence level for prescribing self‐exercises and occlusal splints in the treatment of myalgia is low.

• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences. ISSN 0909-8836. 127(6), s. 500–507. doi: 10.1111/eos.12654. Fulltekst i vitenarkiv Vis sammendrag

  Radiotherapy to the head and neck region negatively influences the osseointegration and survival of dental implants. The effects of cobalt 60 (60Co) ionizing radiation and the impact of backscatter rays were investigated on human mesenchymal stem cells cultured on titanium surfaces. Bone marrow‐derived human mesenchymal stem cells were seeded on titanium (Ti), fluoride‐modified titanium (TiF), and tissue culture plastic. Cells were exposed to ionizing γ ‐radiation in single doses of 2, 6, or 10 Gy using a 60Co source. Density and distribution of cells were evaluated using confocal laser‐scanning microscopy, 21 d post‐irradiation. Lactate dehydrogenase concentration and the levels of total protein and cytokines/chemokines were measured in the cell‐culture medium on days 1, 3, 7, 14, and 21 post‐irradiation. Unirradiated cells were used as the control. Irradiation had no effect on cell viability, collagen and actin expression, or cell distribution, but induced an initial increase in the secretion of interleukin (IL )‐6, IL ‐8, monocyte chemotactic protein 1 (MCP ‐1), and vascular endothelial growth factor (VEGF ), followed by a decrease in secretion after 3 or 7 d. Irradiation resulted in secretion of a lower amount of all analytes examined compared with controls on day 21, irrespective of radiation dose and growth surface. Backscattering from titanium did not influence the cell response significantly, suggesting a clinical potential for achieving successful osseointegration of dental implants placed before radiotherapy.

• Sailer, Irena; Muhlemann, Sven; Kohal, Ralf J.; Spies, Benedikt C.; Pjetursson, Bjarni E. & Lang, Niklaus P. [Vis alle 15 forfattere av denne artikkelen] (2018). Reconstructive aspects: Summary and consensus statements of group 3. The 5th EAO Consensus Conference 2018. Clinical Oral Implants Research. ISSN 0905-7161. 29(Oct), s. 239–242. doi: 10.1111/clr.13302. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: The tasks of this working group were to evaluate the existing evidence on the efficiency and efficacy of the digital and conventional workflows for the fabrication of fixed implant reconstructions, to assess the performance of all‐ceramic fixed implant reconstructions and, finally, to evaluate the outcomes of internally and externally connected implant abutments and reconstructions. Methods: Four reviews were available analyzing the current literature on the respective topics. One review dealt with the efficiency and efficacy of digital and conventional fabrication workflows. Two reviews analyzed the outcomes of all‐ceramic fixed implant reconstructions, one focusing on single‐implant reconstructions and the other evaluating multiple‐unit implant fixed dental prostheses (FDPs). The fourth review evaluated the clinical outcome on external, respectively, internal implant‐abutment connections. These reviews were the basis for the discussions within the group and at the plenary sessions. Results: The present consensus report gives the consensus statements, the clinical recommendations, and the implications for future research as discussed and approved by the plenum of the consensus conference. The four manuscripts by Mühlemann et al., Rabel et al., Pieralli et al., and Pjetursson et al. are published as part of the journal supplement of the present EAO consensus conference.

• Berntsen, Christian Skoe; Kleven, Martin; Heian, Marianne & Hjortsjø, Carl (2018). Clinical comparison of conventional and additive manufactured stabilization splints. Acta Biomaterialia Odontologica Scandinavica. 4(1), s. 81–89. doi: 10.1080/23337931.2018.1497491. Fulltekst i vitenarkiv Vis sammendrag

  The aim of this study was to compare conventional and digital additive manufacturing of hard occlusal stabilization splints (SS) using technical and clinical parameters. 14 subjects were subjected to DC/TMD Axis I clinical examination protocol and Axis II questionnaire. The subjects underwent treatment with splints over a period of 12 weeks. All subjects underwent both conventional alginate impression and intraoral digital scanning. Seven subjects received conventional manufactured stabilization splints (CM-SS), and seven subjects received CAD-CAM additive manufactured stabilization splints (AM-SS). 12 subjects completed the 12 weeks follow-up period. The subjects significantly preferred digital intraoral scanning compared to conventional alginate impression. There was a significant difference in VAS between CM-SS and AM-SS. The mean VAS result was 15 for AM-SS and 42 for CM-SS, 0 represented excellent comfort and 100 very uncomfortable. This was significant. Splint manufacturing method had no influence on treatment outcome. There was no significant difference in mean delta change for unassisted jaw opening from baseline to 12 weeks between the two groups, for CM-SS it was 2 mm difference and for AM-SS the difference was 3 mm. All subjects in both treatment groups showed improved oral function. In this study, the scanning procedure is more accepted by the subjects than alginate impressions, however the first procedure was more time consuming.

• Stanford, Clark; Chvartszaid, David; Huynh-Ba, Guy; Ellingsen, Jan Eirik; Oates, Thomas & Estafanous, Emad [Vis alle 7 forfattere av denne artikkelen] (2018). Implant-Retained Removable Partial Dentures: A Reliable Alternative Line of Treatment. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(1), s. 17–20. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy; Oates, Thomas & Osswald, Martin [Vis alle 7 forfattere av denne artikkelen] (2018). Dental Implant Treatment of Atrophic Arches With or Without Augmentation. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 33(4), s. 735–739. Fulltekst i vitenarkiv
• Dahl, Bjørn Einar; Dahl, Jon Einar & Rønold, Hans Jacob (2018). Internal fit of three-unit fixed dental prostheses produced by computer-aided design/computer-aided manufacturing and the lost-wax metal casting technique assessed using the triple-scan protocol. European Journal of Oral Sciences. ISSN 0909-8836. 126(1), s. 66–73. doi: 10.1111/eos.12394. Fulltekst i vitenarkiv Vis sammendrag

  Suboptimal adaptation of fixed dental prostheses (FDPs) can lead to technical and biological complications. It is unclear if the computer-aided design/computer-aided manufacturing (CAD/CAM) technique improves adaptation of FDPs compared with FDPs made using the lost-wax and metal casting technique. Three-unit FDPs were manufactured by CAD/CAM based on digital impression of a typodont model. The FDPs were made from one of five materials: pre-sintered zirconium dioxide; hot isostatic pressed zirconium dioxide; lithium disilicate glass-ceramic; milled cobalt-chromium; and laser-sintered cobalt-chromium. The FDPs made using the lost-wax and metal casting technique were used as reference. The fit of the FDPs was analysed using the triple-scan method. The fit was evaluated for both single abutments and three-unit FDPs. The average cement space varied between 50 μm and 300 μm. Insignificant differences in internal fit were observed between the CAD/CAM-manufactured FDPs, and none of the FPDs had cement spaces that were statistically significantly different from those of the reference FDP. For all FDPs, the cement space at a marginal band 0.5–1.0 mm from the preparation margin was less than 100 μm. The milled cobalt-chromium FDP had the closest fit. The cement space of FDPs produced using the CAD/CAM technique was similar to that of FDPs produced using the conventional lost-wax and metal casting technique.

• Córdoba, Alba; Manzanaro-Moreno, Nahuel; Colom, Carme; Rønold, Hans Jacob; Lyngstadaas, Ståle Petter & Monjo, Marta [Vis alle 7 forfattere av denne artikkelen] (2018). Quercitrin Nanocoated Implant Surfaces Reduce Osteoclast Activity In Vitro and In Vivo. International Journal of Molecular Sciences. ISSN 1661-6596. 19(11). doi: 10.3390/ijms19113319. Fulltekst i vitenarkiv Vis sammendrag

  In this study, the effect on osteoclast activity in vitro and in vivo of titanium implants that were coated with quercitrin was evaluated. Titanium surfaces were covalently coated with the flavonoid quercitrin. The effect of the surfaces on osteoclastogenesis was first tested in vitro on RAW264.7 cells that were supplemented with receptor activator of nuclear factor kappa-B ligand (RANKL) to generate osteoclast-like cells by tartrate-resistant acid phosphatase (TRAP) inmunostaining after five days of culture, and by analysis of the mRNA expression levels of markers related to bone resorption after seven days of culture. A rabbit tibial model was used to evaluate the in vivo biological response to the implant surfaces after eight weeks of healing, analyzing the lactate dehydrogenase (LDH) and the alkaline phosphatase (ALP) activities in the wound fluid that were present at the implant interface and the peri-implant bone mRNA expression levels of several markers related to inflammation, bone resorption and osteoblast-osteoclast interaction. No differences between groups and control surfaces were found in the wound fluid analyses. Moreover, quercitrin implant surfaces significantly decreased the expression of osteoclast related genes in vitro (Trap, CalcR, Ctsk, H+ATPase, Mmp9) and in vivo (Ctsk, H+ATPase, Mmp9) as well as the expression of RankL in vivo. Moreover, quercitrin surfaces were not cytotoxic for the cells. Thus, quercitrin implant surfaces were biocompatible and decreased osteoclastogenesis in vitro and in vivo. This could be used to improve the performance of dental implants.

• Hjortsjø, Carl (2018). Bittskinnebehandling. I Julsvoll, Elisabeth Heggem (Red.), Temporomandibulær dysfunksjon: Teori, undersøkelse og behandling. Cappelen Damm Akademisk. ISSN 9788202557799. s. 224–236. Fulltekst i vitenarkiv
• Verket, Anders; Lyngstadaas, Ståle Petter; Tiainen, Hanna; Rønold, Hans Jacob & Wohlfahrt, Johan Caspar (2018). Impact of particulate deproteinized bovine bone mineral and porous titanium granules on early stability and osseointegration of dental implants in narrow marginal circumferential bone defects. International Journal of Oral & Maxillofacial Surgery. ISSN 0901-5027. 47(8), s. 1086–1094. doi: 10.1016/j.ijom.2018.02.007. Fulltekst i vitenarkiv Vis sammendrag

  The use of two particulate bone graft substitute materials in experimental narrow marginal peri-implant bone defects was investigated with respect to early bone healing and implant stability. Porous titanium granules, oxidized white porous titanium granules (WPTG), and demineralized bovine bone mineral (DBBM) were characterized in vitro, after which the two latter materials were tested in experimental peri-implant bone defects in six minipigs, with empty defects as control. After mandibular premolar extraction, the top 5 mm of the alveoli were widened to 6 mm in diameter, followed by the placement of six implants, three on each side, in each pig. Six weeks of healing was allowed. The WPTG showed better mechanical properties. No significant differences in resonance frequency analysis were found directly after compacting or healing, and similar quantities of defect bone formation were observed on micro-computed tomography for all groups. Histomorphometric analysis demonstrated a more coronal bone-to-implant contact in the DBBM group, which also displayed more defect bone fill as compared to the WPTG group. The better mechanical properties observed for WPTG appear of negligible relevance for the early stability and osseointegration of implants.

• Satué, María; Monjo, Marta; Rønold, Hans Jacob; Lyngstadaas, Ståle Petter & Ramis, Joana M. (2017). Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: in vivo performance and coating stability. Clinical Oral Implants Research. ISSN 0905-7161. 28(4), s. 424–431. doi: 10.1111/clr.12815. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2017). Challenging paradigms: Update on the use of dental implant therapy for patients With diabetes mellitus. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(3), s. 477–479. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2017). Dental Implants in the Posterior Mandible: Complications and Management. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(1), s. 20–22. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2017). Immediate Implant Placement and Restoration: An Update. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(2), s. 245–248. Fulltekst i vitenarkiv
• Chvartszaid, David; Stanford, Clark; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2017). Implants and the Spectrum of Aging. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(5), s. 965–968. Fulltekst i vitenarkiv
• Osswald, Martin; Stanford, Clark; Ellingsen, Jan Eirik; Chvartszaid, David; Estafanous, Emad & Huynh-Ba, Guy [Vis alle 7 forfattere av denne artikkelen] (2017). The Lucky Fibula. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(6), s. 1215–1217. Fulltekst i vitenarkiv
• Ellingsen, Jan Eirik; Stanford, Clark; Chvartszaid, David; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2017). Implantoplasty: A Valuable Method for the Management of Peri-implantitis? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(4), s. 711–714. Fulltekst i vitenarkiv
• Dahl, Bjørn Einar; Rønold, Hans Jacob & Dahl, Jon Einar (2017). Internal fit of single crowns produced by CAD/CAM and lost-wax metal casting technique assessed by the triple-scan protocol. The Journal of prosthetic dentistry (Print). ISSN 0022-3913. 117(3), s. 400–404. doi: 10.1016/j.prosdent.2016.06.017. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: To digitally study the internal fit of single crown fixed dental prostheses produced by CAD/CAM and by lost-wax and metal casting techniques. Methods: On an upper jaw simulator with KaVo typodont teeth, the left insisor was prepared for single crown. Impression and scans were taken and three copings were manufactured from each group: milled pre-sintered zirconia, milled hot isostatic pressed zirconia, milled lithium disilicate, milled cobalt-chromium, and laser-sintered cobalt- chromium using CAD/CAM technique and cobalt-chromium by the conventional lost-wax and metal casting technique. The internal fit of crowns produced by CAD/CAM technique was compared to crowns produced by metal casting technique. The internal fit was evaluated in buccal-palatinal and in mesio-distal directions using the triple-scan protocol and GOM Inspect software. Results: The internal gaps in mesio-distal and buccal-palatinal directions were statistically smaller for crowns made by conventional lost-wax and metal casting technique compared to crowns produced by CAD/CAM technique (Table 1). Conclusions: The triple-scan method revealed that single crowns made by lost-wax and metal casting technique had better internal fit than crowns produced by CAD/CAM technique.

• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2016). Do We Get Improved Precision of Implant Fixed Dental Prostheses with Digital Scanners and Computer-Aided Design/Computer-Assisted Manufacture? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(4), s. 743–747. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2016). Antibiotics and implant therapy. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(2), s. 273–277. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2016). Implant therapy: When are we helping Our patients? International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(3), s. 513–515. Fulltekst i vitenarkiv
• Stanford, Clark; Estafanous, Emad; Oates, Thomas; Osswald, Martin; Huynh-Ba, Guy & Ellingsen, Jan Eirik [Vis alle 7 forfattere av denne artikkelen] (2016). The Jedi dark side of implant therapy? Peri implant disease(s: Recent updates on prevalence and etiology. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 31(1), s. 17–22. Fulltekst i vitenarkiv
• Olsen-Bergem, Heming; Kristoffersen, Anne Karin; Bjørnland, Tore; Reseland, Janne Elin & Aas, Jørn Arne (2016). Juvenile idiopathic arthritis and rheumatoid arthritis: Bacterial diversity in temporomandibular joint synovial fluid in comparison with immunological and clinical findings. International Journal of Oral & Maxillofacial Surgery. ISSN 0901-5027. 45(3), s. 318–322. doi: 10.1016/j.ijom.2015.08.986. Fulltekst i vitenarkiv
• Chvartszaid, David; Stanford, Clark; Ellingsen, Jan Eirik; Estafanous, Emad; Huynh-Ba, Guy & Oates, Thomas [Vis alle 7 forfattere av denne artikkelen] (2016). Implant Failure. International Journal of Oral & Maxillofacial Implants. ISSN 0882-2786. 32(6), s. 1233–1236. Fulltekst i vitenarkiv
• Printzell, Lisa; Haseid, Carl Fredrik; Ekfeldt, Anders & Hjortsjø, Carl (2016). Clinical performance of enamel-dentine bonded all-ceramic restorations: retrospective evaluation in a postgraduate clinic. Swedish Dental Journal. ISSN 0347-9994. 40, s. 203–212. Fulltekst i vitenarkiv

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• Lauretis, Angela de; Santacroce, Marco; Hussain, Badra; Ma, Qianli; Ellingsen, Jan Eirik & Lyngstadaas, Ståle Petter [Vis alle 8 forfattere av denne artikkelen] (2025). A poloxamer-peroxide forumulation effectively removes pellicle and limits recontamination. Fulltekst i vitenarkiv
• Lauretis, Angela de; Hussain, Badra; Ma, Qianli; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2024). A comparative evaluation of chemical decontamination products on the cleanliness of dental implant surfaces using a dental pellicle model. Fulltekst i vitenarkiv Vis sammendrag

  Dental implants are widely employed for tooth replacement, but complications such as peri-implant infections may arise due to bacterial adhesion and biofilm formation, facilitated by the protein-rich salivary pellicle formed on the implant surface. Ensuring the cleanliness of the implant surface is crucial for long-term success and maintenance of peri-implant health.

• Lauretis, Angela de; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2024). Decontamination dental implant surfaces using a dental pellicle mode. Fulltekst i vitenarkiv
• Lauretis, Angela De; Hussain, Badra; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein (2024). A comparative evaluation of chemical decontamination products on the cleanliness of dental implant surfaces using a dental pellicle model. Fulltekst i vitenarkiv
• Hussain, Badra; Lyngstadaas, Ståle Petter; Ellingsen, Jan Eirik & Haugen, Håvard Jostein (2024). A Comparative Investigation Of Chemical Decontamination Methods For In Situ Cleaning Of Dental Implant Surfaces. Fulltekst i vitenarkiv
• Khan, Sadia Nazir; Koldsland, Odd Carsten & Hjortsjö, Carl (2019). Bacteriostatic effect of filling materials used in implant-abutment-screw-channel: A pilot study. Fulltekst i vitenarkiv
• Johansson, Anders; Bjorvatn, Bjørn; Saxegaard, Erik; Gjerde, Kjersti; Berge, Morten Eirik & Lehmann, Sverre [Vis alle 7 forfattere av denne artikkelen] (2018). Stor interesse for odontologisk søvnmedisin og søvnapné i Norge. Den norske tannlegeforenings Tidende. ISSN 0029-2303. 128(3), s. 202–204. Fulltekst i vitenarkiv
• Hove, Lene Hystad; Young, Alix; Hjortsjø, Carl; Stevning, Karen & Løvik, Sara Emilie (2017). Effect of Whitening Toothpastes on Dental Enamel In Vitro. Fulltekst i vitenarkiv
• Dahl, Bjørn Einar; Rønold, Hans Jacob & Dahl, Jon Einar (2017). Internal Fit of Fixed Dental Prostheses Made From Zirconia. Fulltekst i vitenarkiv
• Sagen, Mina Aker; Kvam, Ketil; Ruyter, Eystein I.; Dahl, Jon Einar & Rønold, Hans Jacob (2017). Adhesion of Surface Modified Zirconia to Dentin Using Resin Cement. Fulltekst i vitenarkiv
• Dahl, Bjørn Einar (2017). Internal fit of FDPs made from different types of zirconia
. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: To compare the internal fit of 3-unit fixed dental prostheses (FDP) made from two types of zirconia using the digital triple-scan protocol. Methods: On an upper jaw simulator with KaVo typodont teeth the right first molar and first premolar was prepared for 3-unit FDP. Digital impression was taken and three copings were manufactured from each group; milled hot isostatic pressed zirconia and milled pre-sintered zirconia using CAD/CAM technique. The internal fit of the FDPs of the two groups was evaluated in buccal-palatal and distal-mesial directions using the triple-scan protocol described by Holst et al. and GOM Inspect software. The statistical analysis was performed with a spreadsheet (Excel 2011 for Mac v14.6.2; Microsoft Corp) using the Student t test (α=.05). Results: The internal gaps in buccal-palatal and distal-mesial directions were larger than the manufacturer´s settings for the production of the copings. No statistically significant differences were observed between the different materials and between first molar and first premolar copings. Conclusions: The triple-scan method revealed that the internal fit of FDPs made by milled hot isostatic pressed zirconia and milled pre-sintered zirconia were not statistically significant different.

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