Håvard Hynne

• Hynne, Håvard; Tashbayev, Behzod; Diep, My Tien; Sødal, Anne Thea Tveit; Badian, Reza A. & Chen, Xiangjun [Vis alle 10 forfattere av denne artikkelen] (2022). The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-13985-6. Fulltekst i vitenarkiv
• Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind & Amdal, Cecilie Delphin [Vis alle 10 forfattere av denne artikkelen] (2022). Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients. International Journal of Molecular Sciences. ISSN 1661-6596. 23(7). doi: 10.3390/ijms23073714.
• Chen, Xiangjun; Badian, Reza; Hynne, Håvard; Tashbayev, Behzod; Hove, Lene Hystad & Jensen, Janicke Liaaen [Vis alle 7 forfattere av denne artikkelen] (2022). Morphology of Meibomian Glands in A 65‐Year‐Old Norwegian Population without Dry Eye Disease. Journal of Clinical Medicine. ISSN 2077-0383. 11(3). doi: 10.3390/jcm11030527.
• Hynne, Håvard; Mørk Sandås, Elise; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Utheim, Tor Paaske & Galtung, Hilde [Vis alle 7 forfattere av denne artikkelen] (2022). Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjögren’s Syndrome. Cells. ISSN 2073-4409. 11(3). doi: 10.3390/cells11030323.
• Chen, Xiangjun; Badian, Reza; Hynne, Håvard; Amdal, Cecilie Delphin; Herlofson, Bente Brokstad & Utheim, Øygunn Aass [Vis alle 10 forfattere av denne artikkelen] (2021). Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer. Scientific Reports. ISSN 2045-2322. 11:22419, s. 1–7. doi: 10.1038/s41598-021-01844-9. Fulltekst i vitenarkiv
• Westgaard, Kristine Løken; Hynne, Håvard; Amdal, Cecilie Delphin; Young, Alix; Singh, Preet Bano & Chen, Xiangjun [Vis alle 12 forfattere av denne artikkelen] (2021). Oral and ocular late effects in head and neck cancer patients treated with radiotherapy. Scientific Reports. ISSN 2045-2322. 11:4026, s. 1–11. doi: 10.1038/s41598-021-83635-w. Fulltekst i vitenarkiv
• Aqrawi, Lara A.; Chen, Xiangjun; Hynne, Håvard; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten [Vis alle 14 forfattere av denne artikkelen] (2020). Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways. Cells. ISSN 2073-4409. 9(9). doi: 10.3390/cells9092050. Fulltekst i vitenarkiv

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• Hynne, Håvard; Sandås, Elise Mørk; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Galtung, Hilde Kanli & Utheim, Tor Paaske [Vis alle 7 forfattere av denne artikkelen] (2021). Metabolomics Identify Patterns Indicating Potential Biomarkers in Primary Sjögren’s Syndrome .
• Hynne, Håvard; Aqrawi, Lara A.; Chen, Xiangjun; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten [Vis alle 14 forfattere av denne artikkelen] (2021). Cytokine profiling, clinical oral and ocular manifestations post radiotherapy .
• Jensen, Janicke Liaaen; Chen, Xiangjun; Hynne, Håvard; Westgaard, Kristine Løken; Hove, Lene Hystad & Young, Alix [Vis alle 14 forfattere av denne artikkelen] (2019). Sjögren’s versus irradiated head-neck cancer patients: oral and ocular investigations.
• Hynne, Håvard; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Amdal, Cecilie Delphin; Hove, Lene Hystad & Young, Alix [Vis alle 10 forfattere av denne artikkelen] (2019). Oral and Ocular Findings in Radiated Head-and Neck Cancer Patients.
• Young, Alix; Singh, Preet Bano; Hynne, Håvard; Løken Westergaard, Kristine; Hove, Lene Hystad & Rykke, Morten [Vis alle 10 forfattere av denne artikkelen] (2019). Oral Investigations in Head and Neck Cancer Patients after Radiotherapy. Vis sammendrag

  Objectives: To investigate oral complaints and findings in head and neck cancer (HNC) patients who had received radiotherapy and compare them with controls. Methods: As part of a larger study, 30 HNC patients (14 female, age 64.2±9.6y) and 26 age- and sex-matched controls (13 female, 62.9±12.9y, p=0.850) were examined at the Dry Mouth Clinic, Faculty of Dentistry, Oslo. Oral health-related quality of life (OHRQoL) was assessed using the short form Oral Health Impact Profile (OHIP-14: high score-low OHRQoL). Self-reported dysgeusia (yes/no) and sense of taste (10-point VAS: high score-good smell sense) were recorded. Taste scores were recorded using taste strips (high score-good taste function). Oral candida counts were determined from cheek and tongue swabs (0=no growth, 1=minimal, 2=moderate, 3=severe). Volatile sulphur compounds (VSC) in mouth air samples were determined by gas chromatography and related to perceptive threshold-levels (H2S≤112ppb, CH3SH≤26ppb). Between-group comparisons were performed using Mann-Whitney U test and Chi-square test. Results: The HNC patients reported significantly poorer OHRQoL than controls (OHIP sum-score: 18.4±12.4 vs 1.2±2.0, p<0.001). They reported significantly poorer sense of taste compared to controls (6.4±2.4 vs 7.8±1.9, p=0.018), and more often dysgeusia (26.7% vs 7.7%, p=0.087). The measured gustatory scores (20.4±6.4 vs 22.3±4.6, p=0.315) were similar for both groups. Candida scores were significantly higher in the patient group (1.6±1.3 vs 0.7±0.9, p=0.024). The percentage of HNC patients who had oral H2S above the threshold level was significantly lower than for the controls (0% vs 27%, p<0.05). This was not the case for CH3SH (5.5% vs 27%, p=0.105). Conclusion: After radiotherapy, these HNC patients experienced negative oral consequences of the treatment. They reported poorer OHRQoL, and had reduced taste sensation and higher oral candida counts. However, the underlying reason for less problems with halitosis in HNC patients than in controls is worth further exploration.

• Hynne, Håvard; Tashbayev, Behzod; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad & Rykke, Morten [Vis alle 14 forfattere av denne artikkelen] (2018). Evaluation of Dry Eye Disease, Oral Dryness and Inflammatory Cytokines in Primary Sjögren´s Syndrome.

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