Merits at the Department of Biomaterials
The Department of Biomaterials has succeeded in attracting considerable funding and acknowledgment over the last ten years with a cumulative funding of 15 million Euros. The department has coordinated several EU and nationally founded project on various type o application from novel bone grafts, implant surface coatings, debridement strategies for infected implants, dental membrane, degradable metals, biomolecule for improved bone healing, soft tissue grafts and others.
We are currently involved in three funded H2020 EU project and three national funded. Here a small summary:
We are currently coordinating OralG -funded by the European Union under the Horizon 2020 Framework Program. The partners in the OralG project are two companies, Régentis-pharma and Corticalis As.The aim of the project is to develop a medical device based on a new patented synthetic bifunctional peptide acting as a non-antibiotic, anti-inflammatory wound-healing agent for protections against severe periodontitis and peri-implantitis.
The H2020 ERA-NET Marine Biotech “BLUETEETH” project focus on the use of chitosan for dental membranes. The project is coordinator by João F. Mano, COMPASS Group (University of Aveiro), where the other partners are Janne Reseland and Håvard Haugen, Már Másson, (University of Iceland) and Dr. Hélène Lauzon, (Primex ehf).
The Department is also participating in an EU-funded Innovative Training Network project MgSafe, "Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants". This project focuses on investigating biodegradable magnesium implants using several complementary imaging techniques. The project brings together more than ten different institutes around Europe in 8 different countries.
InjecTE is a multidisciplinary project assembling international leading researchers (Prof. Ruis Reis/ Prof Manuela Gomes, 3Bs University of Minho, and Prof. Kerstin Galler, University Regensburg) aiming at developing and testing new advanced biomaterials for periodontal and endodontic regeneration. Such materials would have a huge impact in the dental biomaterials field since they would change current healing therapies to regenerative outcomes. Funding is from Norwegian Research Council.
BioNaNOR is a project to develop materials to restore dermal function partners in the project is Prof João Mano, University of Aveiro and Prof. Jonny Blaker, University of Manchester. The BioNaNOR project aims at using a dermis-matrix-mimicking hydrogel based on nano-layered and chemically modified chitosan. This artificial dermis analogue will be designed with one deeper part that provide biological signals for homing and differentiation of mesoderm derived stem cells, and one superficial part that includes molecules that stimulate epithelial cell growth and migration. The funding is from Norwegian Research Council.
Furthermore, the department is and cooperating closely with university academics in the US, UK, Germany, Italy, Spain and France. On average the past ten years we publish around 20 papers and produces 2 PhD a year (as seen below). Several of our researchers have long experience in working with industrial partners (Dentsply Sirona and Straumann) e.g. large industrial development new dental implant surfaces has been carried out by researchers at the department.
Dissertations at the Department of Biomaterials
- Florian Weber - Development of multifunctional polyphenolic coatings for improved peri-implant healing
- Maria H. Pham - Cellular responses to fluoride modified titanium surfaces
- Anne Klemm - Doped TiO2 bone scaffolds - corrosion resistance combined with high compressive strength
- Sigrid Haugen - A study of adiponectin and adiponectin receptor agonist ADP355 on bone and orthodontic tooth movement
- Aman S Chahal - From inert to active: biofunctionalised PEG hydrogels to guide stem cell behaviour
- Manuel Schweikle - Characterisation of mineralised synthetic hydrogel scaffolds for bone repair
- Gaute Floer Johnsen - Contralateral premolars: validation of symmetry
- Maziar G Shabestari - Bone marrow lesions in osteoarthritis: role of angiogenesis and bone turnover
- Øystein Stakkestad - The role of ameloblastin in mesenchymal tissues
- David Wiedmer - TiO2 dark catalysis in biomedical applications
- Sebastian Geissler - Surface functionalization of dental implants for improved biological response and reduced infection risk
- Rivan Sidaly - The role of hypoxia on the formation of dental enamel: a clinical, an experimental animal, and a cell study
- Anders Verket - On surface coatings of titanium-based bone graft materials
- Benjamin Müller - Bone-mimetic TiO2 scaffolds with improved corrosion resistance
- Oscar Villa - Wound healing promoting agents in oral and periodontal surgical procedures
- Helen Pullisaar - Bioinspired ceramic TiO2 scaffolds for bone tissue engineering
- Rui Xing - Enhanced soft tissue integration through abutment surface modification
- Matthias J Frank - Bioactive coating for titanium based bone anchored implants
- Martin S Walter - Surface bioactivation of titanium-zirconium dental implants
- Hanna Tiainen - Ceramic TiO2 scaffolds for bone repair
- Christiane Petzold - UV-induced functionalization of titanium surfaces with a polyunsaturated fatty acid for improved performance of temporary bone fixation devices
- Johan Caspar Wohlfahrt - On the use of titanium based materials as non-resorbable bone substitutes
- Elisabeth Aurstad Riksen - Effects of epigenetic and environmental factors on biomineralization
- Margareth V Tamburstuen - Ameloblastin in mesenchymal cells A study on expression, regulation and putative function of ameloblastin in bone related cells
- Sebastien Taxt-Lamolle - Surface structure, chemistry and bio-performance of titanium implants modified by hydrofluoric acid
- Roya Sabetrasekh - Bone cell growth in artificial scaffolds; the importance of 3D growth, scaffold architecture and surface chemistry
- His Majesty the King's Gold Medal 2021 awarded to Manuel Schweikle for his PhD thesis: Characterisation of mineralised synthetic hydrogel scaffolds for bone repair
- Best Master Thesis Prize 2021 awarded to Victor A. Jankowski for his thesis: Cytotoxic effect and DNA damage of polyphenolic nanocoatings
- S. Petter Lyngstadaas received the 2020 Research Award from the Faculty of Dentistry at University of Oslo
- Student award for outstanding poster presentation at the 30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine in Nagoya 2018 to Anne Klemm for her poster Grain boundary corrosion in Sr and Ca doped TiO2 bone scaffolds
- S. Petter Lyngstadaas received the ScSB research award in recognition of his ground-breaking achievements that have advanced the field of biomaterials at the annual meeting of the Scandinavian Society for Biomaterials (ScSB2018) in Sweden
- His Majesty the King's Gold Medal 2017 awarded to Anders Verket for his PhD thesis: On surface coatings of titanium-based bone graft material
- His Majesty the King's Gold Medal 2015 awarded to Hanna Tiainen for her PhD thesis: Ceramic TiO2 scaffolds for bone repair
- Best poster award at the 8th Annual Meeting of the Scandinavian Society of Biomaterials in Sigulda 2015 to Sandra Recklies for her poster Antibacterial sol-gel coating of ceramic TiO2 scaffolds for bone regeneration by Sandra Recklies, David Wiedmer, Cedric Bossard, and Hanna Tiainen
- European Biomaterials and Tissue Engineering Doctoral Award granted to Hanna Tiainen by the European Society for Biomaterials at ESB2014 in Liverpool
- Best poster award at the 7th Annual Meeting of the Scandinavian Society of Biomaterials in Århus 2014 to David Wiedmer for his poster Antibacterial and antioxidant TiO2 scaffolds for bone regeneration by David Wiedmer, Hanna Tiainen, and Håvard J. Haugen
- His Majesty the King's Gold Medal 2013 awarded to Christiane Petzold for her PhD thesis: UV-induced functionalization of titanium surfaces with a polyunsaturated fatty acid for improved performance of temporary bone fixation devices
- The Norwegian Dental Association's award for teaching and research 2012 to Johan Caspar Wohlfahrt
- His Majesty the King's Gold Medal 2011 awarded to Sebastian Taxt-Lamolle for his PhD thesis: Surface structure, chemistry and bio performance of titanium implants modified by hydrofluoric acid
- Oral Presentation Award 2011 from The Nordic Young Scientist Conference in Dentistry 2011 to Matthias Frank (see interview)
- NOF Hatton Award 2010 for their study: Porous titanium granules in furcation defects- an animal experimental study by J.C. Wohlfart, H.J.Ronold, A.M.Aass, L. Heijl and S.P. Lyngstadaas
- German innovation award for 2009 (Innovationspreis 2009 der Deutschen BioRegionen) to Håvard Haugen, together with co-workers Dr. Aigner, Dr. Perea and Mrs Hofner
- University of Oslo Innovation Prize 2008 to Håvard Haugen, S.P. Lyngstadaas, Jan Eirik Ellingsen and Sébastien Taxt-Lamolle