2019

T-cell receptor in contact with peptide-MHC viewed from the top. T-cell receptor (TCR) molecules on T lymphocytes are essential for the recognition of infectious microorganisms and cancer cells. The recognized molecule is body’s own MHC (HLA in humans) molecules that carry small peptides in their grooves, which contact the variable regions of the TCR.
Publisert 30. sep. 2019 13:56

This article is a theoretical discussion about the diversity of T-cell recognition and how it could be formed. It is a continuation of a previous manuscript published earlier this year (Cohn, Anderson and Dembic in the Scandinavian Journal of Immunology). 

Bildet kan inneholde: barn, baby, ansikt, fotografi, hud.
Publisert 12. sep. 2019 13:45

Døgnrytme, eller kroppens innebygde klokke, påverkar mange av prosessane i kroppen. Døgnrytmen speler òg ei viktig rolle når tannemaljen skal dannast.

Streptococcus pneumoniae growing in petri dishes in the laboratory.
Publisert 21. aug. 2019 09:04

Through hybrid assembly researchers from the University of Oslo and the University of Illinois at Chicago managed to fully sequence and close the genome of the S. pneumoniae serotype 19F strain EF3030.

Bildet kan inneholde: tekst, diagram, linje, plott, parallell.
Publisert 9. aug. 2019 09:49

CRISPR er en type DNA sekvenser som sammen med tilhørende proteiner (Cas) utgjør bakteriers immunforsvar. Porphyromonas gingivalis har 4 ulike CRISPR-Cas systemer som sannsynligvis beskytter den mot tallrike bakterievirus i periodontale lommer.

IL17 Locus on Chromosome 6. Three SNPs used in the analyses, and other genetic factors in their vicinity.
Publisert 8. aug. 2019 11:50

IL-17A and IL-17F are similar pro-inflammatory cytokines found in osteoarthritic joints, and suspected to contribute to development of osteoarthritis.

he T cell receptor – MHC Class II with a peptide interaction is schematically shown.
Publisert 7. aug. 2019 13:49

A recent published review article discusses how T cell receptor (TCR) variable regions (V) might have been naturally selected to recognize self-molecules (MHC) important for presenting foreign pieces of proteins (usually peptides derived from infectious agents like bacteria, viruses and parasites).

Schematic representation of gene regulation during competence in S. pneumoniae and S. mitis.
Publisert 27. mai 2019 14:27

Researchers from the Institute of Oral Biology (IOB) have recently published a mini review article discussing how bacteria from the mitis group of streptococci benefit from natural transformation and why this mechanism is of great importance for them as a group. 

Oppsummerer hvorledes P. gingivalis kan tenkes å gi Alzheimer’s sykdom basert på ulike teorier som er fremsatt i litteraturen
Publisert 25. apr. 2019 13:46

Bakterien Porphyromonas gingivalis ser ut til å kunne spille en viktig rolle for utvikling av Alzheimers sykdom.

Barn får nesespray
Publisert 7. mars 2019 14:33

A groundbreaking research article sheds light on how the oral commensal Streptococcus mitis can be exploited to prevent pneumococcal infections.

Hidden gems identified in the competence for natural transformation in Streptococcus mutans, a bacterium found in the oral cavity and often linked to dental caries.
Publisert 6. feb. 2019 10:47

A new perspective article highlights how bioinformatics tools can help us discover new genes and regulatory circuits in the networks of cell-to-cell-signaling in bacteria.

Publisert 4. feb. 2019 13:16

Stadig flere studier indikerer at periodontitt og Porphyromonas gingivalis kan være viktige faktorer ved utvikling av kreft i munnhule og mage-tarmkanal.

Publisert 28. jan. 2019 13:06

Oppdagelsen av en ny kommunikasjonsvei mellom patogene og ikke-patogene bakterier viser betydningen av å forstå kommunikasjon mellom bakteriearter. 

Publisert 14. jan. 2019 11:06

A new combination of techniques for extracellular vesicle (EV) isolation is developed that is less complicated, time consuming, and harmful to the vesicles compared to existing methods.

Publisert 8. jan. 2019 10:23

Bittesmå blemmer (vesikler) fra periobakterien Porphyromonas gingivalis inneholder bakteriens viktigste virulensfaktorer. Disse vesiklene, som frigjøres fra bakterien, kan på grunn av sin størrelse, trenge inn i hjernen og utløse lesjoner typiske for Alzheimers sykdom.